Robinson, David

Dr

  • 272 Citations
  • 6 h-Index
20102019
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  • 38 Similar Profiles
Trypanosoma brucei brucei Medicine & Life Sciences
African Trypanosomiasis Medicine & Life Sciences
Lysine-tRNA Ligase Medicine & Life Sciences
Methionine-tRNA Ligase Medicine & Life Sciences
Mannosyltransferases Medicine & Life Sciences
Cell Wall Medicine & Life Sciences
Pharmaceutical Preparations Medicine & Life Sciences
Cryptosporidiosis Medicine & Life Sciences

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Research Output 2010 2019

  • 272 Citations
  • 6 h-Index
  • 12 Article

Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase

Torrie, L., Zuccotto, F., Robinson, D., Gray, D., Gilbert, I. & De Rycker, M., 31 May 2019, In : PLoS ONE. 14, 5, p. 1-16 16 p., e0217828.

Research output: Contribution to journalArticle

Open Access
File
Kinetochores
Trypanosoma brucei
kinetochores
Trypanosoma brucei brucei
phosphotransferases (kinases)
49 Downloads (Pure)

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Baragaña, B., Forte, B., Choi, R., Nakazawa Hewitt, S., Bueren-Calabuig, J. A., Pisco, J. P., Peet, C., Dranow, D. M., Robinson, D. A., Jansen, C., Norcross, N. R., Vinayak, S., Anderson, M., Brooks, C. F., Cooper, C. A., Damerow, S., Delves, M., Dowers, K., Duffy, J., Edwards, T. E. & 57 othersHallyburton, I., Horst, B. G., Hulverson, M. A., Ferguson, L., Jiménez-Díaz, M. B., Jumani, R. S., Lorimer, D. D., Love, M. S., Maher, S., Matthews, H., McNamara, C. W., Miller, P., O'Neill, S., Ojo, K. K., Osuna-Cabello, M., Pinto, E., Post, J., Riley, J., Rottmann, M., Sanz, L. M., Scullion, P., Sharma, A., Shepherd, S. M., Shishikura, Y., Simeons, F. R. C., Stebbins, E. E., Stojanovski, L., Straschil, U., Tamaki, F. K., Tamjar, J., Torrie, L. S., Vantaux, A., Witkowski, B., Wittlin, S., Yogavel, M., Zuccotto, F., Angulo-Barturen, I., Sinden, R., Baum, J., Gamo, F-J., Mäser, P., Kyle, D. E., Winzeler, E. A., Myler, P. J., Wyatt, P. G., Floyd, D., Matthews, D., Sharma, A., Striepen, B., Huston, C. D., Gray, D. W., Fairlamb, A. H., Pisliakov, A. V., Walpole, C., Read, K. D., Van Voorhis, W. C. & Gilbert, I. H., 2 Apr 2019, In : Proceedings of the National Academy of Sciences. 116, 14, p. 7015-7020 6 p.

Research output: Contribution to journalArticle

Open Access
File
Lysine-tRNA Ligase
Cryptosporidiosis
Cryptosporidium parvum
Malaria
Plasmodium falciparum
2 Citations (Scopus)
95 Downloads (Pure)

Chemical Validation of Methionyl tRNA Synthetase (MetRS) as a Druggable Target in Leishmania donovani

Torrie, L., Brand, S., Robinson, D., Ko, E. J., Stojanovski, L., Simeons, F. R. C., Wyllie, S., Thomas, J., Ellis, L., Osuna-Cabello, M., Epemolu, R., Nuehs, A., Riley, J., MacLean, L., Manthri, S., Read, K., Gilbert, I., Fairlamb, A. & De Rycker, M., Oct 2017, In : ACS Infectious Diseases. 3, 10, p. 718-727 10 p.

Research output: Contribution to journalArticle

Open Access
File
Methionine-tRNA Ligase
Leishmania donovani
Leishmania
Methionine
Animal Models
3 Citations (Scopus)
95 Downloads (Pure)

Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors

Bayliss, T., Robinson, D., Smith, V., Brand, S., McElroy, S., Torrie, L., Mpamhanga, C., Norval, S., Stojanovski, L., Brenk, R., Frearson, J., Read, K., Gilbert, I. & Wyatt, P., 14 Dec 2017, In : Journal of Medicinal Chemistry. 60, 23, p. 9790-9806 17 p.

Research output: Contribution to journalArticle

Open Access
File
African Trypanosomiasis
Brain
Pharmaceutical Preparations
glycylpeptide N-tetradecanoyltransferase
DDD 85646
6 Citations (Scopus)

Development of small-molecule Trypanosoma brucei N-myristoyltransferase inhibitors: discovery and optimisation of a novel binding mode

Spinks, D., Smith, V., Thompson, S., Robinson, D. A., Luksch, T., Smith, A., Torrie, L. S., McElroy, S., Stojanovski, L., Norval, S., Collie, I. T., Hallyburton, I., Rao, B., Brand, S., Brenk, R., Frearson, J. A., Read, K. D., Wyatt, P. G. & Gilbert, I. H., Nov 2015, In : ChemMedChem. 10, 11, p. 1821-1836 16 p.

Research output: Contribution to journalArticle

Trypanosoma brucei brucei
Molecules
Scaffolds
Leishmania major
X ray crystallography