Dario Alessi

Personal profile

Keywords

QH301 Biology
Biochemistry

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22 Similar Profiles

Phosphotransferases Medicine & Life Sciences

Phosphorylation Chemical Compounds

Protein Kinases Medicine & Life Sciences

Chemical activation Chemical Compounds

3-Phosphoinositide-Dependent Protein Kinases Medicine & Life Sciences

Proto-Oncogene Proteins c-akt Medicine & Life Sciences

Leucine Medicine & Life Sciences

Parkinson Disease Medicine & Life Sciences

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Projects 2012 2023

1 Not started
7 Active
26 Finished

PPM1H Activators for Treatment of Parkinson's Disease

Alessi, D. & Gray, D.

9/09/19 → 8/09/20

Project: Research

Characterization of pT73 Rab10 Protein from XProChem and Supply of pRab8A and pRab10 Protein to Abcam for Assay Development

Alessi, D. & Davies, P.

1/08/19 → 31/07/20

Project: Research

MRC Capital Prioritisation Bid 2019-20

Alessi, D. & Davies, P.

Medical Research Council

1/04/19 → 31/03/20

Project: Research

Genome-wide and chemical screens to uncover novel upstream regulators of the LRRK2 signaling network

Alessi, D.

1/11/18 → 30/04/21

Project: Research

Regulation of the Parkinson's kinase LRRK2

Alessi, D.

Parkinson's UK

3/09/18 → 2/09/21

Project: Research

Research Output 1992 2019

185 Article
4 Review article
3 Comment/debate
2 Meeting abstract
4 More

4 Citations (Scopus)

90 Downloads (Pure)

Crystal structure of the WD40 domain dimer of LRRK2

Zhang, P., Fan, Y., Ru, H., Wang, L., Magupalli, V. G., Taylor, S. S., Alessi, D. R. & Wu, H., 29 Jan 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 5, p. 1579-1584 6 p.

Research output: Contribution to journal › Article

Open Access

File

Leucine

Phosphotransferases

Parkinson Disease

Dimerization

rab GTP-Binding Proteins

1 Citation (Scopus)

49 Downloads (Pure)

Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader

Tovell, H., Testa, A., Zhou, H., Shpiro, N., Crafter, C., Ciulli, A. & Alessi, D., 20 Sep 2019, In : ACS Chemical Biology. 14, 9, p. 2024-2034 11 p.

Research output: Contribution to journal › Article

Open Access

File

Phosphatidylinositol 3-Kinases

Protein Isoforms

Phosphotransferases

Cells

Degradation

32 Downloads (Pure)

Membrane association but not identity is required for LRRK2 activation and phosphorylation of Rab GTPases

Gomez, R. C., Wawro, P., Lis, P., Alessi, D. & Pfeffer, S. R., 2 Dec 2019, In : Journal of Cell Biology. 218, 12, p. 4157-4170 14 p.

Research output: Contribution to journal › Article

Open Access

File

Guanine Nucleotide Dissociation Inhibitors

rab GTP-Binding Proteins

Guanosine Triphosphate

Phosphorylation

Membranes

23 Downloads (Pure)

Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44

Malik, N., Nirujogi, R. S., Peltier, J., Macartney, T., Wightman, M., Prescott, A., Gourlay, R., Trost, M., Alessi, D. & Karapetsas, A., 30 Oct 2019, In : Biochemical Journal. 476, 20, p. 3081-3107 27 p.

Research output: Contribution to journal › Article

Open Access

File

Qa-SNARE Proteins

Phosphorylation

Phosphotransferases

SNARE Proteins

Substrates

12 Downloads (Pure)

PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins

Berndsen, K., Lis, P., Yeshaw, W. M., Wawro, P. S., Nirujogi, R., Wightman, M., Macartney, T., Dorward, M., Knebel, A., Tonelli, F., Pfeffer, S. R. & Alessi, D., 12 Nov 2019, In : eLife. 8, p. 1-37 37 p., e50416.

Research output: Contribution to journal › Article

Open Access

File

Phosphoric Monoester Hydrolases

Phosphorylation

Phosphoprotein Phosphatases

Parkinson Disease

rab GTP-Binding Proteins