Inman, Gareth

Professor

Accepting PhD Students

  • 3420 Citations
  • 26 h-Index
1991 …2020
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Research Output 1991 2019

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Article
2019
2 Citations (Scopus)
117 Downloads (Pure)

Preclinical Evaluation of AZ12601011 and AZ12799734, Inhibitors of Transforming Growth Factor β Superfamily Type 1 Receptors.

Spender, L. C., Ferguson, G. J., Hughes, G. D., Davies, B. R., Goldberg, F. W., Herrera, B., Taylor, R. G., Strathearn, L., Sansom, O. J., Barry, S. T. & Inman, G., 1 Feb 2019, In : Molecular Pharmacology. 95, 2, p. 222-234 13 p.

Research output: Contribution to journalArticle

Open Access
File
Transforming Growth Factors
Activin Receptors
LY-2157299
Bone Morphogenetic Proteins
Bone Morphogenetic Protein Receptors
2018
1 Citation (Scopus)

Differential expression of secreted factors SOSTDC1 and ADAMTS8 cause pro-fibrotic changes in linear morphoea fibroblasts

Badshah, I. I., Brown, S., Weibel, L., Rose, A., Way, B., Sebire, N., Inman, G., Harper, J., Kinsler, V. & O'Shaughnessy, R., 26 Oct 2018, In : British Journal of Dermatology.

Research output: Contribution to journalArticle

Localized Scleroderma
Fibroblasts
Myofibroblasts
Transforming Growth Factors
Therapeutics
121 Downloads (Pure)

Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma

Rose, A. M., Spender, L. C., Stephen, C., Mitchell, A., Rickaby, W., Bray, S., Evans, A. T., Dayal, J., Purdie, K. J., Harwood, C. A., Proby, C. M., Leigh, I. M., Coates, P. J. . & Inman, G. J., 6 Mar 2018, In : Oncotarget. 9, 18, p. 14552-14566 15 p.

Research output: Contribution to journalArticle

Open Access
File
Squamous Cell Carcinoma
Skin
Transforming Growth Factor beta
Inhibin-beta Subunits
Neoplasms
19 Citations (Scopus)
75 Downloads (Pure)

The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature

Inman, G. J., Wang, J., Nagano, A., Alexandrov, L. B., Purdie, K. J., Taylor, R. G., Sherwood, V., Thomson, J., Hogan, S., Spender, L. C., South, A. P., Stratton, M., Chelala, C., Harwood, C. A., Proby, C. M. & Leigh, I. M., 10 Sep 2018, In : Nature Communications. 9, 1, p. 1-14 14 p., 3667.

Research output: Contribution to journalArticle

Open Access
File
Azathioprine
Tumors
tumors
signatures
Skin
2 Citations (Scopus)
67 Downloads (Pure)

The Role of Human Papillomaviruses and Polyomaviruses in BRAF-Inhibitor Induced Cutaneous Squamous Cell Carcinoma and Benign Squamoproliferative Lesions

Purdie, K. J., Proby, C. M., Rizvi, H., Griffin, H., Doorbar, J., Sommerlad, M., Feltkamp, M. C., Van der Meijden, E., Inman, G. J., South, A. P., Leigh, I. M. & Harwood, C. A., 14 Aug 2018, In : Frontiers in Microbiology. 9, 16 p., 1806.

Research output: Contribution to journalArticle

Open Access
File
Polyomavirus
Squamous Cell Carcinoma
Skin
Mutation
Warts
2017
12 Citations (Scopus)
93 Downloads (Pure)

TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis

Cammareri, P., Vincent, D. F., Hodder, M. C., Ridgway, R. A., Murgia, C., Nobis, M., Campbell, A. D., Varga, J., Huels, D. J., Subramani, C., Prescott, K. L. H., Nixon, C., Hedley, A., Barry, S. T., Greten, F. R., Inman, G. J. & Sansom, O. J., Oct 2017, In : Cell Death & Differentiation. 24, 10, p. 1681-1693 13 p.

Research output: Contribution to journalArticle

Open Access
File
Cell Dedifferentiation
Neoplasms
Mutation
Neoplastic Stem Cells
Mitogen-Activated Protein Kinase Kinases
33 Citations (Scopus)
102 Downloads (Pure)

TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling

Hurst, L. A., Dunmore, B. J., Long, L., Crosby, A., Al-Lamki, R., Deighton, J., Southwood, M., Yang, X., Nikolic, M. Z., Herrera, B., Inman, G. J., Bradley, J. R., Rana, A. A., Upton, P. D. & Morrell, N. W., 13 Jan 2017, In : Nature Communications. 8, p. 1-14 14 p., 14079.

Research output: Contribution to journalArticle

Open Access
File
Type II Bone Morphogenetic Protein Receptors
hypertension
necrosis
Pulmonary Hypertension
bones
17 Citations (Scopus)
128 Downloads (Pure)

Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development

Phillips, T. J., Scott, H., Menassa, D. A., Bignell, A. L., Sood, A., Morton, J. S., Akagi, T., Azuma, K., Rogers, M. F., Gilmore, C. E., Inman, G. J., Grant, S., Chung, Y., Aljunaidy, M. M., Cooke, C-L., Steinkraus, B. R., Pocklington, A., Logan, A., Collett, G. P., Kemp, H. & 7 others, Holmans, P. A., Murphy, M. P., Fulga, T. A., Coney, A. M., Akashi, M., Davidge, S. T. & Case, C. P., 22 Aug 2017, In : Scientific Reports. 7, p. 1-16 16 p., 9079.

Research output: Contribution to journalArticle

Open Access
File
Fetal Development
Placenta
Brain
Schizophrenia
Oxidative Stress
2016
24 Citations (Scopus)
50 Downloads (Pure)

Exosome-mediated transfer from the tumor microenvironment increases TGFβ signaling in squamous cell carcinoma

Languino, L. R., Singh, A., Prisco, M., Inman, G. J., Luginbuhl, A., Curry, J. M. & South, A. P., 30 May 2016, In : American Journal of Translational Research. 8, 5, p. 2432-2437 6 p.

Research output: Contribution to journalArticle

Open Access
File
Exosomes
Tumor Microenvironment
Transforming Growth Factor beta
Tumors
Squamous Cell Carcinoma
34 Citations (Scopus)
70 Downloads (Pure)

Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma

Cammareri, P., Rose, A., Vincent, D. F., Wang, J., Nagano, A., Libertini, S., Ridgway, R. A., Athineos, D., Coates, P. J. ., McHugh, A., Pourreyron, C., Dayal, J., Larsson, J., Weidlich, S., Spender, L., Sapkota, G., Purdie, K. J., Proby, C., Harwood, C. A., Leigh, I. & 9 others, Clevers, H., Barker, N., Karlsson, S., Pritchard, C., Marais, R., Chelala, C., South, A., Sansom, O. J. & Inman, G., 25 Aug 2016, In : Nature Communications. 7, p. 1-7 7 p., 12493.

Research output: Contribution to journalArticle

Open Access
File
stem cells
Stem cells
deactivation
Squamous Cell Carcinoma
Stem Cells
7 Citations (Scopus)
172 Downloads (Pure)

Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells

Spender, L. C., Ferguson, G. J., Liu, S., Cui, C., Girotti, M. R., Sibbet, G., Higgs, E. B., Shuttleworth, M. K., Hamilton, T., Lorigan, P., Weller, M., Vincent, D. F., Sansom, O. J., Frame, M., Ten Dijke, P., Marais, R. & Inman, G. J., 13 Dec 2016, In : Oncotarget. 7, 50, p. 81995-82012 18 p.

Research output: Contribution to journalArticle

Open Access
File
Transforming Growth Factors
Transforming Growth Factor beta
Melanoma
Drug Resistance
Neoplasms
2014
25 Citations (Scopus)

E3 ubiquitin ligase HOIP attenuates apoptotic cell death induced by cisplatin

MacKay, C., Carroll, E., Ibrahim, A. F. M., Garg, A., Inman, G. J., Hay, R. T. & Alpi, A. F., 15 Apr 2014, In : Cancer Research. 74, 8, p. 2246-2257 12 p.

Research output: Contribution to journalArticle

Open Access
Ubiquitin-Protein Ligases
Cisplatin
Cell Death
Ubiquitin
Small Interfering RNA
2013
38 Citations (Scopus)

BMP9 is a proliferative and survival factor for human hepatocellular carcinoma cells

Herrera, B., García-Álvaro, M., Cruz, S., Walsh, P., Fernández, M., Roncero, C., Fabregat, I., Sánchez, A. & Inman, G. J., 23 Jul 2013, In : PLoS ONE. 8, 7, e69535.

Research output: Contribution to journalArticle

hepatoma
Liver
Hepatocellular Carcinoma
Hep G2 Cells
Cells
29 Citations (Scopus)

Methylated tissue factor pathway inhibitor 2 (TFPI2) DNA in serum is a biomarker of metastatic melanoma

Nigro, C. L., Wang, H., McHugh, A., Lattanzio, L., Matin, R., Harwood, C., Syed, N., Hatzimichael, E., Briasoulis, E., Merlano, M., Evans, A., Thompson, A., Leigh, I., Fleming, C., Inman, G. J., Proby, C. & Crook, T., May 2013, In : Journal of Investigative Dermatology. 133, 5, p. 1278-1285 8 p.

Research output: Contribution to journalArticle

Biomarkers
Melanoma
DNA
Serum
CpG Islands
2012

Crosstalk between p53 and TGF-β Signalling

Elston, R. & Inman, G. J., 2012, In : Journal of Signal Transduction. 2012, p. 294097

Research output: Contribution to journalArticle

Crosstalk
Tumors
MicroRNAs
Genes
Neoplasms
47 Citations (Scopus)

NT5E (CD73) is epigenetically regulated in malignant melanoma and associated with metastatic site specificity

Wang, H., Lee, S., Lo Nigro, C., Lattanzio, L., Merlano, M., Monteverde, M., Matin, R., Purdie, K., Mladkova, N., Bergamaschi, D., Harwood, C., Syed, N., Szlosarek, P., Briasoulis, E., McHugh, A., Thompson, A., Evans, A., Leigh, I., Fleming, C., Inman, G. J. & 3 others, Hatzimichael, E., Proby, C. & Crook, T., 2012, In : British Journal of Cancer. 106, 8, p. 1446-52 7 p.

Research output: Contribution to journalArticle

Melanoma
Methylation
CpG Islands
Viscera
Epigenomics
34 Citations (Scopus)
22 Citations (Scopus)

Transforming Growth Factor-β directly induces PUMA during the rapid induction of apoptosis in Myc-driven B-cell lymphomas.

Spender, L. C., Carter, M. J., O'Brien, D. I., Clark, L. J., Yu, J., Michalak, E. M., Happo, L., Cragg, M. S. & Inman, G. J., 2012, In : Journal of Biological Chemistry.

Research output: Contribution to journalArticle

Transforming Growth Factors
B-Cell Lymphoma
Cell death
Burkitt Lymphoma
Cells
2011
22 Citations (Scopus)

Differing contributions of LIMK and ROCK to TGF beta-induced transcription, motility and invasion

Morin, P., Wickman, G., Munro, J., Inman, G. J. & Olson, M. F., Jan 2011, In : European Journal of Cell Biology. 90, 1, p. 13-25 13 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Inhibition of germinal centre apoptotic programmes by epstein-barr virus

Spender, L. C. & Inman, G. J., 2011, In : Advances in Hematology. 2011, p. 829525

Research output: Contribution to journalArticle

Germinal Center
Human Herpesvirus 4
B-Lymphocytes
Epstein-Barr Virus Infections
Viral Genes
2010
59 Citations (Scopus)
152 Downloads (Pure)

Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter

Hannigan, A., Smith, P., Kalna, G., Lo Nigro, C., Orange, C., O'Brien, D. I., Shah, R., Syed, N., Spender, L. C., Herrera, B., Thurlow, J. K., Lattanzio, L., Monteverde, M., Maurer, M. E., Buffa, F. M., Mann, J., Chu, D. C. K., West, C. M. L., Patridge, M., Oien, K. A. & 8 others, Cooper, J. A., Frame, M. C., Harris, A. L., Hiller, L., Nicholson, L. J., Gasco, M., Crook, T. & Inman, G. J., Aug 2010, In : Journal of Clinical Investigation. 120, 8, p. 2842-2857 16 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)

Regulation of cell proliferation and apoptosis in neuroblastoma cells by ccp1, a FGF2 downstream gene

Pellicano, F., Thomson, R. E., Inman, G. J. & Iwata, T., 30 Nov 2010, In : BMC Cancer. 10, p. - 12 p., 657.

Research output: Contribution to journalArticle

79 Citations (Scopus)

Autocrine Bone Morphogenetic Protein-9 Signals through Activin Receptor-like Kinase-2/Smad1/Smad4 to Promote Ovarian Cancer Cell Proliferation

Herrera, B., van Dinther, M., ten Dijke, P. & Inman, G. J., 15 Dec 2009, In : Cancer Research. 69, 24, p. 9254-9262 9 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

TGF-beta induces apoptosis in human B cells by transcriptional regulation of BIK and BCL-X-L

Spender, L. C., O'Brien, D. I., Simpson, D., Dutt, D., Gregory, C. D., Allday, M. J., Clark, L. J. & Inman, G. J., Apr 2009, In : Cell Death & Differentiation. 16, 4, p. 593-602 10 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
30 Citations (Scopus)

TGF-beta-mediated activation of RhoA signalling is required for efficient (V12)HaRas and (V600E)BRAF transformation

Fleming, Y. M., Ferguson, G. J., Spender, L. C., Larsson, J., Karlsson, S., Ozanne, B. W., Grosse, R. & Inman, G. J., 19 Feb 2009, In : Oncogene. 28, 7, p. 983-993 11 p.

Research output: Contribution to journalArticle

2005
20 Citations (Scopus)

Linking Smads and transcriptional activation

Inman, G. J., 2005, In : Biochemical Journal. 386, Pt 1, p. e1-e3

Research output: Contribution to journalArticle

Transcriptional Activation
Chemical activation
Transforming Growth Factor beta
Tissue homeostasis
Biological Phenomena
2002
33 Citations (Scopus)

A novel Xenopus Smad-interacting forkhead transcription factor (XFast-3) cooperates with XFast-1 in regulating gastrulation movements

Howell, M., Inman, G. J. & Hill, C. S., 2002, In : Development. 129, 12, p. 2823-2834 12 p.

Research output: Contribution to journalArticle

Transcription Factor 3
Forkhead Transcription Factors
Gastrulation
Xenopus
Transforming Growth Factor beta
75 Citations (Scopus)

Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif

Randall, R. A., Germain, S., Inman, G. J., Bates, P. A. & Hill, C. S., 2002, In : EMBO Journal. 21, 1-2, p. 145-156 12 p.

Research output: Contribution to journalArticle

Proline
Transforming Growth Factor beta
Smad4 Protein
Transcription Factors
Inhibin-beta Subunits
293 Citations (Scopus)

Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity

Inman, G. J., Nicolás, F. J. & Hill, C. S., 2002, In : Molecular Cell. 10, 2, p. 283-294 12 p.

Research output: Contribution to journalArticle

Transforming Growth Factor beta Receptors
Transforming Growth Factor beta
Transducers
Cytoplasm
Epithelial Cells
1106 Citations (Scopus)

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

Inman, G. J., Nicolás, F. J., Callahan, J. F., Harling, J. D., Gaster, L. M., Reith, A. D., Laping, N. J. & Hill, C. S., 1 Jul 2002, In : Molecular Pharmacology. 62, 1, p. 65-74 10 p.

Research output: Contribution to journalArticle

Type I Activin Receptors
Transforming Growth Factor beta1
Transforming Growth Factor beta
Signal Transduction
Bone Morphogenetic Proteins
60 Citations (Scopus)

Stoichiometry of active smad-transcription factor complexes on DNA

Inman, G. J. & Hill, C. S., 27 Dec 2002, In : Journal of Biological Chemistry. 277, 52, p. 51008-16 9 p.

Research output: Contribution to journalArticle

Stoichiometry
Transcription Factors
DNA
Transforming Growth Factor beta
Oligomers
2001
54 Citations (Scopus)

Activators of the Epstein-Barr virus lytic program concomitantly induce apoptosis, but lytic gene expression protects from cell death

Inman, G. J., Binné, U. K., Parker, G. A., Farrell, P. J. & Allday, M. J., 2001, In : Journal of Virology. 75, 5, p. 2400-2410 11 p.

Research output: Contribution to journalArticle

Human herpesvirus 4
Human Herpesvirus 4
cell death
Cell Death
apoptosis
2000
73 Citations (Scopus)

Apoptosis induced by TGF-beta 1 in Burkitt's lymphoma cells is caspase 8 dependent but is death receptor independent

Inman, G. J. & Allday, M. J., 1 Sep 2000, In : Journal of Immunology. 165, 5, p. 2500-10 11 p.

Research output: Contribution to journalArticle

Transforming Growth Factor beta1
Death Domain Receptors
Burkitt Lymphoma
Caspase 8
Transforming Growth Factor beta
45 Citations (Scopus)
Transforming Growth Factor beta1
Burkitt Lymphoma
Human Herpesvirus 4
Cell Line
Transforming Growth Factor beta
1998
305 Citations (Scopus)

Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP

Srivastava, S., Osten, P., Vilim, F. S., Khatri, L., Inman, G., States, B., Daly, C., DeSouza, S., Abagyan, R., Valtschanoff, J. G., Weinberg, R. J. & Ziff, E. B., 1998, In : Neuron. 21, 3, p. 581-591 11 p.

Research output: Contribution to journalArticle

Post-Synaptic Density
AMPA Receptors
Receptor-Interacting Protein Serine-Threonine Kinases
Carrier Proteins
Glutamate Receptors
294 Citations (Scopus)

The AMPA receptor GluR2 C terminus can mediate a reversible, ATP-dependent interaction with NSF and alpha- and beta-SNAPs

Osten, P., Srivastava, S., Inman, G. J., Vilim, F. S., Khatri, L., Lee, L. M., States, B. A., Einheber, S., Milner, T. A., Hanson, P. I. & Ziff, E. B., 1998, In : Neuron. 21, 1, p. 99-110 12 p.

Research output: Contribution to journalArticle

Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins
N-Ethylmaleimide-Sensitive Proteins
AMPA Receptors
Adenosine Triphosphate
SNARE Proteins
1995
96 Citations (Scopus)

DNA damage in human B cells can induce apoptosis, proceeding from G1/S when p53 is transactivation competent and G2/M when it is transactivation defective

Allday, M. J., Inman, G. J., Crawford, D. H. & Farrell, P. J., 1995, In : EMBO Journal. 14, 20, p. 4994-5005 12 p.

Research output: Contribution to journalArticle

Transcriptional Activation
DNA Damage
B-Lymphocytes
Cells
Apoptosis
32 Citations (Scopus)

Epstein-Barr virus EBNA-LP and transcription regulation properties of pRB, p107 and p53 in transfection assays

Inman, G. J. & Farrell, P. J., Sep 1995, In : Journal of General Virology. 76, 9, p. 2141-9 9 p.

Research output: Contribution to journalArticle

Human Herpesvirus 4
Transfection
Proteins
Transcriptional Activation
Simian virus 40
1993
11 Citations (Scopus)

Human papillomaviruses, tumour suppressor genes and cervical cancer

Inman, G. J., Cook, I. D. & Lau, R. K., 1993, In : International journal of STD & AIDS. 4, 3, p. 128-134 7 p.

Research output: Contribution to journalArticle

Human papillomavirus 18
Tumor Suppressor Genes
Cervix Uteri
Uterine Cervical Neoplasms
Squamous Cell Carcinoma
1992
38 Citations (Scopus)

Cell growth effects of Epstein-Barr virus leader protein

Allan, G. J., Inman, G. J., Parker, B. D., Rowe, D. T. & Farrell, P. J., 1992, In : Journal of General Virology. 73 , 6, p. 1547-1551 5 p.

Research output: Contribution to journalArticle

Epstein-Barr Virus Nuclear Antigens
Human Herpesvirus 4
Growth
Proteins
Cell Line
1991
15 Citations (Scopus)

The gene for apocytochrome B of Theileria annulata resides on a small linear extrachromosomal element

Megson, A., Inman, G. J., Hunt, P. D., Baylis, H. A. & Hall, R., 1991, In : Molecular and Biochemical Parasitology. 48, 1, p. 113-115 3 p.

Research output: Contribution to journalArticle