Projects per year
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Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2013 2022
Mode of Action Studies in Kinetoplastid Parasites (Industrial CASE Studentship)
1/09/17 → 30/09/21
Project: Research
Wellcome Centre for Anti-Infectives Research
Cook, S., Fairlamb, A., Ferguson, M., Field, M., Gilbert, I., Gray, D., Horn, D., Read, K. & Wyatt, P.
1/04/17 → 31/03/22
Project: Research
Chemical Biology: Leveraging Phenotypic Hits Against Kinetoplastids (Strategic Grant)
Fairlamb, A., Field, M., Gilbert, I., Gray, D., Horn, D. & Wyatt, P.
1/01/15 → 30/06/20
Project: Research
High-Throughput Decoding of Virulence Mechanisms in African Trypanosomes (Senior Investigator Award)
1/09/13 → 29/02/20
Project: Research
Research Output 2008 2019
Pharmacological validation of N-myristoyltransferase as a drug target in Leishmania donovani
Corpas Lopez, V., Moniz, S., Thomas, M., Wall, R., Torrie, L., Zander-Dinse, D., Tinti, M., Brand, S., Stojanovski, L., Manthri, S., Hallyburton, I., Zuccotto, F., Wyatt, P., De Rycker, M., Horn, D., Ferguson, M., Clos, J., Read, K., Fairlamb, A., Gilbert, I. & 1 others, Jan 2019, In : ACS Infectious Diseases. 5, 1, p. 111-122 12 p.Research output: Contribution to journal › Article
Open Access
File
Leishmania donovani
Pharmacology
Parasites
Enzymes
Pharmaceutical Preparations
Anti-trypanosomal 8-hydroxyl naphthyridines are chelators of divalent transition metals
Wall, R., Moniz, S., Thomas, M., Norval, S., Ko, E. J., Marco, M., Miles, T. J., Gilbert, I., Horn, D., Fairlamb, A. & Wyllie, S., Aug 2018, In : Antimicrobial Agents and Chemotherapy. 62, 8, 15 p., e00235-18.Research output: Contribution to journal › Article
Open Access
File
Naphthyridines
Chelating Agents
Hydroxyl Radical
Metals
Trypanosoma brucei brucei
Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei
Steketee, P. C., Vincent, I. M., Achcar, F., Giordani, F., Kim, D. H., Creek, D. J., Freund, Y., Jacobs, R., Rattigan, K., Horn, D., Field, M. C., MacLeod, A. & Barrett, M. P., 14 May 2018, In : PLoS Neglected Tropical Diseases. 12, 5, p. 1-24 24 p., e0006450.Research output: Contribution to journal › Article
Open Access
File
S-Adenosylmethionine
Trypanosoma brucei brucei
African Trypanosomiasis
Metabolomics
Trypanosomiasis
Clinical and veterinary trypanocidal benzoxaboroles target CPSF3
Wall, R., Rico Vidal, E., Lukac, I., Zuccotto, F., Elg, S., Gilbert, I., Freund, Y. R., Alley, M. R. K., Field, M., Wyllie, S. & Horn, D., 18 Sep 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 38, p. 9616-9621 6 p.Research output: Contribution to journal › Article
Open Access
File
Trypanosomiasis
Cleavage And Polyadenylation Specificity Factor
Clustered Regularly Interspaced Short Palindromic Repeats
Neglected Diseases
African Trypanosomiasis
Codon usage bias controls mRNA and protein abundance in trypanosomatids
Jeacock, L., Correia Faria, J. & Horn, D., 15 Mar 2018, In : eLife. e32496.Research output: Contribution to journal › Article
Open Access
File
Codon
Messenger RNA
Proteins
Genes
Synthetic Genes
Press / Media
Sleeping sickness parasite's pores act as efficient drug uptake mechanism
26/11/13
3 items of media coverage
Press/Media: Research
Thesis
African Trypanosome Genes Specifically Required for Fitness in vivo
Author: Shrimpton, J. W., 2017Supervisor: Horn, D. (Supervisor)
Student thesis: Master's Thesis › Master of Science
File
Folate transport and drug resistance in the African Trypanosome
Author: Dewar, S., 2017Supervisor: Fairlamb, A. (Supervisor) & Horn, D. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
File
VSG expression in African trypanosomes: Gene silencing, cell cycle and developmental control
Author: Hutchinson, S. J., 2016Supervisor: Horn, D. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy