Alessi, Dario

Professor

    • United Kingdom

    1992 …2018
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    Personal profile

    Keywords

    • QH301 Biology
    • Biochemistry

    Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

    • 15 Similar Profiles
    Phosphotransferases Medicine & Life Sciences
    Phosphorylation Chemical Compounds
    Protein Kinases Medicine & Life Sciences
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    3-Phosphoinositide-Dependent Protein Kinases Medicine & Life Sciences
    Leucine Medicine & Life Sciences
    Parkinson Disease Medicine & Life Sciences

    Network Recent external collaboration on country level. Dive into details by clicking on the dots.

    Research Output 1992 2018

    9 Citations

    Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson’s disease kinase

    Lis, P., Burel, S., Steger, M., Mann, M., Brown, F., Diez, F., Tonelli, F., Holton, J. L., Winglok Ho, P., Ho, S-L., Chou, M-Y., Polinski, N. K., Martinez, T. N., Davies, P. & Alessi, D. R., 2 Jan 2018, In : Biochemical Journal. 475, 1, p. 1-22

    Research output: Contribution to journalArticle

    Open Access
    File
    Phospho-Specific Antibodies
    Parkinson Disease
    Phosphorylation
    Phosphotransferases
    Monoclonal Antibodies
    1 Citations

    Disruption of the with no lysine kinase^STE20-proline alanine-rich kinase pathway reduces thehypertension induced by angiotensin II

    Graciela Cervantes-Perez, L., Castaneda-Bueno, M., Jimenez, J. V., Vazquez, N., Rojas-Vega, L., Alessi, D., Bobadilla, N. A. & Gamba, G., 1 Feb 2018, In : Journal of Hypertension. 36, 2, p. 361-367 7 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    Member 3 Solute Carrier Family 12
    Proline
    Angiotensin II
    Alanine
    Lysine
    9 Citations

    Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils

    Fan, Y., Howden, A. J. M., Sarhan, A. R., Lis, P., Ito, G., Martinez, T. N., Brockmann, K., Gasser, T., Alessi, D. R. & Sammler, E., 2 Jan 2018, In : Biochemical Journal. 475, 1, p. 23-44 22 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    Phosphorylation
    Parkinson Disease
    Neutrophils
    Phosphotransferases
    Assays
    2 Citations

    LRRK2 is a negative regulator of phagosome maturation in macrophages

    Härtlova, A., Herbst, S., Peltier, J., Rodgers, A., Bilkei-Gorzo, O., Fearns, A., Dill, B. D., Lee, H., Flynn, R., Cowley, S. A., Davies, P., Lewis, P. A., Ganley, I. G., Martinez, J., Alessi, D. R., Reith, A. D., Trost, M. & Gutierrez, M. G., 22 May 2018, In : The EMBO Journal. 2018, p. 1-17 17 p., e98694

    Research output: Contribution to journalArticle

    Open Access
    File
    Phagosomes
    Macrophages
    Leucine
    Phosphotransferases
    Mycobacterium tuberculosis
    5 Citations

    LRRK2 kinase in Parkinson's disease

    Alessi, D. R. & Sammler, E., 6 Apr 2018, In : Science. 360, 6384, p. 36-37 2 p.

    Research output: Contribution to journalComment/debate

    Open Access
    File
    Leucine
    Parkinson Disease
    Phosphotransferases
    Mutation
    Clinical Trials, Phase I

    Thesis

    Biochemical characterisation of the Parkinson's disease-associated kinase PINK1: Insights from the insect world

    Author: Woodroof, H. I., 2014

    Supervisor: Muqit, M. (Supervisor), Van Aalten, D. (Supervisor) & Alessi, D. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    Exploring the contribution of SGK isoforms to signalling and mediating resistance to Akt inhibitors in breast cancer cells

    Author: Sommer, E., 2013

    Supervisor: Alessi, D. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    Investigation of regulation and downstream signaling pathway of Parkinson’s disease associated kinase, PINK1

    Author: Kondapalli, C., 2013

    Supervisor: Alessi, D. (Supervisor) & Muqit, M. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    Investigation of the physiological function of TTBK2 (tau tubulin kinase 2), a protein kinase mutated in spinocerebellar ataxia type 11 (SCA11)

    Author: Esoof, N., 2014

    Supervisor: Alessi, D. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    Phosphorylation, ubiquitylation and characterisation of specific inhibitors of AMPK-related kinase NUAK1/ARK5

    Author: Banerjee, S., 2013

    Supervisor: Alessi, D. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File