Inman, Gareth

Professor

  • 3612 Citations
  • 28 h-Index
1991 …2020

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2019

Preclinical Evaluation of AZ12601011 and AZ12799734, Inhibitors of Transforming Growth Factor β Superfamily Type 1 Receptors.

Spender, L. C., Ferguson, G. J., Hughes, G. D., Davies, B. R., Goldberg, F. W., Herrera, B., Taylor, R. G., Strathearn, L., Sansom, O. J., Barry, S. T. & Inman, G., 1 Feb 2019, In : Molecular Pharmacology. 95, 2, p. 222-234 13 p.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
194 Downloads (Pure)
2018

Differential expression of secreted factors SOSTDC1 and ADAMTS8 cause pro-fibrotic changes in linear morphoea fibroblasts

Badshah, I. I., Brown, S., Weibel, L., Rose, A., Way, B., Sebire, N., Inman, G., Harper, J., Kinsler, V. & O'Shaughnessy, R., 26 Oct 2018, In : British Journal of Dermatology.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
98 Downloads (Pure)

Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma

Rose, A. M., Spender, L. C., Stephen, C., Mitchell, A., Rickaby, W., Bray, S., Evans, A. T., Dayal, J., Purdie, K. J., Harwood, C. A., Proby, C. M., Leigh, I. M., Coates, P. J. . & Inman, G. J., 6 Mar 2018, In : Oncotarget. 9, 18, p. 14552-14566 15 p.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
178 Downloads (Pure)

The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature

Inman, G. J., Wang, J., Nagano, A., Alexandrov, L. B., Purdie, K. J., Taylor, R. G., Sherwood, V., Thomson, J., Hogan, S., Spender, L. C., South, A. P., Stratton, M., Chelala, C., Harwood, C. A., Proby, C. M. & Leigh, I. M., 10 Sep 2018, In : Nature Communications. 9, 1, p. 1-14 14 p., 3667.

Research output: Contribution to journalArticle

Open Access
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32 Citations (Scopus)
139 Downloads (Pure)

The Role of Human Papillomaviruses and Polyomaviruses in BRAF-Inhibitor Induced Cutaneous Squamous Cell Carcinoma and Benign Squamoproliferative Lesions

Purdie, K. J., Proby, C. M., Rizvi, H., Griffin, H., Doorbar, J., Sommerlad, M., Feltkamp, M. C., Van der Meijden, E., Inman, G. J., South, A. P., Leigh, I. M. & Harwood, C. A., 14 Aug 2018, In : Frontiers in Microbiology. 9, 16 p., 1806.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
128 Downloads (Pure)
2017

TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis

Cammareri, P., Vincent, D. F., Hodder, M. C., Ridgway, R. A., Murgia, C., Nobis, M., Campbell, A. D., Varga, J., Huels, D. J., Subramani, C., Prescott, K. L. H., Nixon, C., Hedley, A., Barry, S. T., Greten, F. R., Inman, G. J. & Sansom, O. J., Oct 2017, In : Cell Death & Differentiation. 24, 10, p. 1681-1693 13 p.

Research output: Contribution to journalArticle

Open Access
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17 Citations (Scopus)
157 Downloads (Pure)

TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling

Hurst, L. A., Dunmore, B. J., Long, L., Crosby, A., Al-Lamki, R., Deighton, J., Southwood, M., Yang, X., Nikolic, M. Z., Herrera, B., Inman, G. J., Bradley, J. R., Rana, A. A., Upton, P. D. & Morrell, N. W., 13 Jan 2017, In : Nature Communications. 8, p. 1-14 14 p., 14079.

Research output: Contribution to journalArticle

Open Access
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49 Citations (Scopus)
166 Downloads (Pure)

Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development

Phillips, T. J., Scott, H., Menassa, D. A., Bignell, A. L., Sood, A., Morton, J. S., Akagi, T., Azuma, K., Rogers, M. F., Gilmore, C. E., Inman, G. J., Grant, S., Chung, Y., Aljunaidy, M. M., Cooke, C-L., Steinkraus, B. R., Pocklington, A., Logan, A., Collett, G. P., Kemp, H. & 7 others, Holmans, P. A., Murphy, M. P., Fulga, T. A., Coney, A. M., Akashi, M., Davidge, S. T. & Case, C. P., 22 Aug 2017, In : Scientific Reports. 7, p. 1-16 16 p., 9079.

Research output: Contribution to journalArticle

Open Access
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19 Citations (Scopus)
181 Downloads (Pure)
2016

Exosome-mediated transfer from the tumor microenvironment increases TGFβ signaling in squamous cell carcinoma

Languino, L. R., Singh, A., Prisco, M., Inman, G. J., Luginbuhl, A., Curry, J. M. & South, A. P., 30 May 2016, In : American Journal of Translational Research. 8, 5, p. 2432-2437 6 p.

Research output: Contribution to journalArticle

Open Access
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32 Citations (Scopus)
54 Downloads (Pure)

Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma

Cammareri, P., Rose, A., Vincent, D. F., Wang, J., Nagano, A., Libertini, S., Ridgway, R. A., Athineos, D., Coates, P. J. ., McHugh, A., Pourreyron, C., Dayal, J., Larsson, J., Weidlich, S., Spender, L., Sapkota, G., Purdie, K. J., Proby, C., Harwood, C. A., Leigh, I. & 9 others, Clevers, H., Barker, N., Karlsson, S., Pritchard, C., Marais, R., Chelala, C., South, A., Sansom, O. J. & Inman, G., 25 Aug 2016, In : Nature Communications. 7, p. 1-7 7 p., 12493.

Research output: Contribution to journalArticle

Open Access
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41 Citations (Scopus)
120 Downloads (Pure)

Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells

Spender, L. C., Ferguson, G. J., Liu, S., Cui, C., Girotti, M. R., Sibbet, G., Higgs, E. B., Shuttleworth, M. K., Hamilton, T., Lorigan, P., Weller, M., Vincent, D. F., Sansom, O. J., Frame, M., Ten Dijke, P., Marais, R. & Inman, G. J., 13 Dec 2016, In : Oncotarget. 7, 50, p. 81995-82012 18 p.

Research output: Contribution to journalArticle

Open Access
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9 Citations (Scopus)
230 Downloads (Pure)
2014

E3 ubiquitin ligase HOIP attenuates apoptotic cell death induced by cisplatin

MacKay, C., Carroll, E., Ibrahim, A. F. M., Garg, A., Inman, G. J., Hay, R. T. & Alpi, A. F., 15 Apr 2014, In : Cancer Research. 74, 8, p. 2246-2257 12 p.

Research output: Contribution to journalArticle

Open Access
33 Citations (Scopus)
2013

BMP9 is a proliferative and survival factor for human hepatocellular carcinoma cells

Herrera, B., García-Álvaro, M., Cruz, S., Walsh, P., Fernández, M., Roncero, C., Fabregat, I., Sánchez, A. & Inman, G. J., 23 Jul 2013, In : PLoS ONE. 8, 7, e69535.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Methylated tissue factor pathway inhibitor 2 (TFPI2) DNA in serum is a biomarker of metastatic melanoma

Nigro, C. L., Wang, H., McHugh, A., Lattanzio, L., Matin, R., Harwood, C., Syed, N., Hatzimichael, E., Briasoulis, E., Merlano, M., Evans, A., Thompson, A., Leigh, I., Fleming, C., Inman, G. J., Proby, C. & Crook, T., May 2013, In : Journal of Investigative Dermatology. 133, 5, p. 1278-1285 8 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)
2012

Crosstalk between p53 and TGF-β Signalling

Elston, R. & Inman, G. J., 2012, In : Journal of Signal Transduction. 2012, p. 294097

Research output: Contribution to journalArticle

NT5E (CD73) is epigenetically regulated in malignant melanoma and associated with metastatic site specificity

Wang, H., Lee, S., Lo Nigro, C., Lattanzio, L., Merlano, M., Monteverde, M., Matin, R., Purdie, K., Mladkova, N., Bergamaschi, D., Harwood, C., Syed, N., Szlosarek, P., Briasoulis, E., McHugh, A., Thompson, A., Evans, A., Leigh, I., Fleming, C., Inman, G. J. & 3 others, Hatzimichael, E., Proby, C. & Crook, T., 2012, In : British Journal of Cancer. 106, 8, p. 1446-52 7 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)
34 Citations (Scopus)

Transforming Growth Factor-β directly induces PUMA during the rapid induction of apoptosis in Myc-driven B-cell lymphomas.

Spender, L. C., Carter, M. J., O'Brien, D. I., Clark, L. J., Yu, J., Michalak, E. M., Happo, L., Cragg, M. S. & Inman, G. J., 2012, In : Journal of Biological Chemistry.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2011

Differing contributions of LIMK and ROCK to TGF beta-induced transcription, motility and invasion

Morin, P., Wickman, G., Munro, J., Inman, G. J. & Olson, M. F., Jan 2011, In : European Journal of Cell Biology. 90, 1, p. 13-25 13 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Inhibition of germinal centre apoptotic programmes by epstein-barr virus

Spender, L. C. & Inman, G. J., 2011, In : Advances in Hematology. 2011, p. 829525

Research output: Contribution to journalArticle

8 Citations (Scopus)
2010

Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter

Hannigan, A., Smith, P., Kalna, G., Lo Nigro, C., Orange, C., O'Brien, D. I., Shah, R., Syed, N., Spender, L. C., Herrera, B., Thurlow, J. K., Lattanzio, L., Monteverde, M., Maurer, M. E., Buffa, F. M., Mann, J., Chu, D. C. K., West, C. M. L., Patridge, M., Oien, K. A. & 8 others, Cooper, J. A., Frame, M. C., Harris, A. L., Hiller, L., Nicholson, L. J., Gasco, M., Crook, T. & Inman, G. J., Aug 2010, In : Journal of Clinical Investigation. 120, 8, p. 2842-2857 16 p.

Research output: Contribution to journalArticle

Open Access
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62 Citations (Scopus)
185 Downloads (Pure)

Regulation of cell proliferation and apoptosis in neuroblastoma cells by ccp1, a FGF2 downstream gene

Pellicano, F., Thomson, R. E., Inman, G. J. & Iwata, T., 30 Nov 2010, In : BMC Cancer. 10, p. - 12 p., 657.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Autocrine Bone Morphogenetic Protein-9 Signals through Activin Receptor-like Kinase-2/Smad1/Smad4 to Promote Ovarian Cancer Cell Proliferation

Herrera, B., van Dinther, M., ten Dijke, P. & Inman, G. J., 15 Dec 2009, In : Cancer Research. 69, 24, p. 9254-9262 9 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)

TGF-beta induces apoptosis in human B cells by transcriptional regulation of BIK and BCL-X-L

Spender, L. C., O'Brien, D. I., Simpson, D., Dutt, D., Gregory, C. D., Allday, M. J., Clark, L. J. & Inman, G. J., Apr 2009, In : Cell Death & Differentiation. 16, 4, p. 593-602 10 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)
28 Citations (Scopus)

TGF-beta-mediated activation of RhoA signalling is required for efficient (V12)HaRas and (V600E)BRAF transformation

Fleming, Y. M., Ferguson, G. J., Spender, L. C., Larsson, J., Karlsson, S., Ozanne, B. W., Grosse, R. & Inman, G. J., 19 Feb 2009, In : Oncogene. 28, 7, p. 983-993 11 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
2005

Linking Smads and transcriptional activation

Inman, G. J., 2005, In : Biochemical Journal. 386, Pt 1, p. e1-e3

Research output: Contribution to journalArticle

21 Citations (Scopus)
2002

A novel Xenopus Smad-interacting forkhead transcription factor (XFast-3) cooperates with XFast-1 in regulating gastrulation movements

Howell, M., Inman, G. J. & Hill, C. S., 2002, In : Development. 129, 12, p. 2823-2834 12 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif

Randall, R. A., Germain, S., Inman, G. J., Bates, P. A. & Hill, C. S., 2002, In : EMBO Journal. 21, 1-2, p. 145-156 12 p.

Research output: Contribution to journalArticle

75 Citations (Scopus)

Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity

Inman, G. J., Nicolás, F. J. & Hill, C. S., 2002, In : Molecular Cell. 10, 2, p. 283-294 12 p.

Research output: Contribution to journalArticle

297 Citations (Scopus)

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

Inman, G. J., Nicolás, F. J., Callahan, J. F., Harling, J. D., Gaster, L. M., Reith, A. D., Laping, N. J. & Hill, C. S., 1 Jul 2002, In : Molecular Pharmacology. 62, 1, p. 65-74 10 p.

Research output: Contribution to journalArticle

1167 Citations (Scopus)

Stoichiometry of active smad-transcription factor complexes on DNA

Inman, G. J. & Hill, C. S., 27 Dec 2002, In : Journal of Biological Chemistry. 277, 52, p. 51008-16 9 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)
2001

Activators of the Epstein-Barr virus lytic program concomitantly induce apoptosis, but lytic gene expression protects from cell death

Inman, G. J., Binné, U. K., Parker, G. A., Farrell, P. J. & Allday, M. J., 2001, In : Journal of Virology. 75, 5, p. 2400-2410 11 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)
2000

Apoptosis induced by TGF-beta 1 in Burkitt's lymphoma cells is caspase 8 dependent but is death receptor independent

Inman, G. J. & Allday, M. J., 1 Sep 2000, In : Journal of Immunology. 165, 5, p. 2500-10 11 p.

Research output: Contribution to journalArticle

75 Citations (Scopus)
46 Citations (Scopus)
1998

Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP

Srivastava, S., Osten, P., Vilim, F. S., Khatri, L., Inman, G., States, B., Daly, C., DeSouza, S., Abagyan, R., Valtschanoff, J. G., Weinberg, R. J. & Ziff, E. B., 1998, In : Neuron. 21, 3, p. 581-591 11 p.

Research output: Contribution to journalArticle

306 Citations (Scopus)

The AMPA receptor GluR2 C terminus can mediate a reversible, ATP-dependent interaction with NSF and alpha- and beta-SNAPs

Osten, P., Srivastava, S., Inman, G. J., Vilim, F. S., Khatri, L., Lee, L. M., States, B. A., Einheber, S., Milner, T. A., Hanson, P. I. & Ziff, E. B., 1998, In : Neuron. 21, 1, p. 99-110 12 p.

Research output: Contribution to journalArticle

299 Citations (Scopus)
1995

DNA damage in human B cells can induce apoptosis, proceeding from G1/S when p53 is transactivation competent and G2/M when it is transactivation defective

Allday, M. J., Inman, G. J., Crawford, D. H. & Farrell, P. J., 1995, In : EMBO Journal. 14, 20, p. 4994-5005 12 p.

Research output: Contribution to journalArticle

96 Citations (Scopus)

Epstein-Barr virus EBNA-LP and transcription regulation properties of pRB, p107 and p53 in transfection assays

Inman, G. J. & Farrell, P. J., Sep 1995, In : Journal of General Virology. 76, 9, p. 2141-9 9 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
1993

Human papillomaviruses, tumour suppressor genes and cervical cancer

Inman, G. J., Cook, I. D. & Lau, R. K., 1993, In : International journal of STD & AIDS. 4, 3, p. 128-134 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
1992

Cell growth effects of Epstein-Barr virus leader protein

Allan, G. J., Inman, G. J., Parker, B. D., Rowe, D. T. & Farrell, P. J., 1992, In : Journal of General Virology. 73 , 6, p. 1547-1551 5 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)
1991

The gene for apocytochrome B of Theileria annulata resides on a small linear extrachromosomal element

Megson, A., Inman, G. J., Hunt, P. D., Baylis, H. A. & Hall, R., 1991, In : Molecular and Biochemical Parasitology. 48, 1, p. 113-115 3 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)