Campbell, David

Dr

  • 8869 Citations
  • 50 h-Index
1984 …2020

Research output per year

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Research Output

  • 8869 Citations
  • 50 h-Index
  • 96 Article
  • 2 Book/Film/Article review
2020

A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis

Quan, C., Du, Q., Li, M., Wang, R., Ouyang, Q., Su, S., Zhu, S., Chen, Q., Sheng, Y., Chen, L., Campbell, D. G., MacKintosh, C., Yang, Z., Ouyang, K., Wang, H. Y. & Chen, S., 4 May 2020, In : Nature Communications. 11, p. 1-14 14 p., 2186.

Research output: Contribution to journalArticle

Open Access
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13 Downloads (Pure)
2019

FAM83D directs protein kinase CK1α to the mitotic spindle for proper spindle positioning

Fulcher, L. J., He, Z., Mei, L., Macartney, T. J., Wood, N. T., Prescott, A. R., Whigham, A., Varghese, J., Gourlay, R., Ball, G., Clarke, R., Campbell, D., Maxwell, C. A. & Sapkota, G. P., 1 Sep 2019, In : EMBO Reports. 20, 9, p. 1-19 19 p., e47495.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
88 Downloads (Pure)

SPEG Controls Calcium Re-Uptake into the Sarcoplasmic Reticulum Through Regulating SERCA2a by Its Second Kinase-Domain

Quan, C., Li, M., Du, Q., Chen, Q., Wang, H., Campbell, D. G., Fang, L., Xue, B., MacKintosh, C., Gao, X., Ouyang, K., Wang, H. & Chen, S., 1 Mar 2019, In : Circulation Research. 124, 5, p. 712-726 15 p.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
202 Downloads (Pure)
2018

PAWS1controls cytoskeletal dynamics and cell migration through association with the SH3 adaptor CD2AP

Cummins, T. D., Wu, K. Z. L., Bozatzi, P., Dingwell, K. S., Macartney, T. J., Wood, N. T., Varghese, J., Gourlay, R., Campbell, D. G., Prescott, A., Griffis, E., Smith, J. C. & Sapkota, G. P., 10 Jan 2018, In : Journal of Cell Science. 131, 1, p. 1-12 12 p., jcs202390.

Research output: Contribution to journalArticle

Open Access
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12 Citations (Scopus)
153 Downloads (Pure)

The DUF1669 domain of FAM83 family proteins anchor casein kinase 1 isoforms

Fulcher, L., Bozatzi, P., Tachie-Menson, T., Wu, K., Cummins, T. D., Bufton, J. C., Pinkas, D. M., Dunbar, K., Shrestha, S., Wood, N., Weidlich, S., Macartney, T., Varghese, J., Gourlay, R., Campbell, D., Dingwell, K. S., Smith, J. C., Bullock, A. N. & Sapkota, G., 22 May 2018, In : Science Signaling. 11, 531, p. 1-16 16 p., eaao2341.

Research output: Contribution to journalArticle

Open Access
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21 Citations (Scopus)
169 Downloads (Pure)
2017

A mutant O-GlcNAcase enriches Drosophila developmental regulators

Selvan, N., Williamson, R., Mariappa, D., Campbell, D. G., Gourlay, R., Ferenbach, A. T., Aristotelous, T., Hopkins-Navratilova, I., Trost, M. & van Aalten, D. M. F., Aug 2017, In : Nature Chemical Biology. 13, 8, p. 882-887 8 p.

Research output: Contribution to journalArticle

Open Access
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17 Citations (Scopus)
162 Downloads (Pure)

Rab-GTPase binding effector protein 2 (RABEP2) is a primed substrate for Glycogen Synthase kinase-3 (GSK3)

Logie, L., Van Aalten, L., Knebel, A., Force, T., Hastie, C. J., MacLauchlan, H., Campbell, D. G., Gourlay, R., Prescott, A., Davidson, J., Fuller, W. & Sutherland, C., 15 Dec 2017, In : Scientific Reports. 7, p. 1-14 14 p., 17682.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
171 Downloads (Pure)
2016

The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids

Hoxhaj, G., Caddye, E., Najafov, A., Houde, V. P., Johnson, C., Dissanayake, K., Toth, R., Campbell, D. G., Prescott, A. R. & MacKintosh, C., 22 Apr 2016, In : eLife. 5, p. 1-18 18 p., e12278.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
136 Downloads (Pure)
2015

Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations

Kristariyanto, Y. A., Choi, S-Y., Rehman, S. A. A., Ritorto, M. S., Campbell, D. G., Morrice, N. A., Toth, R. & Kulathu, Y., 15 Apr 2015, In : Biochemical Journal. 467, 2, p. 345-352 8 p.

Research output: Contribution to journalArticle

Open Access
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42 Citations (Scopus)
155 Downloads (Pure)

Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localization

Herhaus, L., Perez-Oliva, A. B., Cozza, G., Gourlay, R., Weidlich, S., Campbell, D. G., Pinna, L. A. & Sapkota, G. P., 14 Apr 2015, In : Science Signaling. 8, 372, 13 p., ra35.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Fasting and systemic insulin signaling regulate phosphorylation of brain proteins that modulate cell morphology and link to neurological disorders

Li, M., Quan, C., Toth, R., Campbell, D. G., MacKintosh, C., Wang, H. Y. & Chen, S., 11 Dec 2015, In : Journal of Biological Chemistry. 290, p. 30030-30041 12 p.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
161 Downloads (Pure)

K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of K29 polyubiquitin

Kristariyanto, Y. A., Abdul Rehman, S. A., Campbell, D. G., Morrice, N. A., Johnson, C., Toth, R. & Kulathu, Y., 2 Apr 2015, In : Molecular Cell. 58, 1, p. 83-94 12 p.

Research output: Contribution to journalArticle

Open Access
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74 Citations (Scopus)
131 Downloads (Pure)

mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival

Munson, M. J., Allen, G. F. G., Toth, R., Campbell, D. G., Lucocq, J. M. & Ganley, I. G., 2 Sep 2015, In : EMBO Journal. 34, 17, p. 2272-2290 19 p.

Research output: Contribution to journalArticle

Open Access
63 Citations (Scopus)

Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1

Lai, Y-C., Kondapalli, C., Lehneck, R., Procter, J. B., Dill, B. D., Woodroof, H. I., Gourlay, R., Peggie, M., Macartney, T. J., Corti, O., Corvol, J-C., Campbell, D. G., Itzen, A., Trost, M. & Muqit, M. MK., 2015, In : EMBO Journal. 22 p.

Research output: Contribution to journalArticle

Open Access
93 Citations (Scopus)

Phosphorylation of synaptic vesicle protein 2A at Thr84 by casein kinase 1 family kinases controls the specific retrieval of synaptotagmin-1

Zhang, N., Gordon, S. L., Fritsch, M. J., Esoof, N., Campbell, D. G., Gourlay, R., Srikannathasan, V., Macartney, T., Peggie, M., van Aalten, D. M. F., Cousin, M. A. & Alessi, D. R., 11 Feb 2015, In : Journal of Neuroscience. 35, 6, p. 2492-2507 16 p.

Research output: Contribution to journalArticle

Open Access
33 Citations (Scopus)

SIK2 regulates CRTCs, HDAC4 and glucose uptake in adipocytes

Henriksson, E., Säll, J., Gormand, A., Wasserstrom, S., Morrice, N. A., Fritzen, A. M., Foretz, M., Campbell, D. G., Sakamoto, K., Ekelund, M., Degerman, E., Stenkula, K. G. & Göransson, O., 29 Jan 2015, In : Journal of Cell Science. 128, 3, p. 472-486 15 p.

Research output: Contribution to journalArticle

Open Access
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47 Citations (Scopus)
174 Downloads (Pure)
2014

GARNL1, a major RalGAP α subunit in skeletal muscle, regulates insulin-stimulated RalA activation and GLUT4 trafficking via interaction with 14-3-3 proteins

Chen, Q., Quan, C., Xie, B., Chen, L., Zhou, S., Toth, R., Campbell, D. G., Lu, S., Shirakawa, R., Horiuchi, H., Li, C., Yang, Z., MacKintosh, C., Wang, H. Y. & Chen, S., 2014, In : Cellular Signalling. 26, 8, p. 1636-1648 13 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
Open Access
File
10 Citations (Scopus)
140 Downloads (Pure)

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Serine65

Kazlauskaite, A., Kondapalli, C., Gourlay, R., Campbell, D. G., Ritorto, M. S., Hofmann, K., Alessi, D. R., Knebel, A., Trost, M. & Muqit, M. M. K., 15 May 2014, In : Biochemical Journal. 460, 1, p. 127-139 13 p.

Research output: Contribution to journalArticle

Open Access
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371 Citations (Scopus)
104 Downloads (Pure)

Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling

Vogt, J., Dingwell, K. S., Herhaus, L., Gourlay, R., Macartney, T., Campbell, D., Smith, J. C. & Sapkota, G. P., Feb 2014, In : Open Biology. 4, 13 p., 130210.

Research output: Contribution to journalArticle

Open Access
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22 Citations (Scopus)
137 Downloads (Pure)

The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver

Patel, K., Foretz, M., Marion, A., Campbell, D. G., Gourlay, R., Boudaba, N., Tournier, E., Titchenell, P., Peggie, M., Deak, M., Wan, M., Kaestner, K. H., Göransson, O., Viollet, B., Gray, N. S., Birnbaum, M. J., Sutherland, C. & Sakamoto, K., 4 Aug 2014, In : Nature Communications. 5, 4535.

Research output: Contribution to journalArticle

Open Access
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73 Citations (Scopus)
164 Downloads (Pure)

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters

De Los Heros, P., Alessi, D. R., Gourlay, R., Campbell, D. G., Deak, M., Macartney, T. J., Kahle, K. T. & Zhang, J., 15 Mar 2014, In : Biochemical Journal. 458, 3, p. 559-573 15 p.

Research output: Contribution to journalArticle

Open Access
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91 Citations (Scopus)
168 Downloads (Pure)
2013

Protein phosphatase 4 is phosphorylated and inactivated by Cdk in response to spindle toxins and interacts with γ-tubulin

Voss, M., Campbell, K., Saranzewa, N., Campbell, D. G., Hastie, C. J., Peggie, M. W., Martin-Granados, C., Prescott, A. R. & Cohen, P. T. W., 1 Sep 2013, In : Cell Cycle. 12, 17, p. 2876-2887 12 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system

Strickson, S., Campbell, D. G., Emmerich, C. H., Knebel, A., Plater, L., Ritorto, M. S., Shpiro, N. & Cohen, P., 1 May 2013, In : Biochemical Journal. 451, 3, p. 427-437 11 p.

Research output: Contribution to journalArticle

Open Access
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97 Citations (Scopus)
134 Downloads (Pure)
2012

Identification of the Amino Acids 300-600 of IRS-2 as 14-3-3 Binding Region with the Importance of IGF-1/Insulin-Regulated Phosphorylation of Ser-573

Neukamm, S. S., Toth, R., Morrice, N., Campbell, D. G., Mackintosh, C., Lehmann, R., Haering, H-U., Schleicher, E. D. & Weigert, C., 2012, In : PLoS ONE. 7, 8, p. e43296

Research output: Contribution to journalArticle

6 Citations (Scopus)

O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release

Pathak, S., Borodkin, V. S., Albarbarawi, O., Campbell, D. G., Ibrahim, A. & van Aalten, D. M. F., 21 Mar 2012, In : EMBO Journal. 31, 6, p. 1394-1404 11 p.

Research output: Contribution to journalArticle

75 Citations (Scopus)

Phosphorylation of FOXO3a on Ser-7 by p38 promotes its nuclear localization in response to doxorubicin

Ho, K-K., McGuire, V. A., Koo, C-Y., Muir, K. W., de Olano, N., Maifoshie, E., Kelly, D. J., McGovern, U. B., Monteiro, L. J., Gomes, A. R., Nebreda, A. R., Campbell, D. G., Arthur, J. S. C. & Lam, E. W. -F., 6 Jan 2012, In : Journal of Biological Chemistry. 287, 2, p. 1545-1555 11 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

Kondapalli, C., Kazlauskaite, A., Zhang, N., Woodroof, H. I., Campbell, D. G., Gourlay, R., Burchell, L., Walden, H., MacArtney, T. J., Deak, M., Knebel, A., Alessi, D. R. & Muqit, M. M. K., 2012, In : Open Biology. 2, 120080.

Research output: Contribution to journalArticle

336 Citations (Scopus)

ZNRF2 is released from membranes by growth factors and with ZNRF1 regulates the Na+/K+ATPase

Hoxhaj, G., Najafov, A., Toth, R., Campbell, D. G., Prescott, A. R. & MacKintosh, C., 1 Oct 2012, In : Journal of Cell Science. 125, 19, p. 4662-4675 14 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: Analysis of substrate specificity and impact of mutations

Woodroof, H. I., Pogson, J. H., Begley, M., Cantley, L. C., Deak, M., Campbell, D. G., Van Aalten, D. M. F., Whitworth, A. J., Alessi, D. R. & Muqit, M. M. K., 1 Nov 2011, In : Open Biology. 1, NOVEMBER, 110012.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Identification and characterization of AtI-2, an Arabidopsis homologue of an ancient protein phosphatase 1 (PP1) regulatory subunit

Templeton, G. W., Nimick, M., Morrice, N., Campbell, D., Goudreault, M., Gingras, A-C., Takemiya, A., Shimazaki, K. & Moorhead, G. B. G., 1 Apr 2011, In : Biochemical Journal. 435, p. 73-83 11 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways

Richardson, C., Sakamoto, K., de los Heros, P., Deak, M., Campbell, D. G., Prescott, A. R. & Alessi, D. R., 1 Mar 2011, In : Journal of Cell Science. 124, 5, p. 789-800 12 p.

Research output: Contribution to journalArticle

115 Citations (Scopus)

Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop

Loeffler, A. S., Alers, S., Dieterle, A. M., Keppeler, H., Franz-Wachtel, M., Kundu, M., Campbell, D. G., Wesselborg, S., Alessi, D. R. & Stork, B., Jul 2011, In : Autophagy. 7, 7, p. 696-706 11 p.

Research output: Contribution to journalArticle

120 Citations (Scopus)

Visualization and biochemical analyses of the emerging mammalian 14-3-3-phosphoproteome

Johnson, C., Tinti, M., Wood, N. T., Campbell, D. G., Toth, R., Dubois, F., Geraghty, K. M., Wong, B. H. C., Brown, L. J., Tyler, J., Gernez, A., Chen, S., Synowsky, S. & MacKintosh, C., Oct 2011, In : Molecular & Cellular Proteomics. 10, 10, p. - 15 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)
2010

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

Nichols, R. J., Dzamko, N., Morrice, N. A., Campbell, D. G., Deak, M., Ordureau, A., Macartney, T., Tong, Y., Shen, J., Prescott, A. R. & Alessi, D. R., 15 Sep 2010, In : Biochemical Journal. 430, p. 393-404 12 p.

Research output: Contribution to journalArticle

212 Citations (Scopus)

Alternative ERK5 regulation by phosphorylation during the cell cycle

Iñesta-Vaquera, F. A., Campbell, D. G., Tournier, C., Gómez, N., Lizcano, J. M. & Cuenda, A., Dec 2010, In : Cellular Signalling. 22, 12, p. 1829-1837 9 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Bioinformatic and experimental survey of 14-3-3-binding sites

Johnson, C., Crowther, S., Stafford, M. J., Campbell, D. G., Toth, R. & MacKintosh, C., 1 Apr 2010, In : Biochemical Journal. 427, 1, p. 69-78 10 p.

Research output: Contribution to journalArticle

172 Citations (Scopus)
10 Citations (Scopus)

New Roles for the LKB1-NUAK Pathway in Controlling Myosin Phosphatase Complexes and Cell Adhesion

Zagorska, A., Deak, M., Campbell, D. G., Banerjee, S., Hirano, M., Aizawa, S., Prescott, A. R. & Alessi, D. R., 30 Mar 2010, In : Science Signaling. 3, 115, p. - 13 p., ra25.

Research output: Contribution to journalArticle

98 Citations (Scopus)

O-Glcnacylation of TAB1 modulates TAK1-mediated cytokine release

Pathak, S., Campbell, D., Ibrahim, A. & Van Aalten, D. M. F., Nov 2010, In : Glycobiology. 20, 11, p. 1478-1478 1 p., 92.

Research output: Contribution to journalBook/Film/Article review

p38 gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock

Sabio, G., Cerezo-Guisado, M. I., del Reino, P., Inesta-Vaquera, F. A., Rousseau, S., Arthur, J. S. C., Campbell, D. G., Centeno, F. & Cuenda, A., 1 Aug 2010, In : Journal of Cell Science. 123, 15, p. 2596-2604 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Phosphorylation of STIM1 at ERK1/2 target sites modulates store-operated calcium entry

Pozo-Guisado, E., Campbell, D. G., Deak, M., Alvarez-Barrientos, A., Morrice, N. A., Alvarez, I. S., Alessi, D. R. & Martin-Romero, F. J., 15 Sep 2010, In : Journal of Cell Science. 123, 18, p. 3084-3093 10 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)
2009
Open Access
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46 Citations (Scopus)
127 Downloads (Pure)
2008

Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1

Richardson, C., Rafiqi, F. H., Karlsson, H. K. R., Moleleki, N., Vandewalle, A., Campbell, D. G., Morrice, N. A. & Alessi, D. R., 1 Mar 2008, In : Journal of Cell Science. 121, 5, p. 675-684 10 p.

Research output: Contribution to journalArticle

245 Citations (Scopus)

Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators

Chen, S., Murphy, J., Toth, R., Campbell, D. G., Morrice, N. A. & Mackintosh, C., 15 Jan 2008, In : Biochemical Journal. 409, 2, p. 449-459 11 p.

Research output: Contribution to journalArticle

140 Citations (Scopus)

Displacement affinity chromatography of protein phosphatase one (PP1) complexes

Moorhead, G. B. G., Trinkle-Mulcahy, L., Nimick, M., De Wever, V., Campbell, D. G., Gourlay, R., Lam, Y. W. & Lamond, A. I., 1 Jan 2008, In : BMC Biochemistry. 9, 1

Research output: Contribution to journalArticle

49 Citations (Scopus)

Minimum information specification for in situ hybridization and immunohistochemistry experiments (MISFISHIE)

Deutsch, E. W., Ball, C. A., Berman, J. J., Bova, G. S., Brazma, A., Bumgarner, R. E., Campbell, D., Causton, H. C., Christiansen, J. H., Daian, F., Dauga, D., Davidson, D. R., Gimenez, G., Goo, Y. A., Grimmond, S., Henrich, T., Herrmann, B. G., Johnson, M. H., Korb, M., Mills, J. C. & 20 others, Oudes, A. J., Parkinson, H. E., Pascal, L. E., Pollet, N., Quackenbush, J., Ramialison, M., Ringwald, M., Salgado, D., Sansone, S-A., Sherlock, G., Stoeckert, C. J., Swedlow, J., Taylor, R. C., Walashek, L., Warford, A., Wilkinson, D. G., Zhou, Y., Zon, L. I., Liu, A. Y. & True, L. D., Mar 2008, In : Nature Biotechnology. 26, 3, p. 305-312 8 p.

Research output: Contribution to journalArticle

87 Citations (Scopus)

Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex

Mendoza, H., Campbell, D. G., Burness, K., Hastie, J., Ronkina, N., Shim, J-H., Arthur, J. S. C., Davis, R. J., Gaestel, M., Johnson, G. L., Ghosh, S. & Cohen, P., 1 Feb 2008, In : Biochemical Journal. 409, p. 711-722 12 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)