Diabetes represents an immense global health challenge. Taking both forms of the disorderinto account, more than 400 million people world wide are currently living with diabetes and thisis predicted to rise to 700 million by 2045. The cost of diabetes is approximately 10% of the NHS budget in the UK. While treatments have been developed in the last few decades, it remains an unmet medical need to sufficiently restore beta cell quantity and function, which could improve the control of nutrient metabolism by fine-tuning insulin release.
My project aims to discover small molecules which stimulate the regeneration of pancreatic betacells to treat type I and type II diabetes. By exploiting the activity of stem/progenitor cellsalready residing in the organ, this approach has the potential to tackle the underlying cause ofdiabetes through the native tissue's maintenance and repair mechanisms, and thus reducing undesirable side-effects associated with current standard treatments.