Projects per year
Personal profile
Keywords
- QH301 Biology
- Biochemistry
Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.
- 17 Similar Profiles
Phosphotransferases
Medicine & Life Sciences
Phosphorylation
Chemical Compounds
Chemical activation
Chemical Compounds
Protein Kinases
Medicine & Life Sciences
3-Phosphoinositide-Dependent Protein Kinases
Medicine & Life Sciences
Proto-Oncogene Proteins c-akt
Medicine & Life Sciences
Leucine
Medicine & Life Sciences
Parkinson Disease
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2012 2023
Correlating LRRK2 Activation Status to Phospho-Lipids in Parkinson's Disease
Alessi, D. & Sammler, E.
1/11/18 → 31/10/19
Project: Research
Genome-wide and chemical screens to uncover novel upstream regulators of the LRRK2 signaling network
1/11/18 → 30/04/21
Project: Research
Research Output 1992 2019
1
Citation
(Scopus)
41
Downloads
(Pure)
Crystal structure of the WD40 domain dimer of LRRK2
Zhang, P., Fan, Y., Ru, H., Wang, L., Magupalli, V. G., Taylor, S. S., Alessi, D. R. & Wu, H., 29 Jan 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 5, p. 1579-1584 6 p.Research output: Contribution to journal › Article
Open Access
File
Leucine
Phosphotransferases
Parkinson Disease
Dimerization
rab GTP-Binding Proteins
Rapid and reversible knockdown of endogenously tagged endosomal proteins via an optimized HaloPROTAC degrader
Tovell, H., Testa, A., Maniaci, C., Zhou, H., Prescott, A., Macartney, T., Ciulli, A. & Alessi, D., 2019, In : ACS Chemical Biology. 14, 5, p. 882-892 11 p.Research output: Contribution to journal › Article
Open Access
File
Degradation
Clustered Regularly Interspaced Short Palindromic Repeats
Proteins
Ubiquitination
Phosphorylation
A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain
Dhekne, H. S., Yanatori, I., Gomez, R. C., Tonelli, F., Diez, F., Schüle, B., Steger, M., Alessi, D. R. & Pfeffer, S. R., 6 Nov 2018, In : eLife. 7, p. 1-26 26 p., e40202.Research output: Contribution to journal › Article
Open Access
File
Aptitude
Hedgehogs
Cilia
Neurons
Parkinson Disease
Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson’s disease kinase
Lis, P., Burel, S., Steger, M., Mann, M., Brown, F., Diez, F., Tonelli, F., Holton, J. L., Winglok Ho, P., Ho, S-L., Chou, M-Y., Polinski, N. K., Martinez, T. N., Davies, P. & Alessi, D. R., 2 Jan 2018, In : Biochemical Journal. 475, 1, p. 1-22Research output: Contribution to journal › Article
Open Access
File
Phospho-Specific Antibodies
Parkinson Disease
Phosphorylation
Phosphotransferases
Monoclonal Antibodies
Discovery of potent and selective 5-azaindazole inhibitors of leucine-rich repeat kinase 2 (LRRK2): Part 1
Osborne, J., Birchall, K., Tsagris, D. J., Lewis, S. J., Smiljanic-Hurley, E., Taylor, D. L., Levy, A., Alessi, D. & McIver, E. G., 1 Dec 2018, In : Bioorganic & Medicinal Chemistry Letters.Research output: Contribution to journal › Article
Open Access
Leucine
Phosphotransferases
Pharmaceutical Chemistry
Dopaminergic Neurons
Nervous System Diseases
Thesis
Biochemical characterisation of the Parkinson's disease-associated kinase PINK1: Insights from the insect world
Author: Woodroof, H. I., 2014Supervisor: Muqit, M. (Supervisor), Van Aalten, D. (Supervisor) & Alessi, D. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
File
Exploring the contribution of SGK isoforms to signalling and mediating resistance to Akt inhibitors in breast cancer cells
Author: Sommer, E., 2013Supervisor: Alessi, D. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
File
Investigation of regulation and downstream signaling pathway of Parkinson’s disease associated kinase, PINK1
Author: Kondapalli, C., 2013Supervisor: Alessi, D. (Supervisor) & Muqit, M. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
File
Investigation of the physiological function of TTBK2 (tau tubulin kinase 2), a protein kinase mutated in spinocerebellar ataxia type 11 (SCA11)
Author: Esoof, N., 2014Supervisor: Alessi, D. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
File
Phosphorylation, ubiquitylation and characterisation of specific inhibitors of AMPK-related kinase NUAK1/ARK5
Author: Banerjee, S., 2013Supervisor: Alessi, D. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
File