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Lilley, David

Professor

 https://orcid.org/0000-0001-6882-2818

  • United Kingdom

20002021
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Projects 2012 2021

Processing of Branched DNA Molecules During Cytokinesis, Uncovering New Mechanisms of Genome Maintenance

Gartner, A., Lilley, D. & Rouse, J.

Biotechnology and Biological Sciences Research Council

1/12/18 → 30/11/21

Project: Research

Dynamics of Eukaryotic Junction-Resolving Enzyme GEN1 - DNA Junction Interactions

Lilley, D.

Biotechnology and Biological Sciences Research Council

1/10/16 → 30/09/19

Project: Research

The Nucleic Acid Structure Research Group

Lilley, D.

Cancer Research UK

1/01/16 → 31/12/20

Project: Research

Cancer Research-UK Nucleic Acid Structure Research Group: Nucleic Acid Structure and Interactions with Proteins (Programme Grants Years 4 and 5)

Lilley, D.

Project: Research

State of the Art Pulse EPR Instrumentation for Long Range Distance Measurements in Biomacromolecules (Multi-User Equipment Grant) (Joint with University of St Andrews)

Hunter, B., Keeble, D., Lilley, D., Norman, D. & Owen-Hughes, T.

Wellcome Trust

24/09/12 → 23/09/17

Project: Research

Research Output 2000 2019

Junction resolving enzymes use multivalency to keep the Holliday junction dynamic

Zhou, R., Yang, O., Declais, A-C., Jin, H., Gwon, G. H., Freeman, A., Cho, Y., Lilley, D. & Ha, T., 1 Mar 2019, In : Nature Chemical Biology. 15, 3, p. 269-275 7 p.

Research output: Contribution to journal › Article

Cruciform DNA
Enzymes
Genetic Recombination
Bacteriophage T7
Chromosome Segregation
24 Downloads (Pure)

Structure-guided design of a high affinity ligand for a riboswitch

Huang, L., Wang, J., Wilson, T. & Lilley, D., Apr 2019, In : RNA: a Publication of the RNA Society. 25, 4, p. 423-430 8 p.

Research output: Contribution to journal › Article

Open Access
File
Riboswitch
Guanidine
Ligands
Binding Sites
X-Rays
2 Citations (Scopus)
34 Downloads (Pure)

The role of RNA structure in translational regulation by L7Ae protein in archaea

Huang, L., Ashraf, S. & Lilley, D. M. J., Jan 2019, In : RNA: a Publication of the RNA Society. 25, 1, p. 60-69 10 p.

Research output: Contribution to journal › Article

Open Access
File
Archaea
Archaeoglobus fulgidus
RNA
Untranslated Regions
Proteins
18 Downloads (Pure)

A monovalent ion in the DNA binding interface of the eukaryotic junction-resolving enzyme GEN1

Liu, Y., Freeman, A. D. J., Déclais, A-C. & Lilley, D. M. J., 16 Nov 2018, In : Nucleic Acids Research. 46, 20, p. 11089-11098 10 p.

Research output: Contribution to journal › Article

Open Access
File
Ions
DNA
Enzymes
Substrate Specificity
Catalytic Domain

Biochemical and Structural Properties of Fungal Holliday Junction-Resolving Enzymes

Liu, Y., Freeman, A., Déclais, A-C., Gartner, A. & Lilley, D. M. J., 2018, Mechanisms of DNA Recombination and Genome Rearrangements: Methods to Study Homologous Recombination. Spies, M. & Malkova, A. (eds.). Academic Press, Vol. 600. p. 543-568 26 p. (Methods in Enzymology; vol. 600).

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed)

Cruciform DNA
Structural properties
Enzymes
Chaetomium
DNA

Thesis

Sequence Dependence of the Folding of Kink-Turns in RNA

Author: Ashraf, S., 2017

Supervisor: Lilley, D. (Supervisor)

Student thesis: Master's Thesis › Master of Science

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