Barton, Geoffrey

Professor

  • United Kingdom

Accepting PhD Students

  • 19267 Citations
  • 58 h-Index
1987 …2023
If you made any changes in Pure these will be visible here soon.

Research Output 1987 2019

2019
20 Downloads (Pure)

Detection and Mitigation of Spurious Antisense RNA-seq Reads with RoSA

Mourao, K., Schurch, N., Lukoszek, R., Froussios, K., Mackinnon, K., Duc, C., Simpson, G. & Barton, G., 10 Jun 2019, In : F1000 Research. 8, 7 p., 819.

Research output: Contribution to journalArticle

Open Access
File
Antisense RNA
RNA
Gene Expression
Genes
Arabidopsis
29 Downloads (Pure)
Open Access
File
Differential Expression
Eukaryota
RNA
Gene expression
Gene Expression
26 Downloads (Pure)
Open Access
File
RNA Isoforms
Protein Isoforms
RNA
Transcriptome
Drosophila
2018
2 Citations (Scopus)
82 Downloads (Pure)

JABAWS 2.2 Distributed Web Services for Bioinformatics: Protein Disorder, Conservation and RNA Secondary Structure

Troshin, P. V., Procter, J. B., Sherstnev, A., Barton, D. L., Madeira, F. & Barton, G. J., 1 Jun 2018, In : Bioinformatics. 34, 11, p. 1939-1940 2 p., byt045.

Research output: Contribution to journalArticle

Open Access
File
RNA Secondary Structure
Sequence Alignment
Bioinformatics
Computational Biology
RNA
158 Downloads (Pure)

Proteus: an R package for downstream analysis of MaxQuant output

Gierlinski, M., Gastaldello, F., Cole, C. & Barton, G., 20 Sep 2018, In : BioRxiv. 10 p.

Research output: Contribution to journalArticle

Open Access
File
Proteus
Peptides
Mass Spectrometry
Proteins
2017
3 Citations (Scopus)
103 Downloads (Pure)
Open Access
File
Dictyostelium
Adenylyl Cyclases
Genes
Cell Movement
bis(3',5')-cyclic diguanylic acid
36 Downloads (Pure)

Correction: A study of the structural properties of sites modified by the O-linked 6-N-acetylglucosamine transferase

Britto Borges, T. & Barton, G., 27 Dec 2017, In : PLoS ONE. 12, 12, p. 1 1 p., e0190461.

Research output: Contribution to journalComment/debate

Open Access
File
12 Downloads (Pure)

Human Missense Variation is Constrained by Domain Structure and Highlights Functional and Pathogenic Residues

MacGowan, S., Madeira, F., Britto Borges, T., Schmittner, M. S., Cole, C. & Barton, G., 13 Apr 2017, In : BioRxiv. 35 p.

Research output: Contribution to journalArticle

File
RNA Splice Sites
Ligands
Proteins
Sequence Alignment
DNA-Binding Proteins
1 Citation (Scopus)
33 Downloads (Pure)

Improved annotation with de novo transcriptome assembly in four social amoeba species

Singh, R., Lawal, H. M., Schilde, C., Glöckner, G., Barton, G. J., Schaap, P. & Cole, C., 31 Jan 2017, In : BMC Genomics. 18, p. 1-17 17 p., 120.

Research output: Contribution to journalArticle

Open Access
File
Amoeba
Transcriptome
Genome
RNA Sequence Analysis
Molecular Sequence Annotation
13 Citations (Scopus)
65 Downloads (Pure)

Mapping genetic variations to three-dimensional protein structures to enhance variant interpretation: A proposed framework

Glusman, G., Rose, P. W., Prlić, A., Dougherty, J., Duarte, J. M., Hoffman, A. S., Barton, G. J., Bendixen, E., Bergquist, T., Bock, C., Brunk, E., Buljan, M., Burley, S. K., Cai, B., Carter, H., Gao, J. J., Godzik, A., Heuer, M., Hicks, M., Hrabe, T. & 17 others, Karchin, R., Leman, J. K., Lane, L., Masica, D. L., Mooney, S. D., Moult, J., Omenn, G. S., Pearl, F., Pejaver, V., Reynolds, S. M., Rokem, A., Schwede, T., Song, S., Tilgner, H., Valasatava, Y., Zhang, Y. & Deutsch, E. W., 18 Dec 2017, In : Genome Medicine. 9, 1, p. 1-10 10 p., 113.

Research output: Contribution to journalArticle

Open Access
File
Proteins
Education
Protein Databases
Precision Medicine
Mutation
2016
2 Citations (Scopus)
28 Downloads (Pure)

AlmostSignificant: simplifying quality control of high-throughput sequencing data

Ward, J., Cole, C., Febrer, M. & Barton, G. J., 15 Dec 2016, In : Bioinformatics. 32, 24, p. 3850-3851 2 p.

Research output: Contribution to journalArticle

Open Access
File
Quality Control
DNA Sequence Analysis
Sequencing
High Throughput
Quality control
13 Downloads (Pure)

AlmostSignificant: Simplifying quality control of high-throughput sequencing data

Ward, J., Cole, C., Febrer, M. & Barton, G., 16 May 2016, 2 p. BioRxiv.

Research output: Other contribution

File
DNA Sequence Analysis
Quality Control
Documentation
Technology
146 Citations (Scopus)
103 Downloads (Pure)

How many biological replicates are needed in an RNA-seq experiment and which differential expression tool should you use?

Schurch, N. J., Schofield, P., Gierliński, M., Cole, C., Sherstnev, A., Singh, V., Wrobel, N., Gharbi, K., Simpson, G. G., Owen-Hughes, T., Blaxter, M. & Barton, G. J., Jun 2016, In : RNA: a Publication of the RNA Society. 22, 6, p. 839-851 13 p.

Research output: Contribution to journalArticle

Open Access
File
RNA
Genes
Research Design
Genome
Guidelines
15 Downloads (Pure)

Improved Annotation with de novo Transcriptome Assembly in Four Social Amoeba Species

Singh, R., Lawal, H. M., Schilde, C., Gloeckner, G., Barton, G., Schaap, P. & Cole, C., 24 May 2016, 34 p. BioRxiv.

Research output: Other contribution

File
Amoeba
Transcriptome
Genome
Molecular Sequence Annotation
Globus Pallidus
2015
39 Citations (Scopus)
233 Downloads (Pure)

14-3-3-Pred: Improved methods to predict 14-3-3-binding phosphopeptides

Madeira, F., Tinti, M., Murugesan, G., Berrett, E., Stafford, M., Toth, R., Cole, C., MacKintosh, C. & Barton, G. J., 2015, In : Bioinformatics.

Research output: Contribution to journalArticle

Open Access
File
Phosphopeptides
Predict
Position-Specific Scoring Matrices
Prediction
Scoring
502 Citations (Scopus)
211 Downloads (Pure)

JPred4: a protein secondary structure prediction server

Drozdetskiy, A., Cole, C., Procter, J. & Barton, G. J., 1 Jul 2015, In : Nucleic Acids Research. 43, W1, p. W389-W394 6 p.

Research output: Contribution to journalArticle

Open Access
File
Secondary Protein Structure
Sequence Alignment
Equipment and Supplies
29 Citations (Scopus)
106 Downloads (Pure)

Proteotoxic stress reprograms the chromatin landscape of SUMO modification

Seifert, A., Schofield, P., Barton, G. & Hay, R., 7 Jul 2015, In : Science Signaling. 8, 384, p. rs7 14 p.

Research output: Contribution to journalArticle

Open Access
File
Ubiquitin
Chromatin
Proteins
Heat-Shock Response
Hot Temperature
27 Citations (Scopus)
86 Downloads (Pure)

Statistical models for RNA-seq data derived from a two-condition 48-replicate experiment

Gierlinski, M., Cole, C., Schofield, P., Schurch, N. J., Sherstnev, A., Singh, V., Wrobel, N., Gharbi, K., Simpson, G., Owen-Hughes, T., Blaxter, M. & Barton, G. J., 15 Nov 2015, In : Bioinformatics. 31, 22, p. 3625-3630 6 p.

Research output: Contribution to journalArticle

Open Access
File
2014
23 Citations (Scopus)
332 Downloads (Pure)

Elevated O-GlcNAc levels activate epigenetically repressed genes and delay mouse ES cell differentiation without affecting naive to primed cell transition

Speakman, C. M., Domke, T. C. E., Wongpaiboonwattana, W., Sanders, K., Mudaliar, M., van Aalten, D. M. F., Barton, G. J. & Stavridis, M. P., Oct 2014, In : Stem Cells. 32, 10, p. 2605-2615

Research output: Contribution to journalArticle

Open Access
File
Embryonic Stem Cells
Embryoid Bodies
Cell Differentiation
Hydrolases
Up-Regulation
63 Citations (Scopus)
99 Downloads (Pure)

Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis

Cole, C., Kroboth, K., Schurch, N. J., Sandilands, A., Sherstnev, A., O'Regan, G. M., Watson, R. M., McLean, W. H. I., Barton, G. J., Irvine, A. D. & Brown, S. J., Jul 2014, In : Journal of Allergy and Clinical Immunology. 134, 1, p. 82-91 10 p.

Research output: Contribution to journalArticle

Open Access
File
Atopic Dermatitis
Pediatrics
Skin
Genotype
Extracellular Space
12 Citations (Scopus)
282 Downloads (Pure)
Open Access
File
RNA Sequence Analysis
Expressed Sequence Tags
3' Untranslated Regions
3' untranslated regions
sequence analysis
20 Citations (Scopus)
78 Downloads (Pure)

Major transcriptome re-organisation and abrupt changes in signalling, cell cycle and chromatin regulation at neural differentiation in vivo

Olivera-Martinez, I., Schurch, N., Li, R., Song, J., Halley, P. A., Das, R. M., Burt, D. W., Barton, G. J. & Storey, K. G., Aug 2014, In : Development. 141, 16, p. 3266-3276 11 p.

Research output: Contribution to journalArticle

Open Access
File
Transcriptome
Chromatin
Cell Cycle
Genetic Epigenesis
RNA Sequence Analysis
32 Citations (Scopus)
93 Downloads (Pure)

Quantitative proteomics in resected renal cancer tissue for biomarker discovery and profiling

Atrih, A., Mudaliar, M. A. V., Zakikhani, P., Lamont, D. J., Huang, J. T-J., Bray, S. E., Barton, G., Fleming, S. & Nabi, G., 2014, In : British Journal of Cancer. 110, 6, p. 1622-1633 12 p.

Research output: Contribution to journalArticle

Open Access
File
Kidney Neoplasms
Tumor Biomarkers
Proteomics
Renal Cell Carcinoma
Proteins
2013
110 Citations (Scopus)

PGE2 induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway

Mackenzie, K. F., Clark, K., Naqvi, S., McGuire, V. A., Nöehren, G., Kristariyanto, Y., van den Bosch, M., Mudaliar, M., McCarthy, P. C., Pattison, M. J., Pedrioli, P. G. A., Barton, G. J., Toth, R., Prescott, A. & Arthur, J. S. C., 15 Jan 2013, In : Journal of Immunology. 190, 2, p. 565-577 13 p.

Research output: Contribution to journalArticle

Cyclic AMP-Dependent Protein Kinases
Dinoprostone
Interleukin-10
Macrophages
Prostaglandins E
23 Citations (Scopus)

The RNA-binding protein FPA regulates flg22-triggered defense responses and transcription factor activity by alternative polyadenylation

Lyons, R., Iwase, A., Gänsewig, T., Sherstnev, A., Duc, C., Barton, G. J., Hanada, K., Higuchi-Takeuchi, M., Matsui, M., Sugimoto, K., Kazan, K., Simpson, G. G. & Shirasu, K., 9 Oct 2013, In : Scientific Reports. 3, 10 p., 2866.

Research output: Contribution to journalArticle

Polyadenylation
RNA-Binding Proteins
Transcription Factors
Protein Isoforms
Plant RNA
69 Citations (Scopus)

Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects

Saunders, S. P., Goh, C. S. M., Brown, S. J., Palmer, C. N. A., Porter, R. M., Cole, C., Campbell, L. E., Gierlinski, M., Barton, G. J., Schneider, G., Balmain, A., Prescott, A. R., Weidinger, S., Baurecht, H., Kabesch, M., Gieger, C., Lee, Y-A., Tavendale, R., Mukhopadhyay, S., Turner, S. W. & 14 others, Madhok, V. B., Sullivan, F. M., Relton, C., Burn, J., Meggitt, S., Smith, C. H., Allen, M. A., Barker, J. N. W. N., Reynolds, N. J., Cordell, H. J., Irvine, A. D., McLean, W. H. I., Sandilands, A. & Fallon, P. G., Nov 2013, In : Journal of Allergy and Clinical Immunology. 132, 5, p. 1121-1129 9 p.

Research output: Contribution to journalArticle

Atopic Dermatitis
Skin
Genes
Mutation
Single Nucleotide Polymorphism
32 Citations (Scopus)

Transcription Termination and Chimeric RNA Formation Controlled by Arabidopsis thaliana FPA

Duc, C., Sherstnev, A., Cole, C., Barton, G. & Simpson, G. G., 31 Oct 2013, In : PLoS Genetics. 9, 10, e1003867.

Research output: Contribution to journalArticle

Arabidopsis
RNA
Arabidopsis thaliana
transcription (genetics)
mutants
2012
193 Citations (Scopus)

A quantitative spatial proteomics analysis of proteome turnover in human cells

Boisvert, F-M., Ahmad, Y., Gierlinski, M., Charrière, F., Lamont, D., Scott, M., Barton, G. & Lamond, A. I., 1 Mar 2012, In : Molecular & Cellular Proteomics. 11, 3, M111.011429.

Research output: Contribution to journalArticle

Spatial Analysis
Proteome
Proteomics
Cells
Proteins
82 Citations (Scopus)

Direct sequencing of Arabidopsis thaliana RNA reveals patterns of cleavage and polyadenylation

Sherstnev, A., Duc, C., Cole, C., Zacharaki, V., Hornyik, C., Ozsolak, F., Milos, P. M., Barton, G. J. & Simpson, G. G., Aug 2012, In : Nature Structural & Molecular Biology. 19, 8, p. 845-852 8 p.

Research output: Contribution to journalArticle

Polyadenylation
Arabidopsis
Genome
RNA
RNA Sequence Analysis
42 Citations (Scopus)

Haploinsufficiency for AAGAB causes clinically heterogeneous forms of punctate palmoplantar keratoderma

Pohler, E., Mamai, O., Hirst, J., Zamiri, M., Horn, H., Nomura, T., Irvine, A. D., Moran, B., Wilson, N. J., Smith, F. J. D., Goh, C. S. M., Sandilands, A., Cole, C., Barton, G. J., Evans, A. T., Shimizu, H., Akiyama, M., Suehiro, M., Konohana, I., Shboul, M. & 12 others, Teissier, S., Boussofara, L., Denguezli, M., Saad, A., Gribaa, M., Dopping-Hepenstal, P. J., McGrath, J. A., Brown, S. J., Goudie, D. R., Reversade, B., Munro, C. S. & McLean, W. H. I., Nov 2012, In : Nature Genetics. 44, 11, p. 1272-1276 5 p.

Research output: Contribution to journalArticle

Palmoplantar Keratoderma
Haploinsufficiency
Epidermal Growth Factor Receptor
Carrier Proteins
Vesicular Transport Adaptor Proteins
40 Citations (Scopus)

Human box C/D snoRNA processing conservation across multiple cell types

Scott, M. S., Ono, M., Yamada, K., Endo, A., Barton, G. J. & Lamond, A. I., Apr 2012, In : Nucleic Acids Research. 40, 8, p. 3676-3688 13 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)

Live imaging of nascent RNA dynamics reveals distinct types of transcriptional pulse regulation

Muramoto, T., Cannon, D., Gierlinski, M., Corrigan, A., Barton, G. J. & Chubb, J. R., 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 19, p. 7350-7355 6 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity

Tibarewal, P., Zilidis, G., Spinelli, L., Schurch, N., Maccario, H., Gray, A., Perera, N. M., Davidson, L., Barton, G. J. & Leslie, N. R., 2012, In : Science Signaling. 5, 213, p. ra18

Research output: Contribution to journalArticle

PTEN Phosphohydrolase
Phosphoric Monoester Hydrolases
Gene expression
Tumors
Phenotype
32 Citations (Scopus)

The kinomes of apicomplexan parasites

Miranda-Saavedra, D., Gabaldón, T., Barton, G. J., Langsley, G. & Doerig, C., 2012, In : Microbes and Infection. 14, 10, p. 796-810 15 p.

Research output: Contribution to journalArticle

Protein Kinases
Molecular Biology
Parasites
Phosphorylation
Databases

Transcriptome analysis of skin reveals differences between atopic eczema cases stratified for filaggrin genotype

Brown, S., Cole, C., Irvine, A., Barton, G. & McLean, I., Apr 2012, In : British Journal of Dermatology. 166, 4, p. e26-e27 2 p., O-30.

Research output: Contribution to journalArticle

2011
1 Citation (Scopus)

A Dictyostelium SH2 adaptor protein required for correct DIF-1 signaling and pattern formation

Sugden, C., Ross, S., Annesley, S. J., Cole, C., Bloomfield, G., Ivens, A., Skelton, J., Fisher, P. R., Barton, G. & Williams, J. G., 15 May 2011, In : Developmental Biology. 353, 2, p. 290-301 12 p.

Research output: Contribution to journalArticle

170 Citations (Scopus)

A role for Snf2-related nucleosome-spacing enzymes in genome-wide nucleosome organization

Gkikopoulos, T., Schofield, P., Singh, V., Pinskaya, M., Mellor, J., Smolle, M., Workman, J. L., Barton, G. J. & Owen-Hughes, T., 23 Sep 2011, In : Science. 333, 6050, p. 1758-1760 3 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Computational approaches to selecting and optimising targets for structural biology

Overton, I. M. & Barton, G. J., Sep 2011, In : Journal of Neuroscience Methods. 55, 1, p. 311 9 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Global network analysis of drug tolerance, mode of action and virulence in methicillin-resistant S. aureus

Overton, I. M., Graham, S., Gould, K. A., Hinds, J., Botting, C. H., Shirran, S., Barton, G. J. & Coote, P. J., 12 May 2011, In : BMC Systems Biology. 5, p. - 16 p., 68.

Research output: Contribution to journalArticle

87 Citations (Scopus)

Identification of human miRNA precursors that resemble box C/D snoRNAs

Ono, M., Scott, M. S., Yamada, K., Avolio, F., Barton, G. J. & Lamond, A. I., May 2011, In : Nucleic Acids Research. 39, 9, p. 3879-3891 13 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Java bioinformatics analysis web services for multiple sequence alignment-JABAWS:MSA

Troshin, P. V., Procter, J. B. & Barton, G. J., 15 Jul 2011, In : BMC Bioinformatics. 27, 14, p. 2001-2002 2 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

NoD: a Nucleolar localization sequence detector for eukaryotic and viral proteins

Scott, M. S., Troshin, P. V. & Barton, G. J., 3 Aug 2011, In : BMC Bioinformatics. 12, p. - 7 p., 317.

Research output: Contribution to journalArticle

5 Citations (Scopus)

PIMS sequencing extension: a laboratory information management system for DNA sequencing facilities

Troshin, P. V., Postis, V. L. G., Ashworth, D., Baldwin, S. A., McPherson, M. J. & Barton, G. J., 7 Mar 2011, In : BMC Research Notes. 4, 9 p., 48.

Research output: Contribution to journalArticle

Clinical Laboratory Information Systems
Management Information Systems
Information Management
DNA Sequence Analysis
Information management
7 Citations (Scopus)

PNAC: a protein nucleolar association classifier

Scott, M. S., Boisvert, F-M., Lamond, A. I. & Barton, G. J., 27 Jan 2011, In : BMC Genomics. 12, p. - 14 p., 74.

Research output: Contribution to journalArticle

33 Citations (Scopus)
59 Downloads (Pure)

The SWI/SNF complex acts to constrain distribution of the centromeric histone variant Cse4

Gkikopoulos, T., Singh, V., Tsui, K., Awad, S., Renshaw, M. J., Scholfield, P., Barton, G. J., Nislow, C., Tanaka, T. U. & Owen-Hughes, T., 18 May 2011, In : EMBO Journal. 30, 10, p. 1919-1927 9 p.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)

XANNpred: Neural nets that predict the propensity of a protein to yield diffraction-quality crystals

Overton, I. M., van Niekerk, C. A. J. & Barton, G. J., Apr 2011, In : Proteins: Structure, Function, and Bioinformatics. 79, 4, p. 1027-1033 7 p.

Research output: Contribution to journalArticle

2010
26 Citations (Scopus)

Analysis of Human Small Nucleolar RNAs (snoRNA) and the Development of snoRNA Modulator of Gene Expression Vectors

Ono, M., Yamada, K., Avolio, F., Scott, M. S., van Koningsbruggen, S., Barton, G. J. & Lamond, A. I., 1 May 2010, In : Molecular Biology of the Cell. 21, 9, p. 1569-1584 16 p.

Research output: Contribution to journalArticle

83 Citations (Scopus)

Characterization and prediction of protein nucleolar localization sequences

Scott, M. S., Boisvert, F-M., McDowall, M. D., Lamond, A. I. & Barton, G. J., Nov 2010, In : Nucleic Acids Research. 38, 21, p. 7388-7399 12 p.

Research output: Contribution to journalArticle

149 Citations (Scopus)

High-resolution whole-genome sequencing reveals that specific Chromatin Domains from most human chromosomes associate with nucleoli

van Koningsbruggen, S., Gierlinski, M., Schofield, P., Martin, D., Barton, G. J., Ariyurek, Y., den Dunnen, J. T. & Lamond, A. I., 1 Nov 2010, In : Molecular Biology of the Cell. 21, 21, p. 3735-3748 14 p.

Research output: Contribution to journalArticle

146 Citations (Scopus)

Regulation of the miR-212/132 locus by MSK1 and CREB in response to neurotrophins

Remenyi, J., Hunter, C. J., Cole, C., Ando, H., Impey, S., Monk, C. E., Martin, K. J., Barton, G. J., Hutvagner, G. & Arthur, J. S. C., 1 Jun 2010, In : Biochemical Journal. 428, 2, p. 281-291 11 p.

Research output: Contribution to journalArticle