Projects per year
Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Keywords
- QH301 Biology
- Biochemistry
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Collaborations and top research areas from the last five years
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Mutational screen of GBA1, PARKIN and LRRK2
Alessi, D. (Investigator), Muqit, M. (Investigator) & Sammler, E. (Investigator)
1/08/24 → 31/07/26
Project: Research
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Interrogating Tankyrase-mediated Control of Neuronal Degeneration in Frontotemporal Dementia (Dementia Research Leader Fellowship) (Outline) & Full
Alessi, D. (Investigator), Ashford, M. (Investigator), Davies, P. (Investigator), McGurk, L. (Investigator) & Storey, K. (Investigator)
2/10/23 → 1/10/28
Project: Research
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Interrogating LRRK2 Signalling in Bio-Samples Derived From Patients with Parkinson's Disease Carrying the Asian LRRK2 G2385R and R1628P Variants for Biomarker Discovery (Joint with University of Malaya)
Alessi, D. (Investigator) & Sammler, E. (Investigator)
15/09/23 → 14/03/25
Project: Research
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Louis-Jeantet Prize 2023 - Personal Award
Alessi, D. (Investigator)
1/06/23 → 31/05/28
Project: Research
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Shared Proteomics Platform For The MRC PPU And The UK Dementia Research Institute (UK DRI)
Alessi, D. (Investigator)
1/04/23 → 31/03/28
Project: Research
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Clinical and functional evidence for the pathogenicity of the LRRK2 p.Arg1067Gln variant
Tan, A. H., Lim, S.-Y., Toh, T. S., Hor, J. W., Lim, J. L., Lit, L. C., Ahmad-Annuar, A., Tay, Y. W., Foo, J. N., Ng, E., Muthusamy, K. A., Ibrahim, N. M., Ibrahim, K. A., Tan, L. C., Zulkefli, J., Anuar, A. N. K., Black, K., Lis, P., Xie, F. & Cen, Z. & 7 others, , 17 Sept 2024, Research Square.Research output: Working paper/Preprint › Preprint
File2 Downloads (Pure) -
CURTAIN – A unique web-based tool for exploration and sharing of MS-based proteomics data
Phung, T. K. (Lead / Corresponding author), Berndsen, K., Shastry, R., Phan, T. L. C. H. B., Muqit, M. M. K., Alessi, D. R. (Lead / Corresponding author) & Nirujogi, R. S. (Lead / Corresponding author), 13 Feb 2024, In: Proceedings of the National Academy of Sciences. 121, 7, 12 p., e2312376121.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)118 Downloads (Pure) -
Leucine-Rich Repeat Kinases
Alessi, D. R. (Lead / Corresponding author) & Pfeffer, S. R., Aug 2024, In: Annual Review of Biochemistry. 93, p. 261-287 27 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile2 Citations (Scopus)50 Downloads (Pure) -
Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson’s disease
Khan, S. S., Jaimon, E., Lin, Y. E., Nikoloff, J., Tonelli, F., Alessi, D. R. & Pfeffer, S. R. (Lead / Corresponding author), 6 Aug 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 32, 9 p., e2402206121.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)26 Downloads (Pure) -
PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons
Milioto, C., Carcolé, M., Giblin, A., Coneys, R., Attrebi, O., Ahmed, M., Harris, S. S., Lee, B. I., Yang, M., Ellingford, R. A., Nirujogi, R. S., Biggs, D., Salomonsson, S., Zanovello, M., de Oliveira, P., Katona, E., Glaria, I., Mikheenko, A., Geary, B. & Udine, E. & 20 others, , Apr 2024, In: Nature Neuroscience. 27, 4, p. 643-655 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)72 Downloads (Pure)
Datasets
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Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain
Khan, S. (Creator), Sobu, Y. (Creator), Pfeffer, S. (Creator), Dhekne, H. (Creator), Tonelli, F. (Creator), Berndsen, K. (Creator) & Alessi, D. (Creator), Dryad, 1 Nov 2021
DOI: 10.5061/dryad.76hdr7sxx, https://datadryad.org/stash/dataset/doi:10.5061/dryad.76hdr7sxx
Dataset
Prizes
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Jeantet-Collen Prize for Translational Medicine
Alessi, D. (Recipient), 26 Apr 2023
Prize: Prize (including medals and awards)
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Michael J. Fox Foundation - The Robert A. Pritzker Prize for Leadership in Parkinson's Research
Alessi, D. (Recipient), 3 Nov 2023
Prize: Prize (including medals and awards)
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Press release - Dundee team leading groundbreaking cancer and Parkinson’s research given five-year funding boost to continue life-saving work
Alessi, D. (Member)
5 Sept 2024Activity: Other activity types › Public engagement and outreach - media article or participation
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Keynote talk
Alessi, D. (Speaker)
18 May 2024 → 21 May 2024Activity: Talk or presentation types › Keynote
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Invited talk
Alessi, D. (Speaker)
18 Jun 2024 → 21 Jun 2024Activity: Talk or presentation types › Invited talk
Press/Media
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STV news article about Parkinson's research, public engagement and clinical trials in Dundee
6/02/24
1 Media contribution
Press/Media: Research
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Parkinson's disease hope: 'This is a very exciting time'
15/09/23
1 Media contribution
Press/Media: Research