Alessi, Dario

Professor

    • United Kingdom

    1992 …2023
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    Personal profile

    Keywords

    • QH301 Biology
    • Biochemistry

    Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

    • 17 Similar Profiles
    Phosphotransferases Medicine & Life Sciences
    Phosphorylation Chemical Compounds
    Chemical activation Chemical Compounds
    Protein Kinases Medicine & Life Sciences
    3-Phosphoinositide-Dependent Protein Kinases Medicine & Life Sciences
    Proto-Oncogene Proteins c-akt Medicine & Life Sciences
    Leucine Medicine & Life Sciences
    Parkinson Disease Medicine & Life Sciences

    Network Recent external collaboration on country level. Dive into details by clicking on the dots.

    Projects 2012 2023

    Research Output 1992 2019

    1 Citation (Scopus)
    41 Downloads (Pure)

    Crystal structure of the WD40 domain dimer of LRRK2

    Zhang, P., Fan, Y., Ru, H., Wang, L., Magupalli, V. G., Taylor, S. S., Alessi, D. R. & Wu, H., 29 Jan 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 5, p. 1579-1584 6 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    Leucine
    Phosphotransferases
    Parkinson Disease
    Dimerization
    rab GTP-Binding Proteins
    10 Downloads (Pure)

    Rapid and reversible knockdown of endogenously tagged endosomal proteins via an optimized HaloPROTAC degrader

    Tovell, H., Testa, A., Maniaci, C., Zhou, H., Prescott, A., Macartney, T., Ciulli, A. & Alessi, D., 2019, In : ACS Chemical Biology. 14, 5, p. 882-892 11 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    Degradation
    Clustered Regularly Interspaced Short Palindromic Repeats
    Proteins
    Ubiquitination
    Phosphorylation
    7 Citations (Scopus)
    33 Downloads (Pure)

    A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain

    Dhekne, H. S., Yanatori, I., Gomez, R. C., Tonelli, F., Diez, F., Schüle, B., Steger, M., Alessi, D. R. & Pfeffer, S. R., 6 Nov 2018, In : eLife. 7, p. 1-26 26 p., e40202.

    Research output: Contribution to journalArticle

    Open Access
    File
    Aptitude
    Hedgehogs
    Cilia
    Neurons
    Parkinson Disease
    17 Citations (Scopus)
    173 Downloads (Pure)

    Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson’s disease kinase

    Lis, P., Burel, S., Steger, M., Mann, M., Brown, F., Diez, F., Tonelli, F., Holton, J. L., Winglok Ho, P., Ho, S-L., Chou, M-Y., Polinski, N. K., Martinez, T. N., Davies, P. & Alessi, D. R., 2 Jan 2018, In : Biochemical Journal. 475, 1, p. 1-22

    Research output: Contribution to journalArticle

    Open Access
    File
    Phospho-Specific Antibodies
    Parkinson Disease
    Phosphorylation
    Phosphotransferases
    Monoclonal Antibodies
    2 Downloads (Pure)

    Discovery of potent and selective 5-azaindazole inhibitors of leucine-rich repeat kinase 2 (LRRK2): Part 1

    Osborne, J., Birchall, K., Tsagris, D. J., Lewis, S. J., Smiljanic-Hurley, E., Taylor, D. L., Levy, A., Alessi, D. & McIver, E. G., 1 Dec 2018, In : Bioorganic & Medicinal Chemistry Letters.

    Research output: Contribution to journalArticle

    Open Access
    Leucine
    Phosphotransferases
    Pharmaceutical Chemistry
    Dopaminergic Neurons
    Nervous System Diseases

    Thesis

    Biochemical characterisation of the Parkinson's disease-associated kinase PINK1: Insights from the insect world

    Author: Woodroof, H. I., 2014

    Supervisor: Muqit, M. (Supervisor), Van Aalten, D. (Supervisor) & Alessi, D. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    Exploring the contribution of SGK isoforms to signalling and mediating resistance to Akt inhibitors in breast cancer cells

    Author: Sommer, E., 2013

    Supervisor: Alessi, D. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    Investigation of regulation and downstream signaling pathway of Parkinson’s disease associated kinase, PINK1

    Author: Kondapalli, C., 2013

    Supervisor: Alessi, D. (Supervisor) & Muqit, M. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    Investigation of the physiological function of TTBK2 (tau tubulin kinase 2), a protein kinase mutated in spinocerebellar ataxia type 11 (SCA11)

    Author: Esoof, N., 2014

    Supervisor: Alessi, D. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    Phosphorylation, ubiquitylation and characterisation of specific inhibitors of AMPK-related kinase NUAK1/ARK5

    Author: Banerjee, S., 2013

    Supervisor: Alessi, D. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File