Horn, David

Professor

Professor, Biological Chemistry and Drug Discovery

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1 Not started
4 Active
9 Finished

A Platform for Drug Target Deconvolution and Exploitation
Gilbert, I., Horn, D., Pawlowic, M., Wyatt, P. & Wyllie, S.
Wellcome Trust
31/12/20 → 30/12/23
Project: Research
Decoding Mechanisms of gene regulation in African Trypanosomes
Horn, D.
Wellcome Trust
1/03/20 → 28/02/25
Project: Research
Mode of Action Studies in Kinetoplastid Parasites (Industrial CASE Studentship)
Gilbert, I. & Horn, D.
Medical Research Council
1/09/17 → 30/09/21
Project: Research
Wellcome Centre for Anti-Infectives Research
Cook, S., Fairlamb, A., Ferguson, M., Field, M., Gilbert, I., Gray, D., Horn, D., Read, K. & Wyatt, P.
Wellcome Trust
1/04/17 → 31/03/22
Project: Research
A Pipeline of Drugs for Visceral Leishmaniasis and Chagas Disease Through Expertise and Innovation (Preliminary Strategic Award) (Joint with Glaxosmithkline)
Fairlamb, A., Ferguson, M., Field, M., Gilbert, I., Gray, D., Horn, D., Read, K. & Wyatt, P.
Project: Research

70 Article
8 Review article
2 Chapter
2 Comment/debate
More

Spatial integration of transcription and splicing in a dedicated compartment sustains monogenic antigen expression in African trypanosomes
Faria, J., Luzak, V., Müller, L. S. M., Brink, B. G., Hutchinson, S., Glover, L., Horn, D. & Siegel, T. N., Mar 2021, In: Nature Microbiology. 6, p. 289-300 12 p.
Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus)
Instability of aquaglyceroporin (Aqp) 2 contributes to drug resistance in trypanosoma brucei
Quintana, J. F., Bueren-Calabuig, J., Zuccotto, F., Zoltner, M., Canavate Del Pino, R., de Koning, H. P., Horn, D. & Field, M. C., 9 Jul 2020, In: PLoS Neglected Tropical Diseases. 14, 7, 26 p., e0008458.
Research output: Contribution to journal › Article › peer-review

Open Access
File
2 Citations (Scopus)

15 Downloads (Pure)
Para-site-seeing: Exhibition Catalogue
Floyd, A., Yeoman, H., Southern, J., Dillon, R., Cook, S., Fairlamb, A., Ferguson, M., Horn, D., MacLean, L., Manthri, S., Paterson, C., Pearson, L., Prescott, A., Read, K., Shastry, L., Svensen, N. & Thomas, J., 2020
Research output: Non-textual form › Exhibition catalogue

Open Access
File
20 Downloads (Pure)
Setting our sights on infectious diseases
De Rycker, M., Horn, D., Aldridge, B., Amewu, R. K., Barry, C. E., Buckner, F. S., Cook, S., Ferguson, M. A. J., Gobeau, N., Herrmann, J., Herrling, P., Hope, W., Keiser, J., Lafuente-Monasterio, M. J., Leeson, P. D., Leroy, D., Manjunatha, U. H., McCarthy, J., Miles, T. J., Mizrahi, V. & 17 others, Moshynets, O., Niles, J., Overington, J. P., Pottage, J., Rao, S. P. S., Read, K. D., Ribeiro, I., Silver, L. L., Southern, J., Spangenberg, T., Sundar, S., Taylor, C., Van Voorhis, W. C., White, N. J., Wyllie, S., Wyatt, P. G. & Gilbert, I. H., 10 Jan 2020, In: ACS Infectious Diseases. 6, p. 3-13 11 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
4 Citations (Scopus)

33 Downloads (Pure)
Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes
Zoltner, M., Campagnaro, G. D., Taleva, G., Burrell, A., Cerone, M., Leung, K-F., Achcar, F., Horn, D., Vaughan, S., Gadelha, C., Zíková, A., Barrett, M. P., de Koning, H. P. & Field, M., 12 Jun 2020, In: Journal of Biological Chemistry. 295, 24, p. 8331-8347 17 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
7 Citations (Scopus)

23 Downloads (Pure)

1 Participation in conference
1 Public engagement and outreach - public lecture/debate/seminar

3rd Infectious Disease Research Initiative Scotland (IDRIS)
Mattie Pawlowic (Participant) & David Horn (Participant)
6 Mar 2019 → 7 Mar 2019
Activity: Participating in or organising an event types › Participation in conference
Discovery Days 2014
Jonathan Urch (Organiser), Pete Downes (Chair), Karl Leydecker (Presenter), Graeme Hutton (Presenter), Charlotte Proby (Presenter), Amin Abdolvand (Presenter), Doreen Cantrell (Chair), John Rowan (Presenter), Bruce Burton (Presenter), David Horn (Presenter), John Connell (Chair), Ewan Pearson (Presenter), Ruth O'Riordan (Presenter), Graeme Morton (Presenter), Anna Campbell (Presenter), John Baldacchino (Presenter), Karim Labib (Presenter), Stephen Decent (Chair), Fraser Smith (Presenter), Ioannis Anastasopoulos (Presenter), Deborah Peel (Presenter), Christopher Whatley (Chair), Ioan Fazey (Presenter), Graham Chadwick (Presenter), James Livesey (Presenter), Mark Robson (Presenter), Rory McCrimmon (Presenter) & Christopher Connolly (Presenter)
9 Jan 2014 → 10 Jan 2014
Activity: Other activity types › Public engagement and outreach - public lecture/debate/seminar

File

Sleeping sickness parasite's pores act as efficient drug uptake mechanism
David Horn
26/11/13
3 items of Media coverage
Press/Media: Research