Dario Alessi

2019

Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44

Malik, N., Nirujogi, R. S., Peltier, J., Macartney, T., Wightman, M., Prescott, A., Gourlay, R., Trost, M., Alessi, D. (Lead / Corresponding author) & Karapetsas, A. (Lead / Corresponding author), 30 Oct 2019, In: Biochemical Journal. 476, 20, p. 3081-3107 27 p.

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12 Citations (Scopus)

163 Downloads (Pure)

PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins

Berndsen, K., Lis, P., Yeshaw, W. M., Wawro, P. S., Nirujogi, R., Wightman, M., Macartney, T., Dorward, M., Knebel, A., Tonelli, F., Pfeffer, S. R. & Alessi, D. (Lead / Corresponding author), 12 Nov 2019, In: eLife. 8, 37 p., e50416.

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76 Citations (Scopus)

171 Downloads (Pure)

Rapid and reversible knockdown of endogenously tagged endosomal proteins via an optimized HaloPROTAC degrader

Tovell, H., Testa, A., Maniaci, C., Zhou, H., Prescott, A., Macartney, T., Ciulli, A. (Lead / Corresponding author) & Alessi, D. (Lead / Corresponding author), 17 May 2019, In: ACS Chemical Biology. 14, 5, p. 882-892 11 p.

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85 Citations (Scopus)

350 Downloads (Pure)

2018

A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain

Dhekne, H. S., Yanatori, I., Gomez, R. C., Tonelli, F., Diez, F., Schüle, B., Steger, M., Alessi, D. R. & Pfeffer, S. R. (Lead / Corresponding author), 6 Nov 2018, In: eLife. 7, p. 1-26 26 p., e40202.

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142 Citations (Scopus)

298 Downloads (Pure)

Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson’s disease kinase

Lis, P., Burel, S., Steger, M., Mann, M., Brown, F., Diez, F., Tonelli, F., Holton, J. L., Winglok Ho, P., Ho, S.-L., Chou, M.-Y., Polinski, N. K., Martinez, T. N., Davies, P. & Alessi, D. R. (Lead / Corresponding author), 2 Jan 2018, In: Biochemical Journal. 475, 1, p. 1-22 22 p.

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92 Citations (Scopus)

490 Downloads (Pure)

Disruption of the with no lysine kinase-STE20-proline alanine-rich kinase pathway reduces the hypertension induced by angiotensin II

Graciela Cervantes-Perez, L., Castaneda-Bueno, M., Jimenez, J. V., Vazquez, N., Rojas-Vega, L., Alessi, D., Bobadilla, N. A. & Gamba, G. (Lead / Corresponding author), 1 Feb 2018, In: Journal of Hypertension. 36, 2, p. 361-367 7 p.

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1 Citation (Scopus)

286 Downloads (Pure)

Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils

Fan, Y., Howden, A. J. M., Sarhan, A. R., Lis, P., Ito, G., Martinez, T. N., Brockmann, K., Gasser, T., Alessi, D. R. (Lead / Corresponding author) & Sammler, E. (Lead / Corresponding author), 2 Jan 2018, In: Biochemical Journal. 475, 1, p. 23-44 22 p.

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108 Citations (Scopus)

297 Downloads (Pure)

LRRK2 activation in idiopathic Parkinson's disease

Di Maio, R., Hoffman, E. K., Rocha, E. M., Keeney, M. T., Sanders, L. H., De Miranda, B. R., Zharikov, A., Van Laar, A., Stepan, A. F., Lanz, T. A., Kofler, J. K., Burton, E. A., Alessi, D. R., Hastings, T. G. & Timothy Greenamyre, J. (Lead / Corresponding author), 25 Jul 2018, In: Science Translational Medicine. 10, 451, p. 1-12 12 p., eaar5429.

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336 Citations (Scopus)

395 Downloads (Pure)

LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages

Härtlova, A., Herbst, S., Peltier, J., Rodgers, A., Bilkei-Gorzo, O., Fearns, A., Dill, B. D., Lee, H., Flynn, R., Cowley, S. A., Davies, P., Lewis, P. A., Ganley, I. G., Martinez, J., Alessi, D. R., Reith, A. D., Trost, M. (Lead / Corresponding author) & Gutierrez, M. G. (Lead / Corresponding author), 15 Jun 2018, In: The EMBO Journal. 37, 12, 17 p., e98694.

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119 Citations (Scopus)

279 Downloads (Pure)

LRRK2 kinase in Parkinson's disease

Alessi, D. R. (Lead / Corresponding author) & Sammler, E., 6 Apr 2018, In: Science. 360, 6384, p. 36-37 2 p.

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202 Citations (Scopus)

1118 Downloads (Pure)

Mechanism of activation of SGK3 by growth factors-via the Class 1 and Class 3 PI3Ks

Malik, N. (Lead / Corresponding author), Macartney, T., Hornberger, A., Anderson, K., Tovell, H., Prescott, A. R. & Alessi, D. R. (Lead / Corresponding author), 2 Jan 2018, In: Biochemical Journal. 475, 1, p. 117-135 19 p.

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29 Citations (Scopus)

392 Downloads (Pure)

Nigrostriatal pathology with reduced astrocytes in LRRK2 S910/S935 phosphorylation deficient knockin mice

Zhao, Y., Keshiya, S., Atashrazm, F., Gao, J., Ittner, L. M., Alessi, D. R., Halliday, G. M., Fu, Y. & Dzamko, N. (Lead / Corresponding author), 1 Dec 2018, In: Neurobiology of Disease. 120, p. 76-87 12 p.

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17 Citations (Scopus)

348 Downloads (Pure)

PP1 Phosphatase complexes: Undruggable No Longer

Vagnarelli, P. (Lead / Corresponding author) & Alessi, D. R. (Lead / Corresponding author), 23 Aug 2018, In: Cell. 174, 5, p. 1049-1051 3 p.

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9 Citations (Scopus)

125 Downloads (Pure)

Rab29 activation of the Parkinson's disease-associated LRRK2 kinase

Purlyte, E., Dhekne, H. S., Sarhan, A. R., Gomez, R., Lis, P., Wightman, M., Martinez, T. N., Tonelli, F. (Lead / Corresponding author), Pfeffer, S. R. (Lead / Corresponding author) & Alessi, D. R. (Lead / Corresponding author), 4 Jan 2018, In: EMBO Journal. 37, 1, p. 1-18 18 p.

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177 Citations (Scopus)

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Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains

Wang, J., Erazo, T., Ferguson, F. M., Buckley, D. L., Gomez, N., Muñoz-Guardiola, P., Diéguez-Martínez, N., Deng, X., Hao, M., Massefski, W., Fedorov, O., Offei-Addo, N. K., Park, P. M., Dai, L., DiBona, A., Becht, K., Kim, N. D., McKeown, M. R., Roberts, J. M. & Zhang, J. & 8 others, Sim, T., Alessi, D. R., Bradner, J. E., Lizcano, J. M., Blacklow, S. C., Qi, J., Xu, X. (Lead / Corresponding author) & Gray, N. S. (Lead / Corresponding author), 21 Sept 2018, In: ACS Chemical Biology. 13, 9, p. 2438-2448 11 p.

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47 Citations (Scopus)

309 Downloads (Pure)

The Parkinson's disease VPS35[D620N] mutation enhances LRRK2 mediated Rab protein phosphorylation in mouse and human

Mir, R., Tonelli, F., Lis, P., Macartney, T., Polinski, N. K., Martinez, T. N., Chou, M.-Y., Howden, A., König, T., Hotzy, C., Milenkovic, I., Brücke, T., Zimprich, A., Sammler, E. (Lead / Corresponding author) & Alessi, D. (Lead / Corresponding author), 6 Jun 2018, In: Biochemical Journal. 475, 11, p. 1861-1883 19 p.

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140 Citations (Scopus)

343 Downloads (Pure)

2017

B cell-intrinsic function of TAPP adaptors in controlling germinal center responses and autoantibody production in mice

Jayachandran, N., Landego, I., Hou, S., Alessi, D. R. & Marshall, A. J. (Lead / Corresponding author), 10 Feb 2017, In: European Journal of Immunology. 47, 2, p. 280-290 11 p.

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10 Citations (Scopus)

346 Downloads (Pure)

Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation

Maniaci, C., Hughes, S. J., Testa, A., Chen, W., Lamont, D. J., Rocha, S., Alessi, D. R., Romeo, R. & Ciulli, A. (Lead / Corresponding author), 10 Oct 2017, In: Nature Communications. 8, p. 1-14 14 p., 830.

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186 Citations (Scopus)

310 Downloads (Pure)

Integrated single-cell genetic and transcriptional analysis suggests novel drivers of chronic lymphocytic leukemia

Wang, L., Fan, J., Francis, J. M., Georghiou, G., Hergert, S., Li, S., Gambe, R., Zhou, C. W., Yang, C., Xiao, S., Cin, P. D., Bowden, M., Kotliar, D., Shukla, S. A., Brown, J. R., Neuberg, D., Alessi, D. R., Zhang, C.-Z. (Lead / Corresponding author), Kharchenko, P. V. & Livak, K. J. & 1 others, Wu, C. J. (Lead / Corresponding author), 5 Jul 2017, In: Genome Research. 27, p. 1300-1311 11 p.

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62 Citations (Scopus)

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Regulation of membrane ruffling by polarized STIM1 and ORAI1in cortactin-rich domains

M. López-Guerrero, A., Tomas-Martin, P., Pascual-Caro, C., Macartney, T., Rojas-Fernandez, A., Ball, G., Alessi, D. R., Pozo-Guisado, E. & Martin-Romero, F. J. (Lead / Corresponding author), 24 Mar 2017, In: Scientific Reports. 7, 15 p., 383.

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19 Citations (Scopus)

244 Downloads (Pure)

Small-Molecule Inhibitors of LRRK2

Hatcher, J. M., Choi, H. G., Alessi, D. R. & Gray, N. S. (Lead / Corresponding author), 2017, Leucine-Rich Repeat Kinase 2 (LRRK2). Rideout, H. J. (ed.). Springer International Publishing, p. 241-264 24 p. (Advances in neurobiology; vol. 14).

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

27 Citations (Scopus)

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis

Steger, M., Diez, F., Dhekne, H. S., Lis, P., Nirujogi, R. S., Karayel, O., Tonelli, F., Martinez, T. N., Lorentzen, E., Pfeffer, S. R., Alessi, D. R. (Lead / Corresponding author) & Mann, M., 10 Nov 2017, In: eLife. 6, p. 1-22 22 p., e31012.

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286 Citations (Scopus)

368 Downloads (Pure)

USP7 small-molecule inhibitors interfere with ubiquitin binding

Kategaya, L., Di Lello, P., Rougé, L., Pastor, R., Clark, K. R., Drummond, J., Kleinheinz, T., Lin, E., Upton, J.-P., Prakash, S., Heideker, J., McCleland, M., Ritorto, M. S., Alessi, D. R., Trost, M., Bainbridge, T. W., Kwok, M. C. M., Ma, T. P., Stiffler, Z. & Brasher, B. & 24 others, Tang, Y., Jaishankar, P., Hearn, B. R., Renslo, A. R., Arkin, M. R., Cohen, F., Yu, K., Peale, F., Gnad, F., Chang, M. T., Klijn, C., Blackwood, E., Martin, S. E., Forrest, W. F., Ernst, J. A., Ndubaku, C., Wang, X., Beresini, M. H., Tsui, V., Schwerdtfeger, C., Blake, R. A., Murray, J., Maurer, T. (Lead / Corresponding author) & Wertz, I. E. (Lead / Corresponding author), 18 Oct 2017, In: Nature. 550, p. 534-538 5 p.

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237 Citations (Scopus)

1316 Downloads (Pure)

Vomocytosis of live pathogens from macrophages is regulated by the atypical MAP kinase ERK5

Gilbert, A. S., Seoane, P. I., Sephton-Clark, P., Bojarczuk, A., Hotham, R., Giurisato, E., Sarhan, A. R., Hillen, A., Velde, G. V., Gray, N. S., Alessi, D. R., Cunningham, D. L., Tournier, C., Johnston, S. A. & May, R. C. (Lead / Corresponding author), 16 Aug 2017, In: Science Advances. 3, 8, p. 1-9 9 p., e1700898.

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40 Citations (Scopus)

191 Downloads (Pure)

2016

Functional kinomics establishes a critical node of volume-sensitive cation-Cl^- cotransporter regulation in the mammalian brain

Zhang, J. (Lead / Corresponding author), Gao, G., Begum, G., Wang, J., Khanna, A. R., Shmukler, B. E., Daubner, G. M., De Los Heros, P., Davies, P., Varghese, J., Bhuiyan, M. I. H., Duan, J., Zhang, J., Duran, D., Alper, S. L., Sun, D., Elledge, S. J., Alessi, D. R. & Kahle, K. T. (Lead / Corresponding author), 26 Oct 2016, In: Scientific Reports. 6, p. 1-19 19 p., 35986.

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40 Citations (Scopus)

221 Downloads (Pure)

PDK1-SGK1 signaling sustains AKT-independent mTORC1 activation and confers resistance to PI3Kα inhibition

Castel, P., Ellis, H., Bago, R., Toska, E., Razavi, P., Carmona, F. J., kannan, S., Verma, C. S., Dickler, M., Chandarlapaty, S., Brogi, E., Alessi, D., Baselga, J. (Lead / Corresponding author) & Scaltriti, M. (Lead / Corresponding author), 8 Aug 2016, In: Cancer Cell. 30, 2, p. 229-242 14 p.

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171 Citations (Scopus)

649 Downloads (Pure)

Phosphoproteomics reveals that Parkinson’s disease kinase LRRK2 regulates a subset of Rab GTPases

Steger, M., Tonelli, F., Ito, G., Davies, P., Trost, M., Vetter, M., Wachter, S., Lorentzen, E., Duddy, G., Wilson, S., Baptista, M. A. S., Fiske, B. K., Fell, M. J., Morrow, J. A., Reith, A. D., Alessi, D. R. (Lead / Corresponding author) & Mann, M. (Lead / Corresponding author), 29 Jan 2016, In: eLife. 5, p. 1-28 28 p., e12813.

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664 Citations (Scopus)

368 Downloads (Pure)

Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors

Ito, G. (Lead / Corresponding author), Katsemonova, K., Tonelli, F., Lis, P., Baptista, M., Shpiro, N., Duddy, G., Wilson, S., Wing-Lok Ho, P., Ho, S.-L., Reith, A. D. & Alessi, D. R. (Lead / Corresponding author), 30 Aug 2016, In: Biochemical Journal. 473, 17, p. 2671-2685 15 p.

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120 Citations (Scopus)

504 Downloads (Pure)

The hVPS34-SGK3 pathway counteracts inhibition of the PI3K-Akt to maintain mTORC1 and tumour growth

Bago, R., Eskelinen, E.-L., Castel , P., Crafter, C., Bailey, F. P., Shpiro, N., Baselga, J., Cross, D., Eyers, P. & Alessi, D. (Lead / Corresponding author), 1 Sept 2016, In: EMBO Journal. 35, 17, p. 1902-1922 23 p.

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59 Citations (Scopus)

240 Downloads (Pure)

2015

Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation

Kazlauskaite, A., Martínez-Torres, R. J., Wilkie, S., Kumar, A., Peltier, J., Gonzalez, A., Johnson, C., Zhang, J., Hope, A. G., Peggie, M., Trost, M., van Aalten, D. M., Alessi, D. R., Prescott, A. R., Knebel, A., Walden, H. & Muqit, M. M. (Lead / Corresponding author), 1 Aug 2015, In: EMBO Reports. 16, 8, p. 939-954 16 p.

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178 Citations (Scopus)

253 Downloads (Pure)

Critical role of the SPAK protein kinase CCT domain in controlling blood pressure

Zhang, J. (Lead / Corresponding author), Siew, K., Macartney, T., O'Shaughnessy, K. M. (Lead / Corresponding author) & Alessi, D. R. (Lead / Corresponding author), 15 Aug 2015, In: Human Molecular Genetics. 24, 16, p. 4545-4558 14 p.

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32 Citations (Scopus)

171 Downloads (Pure)

Discovery of a pyrrolopyrimidine (JH-II-127), a highly potent, selective, and brain penetrant LRRK2 inhibitor

Hatcher, J. M., Zhang, J., Choi, H. G., Ito, G., Alessi, D. R. (Lead / Corresponding author) & Gray, N. S. (Lead / Corresponding author), 14 May 2015, In: ACS Medicinal Chemistry Letters. 6, 5, p. 584-589 6 p.

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Phosphorylation of synaptic vesicle protein 2A at Thr84 by casein kinase 1 family kinases controls the specific retrieval of synaptotagmin-1

Zhang, N., Gordon, S. L., Fritsch, M. J., Esoof, N., Campbell, D. G., Gourlay, R., Srikannathasan, V., Macartney, T., Peggie, M., van Aalten, D. M. F., Cousin, M. A. (Lead / Corresponding author) & Alessi, D. R. (Lead / Corresponding author), 11 Feb 2015, In: Journal of Neuroscience. 35, 6, p. 2492-2507 16 p.

Research output: Contribution to journal › Article › peer-review

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65 Citations (Scopus)

Photoactivatable prodrugs of antimelanoma agent Vemurafenib

Horbert, R., Pinchuk, B., Davies, P., Alessi, D. & Peifer, C. (Lead / Corresponding author), 18 Sept 2015, In: ACS Chemical Biology. 10, 9, p. 2099-2107 9 p.

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59 Citations (Scopus)

731 Downloads (Pure)

Structural characterization of LRRK2 inhibitors

Gilsbach, B. K., Messias, A. C., Ito, G., Sattler, M., Alessi, D. R., Wittinghofer, A. & Kortholt, A. (Lead / Corresponding author), 14 May 2015, In: Journal of Medicinal Chemistry. 58, 9, p. 3751-3756 6 p.

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA damage responses

Perez-Oliva, A. B. (Lead / Corresponding author), Lachaud, C., Szyniarowski, P., Muñoz, I., Macartney, T., Hickson, I., Rouse, J. (Lead / Corresponding author) & Alessi, D. R. (Lead / Corresponding author), 3 Feb 2015, In: EMBO Journal. 34, 3, p. 326-343 18 p.

Research output: Contribution to journal › Article › peer-review

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45 Citations (Scopus)

2014

A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer

Schönhuber, N., Seidler, B., Schuck, K., Veltkamp, C., Schachtler, C., Zukowska, M., Eser, S., Feyerabend, T. B., Paul, M. C., Eser, P., Klein, S., Lowy, A. M., Banerjee, R., Yang, F., Lee, C.-L., Moding, E. J., Kirsch, D. G., Scheideler, A., Alessi, D. R. & Varela, I. & 8 others, Bradley, A., Kind, A., Schnieke, A. E., Rodewald, H.-R., Rad, R., Schmid, R. M., Schneider, G. & Saur, D. (Lead / Corresponding author), Nov 2014, In: Nature Medicine. 20, 11, p. 1340-1347 8 p.

Research output: Contribution to journal › Article › peer-review

174 Citations (Scopus)

Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

Bago, R. (Lead / Corresponding author), Malik, N., Munson, M. J., Prescott, A. R., Davies, P., Sommer, E., Shpiro, N., Ward, R., Cross, D., Ganley, I. G. & Alessi, D. R. (Lead / Corresponding author), Nov 2014, In: Biochemical Journal. 463, 3, p. 413-427 15 p.

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212 Citations (Scopus)

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Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases

Banerjee, S., Buhrlage, S. J., Huang, H.-T., Deng, X., Zhou, W., Wang, J., Traynor, R., Prescott, A. R., Alessi, D. R. (Lead / Corresponding author) & Gray, N. S. (Lead / Corresponding author), 1 Jan 2014, In: Biochemical Journal. 457, 1, p. 215-225 11 p.

Research output: Contribution to journal › Article › peer-review

64 Citations (Scopus)

Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1β^MYPT1phosphatase complex and the SCF^βTrCP E3 ubiquitin ligase

Banerjee, S. (Lead / Corresponding author), Zagorska, A., Deak, M., Campbell, D. G., Prescott, A. R. & Alessi, D. R. (Lead / Corresponding author), 15 Jul 2014, In: Biochemical Journal. 461, 2, p. 233-245 13 p.

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19 Citations (Scopus)

244 Downloads (Pure)

Investigation of LKB1 Ser⁴³¹ phosphorylation and Cys⁴³³ farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity

Houde, V. P. (Lead / Corresponding author), Ritorto, M. S., Gourlay, R., Davies, P., Shpiro, N., Sakamoto, K. & Alessi, D. R. (Lead / Corresponding author), 15 Feb 2014, In: Biochemical Journal. 458, 1, p. 41-56 16 p.

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41 Citations (Scopus)

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Kinase and channel activity of TRPM6 are co-ordinated by a dimerization motif and pocket interaction

van der Wijst, J. (Lead / Corresponding author), Blanchard, M. G., Woodroof, H. I., Macartney, T. J., Gourlay, R., Hoenderop, J. G., Bindels, R. J. & Alessi, D. R. (Lead / Corresponding author), 13 May 2014, In: Biochemical Journal. 460, 2, p. 165-175 11 p.

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13 Citations (Scopus)

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Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Serine⁶⁵

Kazlauskaite, A. (Lead / Corresponding author), Kondapalli, C., Gourlay, R., Campbell, D. G., Ritorto, M. S., Hofmann, K., Alessi, D. R., Knebel, A., Trost, M. & Muqit, M. M. K. (Lead / Corresponding author), 15 May 2014, In: Biochemical Journal. 460, 1, p. 127-139 13 p.

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630 Citations (Scopus)

202 Downloads (Pure)

Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity

Kazlauskaite, A., Kelly, V., Johnson, C., Baillie, C., Hastie, C. J., Peggie, M., Macartney, T., Woodroof, H. I., Alessi, D. R., Pedrioli, P. G. A. & Muqit, M. M. K., 19 Mar 2014, In: Open Biology. 4, 14 p., 130213.

Research output: Contribution to journal › Article › peer-review

109 Citations (Scopus)

PKB/SGK-resistant GSK-3 signaling following unilateral ureteral obstruction

Voelkl, J., Mia, S., Meissner, A., Ahmed, M. S., Feger, M., Elvira, B., Walker, B., Alessi, D. R., Alesutan, I. & Lang, F., Mar 2014, In: Kidney and Blood Pressure Research. 38, 1, p. 156-164 9 p.

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22 Citations (Scopus)

51 Downloads (Pure)

Screening of DUB activity and specificity by MALDI-TOF mass spectrometry

Ritorto, M. S., Ewan, R., Perez-Oliva, A. B., Knebel, A., Buhrlage, S. J., Wightman, M., Kelly, S. M., Wood, N. T., Virdee, S., Gray, N. S., Morrice, N. A., Alessi, D. R. & Trost, M. (Lead / Corresponding author), 27 Aug 2014, In: Nature Communications. 5, 11 p., 4763.

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252 Citations (Scopus)

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Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation

Schumacher, F.-R., Sorrell, F. J., Alessi, D. R., Bullock, A. N. (Lead / Corresponding author) & Kurz, T. (Lead / Corresponding author), 1 Jun 2014, In: Biochemical Journal. 460, 2, p. 237-246 10 p.

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The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K⁺-Cl^- co-transporters

De Los Heros, P., Alessi, D. R. (Lead / Corresponding author), Gourlay, R., Campbell, D. G., Deak, M., Macartney, T. J., Kahle, K. T. & Zhang, J. (Lead / Corresponding author), 15 Mar 2014, In: Biochemical Journal. 458, 3, p. 559-573 15 p.

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The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters

Alessi, D. R., Zhang, J., Khanna, A., Hochdörfer, T., Shang, Y. & Kahle, K. T. (Lead / Corresponding author), 15 Jul 2014, In: Science Signaling. 7, 334, 10 p., re3.

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205 Citations (Scopus)

2013

Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies

Davies, P., Hinkle, K. M., Sukar, N. N., Sepulveda, B., Mesias, R., Serrano, G., Alessi, D. R., Beach, T. G., Benson, D. L., White, C. L., Cowell, R. M., Das, S. S., West, A. B. (Lead / Corresponding author) & Melrose, H. L. (Lead / Corresponding author), 1 Jul 2013, In: Biochemical Journal. 453, 1, p. 101-113 13 p.

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75 Citations (Scopus)

Alessi, Dario

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