Projects per year
Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Dive into the research topics where Daan van Aalten is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Chemical and Genetic Validation of Aspergillus Fumigatus Cell Wall Targets
van Aalten, D. (Investigator)
1/06/21 → 30/11/26
Project: Research
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Fragment Based Validation of Fungal Cell Wall Target (Summer Studentship)
van Aalten, D. (Investigator)
Project: Research
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Care to Share (ScotPEN - SWEA) (Public Engagement) (Joint with University of Glasgow)
van Aalten, D. (Investigator)
Project: Research
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Molecular Mechanisms of O-GlcNAc Signalling (Sunset Funding for Senior Research Fellowship)
van Aalten, D. (Investigator)
Project: Research
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In Vitro Characterisation of the A319T OGT XLID Mutation (Caroline Faessler)
van Aalten, D. (Investigator)
Project: Research
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An OGT Missense Variant With Impaired Enzyme Activity in a Child With Severe Developmental Delay and Hepatoblastoma
D'Alessio, A. M. (Lead / Corresponding author), Yuan, H., Soria, L. R., Hansen, S. B., Boffa, I., Arena, P., Attianese, B., O'Sullivan, M., Cullinan, N., Pang, L., van Aalten, D. M. F., Brunetti-Pierri, N. & Lynch, S. A., 1 Oct 2025, (E-pub ahead of print) In: American Journal of Medical Genetics, Part A. e64275.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Downloads (Pure) -
Exploiting O-GlcNAc dyshomeostasis to screen O-GlcNAc transferase intellectual disability variants
Yuan, H., Mitchell, C. W., Ferenbach, A. T., Feresin, A., Benke, P. J., Tan, Q. K. & van Aalten, D., 14 Jan 2025, In: Stem Cell Reports. 20, 1, 13 p., 102380.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)26 Downloads (Pure) -
Gfa1 (glutamine fructose-6-phosphate aminotransferase) is essential for Aspergillus fumigatus growth and virulence
Qin, Q., Wei, P., Usman, S., Ahamefule, C. S., Jin, C., Wang, B., Yan, K., van Aalten, D. (Lead / Corresponding author) & Fang, W. (Lead / Corresponding author), 13 Mar 2025, (E-pub ahead of print) In: BMC Biology. 23, 16 p., 80.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)25 Downloads (Pure) -
Multi-domain O-GlcNAcase structures reveal allosteric regulatory mechanisms
Hansen, S. B., Bartual, S. G., Yuan, H., Raimi, O. G., Gorelik, A., Ferenbach, A. T., Lytje, K., Pedersen, J. S., Drace, T., Boesen, T. & van Aalten, D. M. F. (Lead / Corresponding author), 3 Oct 2025, In: Nature Communications. 16, 14 p., 8828.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)13 Downloads (Pure) -
O-GlcNAcylation of the intellectual disability protein DDX3X exerts proteostatic cell cycle control
Mitchell, C. W., Yuan, H., Ferenbach, A. T., Sønderstrup-Jensen, M. & van Aalten, D. (Lead / Corresponding author), Jul 2025, In: Open Biology. 15, 7, 13 p., 250064.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)16 Downloads (Pure)
Datasets
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Cryo-EM structure of human O-GlcNAcase
Hansen, S. B. (Creator), Galan Bartual, S. (Creator), Yuan, H. (Creator), Raimi, O. (Creator), Gorelik, A. (Creator), Ferenbach, A. T. (Creator), Lytje, K. (Creator), Pedersen, J. S. (Creator), Drace, T. (Creator), Boesen, T. (Creator) & van Aalten, D. (Creator), Protein Data Bank (PDB), 17 Sept 2025
DOI: 10.2210/pdb9qen/pdb
Dataset
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Cryo-EM structure of human O-GlcNAcase
Hansen, S. B. (Creator), Galan Bartual, S. (Creator), Yuan, H. (Creator), Raimi, O. (Creator), Gorelik, A. (Creator), Ferenbach, A. T. (Creator), Lytje, K. (Creator), Pedersen, J. S. (Creator), Drace, T. (Creator), Boesen, T. (Creator) & van Aalten, D. (Creator), Electron Microscopy Data Bank, 17 Sept 2025
https://www.ebi.ac.uk/emdb/EMD-53081
Dataset
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Crystal structure of eukaryotic O-GlcNAcase HAT-like domain
Raimi, O. (Creator), Gorelik, A. (Creator), Hopkins Navratilova, I. (Creator), Aristotelous, T. (Creator), Ferenbach, A. T. (Creator) & van Aalten, D. (Creator), Protein Data Bank (PDB), 8 Apr 2020
DOI: 10.2210/pdb6r45/pdb
Dataset
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Project PXD064425 Zscan4 as a candidate conveyor of early developmental defects in O-GlcNAc transferase intellectual disability
van Aalten, D. (Creator) & Pravata, V. (Creator), EMBL-EBI, 3 Oct 2025
https://www.ebi.ac.uk/pride/archive/projects/PXD064425
Dataset
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Cryo-EM structure of O-GlcNAcase from Trichoplax Adhaerens
Hansen, S. B. (Creator), Galan Bartual, S. (Creator), Yuan, H. (Creator), Raimi, O. (Creator), Gorelik, A. (Creator), Ferenbach, A. T. (Creator), Lytje, K. (Creator), Pedersen, J. S. (Creator), Drace, T. (Creator), Boesen, T. (Creator) & van Aalten, D. (Creator), Protein Data Bank (PDB), 17 Sept 2025
DOI: 10.2210/pdb9qep/pdb
Dataset
Press/Media
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'Bacterial raincoat' found to protect bacteria from the environment
Van Aalten, D. M. F. & Stanley-Wall, N. R.
30/07/13 → 1/08/13
3 items of Media coverage
Press/Media: Research
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Breakthrough in understanding role of enzyme in disease
29/10/12
1 item of Media coverage
Press/Media: Research