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  • 57 Similar Profiles
Trypanosomiasis Medicine & Life Sciences
Trypanosoma brucei brucei Medicine & Life Sciences
Parasites Medicine & Life Sciences
Membrane Glycoproteins Medicine & Life Sciences
Melarsoprol Medicine & Life Sciences
Pentamidine Medicine & Life Sciences
African Trypanosomiasis Medicine & Life Sciences
Aquaglyceroporins Medicine & Life Sciences

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Projects 2013 2022

Research Output 2008 2019

2 Downloads (Pure)

A post-transcriptional respiratome regulon in trypanosomes

Trenaman, A., Glover, L., Hutchinson, S. & Horn, D., 25 May 2019, In : Nucleic Acids Research. 15 p.

Research output: Contribution to journalArticle

Open Access
File
Regulon
Trypanosomiasis
Membrane Glycoproteins
Trypanosoma brucei brucei
RNA-Binding Proteins

Chemogenomic profiling of anti-leishmanial efficacy and resistance in the related kinetoplastid parasite Trypanosoma brucei

Collett, C. F., Kitson, C., Baker, N., Steele-Stallard, H. B., Santrot, M-V., Hutchinson, S., Horn, D. & Alsford, S., 3 Jun 2019, In : Antimicrobial Agents and Chemotherapy.

Research output: Contribution to journalArticle

Open Access
Trypanosoma brucei brucei
miltefosine
Parasites
Pharmaceutical Preparations
Leishmania
40 Downloads (Pure)
Open Access
File
Leishmania donovani
Pharmacology
Parasites
Enzymes
Pharmaceutical Preparations
1 Citation (Scopus)
27 Downloads (Pure)

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

Wyllie, S., Brand, S., Thomas, M., De Rycker, M., Chung, C-W., Peña, I., Bingham, R., Bueren-Calabuig, J., Cantizani, J., Cebrian, D., Craggs, P. D., Ferguson, L., Goswami, P., Hobrath, J., Howe, J., Jeacock, L., Ko, E. J., Korczynska, J., MacLean, L., Manthri, S. & 29 othersSantos Martinez, M., Mata-Cantero, L., Moniz, S., Nuhs, A., Osuna-Cabello, M., Pinto, E., Riley, J., Robinson, S., Rowland, P., Simeons, F., Shishikura, Y., Spinks, D., Stojanovski, L., Thomas, J., Thompson, S., Viayna Gaza, E., Wall, R., Zuccotto, F., Horn, D., Ferguson, M., Fairlamb, A., Fiandor, J. M., Martín, J., Gray, D., Miles, T. J., Gilbert, I., Read, K., Marco, M. & Wyatt, P., 7 May 2019, In : Proceedings of the National Academy of Sciences. 116, 19, p. 9318-9323 6 p., 201820175.

Research output: Contribution to journalArticle

Open Access
File
Leishmania infantum
Visceral Leishmaniasis
Proteasome Endopeptidase Complex
Leishmania donovani
Parasites
1 Citation (Scopus)
51 Downloads (Pure)

Anti-trypanosomal 8-hydroxyl naphthyridines are chelators of divalent transition metals

Wall, R., Moniz, S., Thomas, M., Norval, S., Ko, E. J., Marco, M., Miles, T. J., Gilbert, I., Horn, D., Fairlamb, A. & Wyllie, S., Aug 2018, In : Antimicrobial Agents and Chemotherapy. 62, 8, 15 p., e00235-18.

Research output: Contribution to journalArticle

Open Access
File
Naphthyridines
Chelating Agents
Hydroxyl Radical
Metals
Trypanosoma brucei brucei

Press / Media

Thesis

African Trypanosome Genes Specifically Required for Fitness in vivo

Author: Shrimpton, J. W., 2017

Supervisor: Horn, D. (Supervisor)

Student thesis: Master's ThesisMaster of Science

File

Folate transport and drug resistance in the African Trypanosome

Author: Dewar, S., 2017

Supervisor: Fairlamb, A. (Supervisor) & Horn, D. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

VSG expression in African trypanosomes: Gene silencing, cell cycle and developmental control

Author: Hutchinson, S. J., 2016

Supervisor: Horn, D. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy