Alessi, Dario

Projects

Projects per year 2008 2010 2013 2014 2015 2016 2018 2020 2021 2022 2023 2028

• 2 Not started
• 15 Active
• 53 Finished

Projects per year

Search results

• Active

  Linking the GI tract with PD

  Alessi, D., Mowat, C. & Sammler, E.

  1/10/23 → 30/09/24

  Project: Research

• Validation Of LRRK2 Modifiers As Potential PD Therapeutic Targets - Joint with Universite de Lille and University of Padua

  Alessi, D.

  1/08/23 → 31/01/25

  Project: Research

• Interrogating Tankyrase-mediated Control of Neuronal Degeneration in Frontotemporal Dementia (Dementia Research Leader Fellowship) (Outline) & Full

  Alessi, D., Ashford, M., Davies, P., McGurk, L. & Storey, K.

  Alzheimer's Society

  1/07/23 → 30/06/28

  Project: Research

• Louis-Jeantet Prize 2023 - Personal Award

  Alessi, D.

  1/06/23 → 31/05/28

  Project: Research

• Shared Proteomics Platform For The MRC PPU And The UK Dementia Research Institute (UK DRI)

  Alessi, D.

  1/04/23 → 31/03/28

  Project: Research

• Capital Equipment Award. Shared Proteomics Platform For The MRC-PPU And The UK DRI

  Alessi, D.

  1/04/23 → 31/03/24

  Project: Research

• Implementation and Validation of Quantitative Lysosome-specific GCase Assays in Cell Lines and Human Peripheral Blood for use in Clinical Samples

  Alessi, D. & Sammler, E.

  1/03/23 → 31/08/24

  Project: Research

• Development of LRRK2 Type II Inhibitors to Understand Utility of these Compounds for the Treatment of Parkinson's Disease

  Alessi, D., Davies, P., Gilbert, I., Gray, D. & Read, K.

  1/03/23 → 30/11/23

  Project: Research

• LRRK2 Kinase Activity and Global Proteomic Markers in the Gut of PD and IBD Patients (Joint with Icahn School of Medicine Mount Sinai New York & Department Of Pathology & Immunology, Washington University School of Medicine)

  Alessi, D. & Sammler, E.

  1/07/22 → 31/12/23

  Project: Research

• High-Throughput-Analysis to Identify and Characterize PPM1H Protein Phosphatase Activity Enhancers

  Alessi, D. & Davies, P.

  1/02/22 → 1/02/24

  Project: Research

• MRC Climate Crisis Network (Lead: University Of Dundee other instns: Mitocondrial Unit, Human Genetics Unit)

  Alessi, D. & Labib, K.

  Medical Research Council

  1/01/22 → 31/12/23

  Project: Research

• Cell Line Characterisation (other inst: Rutgers University)

  Alessi, D.

  1/11/21 → 31/10/23

  Project: Research

• Differential LRRK2 Dependent Rab Phosphorylation Signatures in Peripheral Blood and Urine in Idiopathic and Monogenetic PD

  Alessi, D. & Sammler, E.

  1/06/21 → 30/11/23

  Project: Research

  • Phospholipids 100%
  • Parkinson Disease 93%
  • Urine 79%
  • bis(monoacylglyceryl)phosphate 66%
  • Mutation 62%

• ASAP - Mapping the LRRK2 Signalling Pathway and its Interplay with other Parkinson's Disease Components

  Alessi, D. & Muqit, M.

  1/10/20 → 30/09/24

  Project: Research

  • Parkinson Disease 100%
  • Phosphotransferases 78%
  • Neurons 67%
  • rab GTP-Binding Proteins 58%
  • Leucine 58%

• MRC QQR

  Alessi, D., Davies, P., Ganley, I., Kulathu, Y., Labib, K., Liang, A., Rouse, J., Rousseau, A., Sapkota, G., Virdee, S. & Walden, H.

  Medical Research Council

  1/04/18 → 1/04/24

  Project: Research

  • Mechanistic Target of Rapamycin Complex 1 100%
  • Ubiquitination 86%
  • Ribosomes 82%
  • Biomedical Research 79%
  • Parkinson Disease 66%
• Not started

  The Influenza Virus Toolkit: A Reagent Sharing Resource for Influenza Research (Joint with Universities of Glasgow and Oxford)

  Alessi, D. & Davies, P.

  Project: Research

• MRC Public Engagement 2014-2015

  Alessi, D.

  Project: Research

• Finished

  MRC Capital Block Grant

  Alessi, D. & Davies, P.

  Medical Research Council

  1/11/22 → 31/03/23

  Project: Research

• Ultra-High Definition Imaging - MRC Equipment Grant

  Alessi, D., Banerjee, S., Cantley, J., Corner, G., Hayes, J., Hoskins, P., Kang, L., McNeilly, A., McSorley, H., Murdoch, C. & Rena, G.

  Medical Research Council

  1/11/22 → 31/03/23

  Project: Research

• Identifying PD Biomarkers In Peripheral Blood Immune Cells Using Mass Spectrometry And Single Cell RNA Sequencing

  Alessi, D.

  14/09/21 → 13/09/23

  Project: Research

• World Class Labs Capital Award 21/22

  Alessi, D. & Davies, P.

  Medical Research Council

  1/04/21 → 31/03/22

  Project: Research

• World Class Labs Capital Funding Offer 2021/22

  Alessi, D. & Davies, P.

  Medical Research Council

  1/04/21 → 31/03/22

  Project: Research

• Stratification Of MRC Funded Scientific Technologies And Reagents For Rapid And Simple Dissemination To The Wider Scientific Community

  Alessi, D. & Davies, P.

  Medical Research Council

  1/01/21 → 31/03/21

  Project: Research

  • Severe acute respiratory syndrome coronavirus 100%
  • Single-Domain Antibodies 85%
  • SARS Virus 85%
  • Reverse Genetics 76%
  • Coronavirinae 76%

• MRC PPU Covid Research

  Alessi, D. & Davies, P.

  Medical Research Council

  18/10/20 → 17/07/21

  Project: Research

  • Coronavirus 100%
  • SARS Virus 87%
  • Severe Acute Respiratory Syndrome 76%
  • Severe acute respiratory syndrome coronavirus 68%
  • Single-Domain Antibodies 58%

• World Class Labs

  Alessi, D. & Davies, P.

  Medical Research Council

  1/10/20 → 31/03/21

  Project: Research

• Funding for new Mass Spec Platform

  Alessi, D. & Davies, P.

  1/04/20 → 31/03/21

  Project: Research

• Characterization of pT73 Rab10 Protein from XProChem and Supply of pRab8A and pRab10 Protein to Abcam for Assay Development

  Alessi, D. & Davies, P.

  1/01/20 → 14/08/21

  Project: Research

• PPM1H Activators for Treatment of Parkinson's Disease

  Alessi, D. & Gray, D.

  1/09/19 → 30/03/21

  Project: Research

• Genome-wide and chemical screens to uncover novel upstream regulators of the LRRK2 signaling network

  Alessi, D.

  1/08/19 → 30/09/21

  Project: Research

  • rab GTP-Binding Proteins 100%
  • Mutation 84%
  • Parkinson Disease 72%
  • Phosphorylation 72%
  • Phosphoric Monoester Hydrolases 68%

• MRC Capital Prioritisation Bid 2019-20

  Alessi, D. & Davies, P.

  Medical Research Council

  1/04/19 → 31/03/20

  Project: Research

• LRRK2 and IBD

  Alessi, D.

  1/11/18 → 31/10/19

  Project: Research

• Correlating LRRK2 Activation Status to Phospho-Lipids in Parkinson's Disease

  Alessi, D. & Sammler, E.

  1/11/18 → 31/12/20

  Project: Research

• Regulation of the Parkinson's kinase LRRK2

  Alessi, D.

  Parkinson's UK

  3/09/18 → 2/09/21

  Project: Research

  • Leucine 100%
  • Phosphotransferases 95%
  • Parkinson Disease 57%
  • Phosphorylation 48%
  • Mutation 38%

• Investigation of the LRRK2 G2385R Mutation (joint with Chinese National Human Genome Center Beijing (SinoGenoMax), Xuanwu Hospital of Capital Medical University)

  Alessi, D. & Davies, P.

  1/08/18 → 31/12/20

  Project: Research

• MRC Capital Prioritisation

  Alessi, D. & Davies, P.

  Medical Research Council

  1/04/18 → 31/03/19

  Project: Research

• Validation of Abcam Rabbit anti-pS1292 LRRK Antibody

  Alessi, D. & Davies, P.

  27/09/17 → 26/09/18

  Project: Research

• LRRK2 Inhibition to Systemic Bacterial Infection (Joint with Ottowa Hospital Research Institute)

  Alessi, D.

  1/07/17 → 30/06/19

  Project: Research

• MRC Capital Prioritisation Bid 2017/18

  Alessi, D.

  Medical Research Council

  1/04/17 → 31/03/18

  Project: Research

• Chemical Knockdown of LRRK2 by Small Molecule Protacs (Joint with Dana-Farber Cancer Institute)

  Alessi, D. & Davies, P.

  2/11/16 → 13/08/18

  Project: Research

• Towards a Unifying Theory of Parkinson's Disease - Investigation of the Biochemical and Genetic Role of Rab GTPases (joint with German Centre for Neurodegenerative Diseases)

  Alessi, D. & Muqit, M.

  Medical Research Council

  17/10/16 → 16/10/18

  Project: Research

  • Parkinson Disease 100%
  • Phosphotransferases 95%
  • Phosphorylation 84%
  • Leucine 83%
  • rab GTP-Binding Proteins 59%

• Validation of Custom Rabbit Monoclonal Antibodies Directed to Rab8 a/b (Total Rab 8b, pT72 Rab 8a) and to Rab10 (total and pT73) made at Abcam

  Alessi, D. & Davies, P.

  1/08/16 → 31/01/18

  Project: Research

• Rab Detection Initiative (Joint with Stanford School of Medicine, Max Plank Institute, Neuroscience Research Australia and Parkinsons Institute California)

  Alessi, D. & Davies, P.

  1/08/16 → 31/07/21

  Project: Research

  • AMP-Activated Protein Kinases 100%
  • Adenosine Monophosphate 21%
  • Adenosine Triphosphate 16%
  • Metformin 15%
  • Neoplasms 15%

• Capital Prioritisation Bid 2016/17

  Alessi, D.

  Medical Research Council

  1/04/16 → 31/03/17

  Project: Research

• Understanding Regulation of Rabs by LRRK2 and Implications to Parkinson's Disease (joint with Max Planck Institute of Biochemistry and Stanford School of Medicine)

  Alessi, D.

  1/08/15 → 31/07/18

  Project: Research

  • Leucine 100%
  • Phosphotransferases 75%
  • Parkinson Disease 16%
  • Dimerization 14%
  • human LRRK2 protein 12%

• Targeting the WNK-SPAK/OSR1-KCC2 Pathway in the Treatment of Neuropsychiatric Disease (Collaborative Funding for Jinwei Zhang)

  Alessi, D.

  Yale University

  1/07/15 → 30/06/16

  Project: Research

• Development of Antibodies Towards LRKK2 Mediated Rab Phosphorylation Sites

  Alessi, D. & Davies, P.

  1/06/15 → 31/08/16

  Project: Research

• Investigation of PINK1 Regulation of Parkin (J Macdonald Menzies Charitable Trust Prize Studentship)

  Alessi, D. & Muqit, M.

  J. Macdonald Menzies Charitable Trust

  11/05/15 → 10/05/19

  Project: Research

• Capital Prioritisation Panel February 2015

  Alessi, D.

  Medical Research Council

  1/04/15 → 31/03/16

  Project: Research

• Validation of Voltage - Dependent Anion Channel Proteins as Substrates of the Parkinson Disease Gene and E3 Ubiquitin Ligase Component FBX07

  Alessi, D. & Sammler, E.

  Anonymous Trust

  1/09/14 → 31/08/16

  Project: Research

• The Dissection of Novel Signalling Networks Controlled by the Salt-Inducible Kinases During the Resolution of Inflammatory Arthritis (Career Development Fellowship)

  Alessi, D. & Clark, K.

  1/05/14 → 30/04/19

  Project: Research