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Horn, David

Professor

 https://orcid.org/0000-0001-5173-9284
20082022
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Projects 2013 2022

Mode of Action Studies in Kinetoplastid Parasites (Industrial CASE Studentship)

Gilbert, I. & Horn, D.

Medical Research Council

1/09/17 → 30/09/21

Project: Research

Wellcome Centre for Anti-Infectives Research

Cook, S., Fairlamb, A., Ferguson, M., Field, M., Gilbert, I., Gray, D., Horn, D., Read, K. & Wyatt, P.

Wellcome Trust

1/04/17 → 31/03/22

Project: Research

Chemical Biology: Leveraging Phenotypic Hits Against Kinetoplastids (Strategic Grant)

Fairlamb, A., Field, M., Gilbert, I., Gray, D., Horn, D. & Wyatt, P.

Wellcome Trust

1/01/15 → 30/06/20

Project: Research

High-Throughput Decoding of Virulence Mechanisms in African Trypanosomes (Senior Investigator Award)

Horn, D.

Wellcome Trust

1/09/13 → 29/02/20

Project: Research

A Pipeline of Drugs for Visceral Leishmaniasis and Chagas Disease Through Expertise and Innovation (Preliminary Strategic Award) (Joint with Glaxosmithkline)

Fairlamb, A., Ferguson, M., Field, M., Gilbert, I., Gray, D., Horn, D., Read, K. & Wyatt, P.

Project: Research

Research Output 2008 2019

2 Downloads (Pure)

A post-transcriptional respiratome regulon in trypanosomes

Trenaman, A., Glover, L., Hutchinson, S. & Horn, D., 25 May 2019, In : Nucleic Acids Research. 15 p.

Research output: Contribution to journal › Article

Open Access
File
Regulon
Trypanosomiasis
Membrane Glycoproteins
Trypanosoma brucei brucei
RNA-Binding Proteins

Chemogenomic profiling of anti-leishmanial efficacy and resistance in the related kinetoplastid parasite Trypanosoma brucei

Collett, C. F., Kitson, C., Baker, N., Steele-Stallard, H. B., Santrot, M-V., Hutchinson, S., Horn, D. & Alsford, S., 3 Jun 2019, In : Antimicrobial Agents and Chemotherapy.

Research output: Contribution to journal › Article

Open Access
Trypanosoma brucei brucei
miltefosine
Parasites
Pharmaceutical Preparations
Leishmania
40 Downloads (Pure)

Pharmacological validation of N-myristoyltransferase as a drug target in Leishmania donovani

Corpas Lopez, V., Moniz, S., Thomas, M., Wall, R., Torrie, L., Zander-Dinse, D., Tinti, M., Brand, S., Stojanovski, L., Manthri, S., Hallyburton, I., Zuccotto, F., Wyatt, P., De Rycker, M., Horn, D., Ferguson, M., Clos, J., Read, K., Fairlamb, A., Gilbert, I. & 1 othersWyllie, S., 11 Jan 2019, In : ACS Infectious Diseases. 5, 1, p. 111-122 12 p.

Research output: Contribution to journal › Article

Open Access
File
Leishmania donovani
Pharmacology
Parasites
Enzymes
Pharmaceutical Preparations
1 Citation (Scopus)
27 Downloads (Pure)

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

Wyllie, S., Brand, S., Thomas, M., De Rycker, M., Chung, C-W., Peña, I., Bingham, R., Bueren-Calabuig, J., Cantizani, J., Cebrian, D., Craggs, P. D., Ferguson, L., Goswami, P., Hobrath, J., Howe, J., Jeacock, L., Ko, E. J., Korczynska, J., MacLean, L., Manthri, S. & 29 othersSantos Martinez, M., Mata-Cantero, L., Moniz, S., Nuhs, A., Osuna-Cabello, M., Pinto, E., Riley, J., Robinson, S., Rowland, P., Simeons, F., Shishikura, Y., Spinks, D., Stojanovski, L., Thomas, J., Thompson, S., Viayna Gaza, E., Wall, R., Zuccotto, F., Horn, D., Ferguson, M., Fairlamb, A., Fiandor, J. M., Martín, J., Gray, D., Miles, T. J., Gilbert, I., Read, K., Marco, M. & Wyatt, P., 7 May 2019, In : Proceedings of the National Academy of Sciences. 116, 19, p. 9318-9323 6 p., 201820175.

Research output: Contribution to journal › Article

Open Access
File
Leishmania infantum
Visceral Leishmaniasis
Proteasome Endopeptidase Complex
Leishmania donovani
Parasites
1 Citation (Scopus)
51 Downloads (Pure)

Anti-trypanosomal 8-hydroxyl naphthyridines are chelators of divalent transition metals

Wall, R., Moniz, S., Thomas, M., Norval, S., Ko, E. J., Marco, M., Miles, T. J., Gilbert, I., Horn, D., Fairlamb, A. & Wyllie, S., Aug 2018, In : Antimicrobial Agents and Chemotherapy. 62, 8, 15 p., e00235-18.

Research output: Contribution to journal › Article

Open Access
File
Naphthyridines
Chelating Agents
Hydroxyl Radical
Metals
Trypanosoma brucei brucei

Press / Media

Sleeping sickness parasite's pores act as efficient drug uptake mechanism

David Horn

26/11/13

3 items of media coverage

Press/Media: Research

Thesis

African Trypanosome Genes Specifically Required for Fitness in vivo

Author: Shrimpton, J. W., 2017

Supervisor: Horn, D. (Supervisor)

Student thesis: Master's Thesis › Master of Science

File

Folate transport and drug resistance in the African Trypanosome

Author: Dewar, S., 2017

Supervisor: Fairlamb, A. (Supervisor) & Horn, D. (Supervisor)

Student thesis: Doctoral Thesis › Doctor of Philosophy

File

VSG expression in African trypanosomes: Gene silencing, cell cycle and developmental control

Author: Hutchinson, S. J., 2016

Supervisor: Horn, D. (Supervisor)

Student thesis: Doctoral Thesis › Doctor of Philosophy