Dario Alessi

Personal profile

Keywords

QH301 Biology
Biochemistry

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Projects

2 Not started
9 Active
25 Finished

Linking the GI tract with PD

Alessi, D., Mowat, C. & Sammler, E.

1/03/20 → 28/02/21

Project: Research

Characterization of pT73 Rab10 Protein from XProChem and Supply of pRab8A and pRab10 Protein to Abcam for Assay Development

Alessi, D. & Davies, P.

1/01/20 → 31/12/20

Project: Research

PPM1H Activators for Treatment of Parkinson's Disease

Alessi, D. & Gray, D.

1/09/19 → 31/08/20

Project: Research

Genome-wide and chemical screens to uncover novel upstream regulators of the LRRK2 signaling network

Alessi, D.

1/08/19 → 31/01/22

Project: Research

MRC Capital Prioritisation Bid 2019-20

Alessi, D. & Davies, P.

Medical Research Council

1/04/19 → 31/03/20

Project: Research

Research Output

189 Article
4 Review article
3 Comment/debate
2 Meeting abstract
4 More

Advances in elucidating the function of leucine-rich repeat protein kinase-2 in normal cells and Parkinson's disease

Taylor, M. & Alessi, D., Apr 2020, In : Current Opinion in Cell Biology. 63, p. 102-113 12 p.

Research output: Contribution to journal › Article

Open Access

File

23 Downloads (Pure)

Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson’s Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation

Fan, Y., Tonelli, F., Padmanabhan, S., Baptista, M., Riley, L., Smith, D., Marras, C., Howden, A., Alessi, D. & Sammler, E., 22 Mar 2020, In : JoVE: Journal of Visualized Experiments. 157, e58956.

Research output: Contribution to journal › Article

Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2 Phosphorylation of Switch 2

Waschbüsch, D., Purlyte, E., Pal, P., McGrath, E., Alessi, D. R. & Khan, A. R., 3 Feb 2020, In : Structure. 28, p. 1-12 12 p.

Research output: Contribution to journal › Article

Open Access

File

24 Downloads (Pure)

Crystal structure of the WD40 domain dimer of LRRK2

Zhang, P., Fan, Y., Ru, H., Wang, L., Magupalli, V. G., Taylor, S. S., Alessi, D. R. & Wu, H., 29 Jan 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 5, p. 1579-1584 6 p.

Research output: Contribution to journal › Article

Open Access

File

5 Citations (Scopus)

119 Downloads (Pure)

Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader

Tovell, H., Testa, A., Zhou, H., Shpiro, N., Crafter, C., Ciulli, A. & Alessi, D., 20 Sep 2019, In : ACS Chemical Biology. 14, 9, p. 2024-2034 11 p.

Research output: Contribution to journal › Article

Open Access

File

4 Citations (Scopus)

74 Downloads (Pure)