Alessi, Dario

Personal profile

Keywords

QH301 Biology
Biochemistry

Fingerprint Dive into the research topics where Dario Alessi is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

16 Similar Profiles

Phosphotransferases Medicine & Life Sciences

Phosphorylation Chemical Compounds

Protein Kinases Medicine & Life Sciences

Chemical activation Chemical Compounds

3-Phosphoinositide-Dependent Protein Kinases Medicine & Life Sciences

Proto-Oncogene Proteins c-akt Medicine & Life Sciences

Leucine Medicine & Life Sciences

Parkinson Disease Medicine & Life Sciences

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Characterization of pT73 Rab10 Protein from XProChem and Supply of pRab8A and pRab10 Protein to Abcam for Assay Development

Alessi, D. & Davies, P.

1/08/19 → 31/07/20

Project: Research

MRC Capital Prioritisation Bid 2019-20

Alessi, D. & Davies, P.

Medical Research Council

1/04/19 → 31/03/20

Project: Research

LRRK2 and IBD

Alessi, D.

1/11/18 → 31/10/19

Project: Research

Correlating LRRK2 Activation Status to Phospho-Lipids in Parkinson's Disease

Alessi, D. & Sammler, E.

1/11/18 → 31/10/19

Project: Research

Genome-wide and chemical screens to uncover novel upstream regulators of the LRRK2 signaling network

Alessi, D.

1/11/18 → 30/04/21

Project: Research

Research Output 1992 2019

180 Article
4 Review article
3 Comment/debate
2 Meeting abstract
4 More

1 Citation (Scopus)

55 Downloads (Pure)

Crystal structure of the WD40 domain dimer of LRRK2

Zhang, P., Fan, Y., Ru, H., Wang, L., Magupalli, V. G., Taylor, S. S., Alessi, D. R. & Wu, H., 29 Jan 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 5, p. 1579-1584 6 p.

Research output: Contribution to journal › Article

Open Access

File

Leucine

Phosphotransferases

Parkinson Disease

Dimerization

rab GTP-Binding Proteins

54 Downloads (Pure)

Rapid and reversible knockdown of endogenously tagged endosomal proteins via an optimized HaloPROTAC degrader

Tovell, H., Testa, A., Maniaci, C., Zhou, H., Prescott, A., Macartney, T., Ciulli, A. & Alessi, D., 17 May 2019, In : ACS Chemical Biology. 14, 5, p. 882-892 11 p.

Research output: Contribution to journal › Article

Open Access

File

Degradation

Clustered Regularly Interspaced Short Palindromic Repeats

Proteins

Ubiquitination

Phosphorylation

7 Citations (Scopus)

52 Downloads (Pure)

A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain

Dhekne, H. S., Yanatori, I., Gomez, R. C., Tonelli, F., Diez, F., Schüle, B., Steger, M., Alessi, D. R. & Pfeffer, S. R., 6 Nov 2018, In : eLife. 7, p. 1-26 26 p., e40202.

Research output: Contribution to journal › Article

Open Access

File

Aptitude

Hedgehogs

Cilia

Neurons

Parkinson Disease

17 Citations (Scopus)

185 Downloads (Pure)

Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson’s disease kinase

Lis, P., Burel, S., Steger, M., Mann, M., Brown, F., Diez, F., Tonelli, F., Holton, J. L., Winglok Ho, P., Ho, S-L., Chou, M-Y., Polinski, N. K., Martinez, T. N., Davies, P. & Alessi, D. R., 2 Jan 2018, In : Biochemical Journal. 475, 1, p. 1-22 22 p.

Research output: Contribution to journal › Article

Open Access

File

Protein Kinases

Parkinson Disease

Phosphotransferases

Antibodies

Proteins

2 Downloads (Pure)

Discovery of potent and selective 5-azaindazole inhibitors of leucine-rich repeat kinase 2 (LRRK2): Part 1

Osborne, J., Birchall, K., Tsagris, D. J., Lewis, S. J., Smiljanic-Hurley, E., Taylor, D. L., Levy, A., Alessi, D. & McIver, E. G., 1 Dec 2018, In : Bioorganic & Medicinal Chemistry Letters.

Research output: Contribution to journal › Article

Open Access

Leucine

Phosphotransferases

Pharmaceutical Chemistry

Dopaminergic Neurons

Nervous System Diseases