Tonelli, Francesca

Dr

  • 460 Citations
  • 8 h-Index
20132019
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Research Output 2013 2019

  • 460 Citations
  • 8 h-Index
  • 10 Article
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Article
2019
3 Citations (Scopus)
90 Downloads (Pure)

A chemical-genetics approach to study the role of atypical Protein Kinase C in Drosophila

Hannaford, M., Loyer, N., Tonelli, F., Zoltner, M. & Januschke, J., 29 Jan 2019, In : Development. 146, 2, p. 1-11 11 p., dev170589.

Research output: Contribution to journalArticle

Open Access
File
Drosophila
Phosphotransferases
Drosophila Proteins
Cell Polarity
Nuclear Envelope
2 Downloads (Pure)

PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins

Berndsen, K., Lis, P., Yeshaw, W. M., Wawro, P. S., Nirujogi, R., Wightman, M., Macartney, T., Dorward, M., Knebel, A., Tonelli, F., Pfeffer, S. R. & Alessi, D., 12 Nov 2019, In : eLife. 8, p. 1-37 37 p., e50416.

Research output: Contribution to journalArticle

Open Access
File
Phosphoric Monoester Hydrolases
Phosphorylation
Phosphoprotein Phosphatases
Parkinson Disease
rab GTP-Binding Proteins
2018
11 Citations (Scopus)
83 Downloads (Pure)

A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain

Dhekne, H. S., Yanatori, I., Gomez, R. C., Tonelli, F., Diez, F., Schüle, B., Steger, M., Alessi, D. R. & Pfeffer, S. R., 6 Nov 2018, In : eLife. 7, p. 1-26 26 p., e40202.

Research output: Contribution to journalArticle

Open Access
File
Aptitude
Hedgehogs
Cilia
Neurons
Parkinson Disease
20 Citations (Scopus)
218 Downloads (Pure)

Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson’s disease kinase

Lis, P., Burel, S., Steger, M., Mann, M., Brown, F., Diez, F., Tonelli, F., Holton, J. L., Winglok Ho, P., Ho, S-L., Chou, M-Y., Polinski, N. K., Martinez, T. N., Davies, P. & Alessi, D. R., 2 Jan 2018, In : Biochemical Journal. 475, 1, p. 1-22 22 p.

Research output: Contribution to journalArticle

Open Access
File
Protein Kinases
Parkinson Disease
Phosphotransferases
Antibodies
Proteins
21 Citations (Scopus)
80 Downloads (Pure)

The Parkinson's disease VPS35[D620N] mutation enhances LRRK2 mediated Rab protein phosphorylation in mouse and human

Mir, R., Tonelli, F., Lis, P., Macartney, T., Polinski, N. K., Martinez, T. N., Chou, M-Y., Howden, A., König, T., Hotzy, C., Milenkovic, I., Brücke, T., Zimprich, A., Sammler, E. & Alessi, D., 6 Jun 2018, In : Biochemical Journal. 475, 11, p. 1861-1883 19 p.

Research output: Contribution to journalArticle

Open Access
File
Phosphorylation
Parkinson Disease
Mutation
Proteins
Phosphotransferases
2017
40 Citations (Scopus)
135 Downloads (Pure)

Rab29 activation of the Parkinson's disease-associated LRRK2 kinase

Purlyte, E., Dhekne, H. S., Sarhan, A. R., Gomez, R., Lis, P., Wightman, M., Martinez, T. N., Tonelli, F., Pfeffer, S. R. & Alessi, D. R., 15 Dec 2017, In : EMBO Journal. 36, 24, p. 3549-3681 18 p., e201798099.

Research output: Contribution to journalArticle

Open Access
File
Phosphorylation
Parkinson Disease
Phosphotransferases
Chemical activation
Biomarkers
59 Citations (Scopus)
186 Downloads (Pure)

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis

Steger, M., Diez, F., Dhekne, H. S., Lis, P., Nirujogi, R. S., Karayel, O., Tonelli, F., Martinez, T. N., Lorentzen, E., Pfeffer, S. R., Alessi, D. R. & Mann, M., 10 Nov 2017, In : eLife. 6, p. 1-22 22 p., e31012.

Research output: Contribution to journalArticle

Open Access
File
rab GTP-Binding Proteins
Phosphorylation
Cilia
Proteomics
Pathology
2016
238 Citations (Scopus)
175 Downloads (Pure)

Phosphoproteomics reveals that Parkinson’s disease kinase LRRK2 regulates a subset of Rab GTPases

Steger, M., Tonelli, F., Ito, G., Davies, P., Trost, M., Vetter, M., Wachter, S., Lorentzen, E., Duddy, G., Wilson, S., Baptista, M. A. S., Fiske, B. K., Fell, M. J., Morrow, J. A., Reith, A. D., Alessi, D. R. & Mann, M., 29 Jan 2016, In : eLife. 5, p. 1-28 28 p., e12813.

Research output: Contribution to journalArticle

Open Access
File
rab GTP-Binding Proteins
Leucine
Parkinson Disease
Phosphotransferases
Guanine Nucleotide Dissociation Inhibitors
42 Citations (Scopus)
171 Downloads (Pure)

Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors

Ito, G., Katsemonova, K., Tonelli, F., Lis, P., Baptista, M., Shpiro, N., Duddy, G., Wilson, S., Wing-Lok Ho, P., Ho, S-L., Reith, A. D. & Alessi, D., 30 Aug 2016, In : Biochemical Journal. 473, 17, p. 2671-2685 15 p.

Research output: Contribution to journalArticle

Open Access
File
Phosphorylation
Leucine
Assays
Phosphotransferases
Fibroblasts
2013
26 Citations (Scopus)

TGFβ1 evokes myoblast apoptotic response via a novel signaling pathway involving S1P transactivation upstream of Rho-kinase-2 activation

Cencetti, F., Bernacchioni, C., Tonelli, F., Roberts, E., Donati, C. & Bruni, P., Nov 2013, In : FASEB Journal. 27, 11, p. 4532-4546 15 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Myoblasts
Transforming Growth Factors
Transcriptional Activation
Chemical activation