David Gray

2021

Structure-Activity Relationships of Pyrazolo[1,5-a]pyrimidin-7(4H)-ones as Antitubercular Agents

Oh, S., Libardo, M. D. J., Azeeza, S., Pauly, G. T., Roma, J. S. O., Sajid, A., Tateishi, Y., Duncombe, C., Goodwin, M., Ioerger, T. R., Wyatt, P. G., Ray, P. C., Gray, D. W., Boshoff, H. I. M. & Barry, C. E., 6 Jan 2021, In: ACS Infectious Diseases. 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

4 Downloads (Pure)

2020

Development of a High-Throughput Screening Assay to Identify Inhibitors of the Major M17-Leucyl Aminopeptidase from Trypanosoma cruzi Using RapidFire Mass Spectrometry

Izquierdo, M., Lin, D., O'Neill, S., Zoltner, M., Webster, L., Hope, A., Gray, D. W., Field, M. C. & González-Bacerio, J., 13 May 2020, In: SLAS Discovery. 8 p.

Research output: Contribution to journal › Article › peer-review

Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase

Torrie, L. S., Robinson, D. A., Thomas, M. G., Hobrath, J. V., Shepherd, S. M., Post, J. M., Ko, E. J., Ferreira, R. A., Mackenzie, C. J., Wrobel, K., Edwards, D. P., Gilbert, I. H., Gray, D. W., Fairlamb, A. H. & De Rycker, M., 8 May 2020, In: ACS Infectious Diseases. 6, 5, p. 1044-1057 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

21 Downloads (Pure)

Targeting N-myristoylation for therapy of B-cell lymphomas

Beauchamp, E., Yap, M. C., Iyer, A., Perinpanayagam, M. A., Gamma, J. M., Vincent, K. M., Lakshmanan, M., Raju, A., Tergaonkar, V., Tan, S. Y., Lim, S. T., Dong, W-F., Postovit, L. M., Read, K. D., Gray, D. W., Wyatt, P. G., Mackey, J. R. & Berthiaume, L. G., 22 Oct 2020, In: Nature Communications. 11, 16 p., 5348.

Research output: Contribution to journal › Article › peer-review

Open Access

File

1 Citation (Scopus)

64 Downloads (Pure)

2019

Burkholderia pseudomallei D-alanine-D-alanine ligase: detailed characterisation and assessment of a potential antibiotic drug target

Díaz‐Sáez, L., Torrie, L. S., McElroy, S. P., Gray, D. & Hunter, W. M., 18 Nov 2019, In: FEBS Journal. 286, 22, p. 4509-4524 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

1 Citation (Scopus)

97 Downloads (Pure)

Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis

Thomas, M. G., De Rycker, M., Ajakane, M., Albrecht, S., Álvarez-Pedraglio, A. I., Boesche, M., Brand, S., Campbell, L., Cantizani-Perez, J., Cleghorn, L. A. T., Copley, R. C. B., Crouch, S. D., Daugan, A., Drewes, G., Ferrer, S., Ghidelli-Disse, S., Gonzalez, S., Gresham, S. L., Hill, A. P., Hindley, S. J. & 32 others, Lowe, R. M., MacKenzie, C. J., MacLean, L., Manthri, S., Martin, F., Miguel-Siles, J., Nguyen, V. L., Norval, S., Osuna-Cabello, M., Woodland, A., Patterson, S., Pena, I., Quesada-Campos, M. T., Reid, I. H., Revill, C., Riley, J., Ruiz-Gomez, J. R., Shishikura, Y., Simeons, F. R. C., Smith, A., Smith, V. C., Spinks, D., Stojanovski, L., Thomas, J., Thompson, S., Underwood, T., Gray, D. W., Fiandor, J. M., Gilbert, I. H., Wyatt, P. G., Read, K. D. & Miles, T. J., 14 Feb 2019, In: Journal of Medicinal Chemistry. 62, 3, p. 1180-1202 23 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

8 Citations (Scopus)

74 Downloads (Pure)

Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase

Torrie, L., Zuccotto, F., Robinson, D., Gray, D., Gilbert, I. & De Rycker, M., 31 May 2019, In: PLoS ONE. 14, 5, p. 1-16 16 p., e0217828.

Research output: Contribution to journal › Article › peer-review

Open Access

File

2 Citations (Scopus)

152 Downloads (Pure)

Identification of Leishmania major UDP-Sugar Pyrophosphorylase Inhibitors Using Biosensor-Based Small Molecule Fragment Library Screening

Prakash, O., Führing, J., Post, J., Shepherd, S. M., Eadsforth, T. C., Gray, D., Fedorov, R. & Routier, F. H., 12 Mar 2019, In: Molecules and Cells. 24, 5, p. 1-16 16 p., 996.

Research output: Contribution to journal › Article › peer-review

Open Access

File

3 Citations (Scopus)

146 Downloads (Pure)

Identification of Novel Trypanosoma cruzi Proteasome Inhibitors Using a Luminescence-Based High-Throughput Screening Assay

Zmuda, F., Sastry, L., Shepherd, S. M., Jones, D., Scott, A., Craggs, P. D., Cortes, A., Gray, D. W., Torrie, L. S. & De Rycker, M., Sep 2019, In: Antimicrobial Agents and Chemotherapy. 63, 9, 15 p., e00309-19.

Research output: Contribution to journal › Article › peer-review

Open Access

File

4 Citations (Scopus)

109 Downloads (Pure)

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Baragaña, B., Forte, B., Choi, R., Nakazawa Hewitt, S., Bueren-Calabuig, J. A., Pisco, J. P., Peet, C., Dranow, D. M., Robinson, D. A., Jansen, C., Norcross, N. R., Vinayak, S., Anderson, M., Brooks, C. F., Cooper, C. A., Damerow, S., Delves, M., Dowers, K., Duffy, J., Edwards, T. E. & 57 others, Hallyburton, I., Horst, B. G., Hulverson, M. A., Ferguson, L., Jiménez-Díaz, M. B., Jumani, R. S., Lorimer, D. D., Love, M. S., Maher, S., Matthews, H., McNamara, C. W., Miller, P., O'Neill, S., Ojo, K. K., Osuna-Cabello, M., Pinto, E., Post, J., Riley, J., Rottmann, M., Sanz, L. M., Scullion, P., Sharma, A., Shepherd, S. M., Shishikura, Y., Simeons, F. R. C., Stebbins, E. E., Stojanovski, L., Straschil, U., Tamaki, F. K., Tamjar, J., Torrie, L. S., Vantaux, A., Witkowski, B., Wittlin, S., Yogavel, M., Zuccotto, F., Angulo-Barturen, I., Sinden, R., Baum, J., Gamo, F-J., Mäser, P., Kyle, D. E., Winzeler, E. A., Myler, P. J., Wyatt, P. G., Floyd, D., Matthews, D., Sharma, A., Striepen, B., Huston, C. D., Gray, D. W., Fairlamb, A. H., Pisliakov, A. V., Walpole, C., Read, K. D., Van Voorhis, W. C. & Gilbert, I. H., 2 Apr 2019, In: Proceedings of the National Academy of Sciences. 116, 14, p. 7015-7020 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

24 Citations (Scopus)

304 Downloads (Pure)

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

Wyllie, S., Brand, S., Thomas, M., De Rycker, M., Chung, C-W., Peña, I., Bingham, R., Bueren-Calabuig, J., Cantizani, J., Cebrian, D., Craggs, P. D., Ferguson, L., Goswami, P., Hobrath, J., Howe, J., Jeacock, L., Ko, E. J., Korczynska, J., MacLean, L., Manthri, S. & 29 others, Santos Martinez, M., Mata-Cantero, L., Moniz, S., Nuhs, A., Osuna-Cabello, M., Pinto, E., Riley, J., Robinson, S., Rowland, P., Simeons, F., Shishikura, Y., Spinks, D., Stojanovski, L., Thomas, J., Thompson, S., Viayna Gaza, E., Wall, R., Zuccotto, F., Horn, D., Ferguson, M., Fairlamb, A., Fiandor, J. M., Martín, J., Gray, D., Miles, T. J., Gilbert, I., Read, K., Marco, M. & Wyatt, P., 7 May 2019, In: Proceedings of the National Academy of Sciences. 116, 19, p. 9318-9323 6 p., 201820175.

Research output: Contribution to journal › Article › peer-review

Open Access

File

32 Citations (Scopus)

157 Downloads (Pure)

Substituted Aminoacetamides as Novel Leads for Malaria Treatment

Norcross, N., Wilson, C., Baragana, B., Hallyburton, I., Osuna-Cabello, M., Norval, S., Riley, J., Fletcher, D., Sinden, R., Delves, M. J., Ruecker, A., Duffy, S., Meister, S., Antonova-Koch, Y., Crespo, B., de Cózar, C., Sanz, L., Gamo, F-J., Avery, V. M., Frearson, J. A. & 8 others, Gray, D., Fairlamb, A., Winzeler, E. A., Waterson, D., Campbell, S. F., Willis, P., Read, K. & Gilbert, I., 17 Jul 2019, In: ChemMedChem. 14, 14, p. 1329-1335 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

2 Citations (Scopus)

59 Downloads (Pure)

Trypanosoma cruzi phosphomannomutase and guanosine diphosphate-mannose pyrophosphorylase ligandability assessment

Zmuda, F., Shepherd, S. M., Ferguson, M. A. J., Gray, D. W., Torrie, L. S. & De Rycker, M., Oct 2019, In: Antimicrobial Agents and Chemotherapy. 63, 10, 11 p., e01082-19.

Research output: Contribution to journal › Article › peer-review

Open Access

File

1 Citation (Scopus)

101 Downloads (Pure)

2018

Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis

Wyllie, S., Thomas, M., Patterson, S., Crouch, S., De Rycker, M., Lowe, R., Gresham, S., Urbaniak, M. D., Otto, T. D., Stojanovski, L., Simeons, F. R. C., Manthri, S., MacLean, L. M., Zuccotto, F., Homeyer, N., Pflaumer, H., Boesche, M., Sastry, L., Connolly, P., Albrecht, S. & 12 others, Berriman, M., Drewes, G., Gray, D. W., Ghidelli-Disse, S., Dixon, S., Fiandor, J. M., Wyatt, P. G., Ferguson, M. A. J., Fairlamb, A. H., Miles, T. J., Read, K. D. & Gilbert, I. H., 9 Aug 2018, In: Nature. 560, 7717, p. 192-197 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

40 Citations (Scopus)

546 Downloads (Pure)

Development of Trypanosoma cruzi in vitro assays to identify compounds suitable for progression in Chagas’ disease drug discovery

MacLean, L., Thomas, J., Lewis, M. D., Cotillo, I., Gray, D. & De Rycker, M., 12 Jul 2018, In: PLoS Neglected Tropical Diseases. 12, 7, p. 1-22 22 p., e0006612.

Research output: Contribution to journal › Article › peer-review

Open Access

File

26 Citations (Scopus)

161 Downloads (Pure)

2017

Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase

Nakazawa Hewitt, S., Dranow, D. M., Horst, B. G., Abendroth, J. A., Forte, B., Hallyburton, I., Jansen, C., Baragana, B., Choi, R., Rivas, K., Hulverson, M. A., Dumais, M., Edwards, T. E., Lorimer, D. D., Fairlamb, A., Gray, D., Read, K., Lehane, A. M., Kirk, K., Myler, P. J. & 6 others, Wernimont, A., Walpole, C., Stacy, R., Barrett, L., Gilbert, I. H. & Van Voorhis, W. C., 13 Jan 2017, In: ACS Infectious Diseases. 3, 1, p. 34-44 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

17 Citations (Scopus)

299 Downloads (Pure)

Drug discovery for male subfertility using high-throughput screening: a new approach to an unsolved problem

Martins Da Silva, S. J., Brown, S. G., Sutton, K., King, L. V., Ruso, H., Gray, D. W., Wyatt, P. G., Kelly, M. C., Barratt, C. L. R. & Hope, A. G., May 2017, In: Human Reproduction. 32, 5, p. 974-984 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

9 Citations (Scopus)

180 Downloads (Pure)

Identifying Inhibitors of Inflammation: A Novel High-Throughput MALDI-TOF Screening Assay for Salt-Inducible Kinases (SIKs)

Heap, R. E., Hope, A. G., Pearson, L-A., Reyskens, K. M. S. E., McElroy, S. P., Hastie, C. J., Porter, D. W., Arthur, J. S. C., Gray, D. W. & Trost, M., 1 Dec 2017, In: SLAS Discovery. 22, 10, p. 1193-1202 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

26 Citations (Scopus)

322 Downloads (Pure)

2016

A substrate mimic allows high-throughput assay of the FabA protein and consequently the identification of a novel inhibitor of Pseudomonas aeruginosa FabA

Moynié, L., Hope, A. G., Finzel, K., Schmidberger, J., Leckie, S. M., Schneider, G., Burkart, M. D., Smith, A. D., Gray, D. W. & Naismith, J. H., 16 Jan 2016, In: Journal of Molecular Biology. 428, 1, p. 108-120 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

188 Downloads (Pure)

Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis

Baragaña, B., Hallyburton, I., Lee, M. C. S., Norcross, N. R., Grimaldi, R., Otto, T. D., Proto, W. R., Blagborough, A. M., Meister, S., Wirjanata, G., Ruecker, A., Upton, L. M., Abraham, T. S., Almeida, M. J., Pradhan, A., Porzelle, A., Santos Martinez, M., Bolscher, J. M., Woodland, A., Luksch, T. & 44 others, Norval, S., Zuccotto, F., Thomas, J., Simeons, F., Stojanovski, L., Osuna-Cabello, M., Brock, P. M., Churcher, T. S., Sala, K. A., Zakutansky, S. E., Jiménez-Díaz, M. B., Sanz, L. M., Riley, J., Basak, R., Campbell, M., Avery, V. M., Sauerwein, R. W., Dechering, K. J., Noviyanti, R., Campo, B., Frearson, J. A., Angulo-Barturen, I., Ferrer-Bazaga, S., Javier Gamo, F., Wyatt, P. G., Leroy, D., Siegl, P., Delves, M. J., Kyle, D. E., Wittlin, S., Marfurt, J., Price, R. N., Sinden, R. E., Winzeler, E. A., Charman, S. A., Bebrevska, L., Gray, D. W., Campbell, S., Fairlamb, A. H., Willis, P. A., Rayner, J. C., Fidock, D. A., Read, K. D. & Gilbert, I. H., 25 May 2016, In: Nature. 537, 7618, p. 122 1 p.

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Discovery of a quinoline-4-carboxamide derivative with a novel mechanism of action, multistage antimalarial activity, and potent in vivo efficacy

Baragaña, B., Norcross, N. R., Wilson, C., Porzelle, A., Hallyburton, I., Grimaldi, R., Osuna-Cabello, M., Norval, S., Riley, J., Stojanovski, L., Simeons, F. R. C., Wyatt, P. G., Delves, M. J., Meister, S., Duffy, S., Avery, V. M., Winzeler, E. A., Sinden, R. E., Wittlin, S., Frearson, J. A. & 7 others, Gray, D. W., Fairlamb, A. H., Waterson, D., Campbell, S. F., Willis, P., Read, K. D. & Gilbert, I. H., 10 Nov 2016, In: Journal of Medicinal Chemistry. 59, 21, p. 9672-9685 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

30 Citations (Scopus)

218 Downloads (Pure)

Identification of novel inhibitors of the type I interferon induction pathway using cell-based high-throughput screening

Gage, Z. O., Vasou, A., Gray, D. W., Randall, R. E. & Adamson, C. S., 1 Oct 2016, In: Journal of Biomolecular Screening. 21, 9, p. 978-988 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

3 Citations (Scopus)

185 Downloads (Pure)

Identification of Trypanocidal Activity for Known Clinical Compounds Using a New Trypanosoma cruzi Hit-Discovery Screening Cascade

De Rycker, M., Thomas, J., Riley, J., Brough, S. J., Miles, T. J. & Gray, D. W., 15 Apr 2016, In: PLoS Neglected Tropical Diseases. 10, 4, 19 p., e0004584.

Research output: Contribution to journal › Article › peer-review

Open Access

File

34 Citations (Scopus)

178 Downloads (Pure)

Trisubstituted Pyrimidines as Efficacious and Fast-acting Antimalarials

Norcross, N. R., Baragana, B., Wilson, C., Hallyburton, I., Osuna-Cabello, M., Norval, S., Riley, J., Stojanovski, L., Simeons, F. R. C., Porzelle, A., Grimaldi, R., Wittlin, S., Duffy, S., Avery, V. M., Meister, S., Sanz, L., Jimenez-Diaz, B., Angulo-Barturen, I., Ferrer, S., Santos Marinez, M. & 10 others, Javier Gamo, F., Frearson, J. A., Gray, D. W., Fairlamb, A. H., Winzeler, E. A., Waterson, D., Campbell, S. F., Willis, P., Read, K. D. & Gilbert, I. H., 14 Jul 2016, In: Journal of Medicinal Chemistry. 59, 13, p. 6101-6120 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

5 Citations (Scopus)

394 Downloads (Pure)

2015

A novel multiple-stage antimalarial agent that inhibits protein synthesis

Baragana, B., Hallyburton, I., Lee, M. C. S., Norcross, N. R., Grimaldi, R., Otto, T. D., Proto, W. R., Blagborough, A. M., Meister, S., Wirjanata, G., Ruecker, A., Upton, L. M., Abraham, T. S., Almeida, M. J., Pradhan, A., Porzelle, A., Santos Martinez, M., Bolscher, J. M., Woodland, A., Luksch, T. & 44 others, Norval, S., Zuccotto, F., Thomas, J., Simeons, F., Stojanovski, L., Osuna-Cabello, M., Brock, P. M., Churcher, T. S., Sala, K. A., Zakutansky, S. E., Belén Jiménez-Díaz, M., Maria Sanz, L., Riley, J., Basak, R., Campbell, M., Avery, V. M., Sauerwein, R. W., Dechering, K. J., Noviyanti, R., Campo, B., Frearson, J. A., Angulo-Barturen, I., Ferrer-Bazaga, S., Javier Gamo, F., Wyatt, P. G., Leroy, D., Siegl, P., Delves, M. J., Kyle, D. E., Wittlin, S., Marfurt, J., Price, R. N., Sinden, R. E., Winzeler, E. A., Charman, S. A., Bebrevska, L., Gray, D. W., Campbell, S., Fairlamb, A. H., Willis, P. A., Rayner, J. C., Fidock, D. A., Read, K. D. & Gilbert, I. H., 18 Jun 2015, In: Nature. 522, 7556, p. 315-320 6 p.

Research output: Contribution to journal › Article › peer-review

187 Citations (Scopus)

Development and validation of a novel Leishmania donovani screening cascade for high-throughput screening using a novel axenic assay with high predictivity of Leishmanicidal intracellular activity

Nühs, A., De Rycker, M., Manthri, S., Comer, E., Scherer, C. A., Schreiber, S. L., Ioset, J-R. & Gray, D. W., 25 Sep 2015, In: PLoS Neglected Tropical Diseases. 9, 9, 17 p., e0004094.

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Discovery of inhibitors of Trypanosoma brucei by phenotypic screening of a focused protein kinase library

Woodland, A., Thompson, S., Cleghorn, L. A. T., Norcross, N., De Rycker, M., Grimaldi, R., Hallyburton, I., Rao, B., Norval, S., Stojanovski, L., Brun, R., Kaiser, M., Frearson, J. A., Gray, D. W., Wyatt, P. G., Read, K. D. & Gilbert, I. H., Nov 2015, In: ChemMedChem. 10, 11, p. 1809-1820 12 p.

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource

Peña, I., Pilar Manzano, M., Cantizani, J., Kessler, A., Alonso-Padilla, J., Bardera, A. I., Alvarez, E., Colmenarejo, G., Cotillo, I., Roquero, I., de Dios-Anton, F., Barroso, V., Rodriguez, A., Gray, D. W., Navarro, M., Kumar, V., Sherstnev, A., Drewry, D. H., Brown, J. R., Fiandor, J. M. & 1 others, Julio Martin, J., 2015, In: Scientific Reports. 5, 12 p., 8771.

Research output: Contribution to journal › Article › peer-review

Open Access

File

142 Citations (Scopus)

311 Downloads (Pure)

2014

Erratum for De Rycker et al., comparison of a high-throughput high-content intracellular leishmania donovani assay with an axenic amastigote assay

De Rycker, M., Hallyburton, I., Thomas, J., Campbell, L., Wyllie, S., Joshi, D., Cameron, S., Gilbert, I. H., Wyatt, P. G., Frearson, J. A., Fairlamb, A. H. & Gray, D. W., Dec 2014, In: Antimicrobial Agents and Chemotherapy. 58, 12, p. 7622 1 p.

Research output: Contribution to journal › Article › peer-review

High-throughput chemical screening for antivirulence developmental phenotypes in Trypanosoma brucei.

McGregor, P., Ivens, A., Shave, S., Collie, I., Gray, D., Auer, M. & Matthews, K. R., Mar 2014, In: Eukaryotic Cell. 13, 3, p. 412-426 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

8 Citations (Scopus)

202 Downloads (Pure)

Identification of small molecule inhibitors of pre-mRNA splicing

Pawellek, A., McElroy, S., Samatov, T., Mitchell, L., Woodland, A., Ryder, U., Gray, D., Lührmann, R. & Lamond, A. I., 12 Dec 2014, In: Journal of Biological Chemistry. 289, 50, p. 34683-34698 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

41 Citations (Scopus)

283 Downloads (Pure)

2013

Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay.

De Rycker, M., Hallyburton, I., Thomas, J., Campbell, L., Wyllie, S., Joshi, D., Cameron, S., Gilbert, I. H., Wyatt, P. G., Frearson, J. A., Fairlamb, A. H. & Gray, D. W., Jul 2013, In: Antimicrobial Agents and Chemotherapy. 57, 7, p. 2913-2922 10 p.

Research output: Contribution to journal › Article › peer-review

93 Citations (Scopus)

Discovery of an Allosteric Inhibitor Binding Site in 3-Oxo-acyl-ACP Reductase from Pseudomonas aeruginosa

Cukier, C. D., Hope, A. G., Elamin, A. A., Moynie, L., Schnell, R., Schach, S., Kneuper, H., Singh, M., Naismith, J. H., Lindqvist, Y., Gray, D. W. & Schneider, G., 2013, In: ACS Chemical Biology. n/a, cb4005063.

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

2012

Allosteric competitive inhibitors of the glucose-1-phosphate Thymidylyltransferase (RmlA) from seudomonas aeruginosa

Alphey, M. S., Pirrie, L., Torrie, L. S., Boulkeroua, W. A., Gardiner, M., Sarkar, A., Maringer, M., Oehlmann, W., Brenk, R., Scherman, M. S., McNeil, M., Rejzek, M., Field, R. A., Singh, M., Gray, D., Westwood, N. J. & Naismith, J. H., 2012, In: ACS Chemical Biology.

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Assessment of pseudomonas aeruginosa N-5,N-10-methylenetetrahydrofolate dehydrogenase - cyclohydrolase as a potential antibacterial drug target

Eadsforth, T. C., Gardiner, M., Maluf, F. V., McElroy, S., James, D., Frearson, J., Gray, D. & Hunter, W. N., 2012, In: PLoS ONE. 7, 4, p. - 11 p., e35973.

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

A static-cidal assay for Trypanosoma brucei to aid hit prioritisation for progression into drug discovery programmes

De Rycker, M., O'Neill, S., Joshi, D., Campbell, L., Gray, D. W. & Fairlamb, A. H., 29 Nov 2012, In: PLoS Neglected Tropical Diseases. 6, 11, p. e1932

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

2010

The identification a novel, selective, non-steroidal, functional glucocorticoid receptor antagonist

Rimland, J., Dunne, A., Hunjan, S. S., Sasse, R., Uings, I., Montanari, D., Caivano, M., Shah, P., Standing, D., Gray, D., Brown, D., Cairns, W., Trump, R., Smith, P. W., Bertheleme, N., D'Alessandro, P., Gul, S., Vimal, M., Smith, D. N. & Watson, S. P., Apr 2010, In: Bioorganic & Medicinal Chemistry Letters. 20, 7, p. 2340-3 4 p.

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

2008

Synthesis of 3-alkyl naphthalenes as novel estrogen receptor ligands

Fang, J., Akwabi-Ameyaw, A., Britton, J. E., Katamreddy, S. R., Navas III, F., Miller, A. B., Williams, S. P., Gray, D. W., Orband-Miller, L. A., Shearin, J. & Heyer, D., 15 Sep 2008, In: Bioorganic & Medicinal Chemistry Letters. 18, 18, p. 5075-5077 3 p.

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

2007

Design and synthesis of an array of selective androgen receptor modulators

Trump, R. P., Blanc, J-B. E., Stewart, E. L., Brown, P. J., Caivano, M., Gray, D. W., Hoekstra, W. J., Willson, T. M., Han, B. & Turnbull, P., 2007, In: Journal of Combinatorial Chemistry. 9, 1, p. 107-14 8 p.

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Pharmacological properties of the enhanced-affinity glucocorticoid fluticasone furoate in vitro and in an in vivo model of respiratory inflammatory disease

Salter, M., Biggadike, K., Matthews, J. L., West, M. R., Haase, M. V., Farrow, S. N., Uings, I. J. & Gray, D. W., 2007, In: American Journal of Physiology: Lung Cellular and Molecular Physiology. 293, 3, p. L660-7 8 p.

Research output: Contribution to journal › Article › peer-review

130 Citations (Scopus)

2006

Array synthesis of progesterone receptor antagonists: 3-aryl-1,2-diazepines

Wiethe, R. W., Stewart, E. L., Drewry, D. H., Gray, D. W., Mehbob, A. & Hoekstra, W. J., 15 Jul 2006, In: Bioorganic & Medicinal Chemistry Letters. 16, 14, p. 3777-9 3 p.

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

GW627368X ((N-{2-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetyl} benzene sulphonamide): a novel, potent and selective prostanoid EP4 receptor antagonist

Wilson, R. J., Giblin, G. M. P., Roomans, S., Rhodes, S. A., Cartwright, K-A., Shield, V. J., Brown, J., Wise, A., Chowdhury, J., Pritchard, S., Coote, J., Noel, L. S., Kenakin, T., Burns-Kurtis, C. L., Morrison, V., Gray, D. W. & Giles, H., 2006, In: British Journal of Pharmacology. 148, 3, p. 326-339 14 p.

Research output: Contribution to journal › Article › peer-review

61 Citations (Scopus)

2005

Discovery of non-steroidal mifepristone mimetics: pyrazoline-based PR antagonists

Jones, D. G., Liang, X., Stewart, E. L., Noe, R. A., Kallander, L. S., Madauss, K. P., Williams, S. P., Thompson, S. K., Gray, D. W. & Hoekstra, W. J., 2005, In: Bioorganic & Medicinal Chemistry Letters. 15, 13, p. 3203-6 4 p.

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Evaluation of cell-based assays for steroid nuclear receptors delivered by recombinant baculoviruses

Katso, R. M., Parham, J. H., Caivano, M., Clay, W. C., Condreay, J. P., Gray, D. W., Lindley, K. M., Mason, S. J., Rieger, J., Wakes, N. C., Cairns, W. J. & Merrihew, R. V., 2005, In: Journal of Biomolecular Screening. 10, 7, p. 715-24 10 p.

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

2004

Functional pharmacology of human prostanoid EP2 and EP4 receptors

Wilson, R. J., Rhodes, S. A., Wood, R. L., Shield, V. J., Noel, L. S., Gray, D. W. & Giles, H., 6 Oct 2004, In: European Journal of Pharmacology. 501, 1-3, p. 49-58 10 p.

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

1999

Receptors mediating CGRP-induced relaxation in the rat isolated thoracic aorta and porcine isolated coronary artery differentiated by h(alpha) CGRP(8-37)

Wisskirchen, F. M., Gray, D. W. & Marshall, I., Sep 1999, In: British Journal of Pharmacology. 128, 2, p. 283-92 10 p.

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

1997

Sodium dependency of constitutive activity at 5-HT(1Dα/1Dβ) receptors

Giles, H., Barrett, V. & Gray, D., 1997, In: Annals of the New York Academy of Sciences. 812, p. 236-239 4 p.

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

1995

Muscarinic cholinoceptor-stimulated synthesis and degradation of inositol 1,4,5-trisphosphate in the rat cerebellar granule cell

Gray, D. W., Whitham, E. M., Challiss, R. A. J. & Nahorski, S. R., 1995, In: Journal of Neurochemistry. 64, 3, p. 1143-51 9 p.

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

1994

Differential effects of lithium on muscarinic cholinoceptor-stimulated CMP-phosphatidate accumulation in cerebellar granule cells, CHO-M3 cells, and SH-SY5Y neuroblastoma cells

Gray, D. W., Challiss, R. A. J. & Nahorski, S. R., 1994, In: Journal of Neurochemistry. 63, 4, p. 1354-60 7 p.

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Modulation of muscarinic cholinoceptor-stimulated inositol 1,4,5-trisphosphate accumulation by N-methyl-D-aspartate in neonatal rat cerebral cortex

Challis, R. A. J., Mistry, R., Gray, D. W. & Nahorski, S. R., 1994, In: Neuropharmacology. 33, 1, p. 15-25 11 p.

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Search results