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Horn, David

Professor

 https://orcid.org/0000-0001-5173-9284
20082025
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  • 55 Similar Profiles
Trypanosomiasis Medicine & Life Sciences
Trypanosoma brucei brucei Medicine & Life Sciences
Parasites Medicine & Life Sciences
Membrane Glycoproteins Medicine & Life Sciences
Melarsoprol Medicine & Life Sciences
Pentamidine Medicine & Life Sciences
Pharmaceutical Preparations Medicine & Life Sciences
African Trypanosomiasis Medicine & Life Sciences

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Projects 2013 2025

Mode of Action Studies in Kinetoplastid Parasites (Industrial CASE Studentship)

Gilbert, I. & Horn, D.

Medical Research Council

1/09/17 → 30/09/21

Project: Research

Wellcome Centre for Anti-Infectives Research

Cook, S., Fairlamb, A., Ferguson, M., Field, M., Gilbert, I., Gray, D., Horn, D., Read, K. & Wyatt, P.

Wellcome Trust

1/04/17 → 31/03/22

Project: Research

Chemical Biology: Leveraging Phenotypic Hits Against Kinetoplastids (Strategic Grant)

Fairlamb, A., Field, M., Gilbert, I., Gray, D., Horn, D. & Wyatt, P.

Wellcome Trust

1/01/15 → 30/06/20

Project: Research

High-Throughput Decoding of Virulence Mechanisms in African Trypanosomes (Senior Investigator Award)

Horn, D.

Wellcome Trust

1/09/13 → 29/02/20

Project: Research

Decoding Mechanisms of gene regulation in African Trypanosomes

Horn, D.

Wellcome Trust

1/03/20 → 28/02/25

Project: Research

Research Output 2008 2019

9 Downloads (Pure)

A post-transcriptional respiratome regulon in trypanosomes

Trenaman, A., Glover, L., Hutchinson, S. & Horn, D., 26 Jul 2019, In : Nucleic Acids Research. 47, 13, p. 7063-7077 15 p.

Research output: Contribution to journal › Article

Open Access
File
Regulon
Trypanosomiasis
Membrane Glycoproteins
Trypanosoma brucei brucei
RNA-Binding Proteins
18 Downloads (Pure)

Chemogenomic Profiling of Antileishmanial Efficacy and Resistance in the Related Kinetoplastid Parasite Trypanosoma brucei

Collett, C. F., Kitson, C., Baker, N., Steele-Stallard, H. B., Santrot, M-V., Hutchinson, S., Horn, D. & Alsford, S., Aug 2019, In : Antimicrobial Agents and Chemotherapy. 63, 8, p. 1-19 19 p., e00795-19.

Research output: Contribution to journal › Article

Open Access
File
Trypanosoma brucei brucei
miltefosine
Parasites
Pharmaceutical Preparations
Leishmania
17 Downloads (Pure)

Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex

Correia Faria, J., Glover, L., Hutchinson, S., Boehm, C., Field, M. C. & Horn, D., 9 Jul 2019, In : Nature Communications. 10, p. 1-14 14 p., 3023.

Research output: Contribution to journal › Article

Open Access
File
Trypanosoma Variant Surface Glycoproteins
Trypanosoma brucei brucei
Membrane Glycoproteins
exclusion
Epigenomics
17 Downloads (Pure)

Persistent DNA Damage Foci and DNA Replication with a Broken Chromosome in the African Trypanosome

Glover, L., Marques, C., Suska, O. & Horn, D., 9 Jul 2019, In : MBio. 10, 4, p. 1-17 17 p., e01252-19.

Research output: Contribution to journal › Article

Open Access
File
Trypanosomiasis
DNA Replication
DNA Damage
Replication Protein A
Chromosomes
2 Citations (Scopus)
95 Downloads (Pure)

Pharmacological validation of N-myristoyltransferase as a drug target in Leishmania donovani

Corpas Lopez, V., Moniz, S., Thomas, M., Wall, R., Torrie, L., Zander-Dinse, D., Tinti, M., Brand, S., Stojanovski, L., Manthri, S., Hallyburton, I., Zuccotto, F., Wyatt, P., De Rycker, M., Horn, D., Ferguson, M., Clos, J., Read, K., Fairlamb, A., Gilbert, I. & 1 others, Wyllie, S., 11 Jan 2019, In : ACS Infectious Diseases. 5, 1, p. 111-122 12 p.

Research output: Contribution to journal › Article

Open Access
File
Leishmania donovani
Pharmacology
Parasites
Enzymes
Pharmaceutical Preparations

Press / Media

Sleeping sickness parasite's pores act as efficient drug uptake mechanism

David Horn

26/11/13

3 items of Media coverage

Press/Media: Research

Thesis

African Trypanosome Genes Specifically Required for Fitness in vivo

Author: Shrimpton, J. W., 2017

Supervisor: Horn, D. (Supervisor)

Student thesis: Master's Thesis › Master of Science

File

Folate transport and drug resistance in the African Trypanosome

Author: Dewar, S., 2017

Supervisor: Fairlamb, A. (Supervisor) & Horn, D. (Supervisor)

Student thesis: Doctoral Thesis › Doctor of Philosophy

File

VSG expression in African trypanosomes: Gene silencing, cell cycle and developmental control

Author: Hutchinson, S. J., 2016

Supervisor: Horn, D. (Supervisor)

Student thesis: Doctoral Thesis › Doctor of Philosophy