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Alessi, Dario

Professor

     https://orcid.org/0000-0002-2140-9185

    • United Kingdom

    1992 …2020

    Research output per year

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    Personal profile

    Keywords

    • QH301 Biology
    • Biochemistry

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    Projects

    Funding for new Mass Spec Platform

    Alessi, D. & Davies, P.

    1/04/20 → 31/03/21

    Project: Research

    Linking the GI tract with PD

    Alessi, D., Mowat, C. & Sammler, E.

    1/03/20 → 28/02/21

    Project: Research

    Characterization of pT73 Rab10 Protein from XProChem and Supply of pRab8A and pRab10 Protein to Abcam for Assay Development

    Alessi, D. & Davies, P.

    1/01/20 → 14/02/21

    Project: Research

    PPM1H Activators for Treatment of Parkinson's Disease

    Alessi, D. & Gray, D.

    1/09/19 → 30/03/21

    Project: Research

    Genome-wide and chemical screens to uncover novel upstream regulators of the LRRK2 signaling network

    Alessi, D.

    1/08/19 → 14/01/23

    Project: Research

    Research Output

    Accurate MS-based Rab10 phosphorylation stoichiometry determination as readout for LRRK2 activity in Parkinson's disease

    Karayel, O., Tonelli, F., Virreira Winter, S., Geyer, P. E., Fan, Y., Sammler, E. M., Alessi, D., Steger, M. & Mann, M., 29 Jun 2020, In : Molecular & Cellular Proteomics.

    Research output: Contribution to journal › Article

    Open Access
    File
    • 4 Downloads (Pure)

    Advances in elucidating the function of leucine-rich repeat protein kinase-2 in normal cells and Parkinson's disease

    Taylor, M. & Alessi, D., Apr 2020, In : Current Opinion in Cell Biology. 63, p. 102-113 12 p.

    Research output: Contribution to journal › Article

    Open Access
    File
    • 1 Citation (Scopus)
    53 Downloads (Pure)

    Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson’s Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation

    Fan, Y., Tonelli, F., Padmanabhan, S., Baptista, M., Riley, L., Smith, D., Marras, C., Howden, A., Alessi, D. & Sammler, E., 22 Mar 2020, In : JoVE: Journal of Visualized Experiments. 157, e58956.

    Research output: Contribution to journal › Article

    • Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2 Phosphorylation of Switch 2

    Waschbüsch, D., Purlyte, E., Pal, P., McGrath, E., Alessi, D. R. & Khan, A. R., 7 Apr 2020, In : Structure. 28, 4, p. 406-417.e6 19 p.

    Research output: Contribution to journal › Article

    Open Access
    File
    • 1 Citation (Scopus)
    36 Downloads (Pure)

    Crystal structure of the WD40 domain dimer of LRRK2

    Zhang, P., Fan, Y., Ru, H., Wang, L., Magupalli, V. G., Taylor, S. S., Alessi, D. R. & Wu, H., 29 Jan 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 5, p. 1579-1584 6 p.

    Research output: Contribution to journal › Article

    Open Access
    File
    • 6 Citations (Scopus)
    133 Downloads (Pure)