Alessi, Dario

Professor

    • United Kingdom

    1992 …2023
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    Personal profile

    Keywords

    • QH301 Biology
    • Biochemistry

    Fingerprint Dive into the research topics where Dario Alessi is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

    • 22 Similar Profiles
    Phosphotransferases Medicine & Life Sciences
    Phosphorylation Chemical Compounds
    Protein Kinases Medicine & Life Sciences
    Chemical activation Chemical Compounds
    3-Phosphoinositide-Dependent Protein Kinases Medicine & Life Sciences
    Proto-Oncogene Proteins c-akt Medicine & Life Sciences
    Leucine Medicine & Life Sciences
    Parkinson Disease Medicine & Life Sciences

    Network Recent external collaboration on country level. Dive into details by clicking on the dots.

    Projects 2012 2023

    Research Output 1992 2019

    3 Citations (Scopus)
    79 Downloads (Pure)

    Crystal structure of the WD40 domain dimer of LRRK2

    Zhang, P., Fan, Y., Ru, H., Wang, L., Magupalli, V. G., Taylor, S. S., Alessi, D. R. & Wu, H., 29 Jan 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 5, p. 1579-1584 6 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    Leucine
    Phosphotransferases
    Parkinson Disease
    Dimerization
    rab GTP-Binding Proteins
    1 Citation (Scopus)
    36 Downloads (Pure)

    Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader

    Tovell, H., Testa, A., Zhou, H., Shpiro, N., Crafter, C., Ciulli, A. & Alessi, D., 20 Sep 2019, In : ACS Chemical Biology. 14, 9, p. 2024-2034 11 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    Phosphatidylinositol 3-Kinases
    Protein Isoforms
    Phosphotransferases
    Cells
    Degradation
    21 Downloads (Pure)

    Membrane association but not identity is required for LRRK2 activation and phosphorylation of Rab GTPases

    Gomez, R. C., Wawro, P., Lis, P., Alessi, D. & Pfeffer, S. R., 17 Oct 2019, In : Journal of Cell Biology. 14 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    Guanine Nucleotide Dissociation Inhibitors
    rab GTP-Binding Proteins
    Guanosine Triphosphate
    Phosphorylation
    Membranes
    15 Downloads (Pure)

    Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44

    Malik, N., Nirujogi, R. S., Peltier, J., Macartney, T., Wightman, M., Prescott, A., Gourlay, R., Trost, M., Alessi, D. & Karapetsas, A., 30 Oct 2019, In : Biochemical Journal. 476, 20, p. 3081-3107 27 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    Qa-SNARE Proteins
    Phosphorylation
    Phosphotransferases
    SNARE Proteins
    Substrates
    3 Downloads (Pure)

    PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins

    Berndsen, K., Lis, P., Yeshaw, W. M., Wawro, P. S., Nirujogi, R., Wightman, M., Macartney, T., Dorward, M., Knebel, A., Tonelli, F., Pfeffer, S. R. & Alessi, D., 12 Nov 2019, In : eLife. 8, p. 1-37 37 p., e50416.

    Research output: Contribution to journalArticle

    Open Access
    File
    Phosphoric Monoester Hydrolases
    Phosphorylation
    Phosphoprotein Phosphatases
    Parkinson Disease
    rab GTP-Binding Proteins

    Thesis

    Advancing understanding of endogenous PINK1-Parkin signalling linked to Parkinson’s disease

    Author: Balk, K. R., 2019

    Supervisor: Muqit, M. (Supervisor) & Alessi, D. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    Biochemical characterisation of the Parkinson's disease-associated kinase PINK1: Insights from the insect world

    Author: Woodroof, H. I., 2014

    Supervisor: Muqit, M. (Supervisor), Van Aalten, D. (Supervisor) & Alessi, D. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    Exploring the contribution of SGK isoforms to signalling and mediating resistance to Akt inhibitors in breast cancer cells

    Author: Sommer, E., 2013

    Supervisor: Alessi, D. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    Investigating the role of PINK1-dependent Rab signalling in Parkinson's disease

    Author: Mulholland, K. E., 2019

    Supervisor: Muqit, M. (Supervisor) & Alessi, D. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    Investigation of regulation and downstream signaling pathway of Parkinson’s disease associated kinase, PINK1

    Author: Kondapalli, C., 2013

    Supervisor: Alessi, D. (Supervisor) & Muqit, M. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File