Research output per year
Research output per year
- 1 - 50 out of 75 results
Search results
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2025
Characterisation of RNA guanine-7 methyltransferase (RNMT) using a small molecule approach
Gray, D. (Lead / Corresponding author), Pearson, L.-A., Petit, A.-P., Mendoza Martinez, C., Bellany, F., Lin, D., Niven, S., Swift, R., Eadsforth, T., Fyfe, P., Paul, M., Postis, V., Hu, X. & Cowling, V., 17 Feb 2025, In: Biochemical Journal. p. 209-224 16 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Pharmacological and structural understanding of the Trypanosoma cruzi proteasome provides key insights for developing site-specific inhibitors
Eadsforth, T., Torrie, L., Rowland, P., Edgar, E. V., MacLean, L., Paterson, C., Robinson, D. A., Shepherd, S. M., Thomas, J., Thomas, M., Gray, D., Postis, V. & De Rycker, M. (Lead / Corresponding author), Jan 2025, In: Journal of Biological Chemistry. 301, 1, 17 p., 108049.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)1 Downloads (Pure) -
2024
Application of an NMR/Crystallography Fragment Screening Platform for the Assessment and Rapid Discovery of New HIV-CA Binding Fragments
Lang, S., Fletcher, D. A., Petit, A.-P., Luise, N., Fyfe, P., Zuccotto, F., Porter, D., Hope, A., Bellany, F., Kerr, C., Mackenzie, C. J., Wyatt, P. G. & Gray, D. W. (Lead / Corresponding author), 2 Jul 2024, In: ChemMedChem. 19, 13, 12 p., e202400025.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)75 Downloads (Pure) -
HTS Library Plate Rejuvenation Using a DMSO-Rich Atmosphere
Hughes, F., Cookson, A. (Lead / Corresponding author), Tamaki, F., Bailey, C., Gray, D., Wrobel, K., Cookson, K., Bell, S. & Tarver, G., Dec 2024, In: SLAS Technology. 29, 6, 10 p., 100204.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Downloads (Pure) -
Identification and Validation of Compounds Targeting Leishmania major Leucyl-Aminopeptidase M17
Aguado, M. E., Carvalho, S., Valdés-Tresanco, M. E., Lin, D., Padilla-Mejia, N., Corpas-Lopez, V., Tesařová, M., Lukeš, J., Gray, D., González-Bacerio, J. (Lead / Corresponding author), Wyllie, S. (Lead / Corresponding author) & Field, M. C. (Lead / Corresponding author), 14 Jun 2024, In: ACS Infectious Diseases. 10, 6, p. 2002-2017 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)74 Downloads (Pure) -
Identification of a potent and selective LAPTc inhibitor by RapidFire-Mass Spectrometry, with antichagasic activity
Izquierdo, M., Lin, D., O'Neill, S., Webster, L. A., Paterson, C., Thomas, J., Aguado, M. E., Colina Araújo, E., Alpízar-Pedraza, D., Joji, H., MacLean, L., Hope, A., Gray, D. W., Zoltner, M., Field, M. C., González-Bacerio, J. (Lead / Corresponding author) & De Rycker, M. (Lead / Corresponding author), 15 Feb 2024, In: PLoS Neglected Tropical Diseases. 18, 2, 20 p., e0011956.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)83 Downloads (Pure) -
2023
Assessment of the drugability of initial malaria infection through miniaturized sporozoite assays and high-throughput screening
Miglianico, M., Bolscher, J. M., Vos, M. W., Koolen, K. J. M., de Bruijni, M., Rajagopal, D. S., Chen, E., Kiczun, M., Gray, D., Campo, B., Sauerwein, R. W. & Dechering, K. J. (Lead / Corresponding author), 23 Feb 2023, In: Communications Biology. 6, 10 p., 216.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)117 Downloads (Pure) -
Author Correction: Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis (Nature, (2018), 560, 7717, (192-197), 10.1038/s41586-018-0356-z)
Wyllie, S., Thomas, M., Patterson, S., Crouch, S., De Rycker, M., Lowe, R., Gresham, S., Urbaniak, M. D., Otto, T. D., Stojanovski, L., Simeons, F. R. C., Manthri, S., MacLean, L. M., Zuccotto, F., Homeyer, N., Pflaumer, H., Boesche, M., Sastry, L., Connolly, P. & Albrecht, S. & 12 others, , 4 Jul 2023, In: Nature. 619, p. E48 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Design and synthesis of covalent inhibitors of FabA
Martin, J. S., Mackenzie, C. J., Lin, D., Homeyer, N., Gray, D. W., Zuccotto, F. & Gilbert, I. H. (Lead / Corresponding author), 11 Apr 2023, In: ACS Omega. 8, 14, p. 12787–12804 18 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)117 Downloads (Pure) -
Design of the Global Health chemical diversity library v2 for screening against infectious diseases
Wilson, C., Gardner, J. M. F., Gray, D., Baragana, B., Wyatt, P., Cookson, A., Thompson, S., Mendoza Martinez, C., Bodkin, M., Gilbert, I. (Lead / Corresponding author) & Tarver, G. (Lead / Corresponding author), 27 Dec 2023, In: PLoS Neglected Tropical Diseases. 17, 12, 13 p., e0011799.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)108 Downloads (Pure) -
2022
Wellcome Centre for Anti-infectives Research Public Engagement Strategy
Floyd, A. (Lead / Corresponding author), Goddard, C. (Contributing member), Gray, D. (Contributing member), Lambert, H. (Contributing member), Mackintosh, A. (Contributing member), Scott-Dearing, E. (Contributing member) & Short, L. (Contributing member), 15 Nov 2022, 8 p. Dundee : University of Dundee.Research output: Other contribution
Open AccessFile10 Downloads (Pure) -
2021
Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies
Armstrong, L. A., Lange, S. M., de Cesare, V., Matthews, S. P., Nirujogi, R. S., Cole, I., Hope, A., Cunningham, F., Toth, R., Mukherjee, R., Bojkova, D., Gruber, F., Gray, D., Wyatt, P. G., Cinatl, J., Dikic, I., Davies, P. & Kulathu, Y. (Lead / Corresponding author), 16 Jul 2021, In: PLoS ONE. 16, 7, 25 p., e0253364.Research output: Contribution to journal › Article › peer-review
Open AccessFile60 Citations (Scopus)166 Downloads (Pure) -
Development of a High-Throughput Screening Assay to Identify Inhibitors of the SARS-CoV-2 Guanine-N7 Methyltransferase Using RapidFire Mass Spectrometry
Pearson, L.-A., Green, C., Lin, D., Petit, A.-P., Gray, D. (Lead / Corresponding author), Cowling, V. & Fordyce, E. (Lead / Corresponding author), Jul 2021, In: SLAS Discovery. 26, 6, p. 749-756 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Citations (Scopus)136 Downloads (Pure) -
Drug screening to identify compounds to act as co-therapies for the treatment of Burkholderia species
Barker, S., Harding, S. V., Gray, D., Richards, M. I., Atkins, H. S. & Harmer, N. J. (Lead / Corresponding author), 25 Mar 2021, In: PLoS ONE. 16, 3, 18 p., e0248119.Research output: Contribution to journal › Article › peer-review
Open AccessFile152 Downloads (Pure) -
Live-imaging rate-of-kill compound profiling for Chagas disease drug discovery with a new automated high-content assay
Svensen, N., Wyllie, S., Gray, D. W. & De Rycker, M. (Lead / Corresponding author), 11 Oct 2021, In: PLoS Neglected Tropical Diseases. 15, 10, 14 p., e0009870.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)83 Downloads (Pure) -
Structure-Activity Relationships of Pyrazolo[1,5-a]pyrimidin-7(4H)-ones as Antitubercular Agents
Oh, S., Libardo, M. D. J., Azeeza, S., Pauly, G. T., Roma, J. S. O., Sajid, A., Tateishi, Y., Duncombe, C., Goodwin, M., Ioerger, T. R., Wyatt, P. G., Ray, P. C., Gray, D. W., Boshoff, H. I. M. & Barry, C. E. (Lead / Corresponding author), 12 Feb 2021, In: ACS Infectious Diseases. 7, 2, p. 479-492 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)123 Downloads (Pure) -
2020
Development of a High-Throughput Screening Assay to Identify Inhibitors of the Major M17-Leucyl Aminopeptidase from Trypanosoma cruzi Using RapidFire Mass Spectrometry
Izquierdo, M., Lin, D., O'Neill, S., Zoltner, M., Webster, L., Hope, A., Gray, D. W., Field, M. C. & González-Bacerio, J. (Lead / Corresponding author), 1 Oct 2020, In: SLAS Discovery. 25, 9, p. 1064-1071 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)70 Downloads (Pure) -
Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase
Torrie, L. S., Robinson, D. A., Thomas, M. G., Hobrath, J. V., Shepherd, S. M., Post, J. M., Ko, E. J., Ferreira, R. A., Mackenzie, C. J., Wrobel, K., Edwards, D. P., Gilbert, I. H., Gray, D. W. (Lead / Corresponding author), Fairlamb, A. H. & De Rycker, M. (Lead / Corresponding author), 8 May 2020, In: ACS Infectious Diseases. 6, 5, p. 1044-1057 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)147 Downloads (Pure) -
Targeting N-myristoylation for therapy of B-cell lymphomas
Beauchamp, E., Yap, M. C., Iyer, A., Perinpanayagam, M. A., Gamma, J. M., Vincent, K. M., Lakshmanan, M., Raju, A., Tergaonkar, V., Tan, S. Y., Lim, S. T., Dong, W.-F., Postovit, L. M., Read, K. D., Gray, D. W., Wyatt, P. G., Mackey, J. R. & Berthiaume, L. G. (Lead / Corresponding author), 22 Oct 2020, In: Nature Communications. 11, 16 p., 5348.Research output: Contribution to journal › Article › peer-review
Open AccessFile45 Citations (Scopus)272 Downloads (Pure) -
2019
Burkholderia pseudomallei D-alanine-D-alanine ligase: detailed characterisation and assessment of a potential antibiotic drug target
Díaz‐Sáez, L., Torrie, L. S., McElroy, S. P., Gray, D. & Hunter, W. M. (Lead / Corresponding author), 18 Nov 2019, In: FEBS Journal. 286, 22, p. 4509-4524 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)328 Downloads (Pure) -
Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis
Thomas, M. G., De Rycker, M., Ajakane, M., Albrecht, S., Álvarez-Pedraglio, A. I., Boesche, M., Brand, S., Campbell, L., Cantizani-Perez, J., Cleghorn, L. A. T., Copley, R. C. B., Crouch, S. D., Daugan, A., Drewes, G., Ferrer, S., Ghidelli-Disse, S., Gonzalez, S., Gresham, S. L., Hill, A. P. & Hindley, S. J. & 32 others, , 14 Feb 2019, In: Journal of Medicinal Chemistry. 62, 3, p. 1180-1202 23 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile39 Citations (Scopus)351 Downloads (Pure) -
Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase
Torrie, L., Zuccotto, F., Robinson, D., Gray, D., Gilbert, I. (Lead / Corresponding author) & De Rycker, M. (Lead / Corresponding author), 31 May 2019, In: PLoS ONE. 14, 5, p. 1-16 16 p., e0217828.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)173 Downloads (Pure) -
Identification of Leishmania major UDP-Sugar Pyrophosphorylase Inhibitors Using Biosensor-Based Small Molecule Fragment Library Screening
Prakash, O., Führing, J., Post, J., Shepherd, S. M., Eadsforth, T. C., Gray, D., Fedorov, R. & Routier, F. H. (Lead / Corresponding author), 12 Mar 2019, In: Molecules. 24, 5, p. 1-16 16 p., 996.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)218 Downloads (Pure) -
Identification of Novel Trypanosoma cruzi Proteasome Inhibitors Using a Luminescence-Based High-Throughput Screening Assay
Zmuda, F., Sastry, L., Shepherd, S. M., Jones, D., Scott, A., Craggs, P. D., Cortes, A., Gray, D. W. (Lead / Corresponding author), Torrie, L. S. & De Rycker, M. (Lead / Corresponding author), Sept 2019, In: Antimicrobial Agents and Chemotherapy. 63, 9, 15 p., e00309-19.Research output: Contribution to journal › Article › peer-review
Open AccessFile19 Citations (Scopus)163 Downloads (Pure) -
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis
Baragaña, B., Forte, B., Choi, R., Nakazawa Hewitt, S., Bueren-Calabuig, J. A., Pisco, J. P., Peet, C., Dranow, D. M., Robinson, D. A., Jansen, C., Norcross, N. R., Vinayak, S., Anderson, M., Brooks, C. F., Cooper, C. A., Damerow, S., Delves, M., Dowers, K., Duffy, J. & Edwards, T. E. & 57 others, , 2 Apr 2019, In: Proceedings of the National Academy of Sciences. 116, 14, p. 7015-7020 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile108 Citations (Scopus)613 Downloads (Pure) -
Parasites: Battle for Survival
Alberti, S. (Curator), Dodd, P. (Artist), Floyd, A. (Collaborator), Goddard, C. (Collaborator), Goggins, S. (Curator), Gray, D. (Collaborator), Hallyburton, I. (Subject), MacLean, L. (Artist), Manthri, S. (Artist), Martin, M. (Collaborator), Norval, S. (Subject), Pawlowic, M. (Artist), Svensen, N. (Artist), Wyatt, P. (Collaborator) & Wyllie, S. (Subject), 6 Dec 2019Research output: Non-textual form › Exhibition
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Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition
Wyllie, S., Brand, S., Thomas, M., De Rycker, M., Chung, C.-W., Peña, I., Bingham, R., Bueren-Calabuig, J., Cantizani, J., Cebrian, D., Craggs, P. D., Ferguson, L., Goswami, P., Hobrath, J., Howe, J., Jeacock, L., Ko, E. J., Korczynska, J., MacLean, L. & Manthri, S. & 29 others, , 7 May 2019, In: Proceedings of the National Academy of Sciences. 116, 19, p. 9318-9323 6 p., 201820175.Research output: Contribution to journal › Article › peer-review
Open AccessFile133 Citations (Scopus)288 Downloads (Pure) -
Substituted Aminoacetamides as Novel Leads for Malaria Treatment
Norcross, N., Wilson, C., Baragana, B., Hallyburton, I., Osuna-Cabello, M., Norval, S., Riley, J., Fletcher, D., Sinden, R., Delves, M. J., Ruecker, A., Duffy, S., Meister, S., Antonova-Koch, Y., Crespo, B., de Cózar, C., Sanz, L., Gamo, F.-J., Avery, V. M. & Frearson, J. A. & 8 others, , 17 Jul 2019, In: ChemMedChem. 14, 14, p. 1329-1335 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)133 Downloads (Pure) -
Trypanosoma cruzi phosphomannomutase and guanosine diphosphate-mannose pyrophosphorylase ligandability assessment
Zmuda, F., Shepherd, S. M., Ferguson, M. A. J., Gray, D. W. (Lead / Corresponding author), Torrie, L. S. & De Rycker, M. (Lead / Corresponding author), Oct 2019, In: Antimicrobial Agents and Chemotherapy. 63, 10, 11 p., e01082-19.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)113 Downloads (Pure) -
2018
Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis
Wyllie, S., Thomas, M., Patterson, S., Crouch, S., De Rycker, M., Lowe, R., Gresham, S., Urbaniak, M. D., Otto, T. D., Stojanovski, L., Simeons, F. R. C., Manthri, S., MacLean, L. M., Zuccotto, F., Homeyer, N., Pflaumer, H., Boesche, M., Sastry, L., Connolly, P. & Albrecht, S. & 12 others, , 9 Aug 2018, In: Nature. 560, 7717, p. 192-197 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile121 Citations (Scopus)920 Downloads (Pure) -
Development of Trypanosoma cruzi in vitro assays to identify compounds suitable for progression in Chagas’ disease drug discovery
MacLean, L. (Lead / Corresponding author), Thomas, J., Lewis, M. D., Cotillo, I., Gray, D. (Lead / Corresponding author) & De Rycker, M., 12 Jul 2018, In: PLoS Neglected Tropical Diseases. 12, 7, p. 1-22 22 p., e0006612.Research output: Contribution to journal › Article › peer-review
Open AccessFile80 Citations (Scopus)240 Downloads (Pure) -
Erratum to: Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need (Nature Reviews Microbiology, (2017), 15, 4, (217-231), 10.1038/nrmicro.2016.193)
Field, M. C., Horn, D., Fairlamb, A. H., Ferguson, M. A. J., Gray, D. W., Read, K. D., De Rycker, M., Torrie, L. S., Wyatt, P. G., Wyllie, S. & Gilbert, I. H., 1 Nov 2018, In: Nature Reviews Microbiology. 16, 11, 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
2017
Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need
Field, M. C., Horn, D., Fairlamb, A. H., Ferguson, M. A. J., Gray, D. W., Read, K. D., De Rycker, M., Torrie, L. S., Wyatt, P. G., Wyllie, S. & Gilbert, I. H. (Lead / Corresponding author), Apr 2017, In: Nature Reviews Microbiology. 15, 4, p. 217-231 15 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile315 Citations (Scopus)563 Downloads (Pure) -
Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase
Nakazawa Hewitt, S., Dranow, D. M., Horst, B. G., Abendroth, J. A., Forte, B., Hallyburton, I., Jansen, C., Baragana, B., Choi, R., Rivas, K., Hulverson, M. A., Dumais, M., Edwards, T. E., Lorimer, D. D., Fairlamb, A., Gray, D., Read, K., Lehane, A. M., Kirk, K. & Myler, P. J. & 6 others, , 13 Jan 2017, In: ACS Infectious Diseases. 3, 1, p. 34-44 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile45 Citations (Scopus)371 Downloads (Pure) -
Drug discovery for male subfertility using high-throughput screening: a new approach to an unsolved problem
Martins Da Silva, S. J. (Lead / Corresponding author), Brown, S. G., Sutton, K., King, L. V., Ruso, H., Gray, D. W., Wyatt, P. G., Kelly, M. C., Barratt, C. L. R. & Hope, A. G., May 2017, In: Human Reproduction. 32, 5, p. 974-984 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile21 Citations (Scopus)280 Downloads (Pure) -
Erratum: Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need
Field, M. C., Horn, D., Fairlamb, A., Ferguson, M., Gray, D., Read, K., De Rycker, M., Torrie, L., Wyatt, P., Wyllie, S. & Gilbert, I. H., 5 Jun 2017, In: Nature Reviews Microbiology. 15, 1 p., 447.Research output: Contribution to journal › Comment/debate › peer-review
Open Access1 Citation (Scopus) -
Identifying Inhibitors of Inflammation: A Novel High-Throughput MALDI-TOF Screening Assay for Salt-Inducible Kinases (SIKs)
Heap, R. E., Hope, A. G., Pearson, L.-A., Reyskens, K. M. S. E., McElroy, S. P., Hastie, C. J., Porter, D. W., Arthur, J. S. C., Gray, D. W. & Trost, M. (Lead / Corresponding author), 1 Dec 2017, In: SLAS Discovery. 22, 10, p. 1193-1202 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile43 Citations (Scopus)484 Downloads (Pure) -
2016
A substrate mimic allows high-throughput assay of the FabA protein and consequently the identification of a novel inhibitor of Pseudomonas aeruginosa FabA
Moynié, L., Hope, A. G., Finzel, K., Schmidberger, J., Leckie, S. M., Schneider, G., Burkart, M. D., Smith, A. D., Gray, D. W. & Naismith, J. H. (Lead / Corresponding author), 16 Jan 2016, In: Journal of Molecular Biology. 428, 1, p. 108-120 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)226 Downloads (Pure) -
Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis
Baragaña, B., Hallyburton, I., Lee, M., Norcross, N. R., Grimaldi, R., Otto, T. D., Proto, W. R., Blagborough, A. M., Meister, S., Wirjanata, G., Ruecker, A., Upton, L. M., Abraham, T. S., Almeida, M. J., Pradhan, A., Porzelle, A., Santos Martinez, M., Bolscher, J. M., Woodland, A. & Luksch, T. & 44 others, , 1 Sept 2016, In: Nature. 537, 7618, p. 122 1 p.Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus) -
Discovery of a quinoline-4-carboxamide derivative with a novel mechanism of action, multistage antimalarial activity, and potent in vivo efficacy
Baragaña, B., Norcross, N. R., Wilson, C., Porzelle, A., Hallyburton, I., Grimaldi, R., Osuna-Cabello, M., Norval, S., Riley, J., Stojanovski, L., Simeons, F. R. C., Wyatt, P. G., Delves, M. J., Meister, S., Duffy, S., Avery, V. M., Winzeler, E. A., Sinden, R. E., Wittlin, S. & Frearson, J. A. & 7 others, , 10 Nov 2016, In: Journal of Medicinal Chemistry. 59, 21, p. 9672-9685 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile74 Citations (Scopus)313 Downloads (Pure) -
Identification of novel inhibitors of the type I interferon induction pathway using cell-based high-throughput screening
Gage, Z. O., Vasou, A., Gray, D. W., Randall, R. E. & Adamson, C. S. (Lead / Corresponding author), 1 Oct 2016, In: Journal of Biomolecular Screening. 21, 9, p. 978-988 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)200 Downloads (Pure) -
Identification of Trypanocidal Activity for Known Clinical Compounds Using a New Trypanosoma cruzi Hit-Discovery Screening Cascade
De Rycker, M. (Lead / Corresponding author), Thomas, J., Riley, J., Brough, S. J., Miles, T. J. & Gray, D. W. (Lead / Corresponding author), 15 Apr 2016, In: PLoS Neglected Tropical Diseases. 10, 4, 19 p., e0004584.Research output: Contribution to journal › Article › peer-review
Open AccessFile60 Citations (Scopus)230 Downloads (Pure) -
Trisubstituted Pyrimidines as Efficacious and Fast-acting Antimalarials
Norcross, N. R., Baragana, B., Wilson, C., Hallyburton, I., Osuna-Cabello, M., Norval, S., Riley, J., Stojanovski, L., Simeons, F. R. C., Porzelle, A., Grimaldi, R., Wittlin, S., Duffy, S., Avery, V. M., Meister, S., Sanz, L., Jimenez-Diaz, B., Angulo-Barturen, I., Ferrer, S. & Santos Marinez, M. & 10 others, , 14 Jul 2016, In: Journal of Medicinal Chemistry. 59, 13, p. 6101-6120 20 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)479 Downloads (Pure) -
2015
A novel multiple-stage antimalarial agent that inhibits protein synthesis
Baragana, B., Hallyburton, I., Lee, M. C. S., Norcross, N. R., Grimaldi, R., Otto, T. D., Proto, W. R., Blagborough, A. M., Meister, S., Wirjanata, G., Ruecker, A., Upton, L. M., Abraham, T. S., Almeida, M. J., Pradhan, A., Porzelle, A., Santos Martinez, M., Bolscher, J. M., Woodland, A. & Luksch, T. & 44 others, , 18 Jun 2015, In: Nature. 522, 7556, p. 315-320 6 p.Research output: Contribution to journal › Article › peer-review
359 Citations (Scopus) -
Development and validation of a novel Leishmania donovani screening cascade for high-throughput screening using a novel axenic assay with high predictivity of Leishmanicidal intracellular activity
Nühs, A., De Rycker, M., Manthri, S., Comer, E., Scherer, C. A., Schreiber, S. L., Ioset, J.-R. & Gray, D. W. (Lead / Corresponding author), 25 Sept 2015, In: PLoS Neglected Tropical Diseases. 9, 9, 17 p., e0004094.Research output: Contribution to journal › Article › peer-review
37 Citations (Scopus) -
Discovery of inhibitors of Trypanosoma brucei by phenotypic screening of a focused protein kinase library
Woodland, A., Thompson, S., Cleghorn, L. A. T., Norcross, N., De Rycker, M., Grimaldi, R., Hallyburton, I., Rao, B., Norval, S., Stojanovski, L., Brun, R., Kaiser, M., Frearson, J. A., Gray, D. W., Wyatt, P. G., Read, K. D. & Gilbert, I. H. (Lead / Corresponding author), Nov 2015, In: ChemMedChem. 10, 11, p. 1809-1820 12 p.Research output: Contribution to journal › Article › peer-review
14 Citations (Scopus) -
Identification of small molecule inhibitors of pre-mRNA splicing
Pawallek, A., McElroy, S., Samatov, T., Mitchell, L., Woodland, A., Ryder, U., Gray, D., Lührmann, R. & Lamond, A. I., 6 Mar 2015, In: Journal of Biological Chemistry. 290, 10, 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access5 Citations (Scopus) -
New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource
Peña, I., Pilar Manzano, M., Cantizani, J., Kessler, A., Alonso-Padilla, J., Bardera, A. I., Alvarez, E., Colmenarejo, G., Cotillo, I., Roquero, I., de Dios-Anton, F., Barroso, V., Rodriguez, A., Gray, D. W., Navarro, M., Kumar, V., Sherstnev, A., Drewry, D. H., Brown, J. R. & Fiandor, J. M. & 1 others, , 2015, In: Scientific Reports. 5, 12 p., 8771.Research output: Contribution to journal › Article › peer-review
Open AccessFile219 Citations (Scopus)389 Downloads (Pure) -
2014
Erratum for De Rycker et al., comparison of a high-throughput high-content intracellular leishmania donovani assay with an axenic amastigote assay
De Rycker, M. (Lead / Corresponding author), Hallyburton, I., Thomas, J., Campbell, L., Wyllie, S., Joshi, D., Cameron, S., Gilbert, I. H., Wyatt, P. G., Frearson, J. A., Fairlamb, A. H. & Gray, D. W., Dec 2014, In: Antimicrobial Agents and Chemotherapy. 58, 12, p. 7622 1 p.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
High-throughput chemical screening for antivirulence developmental phenotypes in Trypanosoma brucei.
McGregor, P., Ivens, A., Shave, S., Collie, I., Gray, D., Auer, M. & Matthews, K. R., Mar 2014, In: Eukaryotic Cell. 13, 3, p. 412-426 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)229 Downloads (Pure)