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Personal profile

Education/Academic qualification

Doctor of Philosophy, University of London

Bachelor of Science, University of Glasgow

Keywords

  • RM Therapeutics. Pharmacology
  • drug discovery

Fingerprint Dive into the research topics where David Gray is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Drug Discovery Medicine & Life Sciences
Parasites Medicine & Life Sciences
Trypanosoma brucei brucei Medicine & Life Sciences
Trypanosoma cruzi Medicine & Life Sciences
Screening Chemical Compounds
Leishmania donovani Medicine & Life Sciences
Pharmaceutical Preparations Medicine & Life Sciences
Malaria Medicine & Life Sciences

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Projects 2013 2022

Research Output 1992 2019

9 Downloads (Pure)
Open Access
File
Burkholderia pseudomallei
Adenosine Monophosphate
Anti-Bacterial Agents
Ligands
Enzymes
3 Citations (Scopus)

Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis

Thomas, M. G., De Rycker, M., Ajakane, M., Albrecht, S., Álvarez-Pedraglio, A. I., Boesche, M., Brand, S., Campbell, L., Cantizani-Perez, J., Cleghorn, L. A. T., Copley, R. C. B., Crouch, S. D., Daugan, A., Drewes, G., Ferrer, S., Ghidelli-Disse, S., Gonzalez, S., Gresham, S. L., Hill, A. P., Hindley, S. J. & 32 others, Lowe, R. M., MacKenzie, C. J., MacLean, L., Manthri, S., Martin, F., Miguel-Siles, J., Nguyen, V. L., Norval, S., Osuna-Cabello, M., Woodland, A., Patterson, S., Pena, I., Quesada-Campos, M. T., Reid, I. H., Revill, C., Riley, J., Ruiz-Gomez, J. R., Shishikura, Y., Simeons, F. R. C., Smith, A., Smith, V. C., Spinks, D., Stojanovski, L., Thomas, J., Thompson, S., Underwood, T., Gray, D. W., Fiandor, J. M., Gilbert, I. H., Wyatt, P. G., Read, K. D. & Miles, T. J., 14 Feb 2019, In : Journal of Medicinal Chemistry. 62, 3, p. 1180-1202 23 p.

Research output: Contribution to journalArticle

Visceral Leishmaniasis
Leishmania major
Leishmania donovani
Standard of Care
Solubility
17 Downloads (Pure)

Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase

Torrie, L., Zuccotto, F., Robinson, D., Gray, D., Gilbert, I. & De Rycker, M., 31 May 2019, In : PLoS ONE. 14, 5, p. 1-16 16 p., e0217828.

Research output: Contribution to journalArticle

Open Access
File
Kinetochores
Trypanosoma brucei
kinetochores
Trypanosoma brucei brucei
phosphotransferases (kinases)
2 Citations (Scopus)
46 Downloads (Pure)

Identification of Leishmania major UDP-Sugar Pyrophosphorylase Inhibitors Using Biosensor-Based Small Molecule Fragment Library Screening

Prakash, O., Führing, J., Post, J., Shepherd, S. M., Eadsforth, T. C., Gray, D., Fedorov, R. & Routier, F. H., 12 Mar 2019, In : Molecules and Cells. 24, 5, p. 1-16 16 p., 996.

Research output: Contribution to journalArticle

Open Access
File
Uridine Diphosphate Sugars
Small Molecule Libraries
Leishmania major
Biosensing Techniques
sugars
8 Downloads (Pure)

Identification of novel Trypanosoma cruzi proteasome inhibitors using a luminescence-based high-throughput screening assay

Zmuda, F., Sastry, L., Shepherd, S. M., Jones, D., Scott, A., Craggs, P. D., Cortes, A., Gray, D. W., Torrie, L. S. & De Rycker, M., 15 Jul 2019, In : Antimicrobial Agents and Chemotherapy.

Research output: Contribution to journalArticle

Open Access
File
High-Throughput Screening Assays
Proteasome Inhibitors
Trypanosoma cruzi
Proteasome Endopeptidase Complex
Luminescence

Activities 2011 2019

  • 8 Other
  • 2 Invited talk
  • 1 Membership of panel

Action Medical Research - Scientific Advisory Panel

David Gray (Member)
2019 → …

Activity: Other activity typesOther

Global Antimicrobial Resistance Investment Fund (GAMRIF) panel

David Gray (Member)
20172018

Activity: Other activity typesOther

Member of MRC/AZ Centre for Lead Discovery (CLD)

David Gray (Member)
Jan 2017 → …

Activity: Other activity typesOther

Dundee Drug Discovery Unit, Diversity screening for tropical diseases

David Gray (Speaker)
Jul 2014

Activity: Talk or presentation typesInvited talk

grant reviewer

David Gray (Reviewer)
2013

Activity: Other activity typesOther

Thesis

Early-stage drug discovery of HIV-1 frameshifting modulators

Author: Fernandes, A. B., 2015

Supervisor: Gray, D. (Supervisor) & Wilson, S. (External person) (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File