David Gray

Personal profile

Research

The Drug Discovery Unit (DDU) within the College of Life Sciences at Dundee has been created to respond to our perceived lack of capacity in the UK for early stage drug discovery in the academic sector. The DDU’s aim is to translate basic science into lead compounds to validate putative drug targets, to use as tools to investigate disease pathways and, when appropriate, advance to pre-clinical drug candidates. The DDU works to Biotech style philosophy and standards incorporating; dynamic, goal driven project management based on Target Product Profiles and Compound Selection Criteria. The DDU is the only fully operational and integrated drug discovery team within UK universities with the full range of disciplines including compound management, screening, molecular pharmacology/enzymology, medicinal chemistry, computational chemistry, DMPK and disease model capabilities, required to produce novel hit and lead candidates.

Since its inception the Unit has developed an international reputation as a leader in the growing academic drug discovery sector.

As Head of Biology within the Drug Discovery Unit (DDU),my role is to develop strategies for people, facilities, equipment and IT to allow the effective support of hit discovery, hits to leads and lead optimisation programs.

We currently support two broad areas, these being neglected diseases (malaria, leishmania, sleeping sickness, TB and Chagas’ disease) and innovative targets; a portfolio to translate new biological findings from Dundee and beyond. We conduct assay development, small molecule screening and an extensive array of mechanism of action and other supporting biology to define and characterise small molecule tools suitable for use in primary biological research and drug discovery.

Teaching

Course coordinator BS32003 – Drug Discovery & Development

BS42004 – Advanced Modern Drug Discovery

M.Res Cancer Biology

Education/Academic qualification

Doctor of Philosophy, University of London

Award Date: 1 Jan 1992

Bachelor of Science, University of Glasgow

Award Date: 1 Jan 1988

Keywords

RM Therapeutics. Pharmacology
drug discovery

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Projects

2 Not started
9 Active
11 Finished

A Drug Target for Shigella (Open Lab Programme)

Gilbert, I., Gray, D. & Read, K.

10/10/19 → 9/10/21

Project: Research

PPM1H Activators for Treatment of Parkinson's Disease

Alessi, D. & Gray, D.

1/09/19 → 30/03/21

Project: Research

The Innovative Targets Portfolio: Basic Life Sciences Research to Novel Therapies, through a Portfolio of Small Molecule Translational Projects

Ferguson, M., Gray, D. & Wyatt, P.

Medical Research Council

1/07/19 → 30/06/21

Project: Research

Development of New Agents for the Treatment of Cryptosporidiosis (DPFS) (Joint with University of Vermont)

Gilbert, I., Gray, D., Pawlowic, M., Read, K. & Wyatt, P.

Medical Research Council

1/05/19 → 31/12/21

Project: Research

Drug Discovery Collaboration - Tau Seeding

Gray, D.

1/03/19 → 31/08/21

Project: Research

Research Output

53 Article
3 Comment/debate
1 Review article

Development of a High-Throughput Screening Assay to Identify Inhibitors of the Major M17-Leucyl Aminopeptidase from Trypanosoma cruzi Using RapidFire Mass Spectrometry

Izquierdo, M., Lin, D., O'Neill, S., Zoltner, M., Webster, L., Hope, A., Gray, D. W., Field, M. C. & González-Bacerio, J., 13 May 2020, In : SLAS Discovery. 8 p.

Research output: Contribution to journal › Article

Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase

Torrie, L. S., Robinson, D. A., Thomas, M. G., Hobrath, J. V., Shepherd, S. M., Post, J. M., Ko, E. J., Ferreira, R. A., Mackenzie, C. J., Wrobel, K., Edwards, D. P., Gilbert, I. H., Gray, D. W., Fairlamb, A. H. & De Rycker, M., 8 May 2020, In : ACS Infectious Diseases. 6, 5, p. 1044-1057 14 p.

Research output: Contribution to journal › Article

Burkholderia pseudomallei D-alanine-D-alanine ligase: detailed characterisation and assessment of a potential antibiotic drug target

Diaz Saez, L., Torrie, L., McElroy, S., Gray, D. & Hunter, B., 1 Jul 2019, In : FEBS Journal. 16 p.

Research output: Contribution to journal › Article

Open Access

File

74 Downloads (Pure)

Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis

Thomas, M. G., De Rycker, M., Ajakane, M., Albrecht, S., Álvarez-Pedraglio, A. I., Boesche, M., Brand, S., Campbell, L., Cantizani-Perez, J., Cleghorn, L. A. T., Copley, R. C. B., Crouch, S. D., Daugan, A., Drewes, G., Ferrer, S., Ghidelli-Disse, S., Gonzalez, S., Gresham, S. L., Hill, A. P., Hindley, S. J. & 32 others, Lowe, R. M., MacKenzie, C. J., MacLean, L., Manthri, S., Martin, F., Miguel-Siles, J., Nguyen, V. L., Norval, S., Osuna-Cabello, M., Woodland, A., Patterson, S., Pena, I., Quesada-Campos, M. T., Reid, I. H., Revill, C., Riley, J., Ruiz-Gomez, J. R., Shishikura, Y., Simeons, F. R. C., Smith, A., Smith, V. C., Spinks, D., Stojanovski, L., Thomas, J., Thompson, S., Underwood, T., Gray, D. W., Fiandor, J. M., Gilbert, I. H., Wyatt, P. G., Read, K. D. & Miles, T. J., 14 Feb 2019, In : Journal of Medicinal Chemistry. 62, 3, p. 1180-1202 23 p.

Research output: Contribution to journal › Article

Open Access

File