Cantrell, Doreen

Professor

1982 …2022

Research output per year

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Research Output

2020
Open Access
File
12 Downloads (Pure)
2019

Antigen receptor control of methionine metabolism in T cells

Sinclair, L. V., Howden, A., Brenes Murillo, A., Spinelli, L., Hukelmann, J., Macintyre, A. N., Liu, X., Thomson, S., Taylor, P., Rathmell, J. C., Locasale, J. W., Lamond, A. & Cantrell, D. A., 27 Mar 2019, In : eLife. 8, p. 1-29 29 p., e44210.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
95 Downloads (Pure)

Move to metabolism

Cantrell, D. A., 29 Mar 2019, In : Nature Reviews Immunology. 19, 1 p., 270.

Research output: Contribution to journalComment/debate

Phenformin, but not metformin, delays development of T-cell acute lymphoblastic leukemia/lymphoma via cell-autonomous AMPK activation

Vara Ciruelos, D., Dandapani, M., Russell, F., Grzes, K. M., Atrih, A., Foretz, M., Viollet, B., Lamont, D., Cantrell, D. & Hardie, G., 16 Apr 2019, In : Cell Reports. 27, 3, p. 690-698.e4

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
101 Downloads (Pure)
3 Citations (Scopus)

Scientific Business Abstracts of the 113th Annual Meeting of the Association of Physicians of Great Britain and Ireland

Deciphering Developmental Disorders (DDD) Study, Cacciottolo, T. M., Perikari, A., van der Klaauw, A., Henning, E., Stadler, L. K. J., Keogh, J., Farooqi, I. S., Tenin, G., Keavney, B., Ryan, E., Budd, R., Bewley, M., Coelho, P., Rumsey, W., Sanchez, Y., McCafferty, J., Dockrell, D., Walmsley, S., Whyte, M. & 31 others, Liu, Y., Choy, M-K., Tenin, G., Abraham, S., Black, G., Keavney, B., Watkins, S., Robertson, K., Collison, D., Rush, C., Marshall, J., McGowan, R., Fraser, R., Gandhi, S., Cooper, C., Howden, A., Hukelmann, J. L., Cantrell, D. A., Mordi, I., Forteath, C., Wong, A., Mohan, M., Palmer, C., Doney, A., Rena, G., Lang, C., Gray, E. H., Williams, R., Williams, S., Hughes, J. & Davies, J., 5 Sep 2019, In : QJM : an International Journal of Medicine. 112, 9, p. 724-729 6 p., 9.

Research output: Contribution to journalMeeting abstract

2018

Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice

Loftus, R. M., Assmann, N., Kedia-Mehta, N., O'Brien, K. L., Garcia, A., Gillespie, C., Hukelmann, J. L., Oefner, P. J., Lamond, A. I., Gardiner, C. M., Dettmer, K., Cantrell, D. A., Sinclair, L. V. & Finlay, D. K., 14 Jun 2018, In : Nature Communications. 9, 1, p. 1-15 15 p., 2341.

Research output: Contribution to journalArticle

Open Access
File
29 Citations (Scopus)
127 Downloads (Pure)

Interleukin-2 shapes the cytotoxic T cell proteome and immune environment sensing programs

Rollings, C., Sinclair, L., Brady, H. J. M., Cantrell, D. & Ross, S., 17 Apr 2018, In : Science Signaling. 11, 526, p. 1-16 16 p., eaap8112.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
201 Downloads (Pure)

Signaling and Function of Interleukin-2 in T Lymphocytes

Ross, S. H. & Cantrell, D. A., 26 Apr 2018, In : Annual Review of Immunology. 36, p. 411-433 23 p.

Research output: Contribution to journalArticle

Open Access
File
37 Citations (Scopus)
164 Downloads (Pure)

Single cell analysis of kynurenine and System L amino acid transport in T cells

Sinclair, L., Neyens, D., Ramsay, G., Taylor, P. & Cantrell, D., 17 May 2018, In : Nature Communications. 9, 1, 11 p., 1981 (2018).

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
115 Downloads (Pure)
2017

Control of amino-acid transport coordinates metabolic reprogramming in T cell malignancy

Grzes, K. M., Swamy, M., Hukelmann, J. L., Emslie, E., Sinclair, L. V. & Cantrell, D. A., 26 May 2017, In : Leukemia. 31, p. 2771-2779 9 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
126 Downloads (Pure)
2016

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy

Swamy, M., Pathak, S., Grzes, K. M., Damerow, S., Sinclair, L. V., van Aalten, D. M. F. & Cantrell, D. A., Jun 2016, In : Nature Immunology. 17, 6, p. 712-720 9 p.

Research output: Contribution to journalArticle

Open Access
File
100 Citations (Scopus)
147 Downloads (Pure)

Mathematical models for immunology: current state of the art and future research directions

Eftimie, R., Gillard, J. J. & Cantrell, D. A., Oct 2016, In : Bulletin of Mathematical Biology. 78, 10, p. 2091-2134 44 p.

Research output: Contribution to journalReview article

Open Access
File
47 Citations (Scopus)
149 Downloads (Pure)

Phosphoproteomic Analyses of Interleukin 2 Signaling Reveal Integrated JAK Kinase-Dependent and -Independent Networks in CD8+ T Cells

Ross, S. H., Rollings, C., Anderson, K. E., Hawkins, P. T., Stephens, L. R. & Cantrell, D. A., 20 Sep 2016, In : Immunity. 45, 3, p. 685-700 16 p.

Research output: Contribution to journalArticle

Open Access
File
28 Citations (Scopus)
247 Downloads (Pure)

Potent and selective chemical probe of hypoxic signaling downstream of HIF-α hydroxylation via VHL inhibition

Frost, J., Galdeano, C., Soares, P., Gadd, M. S., Grzes, K. M., Ellis, L., Epemolu, O., Shimamura, S., Bantscheff, M., Grandi, P., Read, K. D., Cantrell, D. A., Rocha, S. & Ciulli, A., 4 Nov 2016, In : Nature Communications. 7, p. 1-12 12 p., 13312.

Research output: Contribution to journalArticle

Open Access
File
51 Citations (Scopus)
131 Downloads (Pure)

The cytotoxic T cell proteome and its shaping by the kinase mTOR

Hukelmann, J. L., Anderson, K. E., Sinclair, L. V., Grzes, K. M., Brenes Murillo, A., Hawkins, P. T., Stephens, L. R., Lamond, A. I. & Cantrell, D. A., Jan 2016, In : Nature Immunology. 17, 1, p. 104-112 9 p.

Research output: Contribution to journalArticle

Open Access
File
80 Citations (Scopus)
187 Downloads (Pure)
2015

Environmental and metabolic sensors that control T cell biology

Ramsay, G. & Cantrell, D., 2015, In : Frontiers in Immunology. 6, 8 p., 99.

Research output: Contribution to journalArticle

22 Citations (Scopus)

ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation

Stone, E. L., Pepper, M., Katayama, C. D., Kerdiles, Y. M., Lai, C-Y., Emslie, E., Lin, Y. C., Yang, E., Goldrath, A. W., Li, M. O., Cantrell, D. A. & Hedrick, S. M., 17 Feb 2015, In : Immunity. 42, 2, p. 239-251 13 p.

Research output: Contribution to journalArticle

95 Citations (Scopus)

Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells

Pallett, L. J., Gill, U. S., Quaglia, A., Sinclair, L. V., Jover-Cobos, M., Schurich, A., Singh, K. P., Thomas, N., Das, A., Chen, A., Fusai, G., Bertoletti, A., Cantrell, D. A., Kennedy, P. T., Davies, N. A., Haniffa, M. & Maini, M. K., 11 May 2015, In : Nature Medicine. 21, 6, p. 591-600 10 p.

Research output: Contribution to journalArticle

119 Citations (Scopus)

Signaling in lymphocyte activation

Cantrell, D., Jun 2015, In : Cold spring harbor perspectives in biology. 7, 6, 14 p., a018788.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes

Preston, G. C., Sinclair, L. V., Kaskar, A., Hukelmann, J. L., Navarro, M., Ferrero, I., MacDonald, H. R., Cowling, V. H. & Cantrell, D. A., 4 Aug 2015, In : EMBO Journal. 34, 15, p. 2008-2024 17 p.

Research output: Contribution to journalArticle

Open Access
54 Citations (Scopus)
2014

Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells

Zarrouk, M., Finlay, D. K., Foretz, M., Viollet, B. & Cantrell, D. A., 2 Sep 2014, In : PLoS ONE. 9, 9, 7 p., e106710.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
145 Downloads (Pure)

Protein kinase D2 is a digital amplifier of T cell receptor-stimulated diacylglycerol signaling in naïve CD8+ T cells

Navarro, M. N., Feijoo-Carnero, C., Gonzalez Arandilla, A., Trost, M. & Cantrell, D. A., 21 Oct 2014, In : Science Signaling. 7, 348, 12 p., ra99.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Quantitative phosphoproteomics of cytotoxic T cells to reveal Protein Kinase D 2 regulated networks

Navarro, M. N., Goebel, J., Hukelmann, J. L. & Cantrell, D. A., Dec 2014, In : Molecular & Cellular Proteomics. 13, 12, p. 3544-3557 14 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
135 Downloads (Pure)

Serine-threonine kinases in TCR signaling

Navarro, M. N. & Cantrell, D. A., Sep 2014, In : Nature Immunology. 15, 9, p. 808-814 7 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)
2013

AMPKα1: a glucose sensor that controls CD8 T-cell memory

Rolf, J., Zarrouk, M., Finlay, D. K., Foretz, M., Viollet, B. & Cantrell, D. A., Apr 2013, In : European Journal of Immunology. 43, 4, p. 889-896 8 p.

Research output: Contribution to journalArticle

109 Citations (Scopus)

Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

Sinclair, L. V., Rolf, J., Emslie, E., Shi, Y-B., Taylor, P. M. & Cantrell, D. A., May 2013, In : Nature Immunology. 14, 5, p. 500-508 9 p.

Research output: Contribution to journalArticle

326 Citations (Scopus)
Open Access
1 Citation (Scopus)

LKB1 Mediates the Development of Conventional and Innate T Cells via AMP-Dependent Kinase Autonomous Pathways

Zarrouk, M., Rolf, J. & Cantrell, D. A., 22 Mar 2013, In : PLoS ONE. 8, 3, 9 p., e60217.

Research output: Contribution to journalArticle

10 Citations (Scopus)

The BAFF Receptor Transduces Survival Signals by Co-opting the B Cell Receptor Signaling Pathway

Schweighoffer, E., Vanes, L., Nys, J., Cantrell, D., McCleary, S., Smithers, N. & Tybulewicz, V. L. J., 21 Mar 2013, In : Immunity. 38, 3, p. 475-488 14 p.

Research output: Contribution to journalArticle

Open Access
File
107 Citations (Scopus)
75 Downloads (Pure)

The impact of KLF2 modulation on the transcriptional program and function of CD8 T Cells

Preston, G. C., Feijoo-Carnero, C., Schurch, N., Cowling, V. H. & Cantrell, D. A., 2013, In : PLoS ONE. 8, 10, 16 p., e77537.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2012

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8 T cells

Finlay, D. K., Rosenzweig, E., Sinclair, L. V., Feijoo-Carnero, C., Hukelmann, J. L., Rolf, J., Panteleyev, A. A., Okkenhaug, K. & Cantrell, D. A., 17 Dec 2012, In : Journal of Experimental Medicine. 209, 13, p. 2441-2453 13 p.

Research output: Contribution to journalArticle

Open Access
File
273 Citations (Scopus)
326 Downloads (Pure)

Protein kinase D2 has a restricted but critical role in T-cell antigen receptor signalling in mature T-cells

Navarro, M. N., Sinclair, L. V., Feijoo-Carnero, C., Clarke, R., Matthews, S. A. & Cantrell, D. A., 15 Mar 2012, In : Biochemical Journal. 442, 3, p. 649-659 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Protein kinase D isoforms are dispensable for integrin-mediated lymphocyte adhesion and homing to lymphoid tissues

Matthews, S. A., Lek, H. S., Morrison, V. L., Mackenzie, M. G., Zarrouk, M., Cantrell, D. & Fagerholm, S. C., May 2012, In : European Journal of Immunology. 42, 5, p. 1316-1326 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

System L amino acid transporter 1 (slc7a5) expression is crucial for T cell blastogenesis

Sinclair, L. V., Taylor, P. M. & Cantrell, D. A., Sep 2012, In : Immunology. 137, s1, p. 347-347 1 p.

Research output: Contribution to journalMeeting abstract

2011

Metabolism, migration and memory in cytotoxic T cells

Finlay, D. & Cantrell, D. A., Feb 2011, In : Nature Reviews Immunology. 11, 2, p. 109-117 9 p.

Research output: Contribution to journalArticle

146 Citations (Scopus)

Phosphoproteomic analysis reveals an intrinsic pathway for the regulation of histone deacetylase 7 that controls the function of cytotoxic T lymphocytes

Navarro, M. N., Goebel, J., Feijoo-Carnero, C., Morrice, N. & Cantrell, D. A., Apr 2011, In : Nature Immunology. 12, 4, p. 352-361 11 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)

Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism

Macintyre, A. N., Finlay, D., Preston, G., Sinclair, L. V., Waugh, C. M., Tamas, P., Feijoo, C., Okkenhaug, K. & Cantrell, D. A., 25 Feb 2011, In : Immunity. 34, 2, p. 224-236 13 p.

Research output: Contribution to journalArticle

File
164 Citations (Scopus)
220 Downloads (Pure)

Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2

Konopatskaya, O., Matthews, S. A., Harper, M. T., Gilio, K., Cosemans, J. M. E. M., Williams, C. M., Navarro, M. N., Carter, D. A., Heemskerk, J. W. M., Leitges, M., Cantrell, D. & Poole, A. W., 14 Jul 2011, In : Blood. 118, 2, p. 416-424 9 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

The coordination of T-cell function by serine/threonine kinases

Finlay, D. & Cantrell, D., Jan 2011, In : Cold spring harbor perspectives in biology. 3, 1, p. - 10 p., a002261.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2010

LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells

Tamas, P., Macintyre, A., Finlay, D., Clarke, R., Feijoo-Carnero, C., Ashworth, A. & Cantrell, D., Jan 2010, In : European Journal of Immunology. 40, 1, p. 242-253 12 p.

Research output: Contribution to journalArticle

Open Access
File
61 Citations (Scopus)
165 Downloads (Pure)

Phosphoinositide 3-kinase and the mammalian target of rapamycin pathways control T cell migration

Finlay, D. & Cantrell, D., Jan 2010, In : Annals of the New York Academy of Sciences. 1183, p. 149-157 9 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)
19 Citations (Scopus)

Unique functions for protein kinase D1 and protein kinase D2 in mammalian cells

Matthews, S. A., Navarro, M. N., Sinclair, L. V., Emslie, E., Feijoo-Carnero, C. & Cantrell, D. A., 15 Nov 2010, In : Biochemical Journal. 432, p. 153-163 11 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)
2009

New insights into the regulation and function of serine/threonine kinases in T lymphocytes

Matthews, S. A. & Cantrell, D. A., Mar 2009, In : Immunological Reviews. 228, 1, p. 241-252 12 p.

Research output: Contribution to journalReview article

19 Citations (Scopus)

Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes

Finlay, D. K., Sinclair, L. V., Feijoo, C., Waugh, C. M., Hagenbeek, T. J., Spits, H. & Cantrell, D. A., 26 Oct 2009, In : Journal of Experimental Medicine. 206, 11, p. 2441-2454 14 p.

Research output: Contribution to journalArticle

Open Access
File
47 Citations (Scopus)
374 Downloads (Pure)
2008

Corrigendum: Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking (Nature Immunology (2008) vol. 9(6) (513-521))

Sinclair, L. V., Finlay, D., Feijoo, C., Cornish, G. H., Gray, A., Ager, A., Okkenhaug, K., Hagenbeek, T. J., Spits, H. & Cantrell, D. A., Jun 2008, In : Nature Immunology. 9, 6, p. 692 1 p.

Research output: Contribution to journalComment/debate

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

Sinclair, L. V., Finlay, D., Feijoo, C., Cornish, G. H., Gray, A., Ager, A., Okkenhaug, K., Hagenbeek, T. J., Spits, H. & Cantrell, D. A., May 2008, In : Nature Immunology. 9, 5, p. 513-521 9 p.

Research output: Contribution to journalArticle

288 Citations (Scopus)

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

Sauer, S., Bruno, L., Hertweck, A., Finlay, D., Leleu, M., Spivakov, M., Knight, Z. A., Cobb, B. S., Cantrell, D., O'Connor, E., Shokat, K. M., Fisher, A. G. & Merkenschlager, M., 3 Jun 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 22, p. 7797-7802 6 p.

Research output: Contribution to journalArticle

574 Citations (Scopus)