Murugesan, Dinakaran

Dr

  • United Kingdom

  • 75 Citations
  • 4 h-Index
20132018
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  • 28 Similar Profiles
Antimalarials Medicine & Life Sciences
Structure-Activity Relationship Medicine & Life Sciences
Mycobacterium tuberculosis Medicine & Life Sciences
Quinazolinones Medicine & Life Sciences
Indazoles Medicine & Life Sciences
Plasmodium falciparum Medicine & Life Sciences
Inosine Monophosphate Medicine & Life Sciences
Sulfonamides Medicine & Life Sciences

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Research Output 2013 2018

  • 75 Citations
  • 4 h-Index
  • 5 Article
2 Citations

2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization

Murugesan, D., Ray, P. C., Bayliss, T., Prosser, G. A., Harrison, J. R., Green, K., Soares De Melo, C., Feng, T. S., Street, L. J., Chibale, K., Warner, D. F., Mizrahi, V., Epemolu, O., Scullion, P., Ellis, L., Riley, J., Shishikura, Y., Ferguson, L., Osuna-Cabello, M., Read, K. D. & 10 othersGreen, S. R., Lamprecht, D. A., Steyn, A. J. C., Ioerger, T. R., Sacchettini, J., Rhee, K. Y., Arora, K., Barry, C. E., Wyatt, P. G. & Boshoff, H. I. M., 8 Jun 2018, In : ACS Infectious Diseases. 4, 6, p. 954-969 16 p.

Research output: Contribution to journalArticle

Open Access
File
Quinazolinones
Structure-Activity Relationship
Mycobacterium tuberculosis
Adenosine Triphosphate
Allosteric Site
20 Citations

Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis

Park, Y., Pacitto, A., Bayliss, T., Cleghorn, L. A. T., Wang, Z., Hartman, T., Arora, K., Ioerger, T. R., Sacchettini, J., Rizzi, M., Donini, S., Blundell, T. L., Ascher, D. B., Rhee, K., Breda, A., Zhou, N., Dartois, V., Jonnala, S. R., Via, L. E., Mizrahi, V. & 35 othersEpemolu, O., Stojanovski, L., Simeons, F., Osuna-Cabello, M., Ellis, L., MacKenzie, C. J., Smith, A. R. C., Davis, S. H., Murugesan, D., Buchanan, K. I., Turner, P. A., Huggett, M., Zuccotto, F., Rebollo-Lopez, M. J., Lafuente-Monasterio, M. J., Sanz, O., Diaz, G. S., Lelièvre, J., Ballell, L., Selenski, C., Axtman, M., Ghidelli-Disse, S., Pflaumer, H., Bösche, M., Drewes, G., Freiberg, G. M., Kurnick, M. D., Srikumaran, M., Kempf, D. J., Green, S. R., Ray, P. C., Read, K., Wyatt, P., Barry, C. E. & Boshoff, H. I., 13 Jan 2017, In : ACS Infectious Diseases. 3, 1, p. 18-33 16 p.

Research output: Contribution to journalArticle

Indazoles
Inosine Monophosphate
Sulfonamides
Mycobacterium tuberculosis
Oxidoreductases
8 Citations

Discovery and optimisation studies of antimalarial phenotypic hits

Mital, A., Murugesan, D., Kaiser, M., Yeates, C. & Gilbert, I. H., 20 Oct 2015, In : European Journal of Medicinal Chemistry. 103, p. 530-538 9 p.

Research output: Contribution to journalArticle

Antimalarials
Plasmodium falciparum
Malaria
Rodentia
Parasites
29 Citations

Discovery and structure-activity relationships of pyrrolone antimalarials

Murugesan, D., Mital, A., Kaiser, M., Shackleford, D. M., Morizzi, J., Katneni, K., Campbell, M., Hudson, A., Charman, S. A., Yeates, C. & Gilbert, I. H., 2013, In : Journal of Medicinal Chemistry. 56, 7, p. 2975-2990 16 p.

Research output: Contribution to journalArticle

16 Citations

Structure-Activity Relationship Studies of Pyrrolone Antimalarial Agents

Murugesan, D., Kaiser, M., White, K. L., Norval, S., Riley, J., Wyatt, P. G., Charman, S. A., Read, K. D., Yeates, C. & Gilbert, I. H., 2013, In : ChemMedChem.

Research output: Contribution to journalArticle

Antimalarials
Structure-Activity Relationship
Parasites
Derivatives
Humulus