Alessi, Dario

Projects

Projects per year 2008 2010 2013 2014 2015 2016 2018 2020 2021 2022 2023 2028

• 2 Not started
• 15 Active
• 53 Finished

Projects per year

Search results

• Finished

  Ultra-High Definition Imaging - MRC Equipment Grant

  Alessi, D., Banerjee, S., Cantley, J., Corner, G., Hayes, J., Hoskins, P., Kang, L., McNeilly, A., McSorley, H., Murdoch, C. & Rena, G.

  Medical Research Council

  1/11/22 → 31/03/23

  Project: Research

• MRC Capital Block Grant

  Alessi, D. & Davies, P.

  Medical Research Council

  1/11/22 → 31/03/23

  Project: Research

• Identifying PD Biomarkers In Peripheral Blood Immune Cells Using Mass Spectrometry And Single Cell RNA Sequencing

  Alessi, D.

  14/09/21 → 13/09/23

  Project: Research

• World Class Labs Capital Funding Offer 2021/22

  Alessi, D. & Davies, P.

  Medical Research Council

  1/04/21 → 31/03/22

  Project: Research

• World Class Labs Capital Award 21/22

  Alessi, D. & Davies, P.

  Medical Research Council

  1/04/21 → 31/03/22

  Project: Research

• Stratification Of MRC Funded Scientific Technologies And Reagents For Rapid And Simple Dissemination To The Wider Scientific Community

  Alessi, D. & Davies, P.

  Medical Research Council

  1/01/21 → 31/03/21

  Project: Research

  • Severe acute respiratory syndrome coronavirus 100%
  • Single-Domain Antibodies 85%
  • SARS Virus 85%
  • Reverse Genetics 76%
  • Coronavirinae 76%

• MRC PPU Covid Research

  Alessi, D. & Davies, P.

  Medical Research Council

  18/10/20 → 17/07/21

  Project: Research

  • Coronavirus 100%
  • SARS Virus 87%
  • Severe Acute Respiratory Syndrome 76%
  • Severe acute respiratory syndrome coronavirus 68%
  • Single-Domain Antibodies 58%

• World Class Labs

  Alessi, D. & Davies, P.

  Medical Research Council

  1/10/20 → 31/03/21

  Project: Research

• Funding for new Mass Spec Platform

  Alessi, D. & Davies, P.

  1/04/20 → 31/03/21

  Project: Research

• Characterization of pT73 Rab10 Protein from XProChem and Supply of pRab8A and pRab10 Protein to Abcam for Assay Development

  Alessi, D. & Davies, P.

  1/01/20 → 14/08/21

  Project: Research

• PPM1H Activators for Treatment of Parkinson's Disease

  Alessi, D. & Gray, D.

  1/09/19 → 30/03/21

  Project: Research

• Genome-wide and chemical screens to uncover novel upstream regulators of the LRRK2 signaling network

  Alessi, D.

  1/08/19 → 30/09/21

  Project: Research

  • rab GTP-Binding Proteins 100%
  • Mutation 84%
  • Parkinson Disease 72%
  • Phosphorylation 72%
  • Phosphoric Monoester Hydrolases 68%

• MRC Capital Prioritisation Bid 2019-20

  Alessi, D. & Davies, P.

  Medical Research Council

  1/04/19 → 31/03/20

  Project: Research

• Correlating LRRK2 Activation Status to Phospho-Lipids in Parkinson's Disease

  Alessi, D. & Sammler, E.

  1/11/18 → 31/12/20

  Project: Research

• LRRK2 and IBD

  Alessi, D.

  1/11/18 → 31/10/19

  Project: Research

• Regulation of the Parkinson's kinase LRRK2

  Alessi, D.

  Parkinson's UK

  3/09/18 → 2/09/21

  Project: Research

  • Leucine 100%
  • Phosphotransferases 95%
  • Parkinson Disease 57%
  • Phosphorylation 48%
  • Mutation 38%

• Investigation of the LRRK2 G2385R Mutation (joint with Chinese National Human Genome Center Beijing (SinoGenoMax), Xuanwu Hospital of Capital Medical University)

  Alessi, D. & Davies, P.

  1/08/18 → 31/12/20

  Project: Research

• MRC Capital Prioritisation

  Alessi, D. & Davies, P.

  Medical Research Council

  1/04/18 → 31/03/19

  Project: Research

• Validation of Abcam Rabbit anti-pS1292 LRRK Antibody

  Alessi, D. & Davies, P.

  27/09/17 → 26/09/18

  Project: Research

• LRRK2 Inhibition to Systemic Bacterial Infection (Joint with Ottowa Hospital Research Institute)

  Alessi, D.

  1/07/17 → 30/06/19

  Project: Research

• MRC Capital Prioritisation Bid 2017/18

  Alessi, D.

  Medical Research Council

  1/04/17 → 31/03/18

  Project: Research

• Chemical Knockdown of LRRK2 by Small Molecule Protacs (Joint with Dana-Farber Cancer Institute)

  Alessi, D. & Davies, P.

  2/11/16 → 13/08/18

  Project: Research

• Towards a Unifying Theory of Parkinson's Disease - Investigation of the Biochemical and Genetic Role of Rab GTPases (joint with German Centre for Neurodegenerative Diseases)

  Alessi, D. & Muqit, M.

  Medical Research Council

  17/10/16 → 16/10/18

  Project: Research

  • Parkinson Disease 100%
  • Phosphotransferases 95%
  • Phosphorylation 84%
  • Leucine 83%
  • rab GTP-Binding Proteins 59%

• Rab Detection Initiative (Joint with Stanford School of Medicine, Max Plank Institute, Neuroscience Research Australia and Parkinsons Institute California)

  Alessi, D. & Davies, P.

  1/08/16 → 31/07/21

  Project: Research

  • AMP-Activated Protein Kinases 100%
  • Adenosine Monophosphate 21%
  • Adenosine Triphosphate 16%
  • Metformin 15%
  • Neoplasms 15%

• Validation of Custom Rabbit Monoclonal Antibodies Directed to Rab8 a/b (Total Rab 8b, pT72 Rab 8a) and to Rab10 (total and pT73) made at Abcam

  Alessi, D. & Davies, P.

  1/08/16 → 31/01/18

  Project: Research

• Capital Prioritisation Bid 2016/17

  Alessi, D.

  Medical Research Council

  1/04/16 → 31/03/17

  Project: Research

• Understanding Regulation of Rabs by LRRK2 and Implications to Parkinson's Disease (joint with Max Planck Institute of Biochemistry and Stanford School of Medicine)

  Alessi, D.

  1/08/15 → 31/07/18

  Project: Research

  • Leucine 100%
  • Phosphotransferases 75%
  • Parkinson Disease 16%
  • Dimerization 14%
  • human LRRK2 protein 12%

• Targeting the WNK-SPAK/OSR1-KCC2 Pathway in the Treatment of Neuropsychiatric Disease (Collaborative Funding for Jinwei Zhang)

  Alessi, D.

  Yale University

  1/07/15 → 30/06/16

  Project: Research

• Development of Antibodies Towards LRKK2 Mediated Rab Phosphorylation Sites

  Alessi, D. & Davies, P.

  1/06/15 → 31/08/16

  Project: Research

• Investigation of PINK1 Regulation of Parkin (J Macdonald Menzies Charitable Trust Prize Studentship)

  Alessi, D. & Muqit, M.

  J. Macdonald Menzies Charitable Trust

  11/05/15 → 10/05/19

  Project: Research

• Capital Prioritisation Panel February 2015

  Alessi, D.

  Medical Research Council

  1/04/15 → 31/03/16

  Project: Research

• Validation of Voltage - Dependent Anion Channel Proteins as Substrates of the Parkinson Disease Gene and E3 Ubiquitin Ligase Component FBX07

  Alessi, D. & Sammler, E.

  Anonymous Trust

  1/09/14 → 31/08/16

  Project: Research

• The Dissection of Novel Signalling Networks Controlled by the Salt-Inducible Kinases During the Resolution of Inflammatory Arthritis (Career Development Fellowship)

  Alessi, D. & Clark, K.

  1/05/14 → 30/04/19

  Project: Research

• Capital Prioritisation Panel February 2014

  Alessi, D.

  Medical Research Council

  1/04/14 → 1/04/15

  Project: Research

• Study of Differential TRNA Post-Transcriptional Modifications as a Mechanism to Control Proteome Composition

  Alessi, D. & Pedrioli, P.

  Biotechnology and Biological Sciences Research Council

  31/03/14 → 30/03/17

  Project: Research

  • Ubiquitin 100%
  • Mutation 86%
  • Palbociclib 71%
  • Amyotrophic Lateral Sclerosis 8 69%
  • Phosphotransferases 62%

• Development of G2019S LRRK2 Inhibitors for the Treatment of Parkinson's Disease

  Alessi, D.

  15/09/13 → 14/09/15

  Project: Research

• LRRK2 Cell Line Characterization

  Alessi, D.

  1/09/13 → 28/02/14

  Project: Research

• Mid-Career Equipment Grant

  Alessi, D. & Kulathu, Y.

  Medical Research Council

  1/04/13 → 31/03/14

  Project: Research

• European Lead Factory EUC2LID (IMI) (Joint with 29 other Partners)

  Alessi, D., Ferguson, M., Hopkins, A., Hopkins Navratilova, I. & Read, K.

  Scottish Funding Council, COMMISSION OF THE EUROPEAN COMMUNITIES

  1/01/13 → 31/05/18

  Project: Research

  • indole-2-carboxylate 100%
  • Lactams 85%
  • Carbapenems 68%
  • Antibiotics 64%
  • Bacteria 50%

• Generation of Phospho-Ser65 Parkin and Phospho-Thr257 PINK1 Rabbit Monoclonal Antibodies and Characterization of Total PINK1 Rabbit and Mouse Monoclonal Antibodies

  Alessi, D. & Muqit, M.

  1/06/12 → 31/05/13

  Project: Research

• Combining Mass Spectrometry with Genetic and Pharmacological Approaches to Discover and Validate LRRK2 Substrates (Joint with Max Planck, University College London and Harvard University)

  Alessi, D. & Trost, M.

  Michael J. Fox Foundation for Parkinson's Research

  1/04/12 → 30/09/16

  Project: Research

• Role of fbx07 in Parkinson's Disease (Studentship)

  Alessi, D.

  1/10/11 → 30/09/15

  Project: Research

  • Phosphotransferases 100%
  • Leucine 77%
  • Phosphorylation 71%
  • LRRK2-IN-1 60%
  • Mutation 57%

• Generation of LRRK1 Protein and Characterization of LRRK1 Mouse and Rabbit Monoclonal Antibodies

  Alessi, D.

  1/09/11 → 31/08/12

  Project: Research

• Development of Selective LRRK2 Inhibitors (Joint with Harvard University)

  Alessi, D.

  15/07/11 → 14/09/13

  Project: Research

• Role of the PDK1-SGK Pathway in Cancer (CASE Studentship)

  Alessi, D.

  1/10/10 → 30/09/14

  Project: Research

• Pharmacodynamic Biomarkers of LRRK2 Activity

  Alessi, D. & Prescott, A.

  1/10/10 → 30/09/12

  Project: Research

• Development of Novel Models for the Study of Hepatic Insulin Resistance as a Means to an Early Diagnosis and Treatment for Diabetes (Dr Esther Sammler)

  Alessi, D., Cantrell, D., Lambert, J., Marshall, S. & Sammler, E.

  Wellcome Trust

  6/09/10 → 6/05/14

  Project: Research

• Investigating Signalling Pathway Dysfunction Linked to LRRK2

  Alessi, D.

  Michael J. Fox Foundation for Parkinson's Research

  1/09/10 → 31/08/13

  Project: Research

• A Systematic Investigation into the Pathogenesis and Course of Parkinson's Syndrome (Wellcome Trust and MRC Neurodegenerative Diseases Initiative) (Joint with University College London)

  Alessi, D.

  Medical Research Council, Wellcome Trust

  1/09/10 → 31/08/15

  Project: Research

  • Phosphotransferases 100%
  • Leucine 60%
  • Parkinson Disease 36%
  • Phosphorylation 35%
  • Mutation 30%

• Modulation of Renal NaCl Transporter Via Angiotensin II-WNK4-SPAK Signalling Pathway (joint with National University of Mexico)

  Alessi, D.

  Wellcome Trust

  1/07/10 → 31/12/13

  Project: Research

  • Proline 100%
  • Alanine 95%
  • Phosphotransferases 90%
  • Lysine 57%
  • Angiotensin II 53%