Horn, David

Professor

Professor, Biological Chemistry and Drug Discovery

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1 Not started
4 Active
9 Finished

A Platform for Drug Target Deconvolution and Exploitation
Gilbert, I., Horn, D., Pawlowic, M., Wyatt, P. & Wyllie, S.
Wellcome Trust
31/12/20 → 30/12/23
Project: Research
Decoding Mechanisms of gene regulation in African Trypanosomes
Horn, D.
Wellcome Trust
1/03/20 → 28/02/25
Project: Research
Mode of Action Studies in Kinetoplastid Parasites (Industrial CASE Studentship)
Gilbert, I. & Horn, D.
Medical Research Council
1/09/17 → 30/09/21
Project: Research
Wellcome Centre for Anti-Infectives Research
Cook, S., Fairlamb, A., Ferguson, M., Field, M., Gilbert, I., Gray, D., Horn, D., Read, K. & Wyatt, P.
Wellcome Trust
1/04/17 → 31/03/22
Project: Research
A Pipeline of Drugs for Visceral Leishmaniasis and Chagas Disease Through Expertise and Innovation (Preliminary Strategic Award) (Joint with Glaxosmithkline)
Fairlamb, A., Ferguson, M., Field, M., Gilbert, I., Gray, D., Horn, D., Read, K. & Wyatt, P.
Project: Research

68 Article
8 Review article
2 Chapter
2 Comment/debate
More

Spatial integration of transcription and splicing in a dedicated compartment sustains monogenic antigen expression in African trypanosomes
Faria, J., Luzak, V., Müller, L. S. M., Brink, B. G., Hutchinson, S., Glover, L., Horn, D. & Siegel, T. N., 11 Jan 2021, In: Nature Microbiology. 26 p.
Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus)
Instability of aquaglyceroporin (Aqp) 2 contributes to drug resistance in trypanosoma brucei
Quintana, J. F., Bueren-Calabuig, J., Zuccotto, F., Zoltner, M., Canavate Del Pino, R., de Koning, H. P., Horn, D. & Field, M. C., 9 Jul 2020, In: PLoS Neglected Tropical Diseases. 14, 7, 26 p., e0008458.
Research output: Contribution to journal › Article › peer-review

Open Access
File
1 Citation (Scopus)

21 Downloads (Pure)
Para-site-seeing: Exhibition Catalogue
Floyd, A., Yeoman, H., Southern, J., Dillon, R., Cook, S., Fairlamb, A., Ferguson, M., Horn, D., MacLean, L., Manthri, S., Paterson, C., Pearson, L., Prescott, A., Read, K., Shastry, L., Svensen, N. & Thomas, J., 2020
Research output: Non-textual form › Exhibition catalogue

Open Access
File
15 Downloads (Pure)
Setting our sights on infectious diseases
De Rycker, M., Horn, D., Aldridge, B., Amewu, R. K., Barry, C. E., Buckner, F. S., Cook, S., Ferguson, M. A. J., Gobeau, N., Herrmann, J., Herrling, P., Hope, W., Keiser, J., Lafuente-Monasterio, M. J., Leeson, P. D., Leroy, D., Manjunatha, U. H., McCarthy, J., Miles, T. J., Mizrahi, V. & 17 others, Moshynets, O., Niles, J., Overington, J. P., Pottage, J., Rao, S. P. S., Read, K. D., Ribeiro, I., Silver, L. L., Southern, J., Spangenberg, T., Sundar, S., Taylor, C., Van Voorhis, W. C., White, N. J., Wyllie, S., Wyatt, P. G. & Gilbert, I. H., 10 Jan 2020, In: ACS Infectious Diseases. 6, p. 3-13 11 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
78 Downloads (Pure)
Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes
Zoltner, M., Campagnaro, G. D., Taleva, G., Burrell, A., Cerone, M., Leung, K-F., Achcar, F., Horn, D., Vaughan, S., Gadelha, C., Zíková, A., Barrett, M. P., de Koning, H. P. & Field, M., 12 Jun 2020, In: Journal of Biological Chemistry. 295, 24, p. 8331-8347 17 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
3 Citations (Scopus)

28 Downloads (Pure)

1 Participation in conference

3rd Infectious Disease Research Initiative Scotland (IDRIS)
Mattie Pawlowic (Participant) & David Horn (Participant)
6 Mar 2019 → 7 Mar 2019
Activity: Participating in or organising an event types › Participation in conference

Sleeping sickness parasite's pores act as efficient drug uptake mechanism
David Horn
26/11/13
3 items of Media coverage
Press/Media: Research