Projects per year
Personal profile
Research
The Drug Discovery Unit (DDU) within the College of Life Sciences at Dundee has been created to respond to our perceived lack of capacity in the UK for early stage drug discovery in the academic sector. The DDU’s aim is to translate basic science into lead compounds to validate putative drug targets, to use as tools to investigate disease pathways and, when appropriate, advance to pre-clinical drug candidates. The DDU works to Biotech style philosophy and standards incorporating; dynamic, goal driven project management based on Target Product Profiles and Compound Selection Criteria. The DDU is the only fully operational and integrated drug discovery team within UK universities with the full range of disciplines including compound management, screening, molecular pharmacology/enzymology, medicinal chemistry, computational chemistry, DMPK and disease model capabilities, required to produce novel hit and lead candidates.
Since its inception the Unit has developed an international reputation as a leader in the growing academic drug discovery sector.
As Head of Biology within the Drug Discovery Unit (DDU),my role is to develop strategies for people, facilities, equipment and IT to allow the effective support of hit discovery, hits to leads and lead optimisation programs.
We currently support two broad areas, these being neglected diseases (malaria, leishmania, sleeping sickness, TB and Chagas’ disease) and innovative targets; a portfolio to translate new biological findings from Dundee and beyond. We conduct assay development, small molecule screening and an extensive array of mechanism of action and other supporting biology to define and characterise small molecule tools suitable for use in primary biological research and drug discovery.
Teaching
Course coordinator BS32003 – Drug Discovery & Development
BS42004 – Advanced Modern Drug Discovery
M.Res Cancer Biology
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, University of London
Award Date: 1 Jan 1992
Bachelor of Science, University of Glasgow
Award Date: 1 Jan 1988
Keywords
- RM Therapeutics. Pharmacology
- drug discovery
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Network
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MRC IAA 2021 University of Dundee
Ferguson, M., Gilbert, I., Gray, D. & Read, K.
1/04/22 → 31/03/25
Project: Research
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Refining the Drug Discovery Paradigm for Schistosomiasis (Joint with the Universities of Aberystwyth & Cardiff)
Gilbert, I., Gray, D., Read, K. & Wyatt, P.
1/10/21 → 1/04/24
Project: Research
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Dundee - Confidence in Concept 2019
Brady, J., Brady, J., Ferguson, M., Gray, D. & Wyatt, P.
31/03/20 → 1/04/23
Project: Research
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A Drug Target for Shigella (Open Lab Programme)
Gilbert, I., Gray, D. & Read, K.
17/10/19 → 16/02/23
Project: Research
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Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies
Armstrong, L. A., Lange, S. M., de Cesare, V., Matthews, S. P., Nirujogi, R. S., Cole, I., Hope, A., Cunningham, F., Toth, R., Mukherjee, R., Bojkova, D., Gruber, F., Gray, D., Wyatt, P. G., Cinatl, J., Dikic, I., Davies, P. & Kulathu, Y., 16 Jul 2021, In: PLoS ONE. 16, 7, 25 p., e0253364.Research output: Contribution to journal › Article › peer-review
Open AccessFile19 Citations (Scopus)56 Downloads (Pure) -
Development of a High-Throughput Screening Assay to Identify Inhibitors of the SARS-CoV-2 Guanine-N7 Methyltransferase Using RapidFire Mass Spectrometry
Pearson, L-A., Green, C., Lin, D., Petit, A-P., Gray, D., Cowling, V. & Fordyce, E., Jul 2021, In: SLAS Discovery. 26, 6, p. 749-756 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)47 Downloads (Pure) -
Drug screening to identify compounds to act as co-therapies for the treatment of Burkholderia species
Barker, S., Harding, S. V., Gray, D., Richards, M. I., Atkins, H. S. & Harmer, N. J., 25 Mar 2021, In: PLoS ONE. 16, 3, 18 p., e0248119.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)62 Downloads (Pure) -
Live-imaging rate-of-kill compound profiling for Chagas disease drug discovery with a new automated high-content assay
Svensen, N., Wyllie, S., Gray, D. W. & De Rycker, M., 11 Oct 2021, In: PLoS Neglected Tropical Diseases. 15, 10, 14 p., e0009870.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)29 Downloads (Pure) -
Structure-Activity Relationships of Pyrazolo[1,5-a]pyrimidin-7(4H)-ones as Antitubercular Agents
Oh, S., Libardo, M. D. J., Azeeza, S., Pauly, G. T., Roma, J. S. O., Sajid, A., Tateishi, Y., Duncombe, C., Goodwin, M., Ioerger, T. R., Wyatt, P. G., Ray, P. C., Gray, D. W., Boshoff, H. I. M. & Barry, C. E., 12 Feb 2021, In: ACS Infectious Diseases. 7, 2, p. 479-492 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)35 Downloads (Pure)
Prizes
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Accessibility Video Project - Opening our Doors to the Public
Amy Cameron (Organiser), Steve Soave (Contributor), Nicola Stanley-Wall (Contributor), Thibault Rosazza (Contributor), Ian Ganley (Contributor), Francois Singh (Contributor), Esther Sammler (Contributor), Renata Filipe Soares (Contributor), Laura Spinelli (Contributor), Greg Findlay (Contributor), Elizabeth Hogg (Contributor), Carmen Espejo Serrano (Contributor), Alan Prescott (Contributor), Jens Januschke (Contributor), Federico Pelisch (Contributor), Laura Bel Borja (Contributor), David Horn (Contributor), Melanie Ridgway (Contributor), Tom Owen-Hughes (Contributor), Ramasubramanian Sundaramoorthy (Contributor), Geoffrey Barton (Contributor), Rastko Sknepnek (Contributor), Ulrich Zachariae (Contributor), Suzanne Duce (Contributor), Sarah McKim (Contributor), Laura Pugh (Contributor), Jonathan Griffin (Contributor), Ingo Hein (Contributor), Eleanor M. Gilroy (Contributor), Gaynor McKenzie (Contributor), Tony Ly (Contributor), Ananya Kar (Contributor), James Hastie (Contributor), Vincent Postis (Contributor), Alice Dawson (Contributor), Paul Fyfe (Contributor), Olga Semenova (Contributor), David Robinson (Contributor), David Gray (Contributor), Selma Cabrita Gulyurtlu (Contributor), David Zollman (Contributor), Valentina Spiteri (Contributor) & Tom Webb (Contributor)
2022 → …Activity: Other activity types › Other
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Bang goes the Border 2021
Suzanne Duce (Contributor), David Gray (Contributor), Holly Keir (Contributor), Amy Rogers (Contributor) & Ian Gilbert (Chair)
18 Sep 2021Activity: Participating in or organising an event types › Festival/Exhibition
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Open Targets Symposium
David Gray (Speaker)
25 May 2021Activity: Talk or presentation types › Invited talk
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Discovery Days 2020
Miratul Muqit (Speaker), Kim Dale (Speaker), David Gray (Speaker), Senga Robertson-Albertyn (Speaker), Blair Grubb (Presenter), Calum Sutherland (Presenter), Jacquelyn Malcolm (Presenter), Rory McCrimmon (Presenter), Alison McFadden (Presenter), Morris Altman (Presenter), Isla Mackenzie (Presenter), Anita Taylor (Presenter), Jacques Hartmann (Presenter), Mel Woods (Presenter), Jose Luiz Fiadeiro (Presenter), Bill Russell (Presenter), Amy Rogers (Presenter), Jonathan Urch (Organiser), Leanne Wallace (Organiser), John Rowan (Chair) & Wendy Alexander (Chair)
9 Jan 2020 → 10 Jan 2020Activity: Other activity types › Public engagement and outreach - public lecture/debate/seminar
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Action Medical Research - Scientific Advisory Panel
David Gray (Member)
2019 → …Activity: Other activity types › Other
Press / Media
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GSK and the University of Dundee announce new collaboration to develop treatment for Huntington's disease
Susann Schweiger, Rosamund Langston, Jeremy J. Lambert & David Gray
14/12/11
2 items of Media coverage
Press/Media: Research