20082020

Research output per year

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Research Output

2020

Instability of aquaglyceroporin 2 leads to drug resistance in Trypanosoma brucei

Quintana, J. F., Bueren-Calabuig, J., Zuccotto, F., Zoltner, M., Canavate Del Pino, R., de Koning, H. P., Horn, D. & Field, M. C., 9 Jul 2020, In : PLoS Neglected Tropical Diseases. 14, 7, 26 p., e0008458.

Research output: Contribution to journalArticle

Open Access

Setting our sights on infectious diseases

De Rycker, M., Horn, D., Aldridge, B., Amewu, R. K., Barry, C. E., Buckner, F. S., Cook, S., Ferguson, M. A. J., Gobeau, N., Herrmann, J., Herrling, P., Hope, W., Keiser, J., Lafuente-Monasterio, M. J., Leeson, P. D., Leroy, D., Manjunatha, U. H., McCarthy, J., Miles, T. J., Mizrahi, V. & 17 others, Moshynets, O., Niles, J., Overington, J. P., Pottage, J., Rao, S. P. S., Read, K. D., Ribeiro, I., Silver, L. L., Southern, J., Spangenberg, T., Sundar, S., Taylor, C., Van Voorhis, W. C., White, N. J., Wyllie, S., Wyatt, P. G. & Gilbert, I. H., 10 Jan 2020, In : ACS Infectious Diseases. 6, p. 3-13 11 p.

Research output: Contribution to journalArticle

Open Access
File
60 Downloads (Pure)

Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes

Zoltner, M., Campagnaro, G. D., Taleva, G., Burrell, A., Cerone, M., Leung, K-F., Achcar, F., Horn, D., Vaughan, S., Gadelha, C., Zíková, A., Barrett, M. P., de Koning, H. P. & Field, M., 12 Jun 2020, In : Journal of Biological Chemistry. 295, 24, p. 8331-8347 17 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
14 Downloads (Pure)
2019

A post-transcriptional respiratome regulon in trypanosomes

Trenaman, A., Glover, L., Hutchinson, S. & Horn, D., 26 Jul 2019, In : Nucleic Acids Research. 47, 13, p. 7063-7077 15 p.

Research output: Contribution to journalArticle

Open Access
File
58 Downloads (Pure)

Chemogenomic Profiling of Antileishmanial Efficacy and Resistance in the Related Kinetoplastid Parasite Trypanosoma brucei

Collett, C. F., Kitson, C., Baker, N., Steele-Stallard, H. B., Santrot, M-V., Hutchinson, S., Horn, D. & Alsford, S., Aug 2019, In : Antimicrobial Agents and Chemotherapy. 63, 8, p. 1-19 19 p., e00795-19.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
72 Downloads (Pure)

Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex

Correia Faria, J., Glover, L., Hutchinson, S., Boehm, C., Field, M. C. & Horn, D., 9 Jul 2019, In : Nature Communications. 10, p. 1-14 14 p., 3023.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
84 Downloads (Pure)

Para-site-seeing: Departure Lounge: LifeSpace science art reserach gallery, University of Dundee

Floyd, A., Yeoman, H., Southern, J., Dillon, R., Cook, S., Fairlamb, A., Ferguson, M., Horn, D., MacLean, L., Manthri, S., Paterson, C., Pearson, L., Prescott, A., Read, K., Shastry, L., Svensen, N. & Thomas, J., 2019

Research output: Non-textual formExhibition

Persistent DNA Damage Foci and DNA Replication with a Broken Chromosome in the African Trypanosome

Glover, L., Marques, C., Suska, O. & Horn, D., Aug 2019, In : MBio. 10, 4, p. 1-17 17 p., e01252-19.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
78 Downloads (Pure)
Open Access
File
9 Citations (Scopus)
174 Downloads (Pure)

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

Wyllie, S., Brand, S., Thomas, M., De Rycker, M., Chung, C-W., Peña, I., Bingham, R., Bueren-Calabuig, J., Cantizani, J., Cebrian, D., Craggs, P. D., Ferguson, L., Goswami, P., Hobrath, J., Howe, J., Jeacock, L., Ko, E. J., Korczynska, J., MacLean, L., Manthri, S. & 29 others, Santos Martinez, M., Mata-Cantero, L., Moniz, S., Nuhs, A., Osuna-Cabello, M., Pinto, E., Riley, J., Robinson, S., Rowland, P., Simeons, F., Shishikura, Y., Spinks, D., Stojanovski, L., Thomas, J., Thompson, S., Viayna Gaza, E., Wall, R., Zuccotto, F., Horn, D., Ferguson, M., Fairlamb, A., Fiandor, J. M., Martín, J., Gray, D., Miles, T. J., Gilbert, I., Read, K., Marco, M. & Wyatt, P., 7 May 2019, In : Proceedings of the National Academy of Sciences. 116, 19, p. 9318-9323 6 p., 201820175.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
132 Downloads (Pure)
2018

Anti-trypanosomal 8-hydroxyl naphthyridines are chelators of divalent transition metals

Wall, R. J., Moniz, S., Thomas, M., Norval, S., Ko, E. J., Marco, M., Miles, T. J., Gilbert, I., Horn, D., Fairlamb, A. & Wyllie, S., Aug 2018, In : Antimicrobial Agents and Chemotherapy. 62, 8, p. 1-15 15 p., e00235-18.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
158 Downloads (Pure)

Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei

Steketee, P. C., Vincent, I. M., Achcar, F., Giordani, F., Kim, D. H., Creek, D. J., Freund, Y., Jacobs, R., Rattigan, K., Horn, D., Field, M. C., MacLeod, A. & Barrett, M. P., 14 May 2018, In : PLoS Neglected Tropical Diseases. 12, 5, p. 1-24 24 p., e0006450.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
125 Downloads (Pure)

Clinical and veterinary trypanocidal benzoxaboroles target CPSF3

Wall, R., Rico Vidal, E., Lukac, I., Zuccotto, F., Elg, S., Gilbert, I., Freund, Y. R., Alley, M. R. K., Field, M., Wyllie, S. & Horn, D., 18 Sep 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 38, p. 9616-9621 6 p.

Research output: Contribution to journalArticle

Open Access
File
16 Citations (Scopus)
257 Downloads (Pure)

Codon usage bias controls mRNA and protein abundance in trypanosomatids

Jeacock, L., Correia Faria, J. & Horn, D., 15 Mar 2018, In : eLife. 7, 20 p., e32496.

Research output: Contribution to journalArticle

Open Access
File
23 Citations (Scopus)
141 Downloads (Pure)

Faster growth with shorter antigens can explain a VSG hierarchy during African trypanosome infections: a feint attack by parasites

Liu, D., Albergante, L., Newman, T. & Horn, D., 2018, In : Scientific Reports. 8, p. 1-10 10 p., 10922.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
148 Downloads (Pure)

Gluconeogenesis using glycerol as a substrate in bloodstream-form Trypanosoma brucei

Kovarova, J., Nagar, R., Correia Faria, J., Ferguson, M., Barrett, M. P. & Horn, D., 27 Dec 2018, In : PLoS Pathogens. 14, 12, p. 1-22 22 p., e1007475.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
108 Downloads (Pure)

Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles

Zhang, N., Zoltner, M., Leung, K-F., Scullion, P., Hutchinson, S., Del Pino, R. C., Vincent, I. M., Zhang, Y-K., Freund, Y. R., Alley, M. R. K., Jacobs, R. T., Read, K. D., Barrett, M. P., Horn, D. & Field, M. C., 9 Feb 2018, In : PLoS Pathogens. 14, 2, p. 1-25 25 p., e1006850.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
163 Downloads (Pure)

Inducible high-efficiency CRISPR-Cas9-targeted gene editing and precision base editing in African trypanosomes

Rico Vidal, E., Jeacock, L., Kovarova, J. & Horn, D., 21 May 2018, In : Scientific Reports. 8, 1, p. 1-10 10 p., 7960.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
145 Downloads (Pure)

Insights into antitrypanosomal drug mode-of-action from cytology-based profiling

Thomas, J., Baker, N., Dominicus, C., Trenaman, A., Glover, L., Alsford, S. & Horn, D., 26 Nov 2018, In : PLoS Neglected Tropical Diseases. 12, 11, p. 1-19 19 p., e0006980.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
144 Downloads (Pure)

Melarsoprol Resistance in African Trypanosomiasis

Fairlamb, A. & Horn, D., Jun 2018, In : Trends in Parasitology. 34, 6, p. 481-492 12 p.

Research output: Contribution to journalReview article

Open Access
File
17 Citations (Scopus)
140 Downloads (Pure)
2017
Open Access
File
138 Citations (Scopus)
297 Downloads (Pure)

Aquaglyceroporin-null trypanosomes display glycerol transport defects and respiratory-inhibitor sensitivity

Jeacock, L., Baker, N., Wiedemar, N., Mäser, P. & Horn, D., 30 Mar 2017, In : PLoS Pathogens. 13, 3, p. 1-16 16 p., e1006307.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
138 Downloads (Pure)

Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging prodrugs

Meredith, E. L., Kumar, A., Konno, A., Szular, J., Alsford, S., Seifert, K., Horn, D. & Wilkinson, S. R., 6 Oct 2017, In : Molecular Microbiology. 106, 2, p. 207-222 16 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
173 Downloads (Pure)

Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei

Stortz, J. A., Serafim, T. D., Alsford, S., Wilkes, J. M., Fernandez-Cortes, F., Hamilton, G., Briggs, E., Lemgruber, L., Horn, D., Mottram, J. C. & McCulloch, R., 24 Jul 2017, In : PLoS Pathogens. 13, 7, p. 1-36 36 p., e1006477.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
215 Downloads (Pure)

Genome-wide RNAi selection identifies a regulator of transmission stage-enriched gene families and cell-type differentiation in Trypanosoma brucei

Rico, E., Ivens, A., Glover, L., Horn, D. & Matthews, K. R., 23 Mar 2017, In : PLoS Pathogens. 13, 3, p. 1-25 25 p., e1006279.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
160 Downloads (Pure)

Ornithine uptake and the modulation of drug sensitivity in Trypanosoma brucei

Macedo, J. P., Currier, R. B., Wirdnam, C., Horn, D., Alsford, S. & Rentsch, D., Oct 2017, In : FASEB Journal. 31, 10, p. 4649-4660 17 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
177 Downloads (Pure)
2016

Co-dependence between trypanosome nuclear lamina components in nuclear stability and control of gene expression

Maishman, L., Obado, S. O., Alsford, S., Bart, J., Chen, W-M., Ratushny, A. V., Navarro, M., Horn, D., Aitchison, J. D., Chait, B. T., Rout, M. P. & Field, M. C., Dec 2016, In : Nucleic Acids Research. 44, 22, p. 10554-10570 17 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
295 Downloads (Pure)

Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense

Graf, F. E., Ludin, P., Arquint, C., Schmidt, R. S., Schaub, N., Kunz Renggli, C., Munday, J. C., Krezdorn, J., Baker, N., Horn, D., Balmer, O., Caccone, A., de Koning, H. P. & Mäser, P., Sep 2016, In : Cellular and Molecular Life Sciences. 73, 17, p. 3387-3400 14 p.

Research output: Contribution to journalArticle

Open Access
File
16 Citations (Scopus)
146 Downloads (Pure)

Epigenetic Regulation of Virulence Gene Expression in Parasitic Protozoa

Duraisingh, M. T. & Horn, D., 11 May 2016, In : Cell Host & Microbe. 19, 5, p. 629-640 12 p.

Research output: Contribution to journalReview article

Open Access
File
27 Citations (Scopus)
139 Downloads (Pure)

Exploiting the Achilles' heel of membrane trafficking in trypanosomes

Zoltner, M., Horn, D., de Koning, H. P. & Field, M. C., Dec 2016, In : Current Opinion in Microbiology. 34, p. 97-103 7 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
135 Downloads (Pure)

High-resolution analysis of multi-copy variant surface glycoprotein gene expression sites in African trypanosomes

Hutchinson, S., Glover, L. & Horn, D., 18 Oct 2016, In : BMC Genomics. 17, p. 1-11 11 p., 806.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
163 Downloads (Pure)

How Antiparasitic Drugs Work-And Sometimes Stop Working!

Horn, D., 5 May 2016, In : PLoS Pathogens. 12, 5, p. 1-3 3 p., e1005430.

Research output: Contribution to journalArticle

Open Access
File
176 Downloads (Pure)

Pentamidine Is Not a Permeant but a Nanomolar Inhibitor of the Trypanosoma brucei Aquaglyceroporin-2

Song, J., Baker, N., Rothert, M., Henke, B., Jeacock, L., Horn, D. & Beitz, E., 1 Feb 2016, In : PLoS Pathogens. 12, 2, 14 p., e1005436.

Research output: Contribution to journalArticle

Open Access
File
31 Citations (Scopus)
127 Downloads (Pure)

The role of folate transport in antifolate drug action in Trypanosoma brucei

Dewar, S., Sienkiewicz, N., Ong, H. B., Wall, R. J., Horn, D. & Fairlamb, A. H., 18 Nov 2016, In : Journal of Biological Chemistry. 291, p. 24768-24778 11 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
135 Downloads (Pure)

VEX1 controls the allelic exclusion required for antigenic variation in trypanosomes

Glover, L., Hutchinson, S., Alsford, S. & Horn, D., 28 Jun 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 26, p. 7225-7230 6 p.

Research output: Contribution to journalArticle

Open Access
File
33 Citations (Scopus)
364 Downloads (Pure)
2015

Chimerization at the AQP2-AQP3 locus is the genetic basis of melarsoprol-pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates

Graf, F. E., Baker, N., Munday, J. C., de Koning, H. P., Horn, D. & Mäser, P., Aug 2015, In : International Journal for Parasitology: Drugs and Drug Resistance. 5, 2, p. 65-68 4 p.

Research output: Contribution to journalArticle

Open Access
File
28 Citations (Scopus)
130 Downloads (Pure)

Correction: Modulation of the surface proteome through multiple ubiquitylation pathways in African Trypanosomes

Zoltner, M., Leung, K. F., Alsford, S., Horn, D. & Field, M. C., 23 Nov 2015, In : PLoS Pathogens. 11, 11, 3 p., e1005291.

Research output: Contribution to journalArticle

Genome-scale RNAi screens for high-throughput phenotyping in bloodstream-form African trypanosomes

Glover, L., Alsford, S., Baker, N., Turner, D. J., Sanchez-Flores, A., Hutchinson, S., Hertz-Fowler, C., Berriman, M. & Horn, D., Jan 2015, In : Nature Protocols. 10, 1, p. 106-33 28 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Modulation of the surface proteome through multiple ubiquitylation pathways in African Trypanosomes

Zoltner, M., Leung, K. F., Alsford, S., Horn, D. & Field, M. C., 22 Oct 2015, In : PLoS Pathogens. 11, 10, 26 p., e1005236.

Research output: Contribution to journalArticle

Open Access
File
16 Citations (Scopus)
212 Downloads (Pure)

Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency, and drug sensitivity in trypanosomes

Baker, N., Hamilton, G., Wilkes, J. M., Hutchinson, S., Barrett, M. P. & Horn, D., 21 Jul 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 29, p. 9112-9117 6 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2014

Antigenic variation in African trypanosomes

Horn, D., Jul 2014, In : Molecular and Biochemical Parasitology. 195, 2, p. 123-129 7 p.

Research output: Contribution to journalArticle

Open Access
File
117 Citations (Scopus)
133 Downloads (Pure)

Antiparasitic chemotherapy: from genomes to mechanisms

Horn, D. & Duraisingh, M. T., Jan 2014, In : Annual Review of Pharmacology and Toxicology. 54, p. 71-94 24 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Cathepsin-L can resist lysis by human serum in Trypanosoma brucei brucei

Alsford, S., Currier, R. B., Guerra-Assunção, J. A., Clark, T. G. & Horn, D., 15 May 2014, In : PLoS Pathogens. 10, 5, 12 p., e1004130.

Research output: Contribution to journalArticle

File
22 Citations (Scopus)
164 Downloads (Pure)

Genome-wide dissection of the quorum sensing signalling pathway in Trypanosoma brucei

Mony, B. M., MacGregor, P., Ivens, A., Rojas, F., Cowton, A., Young, J., Horn, D. & Matthews, K., 30 Jan 2014, In : Nature. 505, 7485, p. 681-685 5 p.

Research output: Contribution to journalLetter

104 Citations (Scopus)

High-throughput decoding of drug targets and drug resistance mechanisms in African trypanosomes

Horn, D., Jan 2014, In : Parasitology. 141, 1, p. 77-82 6 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Locus-specific control of DNA resection and suppression of subtelomeric VSG recombination by HAT3 in the African trypanosome

Glover, L. & Horn, D., 2014, In : Nucleic Acids Research. 42, 20, p. 12600-12613 14 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
166 Downloads (Pure)

Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs

Munday, J. C., Eze, A. A., Baker, N., Glover, L., Clucas, C., Andrés, D. A., Natto, M. J., Teka, I. A., McDonald, J., Lee, R. S., Graf, F. E., Ludin, P., Burchmore, R. J. S., Turner, C. M. R., Tait, A., MacLeod, A., Mäser, P., Barrett, M. P., Horn, D. & De Koning, H. P., 1 Mar 2014, In : Journal of Antimicrobial Chemotherapy. 69, 3, p. 651-663 13 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)
2013

Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in VSG expression control

Glover, L., Hutchinson, S., Alsford, S., McCulloch, R., Field, M. C. & Horn, D., Dec 2013, In : Cellular Microbiology. 15, 12, p. 1984-1993 10 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)