van Aalten, Daan

Professor

20012022
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  • 13 Similar Profiles
Chitinases Chemical Compounds
Acetylglucosamine Medicine & Life Sciences
Proteins Medicine & Life Sciences
Chitin Medicine & Life Sciences
Enzymes Medicine & Life Sciences
Uridine Diphosphate Medicine & Life Sciences
Substrates Chemical Compounds
Aspergillus fumigatus Medicine & Life Sciences

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Projects 2013 2022

Research Output 2001 2019

Catalytic deficiency of O-GlcNAc transferase leads to X-linked intellectual disability

Pravata, V., Muha, V., Gundogdu, M., Ferenbach, A., Kakade, P., Vandadi, V., Wilmes, A. C., Borodkin, V., Joss, S., Stavridis, M. & van Aalten, D., 11 Jul 2019, In : Proceedings of the National Academy of Sciences. 10 p.

Research output: Contribution to journalArticle

Open Access
File
Intellectual Disability
Host Factor 1 Protein
Catalytic Domain
Missense Mutation
Proteome
28 Downloads (Pure)

Mechanisms of redundancy and specificity of the Aspergillus fumigatus Crh transglycosylases

Fang, W., Sanz, A. B., Galan Bartual, S., Wang, B., Ferenbach, A., Farkaš, V., Hurtado-Guerrero, R., Arroyo, J. & van Aalten, D., 10 Apr 2019, In : Nature Communications. 10, 1, p. 1-10 10 p., 1669.

Research output: Contribution to journalArticle

Open Access
File
Aspergillus
Aspergillus fumigatus
redundancy
Cell Wall
Chitin
12 Citations (Scopus)
84 Downloads (Pure)

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity

Pao, K-C., Wood, N. T., Knebel, A., Rafie, K., Stanley, M., Mabbitt, P. D., Sundaramoorthy, R., Hofmann, K., van Aalten, D. M. F. & Virdee, S., 11 Apr 2018, In : Nature. 556, 7701, p. 381-385 5 p.

Research output: Contribution to journalArticle

Open Access
File
Ubiquitin-Protein Ligases
Esterification
Ubiquitin
Genes
Ubiquitination
1 Citation (Scopus)
58 Downloads (Pure)

Effects of hypo O-GlcNAcylation on Drosophila development

Mariappa, D. N., Ferenbach, A. & van Aalten, D. M. F., 11 May 2018, In : Journal of Biological Chemistry. 293, 19, p. 7209-7221 13 p.

Research output: Contribution to journalArticle

Open Access
File
Clustered Regularly Interspaced Short Palindromic Repeats
Drosophila
Genes
Phenotype
Mediator Complex
40 Downloads (Pure)

Evidence for substrate assisted catalysis in N-acetylphosphoglucosamine mutase

Raimi, O. G., Hurtado Guerrero, R. & van Aalten, D. M. F., 16 Aug 2018, In : The Biochemical journal. 475, 15, p. 2547-2557 11 p.

Research output: Contribution to journalArticle

Open Access
File
Intramolecular Transferases
Phosphoglucomutase
Hexosamines
Phosphoserine
Mutagenesis

Press / Media

'Bacterial raincoat' found to protect bacteria from the environment

Daan van Aalten & Nicola Stanley-Wall

30/07/131/08/13

3 items of media coverage

Press/Media: Research

Breakthrough in understanding role of enzyme in disease

Daan van Aalten

29/10/12

1 item of media coverage

Press/Media: Research

Thesis

Biochemical characterisation of the Parkinson's disease-associated kinase PINK1: Insights from the insect world

Author: Woodroof, H. I., 2014

Supervisor: Muqit, M. (Supervisor), Van Aalten, D. (Supervisor) & Alessi, D. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Function and inhibition of the mitochondrial O-GlcNAc transferase isoform

Author: Trapannone, R., 2015

Supervisor: Van Aalten, D. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

Genetic encoding of a stable O-GlcNAc analogue

Author: Gorelik, A., 2018

Supervisor: van Aalten, D. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

Molecular characterisation of O-GlcNAc transferase

Author: Zheng, X., 2013

Supervisor: Van Aalten, D. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Reductionist animal models to probe protein O-GlcNAcylation

Author: Selvan, N., 2015

Supervisor: Van Aalten, D. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy