Personal profile

Keywords

  • QH301 Biology
  • Biochemistry

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 38 Similar Profiles
Phosphotransferases Medicine & Life Sciences
Phosphorylation Chemical Compounds
Protein Kinases Medicine & Life Sciences
Chemical activation Chemical Compounds
Parkinson Disease Medicine & Life Sciences
Leucine Medicine & Life Sciences
AMP-Activated Protein Kinases Medicine & Life Sciences
3-Phosphoinositide-Dependent Protein Kinases Medicine & Life Sciences

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Research Output 1993 2018

Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson’s disease kinase

Lis, P., Burel, S., Steger, M., Mann, M., Brown, F., Diez, F., Tonelli, F., Holton, J. L., Winglok Ho, P., Ho, S-L., Chou, M-Y., Polinski, N. K., Martinez, T. N., Davies, P. & Alessi, D. R. 2 Jan 2018 In : Biochemical Journal. 475, 1, p. 1-22

Research output: Contribution to journalArticle

Open Access
File
Phospho-Specific Antibodies
Parkinson Disease
Phosphorylation
Phosphotransferases
Monoclonal Antibodies
1 Citations

Disruption of the with no lysine kinase^STE20-proline alanine-rich kinase pathway reduces thehypertension induced by angiotensin II

Graciela Cervantes-Perez, L., Castaneda-Bueno, M., Jimenez, J. V., Vazquez, N., Rojas-Vega, L., Alessi, D., Bobadilla, N. A. & Gamba, G. 1 Feb 2018 In : Journal of Hypertension. 36, 2, p. 361-367 7 p.

Research output: Contribution to journalArticle

Open Access
File
Member 3 Solute Carrier Family 12
Proline
Angiotensin II
Alanine
Lysine

Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils

Fan, Y., Howden, A. J. M., Sarhan, A. R., Lis, P., Ito, G., Martinez, T. N., Brockmann, K., Gasser, T., Alessi, D. R. & Sammler, E. 2 Jan 2018 In : Biochemical Journal. 475, 1, p. 23-44

Research output: Contribution to journalArticle

Open Access
File
Phosphorylation
Parkinson Disease
Neutrophils
Phosphotransferases
Assays

LRRK2 kinase in Parkinson's disease

Alessi, D. R. & Sammler, E. 6 Apr 2018 In : Science. 360, 6384, p. 36-37 2 p.

Research output: Contribution to journalComment/debate

Open Access
File
Leucine
Parkinson Disease
Phosphotransferases
Mutation
Clinical Trials, Phase I

Mechanism of activation of SGK3 by growth factors-via the Class 1 and Class 3 PI3Ks

Malik, N., Macartney, T., Hornberger, A., Anderson, K., Tovell, H., Prescott, A. R. & Alessi, D. R. 2 Jan 2018 In : Biochemical Journal. 475, 1, p. 117-135

Research output: Contribution to journalArticle

Open Access
File
Phosphatidylinositol 3-Kinases
Intercellular Signaling Peptides and Proteins
Chemical activation
Phosphatidylinositols
Phosphotransferases

Thesis

Biochemical characterisation of the Parkinson's disease-associated kinase PINK1: Insights from the insect world

Author: Woodroof, H. I., 2014

Supervisor: Muqit, M. (Supervisor), Van Aalten, D. (Supervisor) & Alessi, D. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Exploring the contribution of SGK isoforms to signalling and mediating resistance to Akt inhibitors in breast cancer cells

Author: Sommer, E., 2013

Supervisor: Alessi, D. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Investigation of regulation and downstream signaling pathway of Parkinson's disease associated kinase, PINK1

Author: Kondapalli, C., 2013

Supervisor: Alessi, D. (Supervisor) & Muqit, M. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Investigation of the physiological function of TTBK2 (tau tubulin kinase 2), a protein kinase mutated in spinocerebellar ataxia type 11 (SCA11)

Author: Esoof, N., 2014

Supervisor: Alessi, D. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Phosphorylation, ubiquitylation and characterisation of specific inhibitors of AMPK-related kinase NUAK1/ARK5

Author: Banerjee, S., 2013

Supervisor: Alessi, D. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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