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Personal profile

Education/Academic qualification

Doctor of Philosophy, University of London

Bachelor of Science, University of Glasgow

Keywords

  • RM Therapeutics. Pharmacology
  • drug discovery

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 1 Similar Profiles
Drug Discovery Medicine & Life Sciences
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Leishmania donovani Medicine & Life Sciences
Parasites Medicine & Life Sciences
Calcitonin Gene-Related Peptide Medicine & Life Sciences
Trypanosoma cruzi Medicine & Life Sciences
Receptors, Prostaglandin E, EP4 Subtype Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2013 2022

Research Output 1992 2018

4 Citations

Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis

Wyllie, S., Thomas, M., Patterson, S., Crouch, S., De Rycker, M., Lowe, R., Gresham, S., Urbaniak, M. D., Otto, T. D., Stojanovski, L., Simeons, F. R. C., Manthri, S., MacLean, L. M., Zuccotto, F., Homeyer, N., Pflaumer, H., Boesche, M., Sastry, L., Connolly, P., Albrecht, S. & 12 othersBerriman, M., Drewes, G., Gray, D. W., Ghidelli-Disse, S., Dixon, S., Fiandor, J. M., Wyatt, P. G., Ferguson, M. A. J., Fairlamb, A. H., Miles, T. J., Read, K. D. & Gilbert, I. H., 9 Aug 2018, In : Nature. 560, 7717, p. 192-197 6 p.

Research output: Contribution to journalArticle

Open Access
File
Visceral Leishmaniasis
Cyclin-Dependent Kinases
Pharmaceutical Preparations
Toxicology
Parasites
1 Citations

Development of Trypanosoma cruzi in vitro assays to identify compounds suitable for progression in Chagas’ disease drug discovery

MacLean, L., Thomas, J., Lewis, M. D., Cotillo, I., Gray, D. & De Rycker, M., 12 Jul 2018, In : PLoS Neglected Tropical Diseases. 12, 7, p. 1-22 22 p., e0006612.

Research output: Contribution to journalArticle

Open Access
File
Chagas Disease
Trypanosoma cruzi
Drug Discovery
Parasites
Ergosterol

Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis

Thomas, M. G., De Rycker, M., Ajakane, M., Albrecht, S., Álvarez-Pedraglio, A. I., Boesche, M., Brand, S., Campbell, L., Cantizani-Perez, J., Cleghorn, L. A. T., Copley, R. C. B., Crouch, S. D., Daugan, A., Drewes, G., Ferrer, S., Ghidelli-Disse, S., Gonzalez, S., Gresham, S. L., Hill, A. P., Hindley, S. J. & 32 othersLowe, R. M., MacKenzie, C. J., MacLean, L., Manthri, S., Martin, F., Miguel-Siles, J., Nguyen, V. L., Norval, S., Osuna-Cabello, M., Woodland, A., Patterson, S., Pena, I., Quesada-Campos, M. T., Reid, I. H., Revill, C., Riley, J., Ruiz-Gomez, J. R., Shishikura, Y., Simeons, F. R. C., Smith, A., Smith, V. C., Spinks, D., Stojanovski, L., Thomas, J., Thompson, S., Underwood, T., Gray, D. W., Fiandor, J. M., Gilbert, I. H., Wyatt, P. G., Read, K. D. & Miles, T. J., 20 Dec 2018, In : Journal of Medicinal Chemistry. 23 p.

Research output: Contribution to journalArticle

Visceral Leishmaniasis
Leishmania major
Leishmania donovani
Standard of Care
Solubility
72 Citations
Open Access
File
Drug Discovery
Public Health
Neglected Diseases
Disease Eradication
African Trypanosomiasis
9 Citations

Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase

Nakazawa Hewitt, S., Dranow, D. M., Horst, B. G., Abendroth, J. A., Forte, B., Hallyburton, I., Jansen, C., Baragana, B., Choi, R., Rivas, K., Hulverson, M. A., Dumais, M., Edwards, T. E., Lorimer, D. D., Fairlamb, A., Gray, D., Read, K., Lehane, A. M., Kirk, K., Myler, P. J. & 6 othersWernimont, A., Walpole, C., Stacy, R., Barrett, L., Gilbert, I. H. & Van Voorhis, W. C., 13 Jan 2017, In : ACS Infectious Diseases. 3, 1, p. 34-44 11 p.

Research output: Contribution to journalArticle

Open Access
File
Pharmaceutical Chemistry
Plasmodium falciparum
Malaria
Crystallography
X Ray Crystallography

Activities 2011 2019

  • 8 Other
  • 2 Invited talk
  • 1 Membership of panel

Action Medical Research - Scientific Advisory Panel

David Gray (Member)
2019 → …

Activity: Other activity typesOther

Member of MRC/AZ Centre for Lead Discovery (CLD)

David Gray (Member)
Jan 2017 → …

Activity: Other activity typesOther

Global Antimicrobial Resistance Investment Fund (GAMRIF) panel

David Gray (Member)
20172018

Activity: Other activity typesOther

Dundee Drug Discovery Unit, Diversity screening for tropical diseases

David Gray (Speaker)
Jul 2014

Activity: Talk or presentation typesInvited talk

external review of infrastructure grants

David Gray (Reviewer)
1 Jan 20131 May 2013

Activity: Other activity typesOther

Thesis

Early-stage drug discovery of HIV-1 frameshifting modulators

Author: Fernandes, A. B., 2015

Supervisor: Gray, D. (Supervisor) & Wilson, S. (External person) (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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