Research output per year
Research output per year
- 12 results
Search results
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2025
NRBP1 and TSC22D proteins impact distal convoluted tubule physiology through modulation of the WNK pathway
Amnekar, R. & Alessi, D., 3 Jan 2025, BioRxiv, 32 p.Research output: Working paper/Preprint › Preprint
Open Access -
2024
Clinical and functional evidence for the pathogenicity of the LRRK2 p.Arg1067Gln variant
Tan, A. H., Lim, S.-Y., Toh, T. S., Hor, J. W., Lim, J. L., Lit, L. C., Ahmad-Annuar, A., Tay, Y. W., Foo, J. N., Ng, E., Muthusamy, K. A., Ibrahim, N. M., Ibrahim, K. A., Tan, L. C., Zulkefli, J., Anuar, A. N. K., Black, K., Lis, P., Xie, F. & Cen, Z. & 7 others, , 17 Sept 2024, Research Square.Research output: Working paper/Preprint › Preprint
File22 Downloads (Pure) -
Endogenous LRRK2 and PINK1 function in a convergent neuroprotective ciliogenesis pathway in the brain
Bagnoli, E., Lin, Y. E., Burel, S., Jaimon, E., Antico, O., Themistokleous, C., Nikolof, J. M., Morella, I., Watzlawik, J. O., Fiesel, F. C., Springer, W., Tonelli, F., Brooks, S. P., Dunnett, S. B., Brambilla, R., Alessi, D., Pfeffer, S. R. & Muqit, M. (Lead / Corresponding author), 11 Jun 2024, BioRxiv, 35 p.Research output: Working paper/Preprint › Preprint
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Lysosome damage triggers acute formation of ER to lysosomes membrane tethers mediated by the bridge-like lipid transport protein VPS13C
Wang, X., Xu, P., Bentley-DeSousa, A., Hancock-Cerutti, W. F., Cai, S., Johnson, B. T., Tonelli, F., Talaia, G., Alessi, D., Ferguson, S. M. F. & De Camilli, P. (Lead / Corresponding author), 8 Jun 2024, BioRxiv, 42 p.Research output: Working paper/Preprint › Preprint
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NRBP1 pseudokinase binds to and activates the WNK pathway in response to osmotic stress
Amnekar, R. (Lead / Corresponding author), Dite, T. D., Lis, P., Bell, S., Brown, F., Johnson, C., Wilkinson, S. G., Raggett, S. L., Dorward, M., Wightman, M., Macartney, T., Filipe Soares, R., Lamoliatte, F. & Alessi, D. (Lead / Corresponding author), 20 Dec 2024, BioRxiv, 50 p.Research output: Working paper/Preprint › Preprint
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PSMF1 variants cause a phenotypic spectrum from early-onset Parkinson’s disease to perinatal lethality by disrupting mitochondrial pathways
Magrinelli, F., Jaconelli, M., Nirujogi, R., Lis, P. & Alessi, D., 20 Jun 2024, medRxiv, 35 p.Research output: Working paper/Preprint › Preprint
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Regulation of Leucine-Rich Repeat Kinase 2 by inflammation and IL-4
Dikovskaya, D., Pemberton, R., Taylor, M., Tasegian, A., Zeneviciute, K., Sammler, E. M., Howden, A. J. M., Alessi, D. R. & Swamy, M., 2 May 2024, BioRxiv, 34 p.Research output: Working paper/Preprint › Preprint
File24 Downloads (Pure) -
Restoration of striatal neuroprotective pathways by kinase inhibitor treatment of Parkinson’s linked-LRRK2 mutant mice
Jaimon, E., Lin, Y. E., Tonelli, F., Antico, O., Alessi, D. & Pfeffer, S. R. (Lead / Corresponding author), 3 Aug 2024, BioRxiv, 28 p.Research output: Working paper/Preprint › Preprint
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Tagless LysoIP method for molecular profiling of lysosomal content in clinical samples
Saarela, D., Lis, P., Gomes, S., Nirujogi, R., Dong, W., Rawat, E. S., Glendinning, S., Zeneviciute, K., Bagnoli, E., Fasimoye, R., Lin, C., Nyame, K., Boros, F. A., Zunke, F., Lamoliatte, F., Elshani, S., Jaconelli, M., Jans, J. J. M. J., Huisman, M. A. & Posern, C. & 6 others, , 27 May 2024, BioRxiv, 31 p.Research output: Working paper/Preprint › Preprint
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2022
A mitochondrial blood-based patient stratification candidate biomarker for Parkinson’s disease
Fox BioNet Investigators, Qi, R., Sammler, E., Gonzalez-Hunt, C. P., Pena, N., Rouanet, J. P., Goodson, S., Fuzatti, M., Blandini, F., Erickson, K. I., Weinstein, A. M., Padmanabhan, S., Tonelli, F., Alessi, D., Shiva, S. & Sanders, L. H., 9 Feb 2022, BioRxiv.Research output: Working paper/Preprint › Preprint
Open AccessFile93 Downloads (Pure) -
Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration
Banerjee, P., Mehta, A., Nirujogi, R., Cooper, J., James, O. G., Nanda, J., Longden, J., Burr, K., Salzinger, A., Paza, E., Newton, J., Story, D., Pal, S., Smith, C., Alessi, D., Selvaraj, B. T., Priller, J. & Chandran, S., 12 May 2022, BioRxiv.Research output: Working paper/Preprint › Preprint
Open AccessFile82 Downloads (Pure) -
Structural basis of human LRRK2 membrane recruitment and activation
Zhu, H., Tonelli, F., Alessi, D. & Sun, J., 26 Apr 2022, BioRxiv.Research output: Working paper/Preprint › Preprint
Open AccessFile105 Downloads (Pure)