Cantrell, Doreen

Professor

1990 …2022
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Research Output 1990 2020

2020
Open Access
T-cells
Proteome
Metabolic Networks and Pathways
Chemical activation
T-Lymphocytes
2019
10 Citations (Scopus)
78 Downloads (Pure)

Antigen receptor control of methionine metabolism in T cells

Sinclair, L. V., Howden, A., Brenes Murillo, A., Spinelli, L., Hukelmann, J., Macintyre, A. N., Liu, X., Thomson, S., Taylor, P., Rathmell, J. C., Locasale, J. W., Lamond, A. & Cantrell, D. A., 27 Mar 2019, In : eLife. 8, 29 p., e44210.

Research output: Contribution to journalArticle

Open Access
File
Antigen Receptors
T-cells
Metabolism
Methionine
T-Lymphocytes

Move to metabolism

Cantrell, D. A., 29 Mar 2019, In : Nature Reviews Immunology. 19, 1 p., 270.

Research output: Contribution to journalComment/debate

Calcium-Calmodulin-Dependent Protein Kinases
AMP-Activated Protein Kinases
T-Cell Antigen Receptor
Phosphotransferases
Adenosine Triphosphate
3 Citations (Scopus)
84 Downloads (Pure)

Phenformin, but not metformin, delays development of T-cell acute lymphoblastic leukemia/lymphoma via cell-autonomous AMPK activation

Vara Ciruelos, D., Dandapani, M., Russell, F., Grzes, K. M., Atrih, A., Foretz, M., Viollet, B., Lamont, D., Cantrell, D. & Hardie, G., 16 Apr 2019, In : Cell Reports. 27, 3, p. 690-698.e4

Research output: Contribution to journalArticle

Open Access
File
Phenformin
AMP-Activated Protein Kinases
T-cells
Metformin
Precursor Cell Lymphoblastic Leukemia-Lymphoma
2 Citations (Scopus)
Proteome
Cell Differentiation
T-Lymphocytes
Phenotype
Mass Spectrometry

Scientific Business Abstracts of the 113th Annual Meeting of the Association of Physicians of Great Britain and Ireland

Deciphering Developmental Disorders (DDD) Study, Cacciottolo, T. M., Perikari, A., van der Klaauw, A., Henning, E., Stadler, L. K. J., Keogh, J., Farooqi, I. S., Tenin, G., Keavney, B., Ryan, E., Budd, R., Bewley, M., Coelho, P., Rumsey, W., Sanchez, Y., McCafferty, J., Dockrell, D., Walmsley, S., Whyte, M. & 31 others, Liu, Y., Choy, M-K., Tenin, G., Abraham, S., Black, G., Keavney, B., Watkins, S., Robertson, K., Collison, D., Rush, C., Marshall, J., McGowan, R., Fraser, R., Gandhi, S., Cooper, C., Howden, A., Hukelmann, J. L., Cantrell, D. A., Mordi, I., Forteath, C., Wong, A., Mohan, M., Palmer, C., Doney, A., Rena, G., Lang, C., Gray, E. H., Williams, R., Williams, S., Hughes, J. & Davies, J., 5 Sep 2019, In : QJM : an International Journal of Medicine. 112, 9, p. 724-729 6 p., 9.

Research output: Contribution to journalMeeting abstract

Ireland
Metformin
Blood Pressure
Physicians
Left Ventricular Hypertrophy
2018
25 Citations (Scopus)
112 Downloads (Pure)

Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice

Loftus, R. M., Assmann, N., Kedia-Mehta, N., O'Brien, K. L., Garcia, A., Gillespie, C., Hukelmann, J. L., Oefner, P. J., Lamond, A. I., Gardiner, C. M., Dettmer, K., Cantrell, D. A., Sinclair, L. V. & Finlay, D. K., 14 Jun 2018, In : Nature Communications. 9, 1, p. 1-15 15 p., 2341.

Research output: Contribution to journalArticle

Open Access
File
Natural Killer Cells
mice
amino acids
Lymphocytes
Glutamine
12 Citations (Scopus)
182 Downloads (Pure)

Interleukin-2 shapes the cytotoxic T cell proteome and immune environment sensing programs

Rollings, C., Sinclair, L., Brady, H. J. M., Cantrell, D. & Ross, S., 17 Apr 2018, In : Science Signaling. 11, 526, p. 1-16 16 p., eaap8112.

Research output: Contribution to journalArticle

Open Access
File
T-cells
Proteome
Interleukin-2
T-Lymphocytes
Cytotoxic T-Lymphocytes
29 Citations (Scopus)
145 Downloads (Pure)

Signaling and Function of Interleukin-2 in T Lymphocytes

Ross, S. H. & Cantrell, D. A., 26 Apr 2018, In : Annual Review of Immunology. 36, p. 411-433 23 p.

Research output: Contribution to journalArticle

Open Access
File
Interleukin-2
T-Lymphocytes
STAT5 Transcription Factor
Janus Kinases
Interleukin-2 Receptors
11 Citations (Scopus)
100 Downloads (Pure)

Single cell analysis of kynurenine and System L amino acid transport in T cells

Sinclair, L., Neyens, D., Ramsay, G., Taylor, P. & Cantrell, D., 17 May 2018, In : Nature Communications. 9, 1, 11 p., 1981 (2018).

Research output: Contribution to journalArticle

Open Access
File
Amino Acid Transport System L
Single-Cell Analysis
Kynurenine
T-cells
Systems Analysis
2017
11 Citations (Scopus)
110 Downloads (Pure)

Control of amino-acid transport coordinates metabolic reprogramming in T cell malignancy

Grzes, K. M., Swamy, M., Hukelmann, J. L., Emslie, E., Sinclair, L. V. & Cantrell, D. A., 26 May 2017, In : Leukemia. 31, p. 2771-2779 9 p.

Research output: Contribution to journalArticle

Open Access
File
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
T-Lymphocytes
Amino Acids
Large Neutral Amino Acid-Transporter 1
Leucine
2016
97 Citations (Scopus)
130 Downloads (Pure)

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy

Swamy, M., Pathak, S., Grzes, K. M., Damerow, S., Sinclair, L. V., van Aalten, D. M. F. & Cantrell, D. A., Jun 2016, In : Nature Immunology. 17, 6, p. 712-720 9 p.

Research output: Contribution to journalArticle

Open Access
File
Glutamine
T-Lymphocytes
Glucose
Glycosyltransferases
Neoplasms
41 Citations (Scopus)
130 Downloads (Pure)

Mathematical models for immunology: current state of the art and future research directions

Eftimie, R., Gillard, J. J. & Cantrell, D. A., Oct 2016, In : Bulletin of Mathematical Biology. 78, 10, p. 2091-2134 44 p.

Research output: Contribution to journalReview article

Open Access
File
Immunology
Allergy and Immunology
immunology
Theoretical Models
mathematical models
27 Citations (Scopus)
230 Downloads (Pure)

Phosphoproteomic Analyses of Interleukin 2 Signaling Reveal Integrated JAK Kinase-Dependent and -Independent Networks in CD8+ T Cells

Ross, S. H., Rollings, C., Anderson, K. E., Hawkins, P. T., Stephens, L. R. & Cantrell, D. A., 20 Sep 2016, In : Immunity. 45, 3, p. 685-700 16 p.

Research output: Contribution to journalArticle

Open Access
File
Janus Kinases
Interleukin-2
Phosphotransferases
T-Lymphocytes
Phosphorylation
48 Citations (Scopus)
119 Downloads (Pure)

Potent and selective chemical probe of hypoxic signaling downstream of HIF-α hydroxylation via VHL inhibition

Frost, J., Galdeano, C., Soares, P., Gadd, M. S., Grzes, K. M., Ellis, L., Epemolu, O., Shimamura, S., Bantscheff, M., Grandi, P., Read, K. D., Cantrell, D. A., Rocha, S. & Ciulli, A., 4 Nov 2016, In : Nature Communications. 7, p. 1-12 12 p., 13312.

Research output: Contribution to journalArticle

Open Access
File
Hydroxylation
hypoxia
probes
Prolyl-Hydroxylase Inhibitors
Prolyl Hydroxylases
79 Citations (Scopus)
168 Downloads (Pure)

The cytotoxic T cell proteome and its shaping by the kinase mTOR

Hukelmann, J. L., Anderson, K. E., Sinclair, L. V., Grzes, K. M., Brenes Murillo, A., Hawkins, P. T., Stephens, L. R., Lamond, A. I. & Cantrell, D. A., Jan 2016, In : Nature Immunology. 17, 1, p. 104-112 9 p.

Research output: Contribution to journalArticle

Open Access
File
Cytotoxic T-Lymphocytes
Proteome
Phosphotransferases
T-Lymphocytes
Proteomics
2015
22 Citations (Scopus)

Environmental and metabolic sensors that control T cell biology

Ramsay, G. & Cantrell, D., 2015, In : Frontiers in Immunology. 6, 8 p., 99.

Research output: Contribution to journalArticle

Cell Biology
T-Lymphocytes
Hypoxia-Inducible Factor 1
Aryl Hydrocarbon Receptors
Protein-Serine-Threonine Kinases
95 Citations (Scopus)

ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation

Stone, E. L., Pepper, M., Katayama, C. D., Kerdiles, Y. M., Lai, C-Y., Emslie, E., Lin, Y. C., Yang, E., Goldrath, A. W., Li, M. O., Cantrell, D. A. & Hedrick, S. M., 17 Feb 2015, In : Immunity. 42, 2, p. 239-251 13 p.

Research output: Contribution to journalArticle

Helper-Inducer T-Lymphocytes
Cell Differentiation
Transcription Factors
Germinal Center
1-Phosphatidylinositol 4-Kinase
113 Citations (Scopus)

Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells

Pallett, L. J., Gill, U. S., Quaglia, A., Sinclair, L. V., Jover-Cobos, M., Schurich, A., Singh, K. P., Thomas, N., Das, A., Chen, A., Fusai, G., Bertoletti, A., Cantrell, D. A., Kennedy, P. T., Davies, N. A., Haniffa, M. & Maini, M. K., 11 May 2015, In : Nature Medicine. 21, 6, p. 591-600 10 p.

Research output: Contribution to journalArticle

Arginase
Hepatitis B
Viruses
Liver
T-cells
21 Citations (Scopus)

Signaling in lymphocyte activation

Cantrell, D., Jun 2015, In : Cold spring harbor perspectives in biology. 7, 6, 14 p., a018788.

Research output: Contribution to journalArticle

Lymphocytes
Lymphocyte Activation
Chemical activation
Lipids
B-Cell Antigen Receptors
54 Citations (Scopus)

Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes

Preston, G. C., Sinclair, L. V., Kaskar, A., Hukelmann, J. L., Navarro, M., Ferrero, I., MacDonald, H. R., Cowling, V. H. & Cantrell, D. A., 4 Aug 2015, In : EMBO Journal. 34, 15, p. 2008-2024 17 p.

Research output: Contribution to journalArticle

Open Access
Antigen Receptors
T-cells
Interleukin-2
Tuning
T-Lymphocytes
2014
11 Citations (Scopus)
125 Downloads (Pure)

Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells

Zarrouk, M., Finlay, D. K., Foretz, M., Viollet, B. & Cantrell, D. A., 2 Sep 2014, In : PLoS ONE. 9, 9, 7 p., e106710.

Research output: Contribution to journalArticle

Open Access
File
metformin
AMP-activated protein kinase
T-cells
Adenine Nucleotides
Metformin
15 Citations (Scopus)

Protein kinase D2 is a digital amplifier of T cell receptor-stimulated diacylglycerol signaling in naïve CD8+ T cells

Navarro, M. N., Feijoo-Carnero, C., Gonzalez Arandilla, A., Trost, M. & Cantrell, D. A., 21 Oct 2014, In : Science Signaling. 7, 348, 12 p., ra99.

Research output: Contribution to journalArticle

T-cells
Diglycerides
T-Cell Antigen Receptor
T-Lymphocytes
Phosphotransferases
12 Citations (Scopus)
114 Downloads (Pure)

Quantitative phosphoproteomics of cytotoxic T cells to reveal Protein Kinase D 2 regulated networks

Navarro, M. N., Goebel, J., Hukelmann, J. L. & Cantrell, D. A., Dec 2014, In : Molecular & Cellular Proteomics. 13, 12, p. 3544-3557 14 p.

Research output: Contribution to journalArticle

Open Access
File
T-cells
T-Lymphocytes
Phosphorylation
Proteins
Substrates
43 Citations (Scopus)

Serine-threonine kinases in TCR signaling

Navarro, M. N. & Cantrell, D. A., Sep 2014, In : Nature Immunology. 15, 9, p. 808-814 7 p.

Research output: Contribution to journalArticle

Protein-Serine-Threonine Kinases
T-Lymphocytes
T-Cell Antigen Receptor
2013
108 Citations (Scopus)

AMPKα1: a glucose sensor that controls CD8 T-cell memory

Rolf, J., Zarrouk, M., Finlay, D. K., Foretz, M., Viollet, B. & Cantrell, D. A., Apr 2013, In : European Journal of Immunology. 43, 4, p. 889-896 8 p.

Research output: Contribution to journalArticle

319 Citations (Scopus)

Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

Sinclair, L. V., Rolf, J., Emslie, E., Shi, Y-B., Taylor, P. M. & Cantrell, D. A., May 2013, In : Nature Immunology. 14, 5, p. 500-508 9 p.

Research output: Contribution to journalArticle

Antigen Receptors
Cell Differentiation
Neutral Amino Acids
T-Lymphocytes
Amino Acids
1 Citation (Scopus)
Open Access
Antigen Receptors
Allergy and Immunology
Cell Differentiation
Lymph Nodes
T-Lymphocytes
10 Citations (Scopus)

LKB1 Mediates the Development of Conventional and Innate T Cells via AMP-Dependent Kinase Autonomous Pathways

Zarrouk, M., Rolf, J. & Cantrell, D. A., 22 Mar 2013, In : PLoS ONE. 8, 3, 9 p., e60217.

Research output: Contribution to journalArticle

106 Citations (Scopus)
58 Downloads (Pure)

The BAFF Receptor Transduces Survival Signals by Co-opting the B Cell Receptor Signaling Pathway

Schweighoffer, E., Vanes, L., Nys, J., Cantrell, D., McCleary, S., Smithers, N. & Tybulewicz, V. L. J., 21 Mar 2013, In : Immunity. 38, 3, p. 475-488 14 p.

Research output: Contribution to journalArticle

Open Access
File
B-Cell Activation Factor Receptor
B-Cell Antigen Receptors
B-Lymphocytes
Cell Survival
Immunoglobulin Subunits
12 Citations (Scopus)

The impact of KLF2 modulation on the transcriptional program and function of CD8 T Cells

Preston, G. C., Feijoo-Carnero, C., Schurch, N., Cowling, V. H. & Cantrell, D. A., 2013, In : PLoS ONE. 8, 10, 16 p., e77537.

Research output: Contribution to journalArticle

T-cells
T-lymphocytes
Modulation
T-Lymphocytes
Down-Regulation
2012
267 Citations (Scopus)
309 Downloads (Pure)

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8 T cells

Finlay, D. K., Rosenzweig, E., Sinclair, L. V., Feijoo-Carnero, C., Hukelmann, J. L., Rolf, J., Panteleyev, A. A., Okkenhaug, K. & Cantrell, D. A., 17 Dec 2012, In : Journal of Experimental Medicine. 209, 13, p. 2441-2453 13 p.

Research output: Contribution to journalArticle

Open Access
File
Hypoxia-Inducible Factor 1
Phosphatidylinositol 3-Kinase
T-Lymphocytes
Glucose
Glycolysis
14 Citations (Scopus)

Protein kinase D2 has a restricted but critical role in T-cell antigen receptor signalling in mature T-cells

Navarro, M. N., Sinclair, L. V., Feijoo-Carnero, C., Clarke, R., Matthews, S. A. & Cantrell, D. A., 15 Mar 2012, In : Biochemical Journal. 442, 3, p. 649-659 11 p.

Research output: Contribution to journalArticle

T-cells
T-Cell Antigen Receptor
T-Lymphocytes
Chemical activation
Thymus
9 Citations (Scopus)

Protein kinase D isoforms are dispensable for integrin-mediated lymphocyte adhesion and homing to lymphoid tissues

Matthews, S. A., Lek, H. S., Morrison, V. L., Mackenzie, M. G., Zarrouk, M., Cantrell, D. & Fagerholm, S. C., May 2012, In : European Journal of Immunology. 42, 5, p. 1316-1326 11 p.

Research output: Contribution to journalArticle

System L amino acid transporter 1 (slc7a5) expression is crucial for T cell blastogenesis

Sinclair, L. V., Taylor, P. M. & Cantrell, D. A., Sep 2012, In : Immunology. 137, s1, p. 347-347 1 p.

Research output: Contribution to journalMeeting abstract

2011
145 Citations (Scopus)

Metabolism, migration and memory in cytotoxic T cells

Finlay, D. & Cantrell, D. A., Feb 2011, In : Nature Reviews Immunology. 11, 2, p. 109-117 9 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)

Phosphoproteomic analysis reveals an intrinsic pathway for the regulation of histone deacetylase 7 that controls the function of cytotoxic T lymphocytes

Navarro, M. N., Goebel, J., Feijoo-Carnero, C., Morrice, N. & Cantrell, D. A., Apr 2011, In : Nature Immunology. 12, 4, p. 352-361 11 p.

Research output: Contribution to journalArticle

160 Citations (Scopus)
202 Downloads (Pure)

Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism

Macintyre, A. N., Finlay, D., Preston, G., Sinclair, L. V., Waugh, C. M., Tamas, P., Feijoo, C., Okkenhaug, K. & Cantrell, D. A., 25 Feb 2011, In : Immunity. 34, 2, p. 224-236 13 p.

Research output: Contribution to journalArticle

File
29 Citations (Scopus)

Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2

Konopatskaya, O., Matthews, S. A., Harper, M. T., Gilio, K., Cosemans, J. M. E. M., Williams, C. M., Navarro, M. N., Carter, D. A., Heemskerk, J. W. M., Leitges, M., Cantrell, D. & Poole, A. W., 14 Jul 2011, In : Blood. 118, 2, p. 416-424 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

The coordination of T-cell function by serine/threonine kinases

Finlay, D. & Cantrell, D., Jan 2011, In : Cold spring harbor perspectives in biology. 3, 1, p. - 10 p., a002261.

Research output: Contribution to journalArticle

2010
60 Citations (Scopus)
147 Downloads (Pure)

LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells

Tamas, P., Macintyre, A., Finlay, D., Clarke, R., Feijoo-Carnero, C., Ashworth, A. & Cantrell, D., Jan 2010, In : European Journal of Immunology. 40, 1, p. 242-253 12 p.

Research output: Contribution to journalArticle

Open Access
File
58 Citations (Scopus)

Phosphoinositide 3-kinase and the mammalian target of rapamycin pathways control T cell migration

Finlay, D. & Cantrell, D., Jan 2010, In : Annals of the New York Academy of Sciences. 1183, p. 149-157 9 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
46 Citations (Scopus)

Unique functions for protein kinase D1 and protein kinase D2 in mammalian cells

Matthews, S. A., Navarro, M. N., Sinclair, L. V., Emslie, E., Feijoo-Carnero, C. & Cantrell, D. A., 15 Nov 2010, In : Biochemical Journal. 432, p. 153-163 11 p.

Research output: Contribution to journalArticle

2009
19 Citations (Scopus)

New insights into the regulation and function of serine/threonine kinases in T lymphocytes

Matthews, S. A. & Cantrell, D. A., Mar 2009, In : Immunological Reviews. 228, 1, p. 241-252 12 p.

Research output: Contribution to journalReview article

47 Citations (Scopus)
357 Downloads (Pure)

Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes

Finlay, D. K., Sinclair, L. V., Feijoo, C., Waugh, C. M., Hagenbeek, T. J., Spits, H. & Cantrell, D. A., 26 Oct 2009, In : Journal of Experimental Medicine. 206, 11, p. 2441-2454 14 p.

Research output: Contribution to journalArticle

Open Access
File
2008

Corrigendum: Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking (Nature Immunology (2008) vol. 9(6) (513-521))

Sinclair, L. V., Finlay, D., Feijoo, C., Cornish, G. H., Gray, A., Ager, A., Okkenhaug, K., Hagenbeek, T. J., Spits, H. & Cantrell, D. A., Jun 2008, In : Nature Immunology. 9, 6, p. 692 1 p.

Research output: Contribution to journalComment/debate

287 Citations (Scopus)

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

Sinclair, L. V., Finlay, D., Feijoo, C., Cornish, G. H., Gray, A., Ager, A., Okkenhaug, K., Hagenbeek, T. J., Spits, H. & Cantrell, D. A., May 2008, In : Nature Immunology. 9, 5, p. 513-521 9 p.

Research output: Contribution to journalArticle

569 Citations (Scopus)

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

Sauer, S., Bruno, L., Hertweck, A., Finlay, D., Leleu, M., Spivakov, M., Knight, Z. A., Cobb, B. S., Cantrell, D., O'Connor, E., Shokat, K. M., Fisher, A. G. & Merkenschlager, M., 3 Jun 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 22, p. 7797-7802 6 p.

Research output: Contribution to journalArticle