Frederick Simeons

2024

Acceleration of infectious disease drug discovery and development using a humanized model of drug metabolism

MacLeod, A. K., Coquelin, K.-S., Huertas, L., Simeons, F. R. C., Riley, J., Casado, P., Guijarro, L., Casanueva, R., Frame, L., Pinto, E. G., Ferguson, L., Duncan, C., Mutter, N., Shishikura, Y., Henderson, C. J., Cebrian, D., Wolf, C. R. & Read, K. D. (Lead / Corresponding author), 13 Feb 2024, In: Proceedings of the National Academy of Sciences. 121, 7, p. 1-12 12 p., 2315069121.

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7 Citations (Scopus)

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Rational Exploration of 2,4-Diaminopyrimidines as DHFR Inhibitors Active against Mycobacterium abscessus and Mycobacterium avium, Two Emerging Human Pathogens

Andrade Meirelles, M., Almeida, V. M., Sullivan, J. R., de Toledo, I., dos Reis, C. V., Cunha, M. R., Zigweid, R., Shim, A., Sankaran, B., Woodward, E. L., Seibold, S., Liu, L., Mian, M. R., Battaile, K. P., Riley, J., Duncan, C., Simeons, F. R. C., Ferguson, L., Joji, H. & Read, K. D. & 5 others, Lovell, S., Staker, B. L., Behr, M. A., Pilli, R. A. (Lead / Corresponding author) & Couñago, R. M. (Lead / Corresponding author), 14 Nov 2024, In: Journal of Medicinal Chemistry. 67, 21, p. 19143-19164 22 p.

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2023

Development of a 2,4-diaminothiazole series for the treatment of human African trypanosomiasis highlights the importance of static-cidal screening of analogues

Cleghorn, L. A. T., Wall, R. J., Albrecht, S., MacGowan, S. A., Norval, S., De Rycker, M., Woodland, A., Spinks, D., Thompson, S., Patterson, S., Corpas Lopez, V., Dey, G., Collie, I. T., Hallyburton, I., Kime, R., Simeons, F. R. C., Stojanovski, L., Frearson, J. A., Wyatt, P. G. & Read, K. D. & 2 others, Gilbert, I. H. (Lead / Corresponding author) & Wyllie, S. (Lead / Corresponding author), 13 Jul 2023, In: Journal of Medicinal Chemistry. 66, 13, p. 8896–8916 21 p.

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4 Citations (Scopus)

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Structure Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma cruzi Proteasome Inhibitors

Thomas, M. G., McGonagle, K., Rowland, P., Robinson, D. A., Dodd, P. G., Camino-Díaz, I., Campbell, L., Cantizani, J., Castañeda, P., Conn, D., Craggs, P. D., Edwards, D., Ferguson, L., Fosberry, A., Frame, L., Goswami, P., Hu, X., Korczynska, J., MacLean, L. & Martin, J. & 21 others, Mutter, N., Osuna-Cabello, M., Paterson, C., Peña, I., Pinto, E. G., Pont, C., Riley, J., Shishikura, Y., Simeons, F. R. C., Stojanovski, L., Thomas, J., Wrobel, K., Young, R. J., Zmuda, F., Zuccotto, F., Read, K. D., Gilbert, I. H., Marco, M., Miles, T., Manzano, P. (Lead / Corresponding author) & De Rycker, M. (Lead / Corresponding author), 10 Aug 2023, In: Journal of Medicinal Chemistry. 66, 15, p. 10413-10431 19 p.

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12 Citations (Scopus)

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2022

Identification and development of a series of disubstituted piperazines for the treatment of Chagas disease

McGonagle, K., Tarver, G. J., Cantizani, J., Cotillo, I., Dodd, P. G., Ferguson, L., Gilbert, I. H., Marco, M., Miles, T., Naylor, C., Osuna-Cabello, M., Paterson, C., Read, K. D., Pinto, E. G., Riley, J., Scullion, P., Shishikura, Y., Simeons, F., Stojanovski, L. & Svensen, N. & 5 others, Thomas, J., Wyatt, P. G., Manzano, P. (Lead / Corresponding author), De Rycker, M. (Lead / Corresponding author) & Thomas, M. G. (Lead / Corresponding author), 5 Aug 2022, In: European Journal of Medicinal Chemistry. 238, 14 p., 114421.

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5 Citations (Scopus)

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Repositioning of a diaminothiazole series confirmed to target the cyclin-dependent kinase CRK12 for use in the treatment of African animal trypanosomiasis

Smith, A., Wall, R., Patterson, S., Rowan, T., Rico Vidal, E., Stojanovski, L., Huggett, M., Hampton, S., Thomas, M. G., Corpas Lopez, V., Gillingwater, K., Duke, J., Napier, G., Peter, R., Vitouley, H. S., Harrison, J., Milne, R., Jeacock, L., Baker, N. & Davis, S. & 9 others, Simeons, F., Riley, J., Horn, D., Brun, R., Zuccotto, F., Witty, M. J., Wyllie, S. (Lead / Corresponding author), Read, K. D. (Lead / Corresponding author) & Gilbert, I. H. (Lead / Corresponding author), 14 Apr 2022, In: Journal of Medicinal Chemistry. 65, 7, p. 5606-5624 19 p.

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7 Citations (Scopus)

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2021

Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis

Thomas, M., Brand, S., De Rycker, M., Zuccotto, F., Lukac, I., Dodd, P., Ko, E.-J., Manthri, S., McGonagle, K., Osuna-Cabello, M., Riley, J., Pont, C., Simeons, F., Stojanovski, L., Thomas, J., Thompson, S., Viayna, E., Fiandor, J. M., Martín, J. & Wyatt, P. G. & 4 others, Miles, T. J., Read, K. D., Marco, M. (Lead / Corresponding author) & Gilbert, I. H. (Lead / Corresponding author), 13 May 2021, In: Journal of Medicinal Chemistry. 64, 9, p. 5905-5930 26 p.

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33 Citations (Scopus)

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2020

Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent In Vitro Antileishmanial Activity: Initial SAR and Assessment of In Vivo Activity

Thomas, M. (Lead / Corresponding author), De Rycker, M., Wall, R. J., Spinks, D., Epemolu, O., Manthri, S., Norval, S., Osuna-Cabello, M., Patterson, S., Riley, J., Simeons, F. R. C., Stojanovski, L., Thomas, J., Thompson, S., Naylor, C., Fiandor, J. M., Wyatt, P. G., Marco, M., Wyllie, S. & Read, K. D. & 2 others, Miles, T. J. & Gilbert, I. H. (Lead / Corresponding author), 10 Sept 2020, In: Journal of Medicinal Chemistry. 63, 17, p. 9523-9539 17 p.

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10 Citations (Scopus)

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Identification of 6-amino-1H-pyrazolo[3,4-d]pyrimidines with in vivo efficacy against visceral leishmaniasis

Thomas, M. G., De Rycker, M., Ajakane, M., Crouch, S. D., Campbell, L., Daugan, A., Fra, G., Guerrero, C., Mackenzie, C. J., MacLean, L., Manthri, S., Martin, F., Norval, S., Osuna-Cabello, M., Riley, J., Shishikura, Y., Miguel-Siles, J., Simeons, F. R. C., Stojanovski, L. & Thomas, J. & 7 others, Thompson, S., Velasco, R. F., Fiandor, J. M., Wyatt, P. G., Read, K. D., Gilbert, I. H. (Lead / Corresponding author) & Miles, T. J. (Lead / Corresponding author), 21 Oct 2020, In: RSC Medicinal Chemistry. 11, 10, p. 1168-1177 10 p.

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3 Citations (Scopus)

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2019

Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis

Thomas, M. G., De Rycker, M., Ajakane, M., Albrecht, S., Álvarez-Pedraglio, A. I., Boesche, M., Brand, S., Campbell, L., Cantizani-Perez, J., Cleghorn, L. A. T., Copley, R. C. B., Crouch, S. D., Daugan, A., Drewes, G., Ferrer, S., Ghidelli-Disse, S., Gonzalez, S., Gresham, S. L., Hill, A. P. & Hindley, S. J. & 32 others, Lowe, R. M., MacKenzie, C. J., MacLean, L., Manthri, S., Martin, F., Miguel-Siles, J., Nguyen, V. L., Norval, S., Osuna-Cabello, M., Woodland, A., Patterson, S., Pena, I., Quesada-Campos, M. T., Reid, I. H., Revill, C., Riley, J., Ruiz-Gomez, J. R., Shishikura, Y., Simeons, F. R. C., Smith, A., Smith, V. C., Spinks, D., Stojanovski, L., Thomas, J., Thompson, S., Underwood, T., Gray, D. W., Fiandor, J. M., Gilbert, I. H., Wyatt, P. G. (Lead / Corresponding author), Read, K. D. (Lead / Corresponding author) & Miles, T. J. (Lead / Corresponding author), 14 Feb 2019, In: Journal of Medicinal Chemistry. 62, 3, p. 1180-1202 23 p.

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40 Citations (Scopus)

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Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Baragaña, B., Forte, B., Choi, R., Nakazawa Hewitt, S., Bueren-Calabuig, J. A., Pisco, J. P., Peet, C., Dranow, D. M., Robinson, D. A., Jansen, C., Norcross, N. R., Vinayak, S., Anderson, M., Brooks, C. F., Cooper, C. A., Damerow, S., Delves, M., Dowers, K., Duffy, J. & Edwards, T. E. & 57 others, Hallyburton, I., Horst, B. G., Hulverson, M. A., Ferguson, L., Jiménez-Díaz, M. B., Jumani, R. S., Lorimer, D. D., Love, M. S., Maher, S., Matthews, H., McNamara, C. W., Miller, P., O'Neill, S., Ojo, K. K., Osuna-Cabello, M., Pinto, E., Post, J., Riley, J., Rottmann, M., Sanz, L. M., Scullion, P., Sharma, A., Shepherd, S. M., Shishikura, Y., Simeons, F. R. C., Stebbins, E. E., Stojanovski, L., Straschil, U., Tamaki, F. K., Tamjar, J., Torrie, L. S., Vantaux, A., Witkowski, B., Wittlin, S., Yogavel, M., Zuccotto, F., Angulo-Barturen, I., Sinden, R., Baum, J., Gamo, F.-J., Mäser, P., Kyle, D. E., Winzeler, E. A., Myler, P. J., Wyatt, P. G., Floyd, D., Matthews, D., Sharma, A., Striepen, B., Huston, C. D., Gray, D. W., Fairlamb, A. H., Pisliakov, A. V., Walpole, C., Read, K. D., Van Voorhis, W. C. & Gilbert, I. H. (Lead / Corresponding author), 2 Apr 2019, In: Proceedings of the National Academy of Sciences. 116, 14, p. 7015-7020 6 p.

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110 Citations (Scopus)

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Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

Wyllie, S., Brand, S., Thomas, M., De Rycker, M., Chung, C.-W., Peña, I., Bingham, R., Bueren-Calabuig, J., Cantizani, J., Cebrian, D., Craggs, P. D., Ferguson, L., Goswami, P., Hobrath, J., Howe, J., Jeacock, L., Ko, E. J., Korczynska, J., MacLean, L. & Manthri, S. & 29 others, Santos Martinez, M., Mata-Cantero, L., Moniz, S., Nuhs, A., Osuna-Cabello, M., Pinto, E., Riley, J., Robinson, S., Rowland, P., Simeons, F., Shishikura, Y., Spinks, D., Stojanovski, L., Thomas, J., Thompson, S., Viayna Gaza, E., Wall, R., Zuccotto, F., Horn, D., Ferguson, M., Fairlamb, A., Fiandor, J. M., Martín, J., Gray, D., Miles, T. J., Gilbert, I., Read, K. (Lead / Corresponding author), Marco, M. (Lead / Corresponding author) & Wyatt, P. (Lead / Corresponding author), 7 May 2019, In: Proceedings of the National Academy of Sciences. 116, 19, p. 9318-9323 6 p., 201820175.

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135 Citations (Scopus)

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2018

A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors

Harrison, J. R., Brand, S., Smith, V., Robinson, D. A., Thompson, S., Smith, A., Davies, K., Mok, N., Torrie, L. S., Collie, I., Hallyburton, I., Norval, S., Simeons, F. R. C., Stojanovski, L., Frearson, J. A., Brenk, R., Wyatt, P. G., Gilbert, I. H. (Lead / Corresponding author) & Read, K. D. (Lead / Corresponding author), 12 Sept 2018, In: Journal of Medicinal Chemistry. 61, 18, p. 8374–8389 16 p.

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48 Citations (Scopus)

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Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis

Wyllie, S., Thomas, M., Patterson, S., Crouch, S., De Rycker, M., Lowe, R., Gresham, S., Urbaniak, M. D., Otto, T. D., Stojanovski, L., Simeons, F. R. C., Manthri, S., MacLean, L. M., Zuccotto, F., Homeyer, N., Pflaumer, H., Boesche, M., Sastry, L., Connolly, P. & Albrecht, S. & 12 others, Berriman, M., Drewes, G., Gray, D. W., Ghidelli-Disse, S., Dixon, S., Fiandor, J. M., Wyatt, P. G., Ferguson, M. A. J., Fairlamb, A. H., Miles, T. J. (Lead / Corresponding author), Read, K. D. (Lead / Corresponding author) & Gilbert, I. H. (Lead / Corresponding author), 9 Aug 2018, In: Nature. 560, 7717, p. 192-197 6 p.

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125 Citations (Scopus)

970 Downloads (Pure)

2017

Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi

Brand, S., Ko, E. J., Viayna, E., Thompson, S., Spinks, D., Thomas, M., Sandberg, L., Francisco, A. F., Jayawardhana, S., Smith, V. C., Jansen, C., De Rycker, M., Thomas, J., MacLean, L., Osuna-Cabello, M., Riley, J., Scullion, P., Stojanovski, L., Simeons, F. R. C. & Epemolu, O. & 16 others, Shishikura, Y., Crouch, S. D., Bakshi, T. S., Nixon, C. J., Reid, I. H., Hill, A. P., Underwood, T. Z., Hindley, S. J., Robinson, S. A., Kelly, J. M., Fiandor, J. M., Wyatt, P. G., Marco, M., Miles, T. J. (Lead / Corresponding author), Read, K. D. (Lead / Corresponding author) & Gilbert, I. H. (Lead / Corresponding author), 14 Sept 2017, In: Journal of Medicinal Chemistry. 60, 17, p. 7284-7299 16 p.

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44 Citations (Scopus)

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2014

Lead optimization of a pyrazole sulfonamide series of trypanosoma brucei N -myristoyltransferase inhibitors: Identification and evaluation of CNS penetrant compounds as potential treatments for stage 2 human african trypanosomiasis

Brand, S., Norcross, N. R., Thompson, S., Harrison, J. R., Smith, V. C., Robinson, D. A., Torrie, L. S., McElroy, S. P., Hallyburton, I., Norval, S., Scullion, P., Stojanovski, L., Simeons, F. R. C., Van Aalten, D., Frearson, J. A., Brenk, R., Fairlamb, A. H., Ferguson, M. A. J., Wyatt, P. G. & Gilbert, I. H. & 1 others, Read, K. D., 11 Dec 2014, In: Journal of Medicinal Chemistry. 57, 23, p. 9855-9869 15 p.

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63 Citations (Scopus)

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Simeons, Frederick

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