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Trypanosomiasis Medicine & Life Sciences
Trypanosoma brucei brucei Medicine & Life Sciences
Parasites Medicine & Life Sciences
Membrane Glycoproteins Medicine & Life Sciences
Melarsoprol Medicine & Life Sciences
African Trypanosomiasis Medicine & Life Sciences
Aquaglyceroporins Medicine & Life Sciences
Pentamidine Medicine & Life Sciences

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Projects 2013 2022

Research Output 2008 2019

9 Downloads (Pure)
Open Access
File
Leishmania donovani
Pharmacology
Parasites
Enzymes
Pharmaceutical Preparations
1 Citations (Scopus)
5 Downloads (Pure)

Anti-trypanosomal 8-hydroxyl naphthyridines are chelators of divalent transition metals

Wall, R., Moniz, S., Thomas, M., Norval, S., Ko, E. J., Marco, M., Miles, T. J., Gilbert, I., Horn, D., Fairlamb, A. & Wyllie, S., Aug 2018, In : Antimicrobial Agents and Chemotherapy. 62, 8, 15 p., e00235-18.

Research output: Contribution to journalArticle

Open Access
File
Naphthyridines
Chelating Agents
Hydroxyl Radical
Metals
Trypanosoma brucei brucei
4 Citations (Scopus)
7 Downloads (Pure)

Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei

Steketee, P. C., Vincent, I. M., Achcar, F., Giordani, F., Kim, D. H., Creek, D. J., Freund, Y., Jacobs, R., Rattigan, K., Horn, D., Field, M. C., MacLeod, A. & Barrett, M. P., 14 May 2018, In : PLoS Neglected Tropical Diseases. 12, 5, p. 1-24 24 p., e0006450.

Research output: Contribution to journalArticle

Open Access
File
S-Adenosylmethionine
Trypanosoma brucei brucei
African Trypanosomiasis
Metabolomics
Trypanosomiasis
1 Citations (Scopus)
36 Downloads (Pure)

Clinical and veterinary trypanocidal benzoxaboroles target CPSF3

Wall, R., Rico Vidal, E., Lukac, I., Zuccotto, F., Elg, S., Gilbert, I., Freund, Y. R., Alley, M. R. K., Field, M., Wyllie, S. & Horn, D., 18 Sep 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 38, p. 9616-9621 6 p.

Research output: Contribution to journalArticle

Open Access
File
Trypanosomiasis
Cleavage And Polyadenylation Specificity Factor
Clustered Regularly Interspaced Short Palindromic Repeats
Neglected Diseases
African Trypanosomiasis
7 Citations (Scopus)
12 Downloads (Pure)

Codon usage bias controls mRNA and protein abundance in trypanosomatids

Jeacock, L., Correia Faria, J. & Horn, D., 15 Mar 2018, In : eLife. e32496.

Research output: Contribution to journalArticle

Open Access
File
Codon
Messenger RNA
Proteins
Genes
Synthetic Genes

Press / Media

Thesis

African Trypanosome Genes Specifically Required for Fitness in vivo

Author: Shrimpton, J. W., 2017

Supervisor: Horn, D. (Supervisor)

Student thesis: Master's ThesisMaster of Science

File

Folate transport and drug resistance in the African Trypanosome

Author: Dewar, S., 2017

Supervisor: Fairlamb, A. (Supervisor) & Horn, D. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

VSG expression in African trypanosomes: Gene silencing, cell cycle and developmental control

Author: Hutchinson, S. J., 2016

Supervisor: Horn, D. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy