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Gray, David

Dr

 https://orcid.org/0000-0001-9512-3828
1992 …2022
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Personal profile

Education/Academic qualification

Doctor of Philosophy, University of London

Bachelor of Science, University of Glasgow

Keywords

  • RM Therapeutics. Pharmacology
  • drug discovery

Fingerprint Dive into the research topics where David Gray is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 1 Similar Profiles
Drug Discovery Medicine & Life Sciences
Parasites Medicine & Life Sciences
Trypanosoma brucei brucei Medicine & Life Sciences
Trypanosoma cruzi Medicine & Life Sciences
Screening Chemical Compounds
Leishmania donovani Medicine & Life Sciences
Pharmaceutical Preparations Medicine & Life Sciences
Malaria Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2013 2022

PPM1H Activators for Treatment of Parkinson's Disease

Alessi, D. & Gray, D.

9/09/19 → 8/09/20

Project: Research

The Innovative Targets Portfolio: Basic Life Sciences Research to Novel Therapies, through a Portfolio of Small Molecule Translational Projects

Ferguson, M., Gray, D. & Wyatt, P.

Medical Research Council

1/07/19 → 30/06/21

Project: Research

Development of New Agents for the Treatment of Cryptosporidiosis (DPFS) (Joint with University of Vermont)

Gilbert, I., Gray, D., Pawlowic, M., Read, K. & Wyatt, P.

Medical Research Council

1/05/19 → 31/12/21

Project: Research

Drug Discovery Collaboration - Tau Seeding

Gray, D.

1/03/19 → 31/08/21

Project: Research

Structure-Guided Drug Discovery for Malaria and Tuberculosis (joint with Structural Genomics Consortium)

Gilbert, I., Gray, D., Read, K. & Wyatt, P.

Bill and Melinda Gates Foundation

1/01/19 → 1/07/21

Project: Research

Research Output 1992 2019

22 Downloads (Pure)

Burkholderia pseudomallei D-alanine-D-alanine ligase: detailed characterisation and assessment of a potential antibiotic drug target

Diaz Saez, L., Torrie, L., McElroy, S., Gray, D. & Hunter, B., 1 Jul 2019, In : FEBS Journal. 16 p.

Research output: Contribution to journal › Article

Open Access
File
Burkholderia pseudomallei
Adenosine Monophosphate
Anti-Bacterial Agents
Ligands
Enzymes
4 Citations (Scopus)

Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis

Thomas, M. G., De Rycker, M., Ajakane, M., Albrecht, S., Álvarez-Pedraglio, A. I., Boesche, M., Brand, S., Campbell, L., Cantizani-Perez, J., Cleghorn, L. A. T., Copley, R. C. B., Crouch, S. D., Daugan, A., Drewes, G., Ferrer, S., Ghidelli-Disse, S., Gonzalez, S., Gresham, S. L., Hill, A. P., Hindley, S. J. & 32 others, Lowe, R. M., MacKenzie, C. J., MacLean, L., Manthri, S., Martin, F., Miguel-Siles, J., Nguyen, V. L., Norval, S., Osuna-Cabello, M., Woodland, A., Patterson, S., Pena, I., Quesada-Campos, M. T., Reid, I. H., Revill, C., Riley, J., Ruiz-Gomez, J. R., Shishikura, Y., Simeons, F. R. C., Smith, A., Smith, V. C., Spinks, D., Stojanovski, L., Thomas, J., Thompson, S., Underwood, T., Gray, D. W., Fiandor, J. M., Gilbert, I. H., Wyatt, P. G., Read, K. D. & Miles, T. J., 14 Feb 2019, In : Journal of Medicinal Chemistry. 62, 3, p. 1180-1202 23 p.

Research output: Contribution to journal › Article

Visceral Leishmaniasis
Leishmania major
Leishmania donovani
Standard of Care
Solubility
34 Downloads (Pure)

Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase

Torrie, L., Zuccotto, F., Robinson, D., Gray, D., Gilbert, I. & De Rycker, M., 31 May 2019, In : PLoS ONE. 14, 5, p. 1-16 16 p., e0217828.

Research output: Contribution to journal › Article

Open Access
File
Kinetochores
Trypanosoma brucei
kinetochores
Trypanosoma brucei brucei
phosphotransferases (kinases)
2 Citations (Scopus)
60 Downloads (Pure)

Identification of Leishmania major UDP-Sugar Pyrophosphorylase Inhibitors Using Biosensor-Based Small Molecule Fragment Library Screening

Prakash, O., Führing, J., Post, J., Shepherd, S. M., Eadsforth, T. C., Gray, D., Fedorov, R. & Routier, F. H., 12 Mar 2019, In : Molecules and Cells. 24, 5, p. 1-16 16 p., 996.

Research output: Contribution to journal › Article

Open Access
File
Uridine Diphosphate Sugars
Small Molecule Libraries
Leishmania major
Biosensing Techniques
sugars
29 Downloads (Pure)

Identification of Novel Trypanosoma cruzi Proteasome Inhibitors Using a Luminescence-Based High-Throughput Screening Assay

Zmuda, F., Sastry, L., Shepherd, S. M., Jones, D., Scott, A., Craggs, P. D., Cortes, A., Gray, D. W., Torrie, L. S. & De Rycker, M., Sep 2019, In : Antimicrobial Agents and Chemotherapy. 63, 9, p. 1-15 15 p., e00309-19.

Research output: Contribution to journal › Article

Open Access
File
High-Throughput Screening Assays
Proteasome Inhibitors
Trypanosoma cruzi
Proteasome Endopeptidase Complex
Luminescence

Activities 2011 2019

  • 8 Other
  • 2 Invited talk
  • 1 Membership of panel

Action Medical Research - Scientific Advisory Panel

David Gray (Member)
2019 → …

Activity: Other activity types › Other

Global Antimicrobial Resistance Investment Fund (GAMRIF) panel

David Gray (Member)
2017 → 2018

Activity: Other activity types › Other

Member of MRC/AZ Centre for Lead Discovery (CLD)

David Gray (Member)
Jan 2017 → …

Activity: Other activity types › Other

Dundee Drug Discovery Unit, Diversity screening for tropical diseases

David Gray (Speaker)
Jul 2014

Activity: Talk or presentation types › Invited talk

grant reviewer

David Gray (Reviewer)
2013

Activity: Other activity types › Other

Press / Media

GSK and the University of Dundee announce new collaboration to develop treatment for Huntington's disease

Susann Schweiger, Rosamund Langston, Jeremy J. Lambert & David Gray

14/12/11

2 items of Media coverage

Press/Media: Research

Thesis

Early-stage drug discovery of HIV-1 frameshifting modulators

Author: Fernandes, A. B., 2015

Supervisor: Gray, D. (Supervisor) & Wilson, S. (External person) (Supervisor)

Student thesis: Doctoral Thesis › Doctor of Philosophy

File