Alessi, Dario

Projects

Projects per year 2008 2010 2015 2016 2018 2020 2021 2022 2023 2028

• 5 Not started
• 5 Active
• 66 Finished

Projects per year

Search results

• Finished

  World Class Labs Capital Equipment Funding Block Grant

  Alessi, D. (Investigator) & Davies, P. (Investigator)

  Medical Research Council

  17/10/23 → 31/03/24

  Project: Research

• Linking the GI tract with PD

  Alessi, D. (Investigator), Mowat, C. (Investigator) & Sammler, E. (Investigator)

  1/10/23 → 30/09/24

  Project: Research

  • Discretion 100%
  • Medical Research Council 100%
  • Medical 100%
  • viewer 100%
  • Clinical 100%

• Interrogating LRRK2 Signalling in Bio-Samples Derived From Patients with Parkinson's Disease Carrying the Asian LRRK2 G2385R and R1628P Variants for Biomarker Discovery (Joint with University of Malaya)

  Alessi, D. (Investigator) & Sammler, E. (Investigator)

  15/09/23 → 14/03/25

  Project: Research

• Validation Of LRRK2 Modifiers As Potential PD Therapeutic Targets - Joint with Universite de Lille and University of Padua

  Alessi, D. (Investigator)

  26/06/23 → 25/12/24

  Project: Research

• Capital Equipment Award. Shared Proteomics Platform For The MRC-PPU And The UK DRI

  Alessi, D. (Investigator)

  1/04/23 → 31/03/24

  Project: Research

• Development of LRRK2 Type II Inhibitors to Understand Utility of these Compounds for the Treatment of Parkinson's Disease

  Alessi, D. (Investigator), Davies, P. (Investigator), Gilbert, I. (Investigator), Gray, D. (Investigator) & Read, K. (Investigator)

  1/03/23 → 29/02/24

  Project: Research

• MRC Capital Block Grant

  Alessi, D. (Investigator) & Davies, P. (Investigator)

  Medical Research Council

  1/11/22 → 31/03/23

  Project: Research

• Ultra-High Definition Imaging - MRC Equipment Grant

  Alessi, D. (Investigator), Banerjee, S. (Investigator), Cantley, J. (Investigator), Corner, G. (Investigator), Hayes, J. (Investigator), Hoskins, P. (Investigator), Kang, L. (Investigator), McNeilly, A. (Investigator), McSorley, H. (Investigator), Murdoch, C. (Investigator) & Rena, G. (Investigator)

  Medical Research Council

  1/11/22 → 31/03/23

  Project: Research

• LRRK2 Kinase Activity and Global Proteomic Markers in the Gut of PD and IBD Patients (Joint with Icahn School of Medicine Mount Sinai New York & Department Of Pathology & Immunology, Washington University School of Medicine)

  Alessi, D. (Investigator) & Sammler, E. (Investigator)

  1/07/22 → 31/08/24

  Project: Research

• High-Throughput-Analysis to Identify and Characterize PPM1H Protein Phosphatase Activity Enhancers

  Alessi, D. (Investigator) & Davies, P. (Investigator)

  1/02/22 → 1/02/24

  Project: Research

• MRC Climate Crisis Network (Lead: University Of Dundee other instns: Mitocondrial Unit, Human Genetics Unit)

  Alessi, D. (Investigator) & Labib, K. (Investigator)

  Medical Research Council

  1/01/22 → 31/12/24

  Project: Research

• Cell Line Characterisation (other inst: Rutgers University)

  Alessi, D. (Investigator)

  1/11/21 → 31/10/23

  Project: Research

• Identifying PD Biomarkers In Peripheral Blood Immune Cells Using Mass Spectrometry And Single Cell RNA Sequencing

  Alessi, D. (Investigator)

  14/09/21 → 1/09/24

  Project: Research

• Differential LRRK2 Dependent Rab Phosphorylation Signatures in Peripheral Blood and Urine in Idiopathic and Monogenetic PD

  Alessi, D. (Investigator) & Sammler, E. (Investigator)

  1/06/21 → 31/07/24

  Project: Research

  • Parkinson's Disease 100%
  • Phospholipids 50%
  • Bisphosphonates 50%
  • Leucine-rich Repeat Kinase 2 (LRRK2) 50%
  • Mutation Carriers 50%

• World Class Labs Capital Award 21/22

  Alessi, D. (Investigator) & Davies, P. (Investigator)

  Medical Research Council

  1/04/21 → 31/03/22

  Project: Research

  • E3 Ligase 100%
  • Ligase 100%
  • Bromodomain-containing Protein 4 (BRD4) 70%
  • Ubiquitination 70%
  • Degrader 66%

• World Class Labs Capital Funding Offer 2021/22

  Alessi, D. (Investigator) & Davies, P. (Investigator)

  Medical Research Council

  1/04/21 → 31/03/22

  Project: Research

• Stratification Of MRC Funded Scientific Technologies And Reagents For Rapid And Simple Dissemination To The Wider Scientific Community

  Alessi, D. (Investigator) & Davies, P. (Investigator)

  Medical Research Council

  1/01/21 → 31/03/21

  Project: Research

  • COVID-19 100%
  • Severe Acute Respiratory Syndrome Coronavirus 2 100%
  • Biochemical Characterization 50%
  • Nsp3 50%
  • Protease Activity 50%

• MRC PPU Covid Research

  Alessi, D. (Investigator) & Davies, P. (Investigator)

  Medical Research Council

  18/10/20 → 17/07/21

  Project: Research

  • COVID-19 100%
  • Coronavirus 66%
  • Coronavirinae 66%
  • Severe Acute Respiratory Syndrome Coronavirus 2 66%
  • SARS Coronavirus 66%

• World Class Labs

  Alessi, D. (Investigator) & Davies, P. (Investigator)

  Medical Research Council

  1/10/20 → 31/03/21

  Project: Research

• ASAP - Mapping the LRRK2 Signalling Pathway and its Interplay with other Parkinson's Disease Components

  Alessi, D. (Investigator) & Muqit, M. (Investigator)

  Aligning Science Across Parkinson's (ASAP), Michael J. Fox Foundation for Parkinson's Research

  1/10/20 → 1/10/24

  Project: Research

  • Kinase 100%
  • Phosphotransferase 100%
  • Leucine-rich Repeat Kinase 2 (LRRK2) 89%
  • Leucine-Rich Repeat 61%
  • Parkinson's Disease 53%

• Funding for new Mass Spec Platform

  Alessi, D. (Investigator) & Davies, P. (Investigator)

  1/04/20 → 31/03/21

  Project: Research

• Characterization of pT73 Rab10 Protein from XProChem and Supply of pRab8A and pRab10 Protein to Abcam for Assay Development

  Alessi, D. (Investigator) & Davies, P. (Investigator)

  1/01/20 → 14/08/21

  Project: Research

• PPM1H Activators for Treatment of Parkinson's Disease

  Alessi, D. (Investigator) & Gray, D. (Investigator)

  1/09/19 → 30/03/21

  Project: Research

• Genome-wide and chemical screens to uncover novel upstream regulators of the LRRK2 signaling network

  Alessi, D. (Investigator)

  1/08/19 → 30/09/21

  Project: Research

  • Leucine-rich Repeat Kinase 2 (LRRK2) 100%
  • LRRK2 76%
  • PPM1H 38%
  • Rab Proteins 36%
  • Phosphatase 33%

• MRC Capital Prioritisation Bid 2019-20

  Alessi, D. (Investigator) & Davies, P. (Investigator)

  Medical Research Council

  1/04/19 → 31/03/20

  Project: Research

• Correlating LRRK2 Activation Status to Phospho-Lipids in Parkinson's Disease

  Alessi, D. (Investigator) & Sammler, E. (Investigator)

  1/11/18 → 31/12/20

  Project: Research

• LRRK2 and IBD

  Alessi, D. (Investigator)

  1/11/18 → 31/10/19

  Project: Research

• Regulation of the Parkinson's kinase LRRK2

  Alessi, D. (Investigator)

  Parkinson's UK

  3/09/18 → 2/09/21

  Project: Research

  • Leucine-rich Repeat Kinase 2 (LRRK2) 100%
  • Leucine-Rich Repeat 91%
  • Kinase 85%
  • Phosphotransferase 85%
  • Parkinson's Disease 41%

• Investigation of the LRRK2 G2385R Mutation (joint with Chinese National Human Genome Center Beijing (SinoGenoMax), Xuanwu Hospital of Capital Medical University)

  Alessi, D. (Investigator) & Davies, P. (Investigator)

  1/08/18 → 31/12/20

  Project: Research

• MRC Capital Prioritisation

  Alessi, D. (Investigator) & Davies, P. (Investigator)

  Medical Research Council

  1/04/18 → 31/03/19

  Project: Research

• MRC QQR

  Alessi, D. (Investigator), Davies, P. (Investigator), Ganley, I. (Investigator), Kulathu, Y. (Investigator), Labib, K. (Investigator), Liang, A. (Investigator), Rouse, J. (Investigator), Rousseau, A. (Investigator), Sapkota, G. (Investigator), Virdee, S. (Investigator) & Walden, H. (Investigator)

  Medical Research Council

  1/04/18 → 1/04/24

  Project: Research

  • Ubiquitination 100%
  • Protein Phosphorylation 100%
  • Video Project 80%
  • Audio 80%
  • Parkinson's Disease 80%

• Validation of Abcam Rabbit anti-pS1292 LRRK Antibody

  Alessi, D. (Investigator) & Davies, P. (Investigator)

  27/09/17 → 26/09/18

  Project: Research

• LRRK2 Inhibition to Systemic Bacterial Infection (Joint with Ottowa Hospital Research Institute)

  Alessi, D. (Investigator)

  1/07/17 → 30/06/19

  Project: Research

• MRC Capital Prioritisation Bid 2017/18

  Alessi, D. (Investigator)

  Medical Research Council

  1/04/17 → 31/03/18

  Project: Research

• Chemical Knockdown of LRRK2 by Small Molecule Protacs (Joint with Dana-Farber Cancer Institute)

  Alessi, D. (Investigator) & Davies, P. (Investigator)

  2/11/16 → 13/08/18

  Project: Research

• Towards a Unifying Theory of Parkinson's Disease - Investigation of the Biochemical and Genetic Role of Rab GTPases (joint with German Centre for Neurodegenerative Diseases)

  Alessi, D. (Investigator) & Muqit, M. (Investigator)

  Medical Research Council

  17/10/16 → 16/10/18

  Project: Research

  • Leucine-rich Repeat Kinase 2 (LRRK2) 100%
  • Leucine-Rich Repeat 69%
  • Kinase 66%
  • Phosphotransferase 66%
  • LRRK2 53%

• Validation of Custom Rabbit Monoclonal Antibodies Directed to Rab8 a/b (Total Rab 8b, pT72 Rab 8a) and to Rab10 (total and pT73) made at Abcam

  Alessi, D. (Investigator) & Davies, P. (Investigator)

  1/08/16 → 31/01/18

  Project: Research

• Rab Detection Initiative (Joint with Stanford School of Medicine, Max Plank Institute, Neuroscience Research Australia and Parkinsons Institute California)

  Alessi, D. (Investigator) & Davies, P. (Investigator)

  1/08/16 → 31/07/21

  Project: Research

  • AMP-activated Protein Kinase 100%
  • Hydroxymethylglutaryl Coenzyme A Reductase Kinase 76%
  • Malignant Neoplasm 35%
  • Liver Kinase B1 (LKB1) 21%
  • Adenosine Monophosphate 18%

• Capital Prioritisation Bid 2016/17

  Alessi, D. (Investigator)

  Medical Research Council

  1/04/16 → 31/03/17

  Project: Research

• Understanding Regulation of Rabs by LRRK2 and Implications to Parkinson's Disease (joint with Max Planck Institute of Biochemistry and Stanford School of Medicine)

  Alessi, D. (Investigator)

  1/08/15 → 31/07/18

  Project: Research

  • Leucine-Rich Repeat 100%
  • WD40 Repeat 100%
  • Crystal Structure 100%
  • Phosphotransferase 100%
  • Kinase 100%

• Targeting the WNK-SPAK/OSR1-KCC2 Pathway in the Treatment of Neuropsychiatric Disease (Collaborative Funding for Jinwei Zhang)

  Alessi, D. (Investigator)

  Yale University

  1/07/15 → 30/06/16

  Project: Research

• Development of Antibodies Towards LRKK2 Mediated Rab Phosphorylation Sites

  Alessi, D. (Investigator) & Davies, P. (Investigator)

  1/06/15 → 31/08/16

  Project: Research

• Investigation of PINK1 Regulation of Parkin (J Macdonald Menzies Charitable Trust Prize Studentship)

  Alessi, D. (Investigator) & Muqit, M. (Investigator)

  J. Macdonald Menzies Charitable Trust

  11/05/15 → 10/05/19

  Project: Research

• Capital Prioritisation Panel February 2015

  Alessi, D. (Investigator)

  Medical Research Council

  1/04/15 → 31/03/16

  Project: Research

• Validation of Voltage - Dependent Anion Channel Proteins as Substrates of the Parkinson Disease Gene and E3 Ubiquitin Ligase Component FBX07

  Alessi, D. (Investigator) & Sammler, E. (Investigator)

  Anonymous Trust

  1/09/14 → 31/08/16

  Project: Research

• The Dissection of Novel Signalling Networks Controlled by the Salt-Inducible Kinases During the Resolution of Inflammatory Arthritis (Career Development Fellowship)

  Alessi, D. (Investigator) & Clark, K. (Investigator)

  1/05/14 → 30/04/19

  Project: Research

• Capital Prioritisation Panel February 2014

  Alessi, D. (Investigator)

  Medical Research Council

  1/04/14 → 1/04/15

  Project: Research

• Study of Differential TRNA Post-Transcriptional Modifications as a Mechanism to Control Proteome Composition

  Alessi, D. (Investigator) & Pedrioli, P. (Investigator)

  Biotechnology and Biological Sciences Research Council

  31/03/14 → 30/03/17

  Project: Research

  • Ubiquitin 100%
  • Kinase 92%
  • Phosphotransferase 92%
  • Phosphorylation 85%
  • Parkin 82%

• Development of G2019S LRRK2 Inhibitors for the Treatment of Parkinson's Disease

  Alessi, D. (Investigator)

  15/09/13 → 14/09/15

  Project: Research

• LRRK2 Cell Line Characterization

  Alessi, D. (Investigator)

  1/09/13 → 28/02/14

  Project: Research