Inman, Gareth

Professor

  • 3576 Citations
  • 28 h-Index
1991 …2020

Research output per year

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Research Output

2019

Azathioprine: friend or foe?

Leigh, I. M., Proby, C. M., Inman, G. J. & Harwood, C. A., May 2019, In : British Journal of Dermatology. 180, 5, p. 961-963 3 p.

Research output: Contribution to journalEditorial

1 Citation (Scopus)

Preclinical Evaluation of AZ12601011 and AZ12799734, Inhibitors of Transforming Growth Factor β Superfamily Type 1 Receptors.

Spender, L. C., Ferguson, G. J., Hughes, G. D., Davies, B. R., Goldberg, F. W., Herrera, B., Taylor, R. G., Strathearn, L., Sansom, O. J., Barry, S. T. & Inman, G., 1 Feb 2019, In : Molecular Pharmacology. 95, 2, p. 222-234 13 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
183 Downloads (Pure)
2018

Differential expression of secreted factors SOSTDC1 and ADAMTS8 cause pro-fibrotic changes in linear morphoea fibroblasts

Badshah, I. I., Brown, S., Weibel, L., Rose, A., Way, B., Sebire, N., Inman, G., Harper, J., Kinsler, V. & O'Shaughnessy, R., 26 Oct 2018, In : British Journal of Dermatology.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
73 Downloads (Pure)

Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma

Rose, A. M., Spender, L. C., Stephen, C., Mitchell, A., Rickaby, W., Bray, S., Evans, A. T., Dayal, J., Purdie, K. J., Harwood, C. A., Proby, C. M., Leigh, I. M., Coates, P. J. . & Inman, G. J., 6 Mar 2018, In : Oncotarget. 9, 18, p. 14552-14566 15 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
172 Downloads (Pure)

The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature

Inman, G. J., Wang, J., Nagano, A., Alexandrov, L. B., Purdie, K. J., Taylor, R. G., Sherwood, V., Thomson, J., Hogan, S., Spender, L. C., South, A. P., Stratton, M., Chelala, C., Harwood, C. A., Proby, C. M. & Leigh, I. M., 10 Sep 2018, In : Nature Communications. 9, 1, p. 1-14 14 p., 3667.

Research output: Contribution to journalArticle

Open Access
File
30 Citations (Scopus)
129 Downloads (Pure)

The Role of Human Papillomaviruses and Polyomaviruses in BRAF-Inhibitor Induced Cutaneous Squamous Cell Carcinoma and Benign Squamoproliferative Lesions

Purdie, K. J., Proby, C. M., Rizvi, H., Griffin, H., Doorbar, J., Sommerlad, M., Feltkamp, M. C., Van der Meijden, E., Inman, G. J., South, A. P., Leigh, I. M. & Harwood, C. A., 14 Aug 2018, In : Frontiers in Microbiology. 9, 16 p., 1806.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
118 Downloads (Pure)
2017

Loss of TGF-β signaling drives cSCC from skin stem cells: more evidence

Rose, A. M., Sansom, O. J. & Inman, G. J., 4 Mar 2017, In : Cell Cycle. 16, 5, p. 386-387 2 p.

Research output: Contribution to journalEditorial

Open Access
File
2 Citations (Scopus)
110 Downloads (Pure)

Targeting BRAF-mutant tumours with TGFBR1 inhibitors

Spender, L. C. & Inman, G. J., 31 Jan 2017, In : Aging-US. 9, 1, p. 5-6 2 p.

Research output: Contribution to journalEditorial

Open Access
File
148 Downloads (Pure)

TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis

Cammareri, P., Vincent, D. F., Hodder, M. C., Ridgway, R. A., Murgia, C., Nobis, M., Campbell, A. D., Varga, J., Huels, D. J., Subramani, C., Prescott, K. L. H., Nixon, C., Hedley, A., Barry, S. T., Greten, F. R., Inman, G. J. & Sansom, O. J., Oct 2017, In : Cell Death & Differentiation. 24, 10, p. 1681-1693 13 p.

Research output: Contribution to journalArticle

Open Access
File
16 Citations (Scopus)
150 Downloads (Pure)

TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling

Hurst, L. A., Dunmore, B. J., Long, L., Crosby, A., Al-Lamki, R., Deighton, J., Southwood, M., Yang, X., Nikolic, M. Z., Herrera, B., Inman, G. J., Bradley, J. R., Rana, A. A., Upton, P. D. & Morrell, N. W., 13 Jan 2017, In : Nature Communications. 8, p. 1-14 14 p., 14079.

Research output: Contribution to journalArticle

Open Access
File
42 Citations (Scopus)
156 Downloads (Pure)

Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development

Phillips, T. J., Scott, H., Menassa, D. A., Bignell, A. L., Sood, A., Morton, J. S., Akagi, T., Azuma, K., Rogers, M. F., Gilmore, C. E., Inman, G. J., Grant, S., Chung, Y., Aljunaidy, M. M., Cooke, C-L., Steinkraus, B. R., Pocklington, A., Logan, A., Collett, G. P., Kemp, H. & 7 others, Holmans, P. A., Murphy, M. P., Fulga, T. A., Coney, A. M., Akashi, M., Davidge, S. T. & Case, C. P., 22 Aug 2017, In : Scientific Reports. 7, p. 1-16 16 p., 9079.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
173 Downloads (Pure)
2016

Exosome-mediated transfer from the tumor microenvironment increases TGFβ signaling in squamous cell carcinoma

Languino, L. R., Singh, A., Prisco, M., Inman, G. J., Luginbuhl, A., Curry, J. M. & South, A. P., 30 May 2016, In : American Journal of Translational Research. 8, 5, p. 2432-2437 6 p.

Research output: Contribution to journalArticle

Open Access
File
32 Citations (Scopus)
53 Downloads (Pure)
Open Access
File
116 Downloads (Pure)

Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma

Cammareri, P., Rose, A., Vincent, D. F., Wang, J., Nagano, A., Libertini, S., Ridgway, R. A., Athineos, D., Coates, P. J. ., McHugh, A., Pourreyron, C., Dayal, J., Larsson, J., Weidlich, S., Spender, L., Sapkota, G., Purdie, K. J., Proby, C., Harwood, C. A., Leigh, I. & 9 others, Clevers, H., Barker, N., Karlsson, S., Pritchard, C., Marais, R., Chelala, C., South, A., Sansom, O. J. & Inman, G., 25 Aug 2016, In : Nature Communications. 7, p. 1-7 7 p., 12493.

Research output: Contribution to journalArticle

Open Access
File
40 Citations (Scopus)
114 Downloads (Pure)

Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells

Spender, L. C., Ferguson, G. J., Liu, S., Cui, C., Girotti, M. R., Sibbet, G., Higgs, E. B., Shuttleworth, M. K., Hamilton, T., Lorigan, P., Weller, M., Vincent, D. F., Sansom, O. J., Frame, M., Ten Dijke, P., Marais, R. & Inman, G. J., 13 Dec 2016, In : Oncotarget. 7, 50, p. 81995-82012 18 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
222 Downloads (Pure)
2014

Developments in Burkitt's lymphoma: novel cooperations in oncogenic MYC signaling

Spender, L. C. & Inman, G. J., 2014, In : Cancer Management and Research. 6, p. 27-38 12 p.

Research output: Contribution to journalReview article

16 Citations (Scopus)

E3 ubiquitin ligase HOIP attenuates apoptotic cell death induced by cisplatin

MacKay, C., Carroll, E., Ibrahim, A. F. M., Garg, A., Inman, G. J., Hay, R. T. & Alpi, A. F., 15 Apr 2014, In : Cancer Research. 74, 8, p. 2246-2257 12 p.

Research output: Contribution to journalArticle

Open Access
31 Citations (Scopus)
2013

A two gene serum epigenetic signature detects metastatic melanoma with high sensitivity and specificity

Wang, H., McHugh, A., Matin, R., Fleming, C., Leigh, I., Harwood, C., Inman, G., Crook, T. & Proby, C., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S235 1 p., 1379.

Research output: Contribution to journalMeeting abstract

BMP9 is a proliferative and survival factor for human hepatocellular carcinoma cells

Herrera, B., García-Álvaro, M., Cruz, S., Walsh, P., Fernández, M., Roncero, C., Fabregat, I., Sánchez, A. & Inman, G. J., 23 Jul 2013, In : PLoS ONE. 8, 7, e69535.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Methylated tissue factor pathway inhibitor 2 (TFPI2) DNA in serum is a biomarker of metastatic melanoma

Nigro, C. L., Wang, H., McHugh, A., Lattanzio, L., Matin, R., Harwood, C., Syed, N., Hatzimichael, E., Briasoulis, E., Merlano, M., Evans, A., Thompson, A., Leigh, I., Fleming, C., Inman, G. J., Proby, C. & Crook, T., May 2013, In : Journal of Investigative Dermatology. 133, 5, p. 1278-1285 8 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
2012

Crosstalk between p53 and TGF-β Signalling

Elston, R. & Inman, G. J., 2012, In : Journal of Signal Transduction. 2012, p. 294097

Research output: Contribution to journalArticle

NT5E (CD73) is epigenetically regulated in malignant melanoma and associated with metastatic site specificity

Wang, H., Lee, S., Lo Nigro, C., Lattanzio, L., Merlano, M., Monteverde, M., Matin, R., Purdie, K., Mladkova, N., Bergamaschi, D., Harwood, C., Syed, N., Szlosarek, P., Briasoulis, E., McHugh, A., Thompson, A., Evans, A., Leigh, I., Fleming, C., Inman, G. J. & 3 others, Hatzimichael, E., Proby, C. & Crook, T., 2012, In : British Journal of Cancer. 106, 8, p. 1446-52 7 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)
34 Citations (Scopus)

Transforming Growth Factor-β directly induces PUMA during the rapid induction of apoptosis in Myc-driven B-cell lymphomas.

Spender, L. C., Carter, M. J., O'Brien, D. I., Clark, L. J., Yu, J., Michalak, E. M., Happo, L., Cragg, M. S. & Inman, G. J., 2012, In : Journal of Biological Chemistry.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2011

Differing contributions of LIMK and ROCK to TGF beta-induced transcription, motility and invasion

Morin, P., Wickman, G., Munro, J., Inman, G. J. & Olson, M. F., Jan 2011, In : European Journal of Cell Biology. 90, 1, p. 13-25 13 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Epigenetic dysregulation of novel candidate genes in malignant melanoma

Wang, H., McHugh, A. T., Matin, R., Fleming, C., Leigh, I. M., Harwood, C., Crook, T., Inman, G. & Proby, C., 11 Apr 2011, In : British Journal of Dermatology. 164, 4, p. 916-916 1 p.

Research output: Contribution to journalBook/Film/Article review

Epigenetic Dysregulation of Novel Genes in Melanoma

Wang, H., McHugh, A., Matin, R., Fleming, C., Leigh, I., Harwood, C., Crook, T., Inman, G. & Proby, C., Sep 2011, In : Journal of Investigative Dermatology. 131, p. S114-S114 1 p.

Research output: Contribution to journalBook/Film/Article review

Inhibition of germinal centre apoptotic programmes by epstein-barr virus

Spender, L. C. & Inman, G. J., 2011, In : Advances in Hematology. 2011, p. 829525

Research output: Contribution to journalArticle

8 Citations (Scopus)

Switching TGF beta from a tumor suppressor to a tumor promoter

Inman, G. J., Feb 2011, In : Current Opinion in Genetics & Development. 21, 1, p. 93-99 7 p.

Research output: Contribution to journalReview article

135 Citations (Scopus)
2010

Alterations In Wnt Signalling In the Megakaryocytic Lineage Leads to Bone Marrow Failure and Myelofibrosis

Calaminus, S. D., Inman, G., Ghaevert, C., Sansom, O., Watson, S. P., Holyoake, T. L. & Machesky, L., 19 Nov 2010, In : Blood. 116, 21, p. 276-276 1 p.

Research output: Contribution to journalMeeting abstract

Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter

Hannigan, A., Smith, P., Kalna, G., Lo Nigro, C., Orange, C., O'Brien, D. I., Shah, R., Syed, N., Spender, L. C., Herrera, B., Thurlow, J. K., Lattanzio, L., Monteverde, M., Maurer, M. E., Buffa, F. M., Mann, J., Chu, D. C. K., West, C. M. L., Patridge, M., Oien, K. A. & 8 others, Cooper, J. A., Frame, M. C., Harris, A. L., Hiller, L., Nicholson, L. J., Gasco, M., Crook, T. & Inman, G. J., Aug 2010, In : Journal of Clinical Investigation. 120, 8, p. 2842-2857 16 p.

Research output: Contribution to journalArticle

Open Access
File
62 Citations (Scopus)
181 Downloads (Pure)

Regulation of cell proliferation and apoptosis in neuroblastoma cells by ccp1, a FGF2 downstream gene

Pellicano, F., Thomson, R. E., Inman, G. J. & Iwata, T., 30 Nov 2010, In : BMC Cancer. 10, p. - 12 p., 657.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Autocrine Bone Morphogenetic Protein-9 Signals through Activin Receptor-like Kinase-2/Smad1/Smad4 to Promote Ovarian Cancer Cell Proliferation

Herrera, B., van Dinther, M., ten Dijke, P. & Inman, G. J., 15 Dec 2009, In : Cancer Research. 69, 24, p. 9254-9262 9 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)

Targeting the BCL-2 family in malignancies of germinal centre origin

Spender, L. C. & Inman, G. J., Dec 2009, In : Expert Opinion on Therapeutic Targets. 13, 12, p. 1459-1472 14 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)

TGF-beta induces apoptosis in human B cells by transcriptional regulation of BIK and BCL-X-L

Spender, L. C., O'Brien, D. I., Simpson, D., Dutt, D., Gregory, C. D., Allday, M. J., Clark, L. J. & Inman, G. J., Apr 2009, In : Cell Death & Differentiation. 16, 4, p. 593-602 10 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)
28 Citations (Scopus)

TGF-beta-mediated activation of RhoA signalling is required for efficient (V12)HaRas and (V600E)BRAF transformation

Fleming, Y. M., Ferguson, G. J., Spender, L. C., Larsson, J., Karlsson, S., Ozanne, B. W., Grosse, R. & Inman, G. J., 19 Feb 2009, In : Oncogene. 28, 7, p. 983-993 11 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
2008

NCAM Is at the Heart of Reciprocal Regulation of E-Cadherin- and Integrin-Mediated Adhesions via Signaling Modulation

Frame, M. C. & Inman, G. J., 14 Oct 2008, In : Developmental Cell. 15, 4, p. 494-496 3 p.

Research output: Contribution to journalEditorial

21 Citations (Scopus)

TSC22 in mammary gland development and breast cancer

Huser, C., Heath, V., Pringle, M-A., Bell, A. K., Crighton, D., Ryan, K., Inman, G., Stein, T. & Gusterson, B., 2008, In : Breast Cancer Research. 10, p. S11 1 p.

Research output: Contribution to journalMeeting abstract

2005

Linking Smads and transcriptional activation

Inman, G. J., 2005, In : Biochemical Journal. 386, Pt 1, p. e1-e3

Research output: Contribution to journalArticle

21 Citations (Scopus)
2002

A novel Xenopus Smad-interacting forkhead transcription factor (XFast-3) cooperates with XFast-1 in regulating gastrulation movements

Howell, M., Inman, G. J. & Hill, C. S., 2002, In : Development. 129, 12, p. 2823-2834 12 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif

Randall, R. A., Germain, S., Inman, G. J., Bates, P. A. & Hill, C. S., 2002, In : EMBO Journal. 21, 1-2, p. 145-156 12 p.

Research output: Contribution to journalArticle

75 Citations (Scopus)

Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity

Inman, G. J., Nicolás, F. J. & Hill, C. S., 2002, In : Molecular Cell. 10, 2, p. 283-294 12 p.

Research output: Contribution to journalArticle

296 Citations (Scopus)

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

Inman, G. J., Nicolás, F. J., Callahan, J. F., Harling, J. D., Gaster, L. M., Reith, A. D., Laping, N. J. & Hill, C. S., 1 Jul 2002, In : Molecular Pharmacology. 62, 1, p. 65-74 10 p.

Research output: Contribution to journalArticle

1157 Citations (Scopus)

Stoichiometry of active smad-transcription factor complexes on DNA

Inman, G. J. & Hill, C. S., 27 Dec 2002, In : Journal of Biological Chemistry. 277, 52, p. 51008-16 9 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)
2001

Activators of the Epstein-Barr virus lytic program concomitantly induce apoptosis, but lytic gene expression protects from cell death

Inman, G. J., Binné, U. K., Parker, G. A., Farrell, P. J. & Allday, M. J., 2001, In : Journal of Virology. 75, 5, p. 2400-2410 11 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)
2000

Apoptosis induced by TGF-beta 1 in Burkitt's lymphoma cells is caspase 8 dependent but is death receptor independent

Inman, G. J. & Allday, M. J., 1 Sep 2000, In : Journal of Immunology. 165, 5, p. 2500-10 11 p.

Research output: Contribution to journalArticle

75 Citations (Scopus)
46 Citations (Scopus)
1998

Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP

Srivastava, S., Osten, P., Vilim, F. S., Khatri, L., Inman, G., States, B., Daly, C., DeSouza, S., Abagyan, R., Valtschanoff, J. G., Weinberg, R. J. & Ziff, E. B., 1998, In : Neuron. 21, 3, p. 581-591 11 p.

Research output: Contribution to journalArticle

306 Citations (Scopus)