Barton, Geoffrey

Professor

  • United Kingdom

  • 20339 Citations
  • 58 h-Index
1987 …2024

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2020
Open Access
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35 Downloads (Pure)

Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification

Parker, M. T., Knop, K., Sherwood, A. V., Schurch, N. J., Mackinnon, K., Gould, P. D., Hall, A. J. W., Barton, G. J. & Simpson, G. G., 14 Jan 2020, In : eLife. 9, p. 1-35 35 p., e49658.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
47 Downloads (Pure)
2019

Detection and Mitigation of Spurious Antisense RNA-seq Reads with RoSA

Mourão, K., Schurch, N. J., Lukoszek, R., Froussios, K., Mackinnon, K., Duc, C., Simpson, G. & Barton, G., 7 Jun 2019, In : F1000 Research. 8, p. 1-7 7 p., 819.

Research output: Contribution to journalArticle

Open Access
File
86 Downloads (Pure)
Open Access
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67 Downloads (Pure)
Open Access
File
2 Citations (Scopus)
76 Downloads (Pure)

The Dundee Resource for Sequence Analysis and Structure Prediction

MacGowan, S., Madeira, F., Britto-Borges, T., Warowny, M., Drozdetskiy, A., Procter, J. & Barton, G., 11 Nov 2019, In : Protein Science.

Research output: Contribution to journalArticle

Open Access
File
53 Downloads (Pure)
2018

JABAWS 2.2 Distributed Web Services for Bioinformatics: Protein Disorder, Conservation and RNA Secondary Structure

Troshin, P. V., Procter, J. B., Sherstnev, A., Barton, D. L., Madeira, F. & Barton, G. J., 1 Jun 2018, In : Bioinformatics. 34, 11, p. 1939-1940 2 p., byt045.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
160 Downloads (Pure)

Proteus: an R package for downstream analysis of MaxQuant output

Gierlinski, M., Gastaldello, F., Cole, C. & Barton, G., 20 Sep 2018, In : BioRxiv. 10 p.

Research output: Contribution to journalArticle

Open Access
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341 Downloads (Pure)
2017
Open Access
File
5 Citations (Scopus)
173 Downloads (Pure)

Human Missense Variation is Constrained by Domain Structure and Highlights Functional and Pathogenic Residues

MacGowan, S., Madeira, F., Britto Borges, T., Schmittner, M. S., Cole, C. & Barton, G., 13 Apr 2017, In : BioRxiv. 35 p.

Research output: Contribution to journalArticle

File
75 Downloads (Pure)

Improved annotation with de novo transcriptome assembly in four social amoeba species

Singh, R., Lawal, H. M., Schilde, C., Glöckner, G., Barton, G. J., Schaap, P. & Cole, C., 31 Jan 2017, In : BMC Genomics. 18, p. 1-17 17 p., 120.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
95 Downloads (Pure)

Mapping genetic variations to three-dimensional protein structures to enhance variant interpretation: A proposed framework

Glusman, G., Rose, P. W., Prlić, A., Dougherty, J., Duarte, J. M., Hoffman, A. S., Barton, G. J., Bendixen, E., Bergquist, T., Bock, C., Brunk, E., Buljan, M., Burley, S. K., Cai, B., Carter, H., Gao, J. J., Godzik, A., Heuer, M., Hicks, M., Hrabe, T. & 17 others, Karchin, R., Leman, J. K., Lane, L., Masica, D. L., Mooney, S. D., Moult, J., Omenn, G. S., Pearl, F., Pejaver, V., Reynolds, S. M., Rokem, A., Schwede, T., Song, S., Tilgner, H., Valasatava, Y., Zhang, Y. & Deutsch, E. W., 18 Dec 2017, In : Genome Medicine. 9, 1, p. 1-10 10 p., 113.

Research output: Contribution to journalArticle

Open Access
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17 Citations (Scopus)
134 Downloads (Pure)
2016

AlmostSignificant: simplifying quality control of high-throughput sequencing data

Ward, J., Cole, C., Febrer, M. & Barton, G. J., 15 Dec 2016, In : Bioinformatics. 32, 24, p. 3850-3851 2 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
81 Downloads (Pure)

How many biological replicates are needed in an RNA-seq experiment and which differential expression tool should you use?

Schurch, N. J., Schofield, P., Gierliński, M., Cole, C., Sherstnev, A., Singh, V., Wrobel, N., Gharbi, K., Simpson, G. G., Owen-Hughes, T., Blaxter, M. & Barton, G. J., Jun 2016, In : RNA: a Publication of the RNA Society. 22, 6, p. 839-851 13 p.

Research output: Contribution to journalArticle

Open Access
File
191 Citations (Scopus)
185 Downloads (Pure)
2015

14-3-3-Pred: Improved methods to predict 14-3-3-binding phosphopeptides

Madeira, F., Tinti, M., Murugesan, G., Berrett, E., Stafford, M., Toth, R., Cole, C., MacKintosh, C. & Barton, G. J., 2015, In : Bioinformatics.

Research output: Contribution to journalArticle

Open Access
File
54 Citations (Scopus)
305 Downloads (Pure)

JPred4: a protein secondary structure prediction server

Drozdetskiy, A., Cole, C., Procter, J. & Barton, G. J., 1 Jul 2015, In : Nucleic Acids Research. 43, W1, p. W389-W394 6 p.

Research output: Contribution to journalArticle

Open Access
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631 Citations (Scopus)
279 Downloads (Pure)

Proteotoxic stress reprograms the chromatin landscape of SUMO modification

Seifert, A., Schofield, P., Barton, G. & Hay, R., 7 Jul 2015, In : Science Signaling. 8, 384, p. rs7 14 p.

Research output: Contribution to journalArticle

Open Access
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35 Citations (Scopus)
198 Downloads (Pure)

Statistical models for RNA-seq data derived from a two-condition 48-replicate experiment

Gierlinski, M., Cole, C., Schofield, P., Schurch, N. J., Sherstnev, A., Singh, V., Wrobel, N., Gharbi, K., Simpson, G., Owen-Hughes, T., Blaxter, M. & Barton, G. J., 15 Nov 2015, In : Bioinformatics. 31, 22, p. 3625-3630 6 p.

Research output: Contribution to journalArticle

Open Access
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30 Citations (Scopus)
153 Downloads (Pure)
2014

Elevated O-GlcNAc levels activate epigenetically repressed genes and delay mouse ES cell differentiation without affecting naive to primed cell transition

Speakman, C. M., Domke, T. C. E., Wongpaiboonwattana, W., Sanders, K., Mudaliar, M., van Aalten, D. M. F., Barton, G. J. & Stavridis, M. P., Oct 2014, In : Stem Cells. 32, 10, p. 2605-2615

Research output: Contribution to journalArticle

Open Access
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25 Citations (Scopus)
401 Downloads (Pure)

Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis

Cole, C., Kroboth, K., Schurch, N. J., Sandilands, A., Sherstnev, A., O'Regan, G. M., Watson, R. M., McLean, W. H. I., Barton, G. J., Irvine, A. D. & Brown, S. J., Jul 2014, In : Journal of Allergy and Clinical Immunology. 134, 1, p. 82-91 10 p.

Research output: Contribution to journalArticle

Open Access
File
72 Citations (Scopus)
174 Downloads (Pure)
Open Access
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15 Citations (Scopus)
360 Downloads (Pure)

Major transcriptome re-organisation and abrupt changes in signalling, cell cycle and chromatin regulation at neural differentiation in vivo

Olivera-Martinez, I., Schurch, N., Li, R., Song, J., Halley, P. A., Das, R. M., Burt, D. W., Barton, G. J. & Storey, K. G., Aug 2014, In : Development. 141, 16, p. 3266-3276 11 p.

Research output: Contribution to journalArticle

Open Access
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23 Citations (Scopus)
129 Downloads (Pure)

Quantitative proteomics in resected renal cancer tissue for biomarker discovery and profiling

Atrih, A., Mudaliar, M. A. V., Zakikhani, P., Lamont, D. J., Huang, J. T-J., Bray, S. E., Barton, G., Fleming, S. & Nabi, G., 2014, In : British Journal of Cancer. 110, 6, p. 1622-1633 12 p.

Research output: Contribution to journalArticle

Open Access
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38 Citations (Scopus)
158 Downloads (Pure)
2013

PGE2 induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway

Mackenzie, K. F., Clark, K., Naqvi, S., McGuire, V. A., Nöehren, G., Kristariyanto, Y., van den Bosch, M., Mudaliar, M., McCarthy, P. C., Pattison, M. J., Pedrioli, P. G. A., Barton, G. J., Toth, R., Prescott, A. & Arthur, J. S. C., 15 Jan 2013, In : Journal of Immunology. 190, 2, p. 565-577 13 p.

Research output: Contribution to journalArticle

120 Citations (Scopus)

The RNA-binding protein FPA regulates flg22-triggered defense responses and transcription factor activity by alternative polyadenylation

Lyons, R., Iwase, A., Gänsewig, T., Sherstnev, A., Duc, C., Barton, G. J., Hanada, K., Higuchi-Takeuchi, M., Matsui, M., Sugimoto, K., Kazan, K., Simpson, G. G. & Shirasu, K., 9 Oct 2013, In : Scientific Reports. 3, 10 p., 2866.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects

Saunders, S. P., Goh, C. S. M., Brown, S. J., Palmer, C. N. A., Porter, R. M., Cole, C., Campbell, L. E., Gierlinski, M., Barton, G. J., Schneider, G., Balmain, A., Prescott, A. R., Weidinger, S., Baurecht, H., Kabesch, M., Gieger, C., Lee, Y-A., Tavendale, R., Mukhopadhyay, S., Turner, S. W. & 14 others, Madhok, V. B., Sullivan, F. M., Relton, C., Burn, J., Meggitt, S., Smith, C. H., Allen, M. A., Barker, J. N. W. N., Reynolds, N. J., Cordell, H. J., Irvine, A. D., McLean, W. H. I., Sandilands, A. & Fallon, P. G., Nov 2013, In : Journal of Allergy and Clinical Immunology. 132, 5, p. 1121-1129 9 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)

Transcription Termination and Chimeric RNA Formation Controlled by Arabidopsis thaliana FPA

Duc, C., Sherstnev, A., Cole, C., Barton, G. & Simpson, G. G., 31 Oct 2013, In : PLoS Genetics. 9, 10, e1003867.

Research output: Contribution to journalArticle

40 Citations (Scopus)
2012

A quantitative spatial proteomics analysis of proteome turnover in human cells

Boisvert, F-M., Ahmad, Y., Gierlinski, M., Charrière, F., Lamont, D., Scott, M., Barton, G. & Lamond, A. I., 1 Mar 2012, In : Molecular & Cellular Proteomics. 11, 3, M111.011429.

Research output: Contribution to journalArticle

212 Citations (Scopus)

Direct sequencing of Arabidopsis thaliana RNA reveals patterns of cleavage and polyadenylation

Sherstnev, A., Duc, C., Cole, C., Zacharaki, V., Hornyik, C., Ozsolak, F., Milos, P. M., Barton, G. J. & Simpson, G. G., Aug 2012, In : Nature Structural & Molecular Biology. 19, 8, p. 845-852 8 p.

Research output: Contribution to journalArticle

93 Citations (Scopus)

Haploinsufficiency for AAGAB causes clinically heterogeneous forms of punctate palmoplantar keratoderma

Pohler, E., Mamai, O., Hirst, J., Zamiri, M., Horn, H., Nomura, T., Irvine, A. D., Moran, B., Wilson, N. J., Smith, F. J. D., Goh, C. S. M., Sandilands, A., Cole, C., Barton, G. J., Evans, A. T., Shimizu, H., Akiyama, M., Suehiro, M., Konohana, I., Shboul, M. & 12 others, Teissier, S., Boussofara, L., Denguezli, M., Saad, A., Gribaa, M., Dopping-Hepenstal, P. J., McGrath, J. A., Brown, S. J., Goudie, D. R., Reversade, B., Munro, C. S. & McLean, W. H. I., Nov 2012, In : Nature Genetics. 44, 11, p. 1272-1276 5 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Human box C/D snoRNA processing conservation across multiple cell types

Scott, M. S., Ono, M., Yamada, K., Endo, A., Barton, G. J. & Lamond, A. I., Apr 2012, In : Nucleic Acids Research. 40, 8, p. 3676-3688 13 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Live imaging of nascent RNA dynamics reveals distinct types of transcriptional pulse regulation

Muramoto, T., Cannon, D., Gierlinski, M., Corrigan, A., Barton, G. J. & Chubb, J. R., 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 19, p. 7350-7355 6 p.

Research output: Contribution to journalArticle

76 Citations (Scopus)

PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity

Tibarewal, P., Zilidis, G., Spinelli, L., Schurch, N., Maccario, H., Gray, A., Perera, N. M., Davidson, L., Barton, G. J. & Leslie, N. R., 2012, In : Science Signaling. 5, 213, p. ra18

Research output: Contribution to journalArticle

73 Citations (Scopus)

The kinomes of apicomplexan parasites

Miranda-Saavedra, D., Gabaldón, T., Barton, G. J., Langsley, G. & Doerig, C., 2012, In : Microbes and Infection. 14, 10, p. 796-810 15 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Transcriptome analysis of skin reveals differences between atopic eczema cases stratified for filaggrin genotype

Brown, S., Cole, C., Irvine, A., Barton, G. & McLean, I., Apr 2012, In : British Journal of Dermatology. 166, 4, p. e26-e27 2 p., O-30.

Research output: Contribution to journalArticle

2011

A Dictyostelium SH2 adaptor protein required for correct DIF-1 signaling and pattern formation

Sugden, C., Ross, S., Annesley, S. J., Cole, C., Bloomfield, G., Ivens, A., Skelton, J., Fisher, P. R., Barton, G. & Williams, J. G., 15 May 2011, In : Developmental Biology. 353, 2, p. 290-301 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

A role for Snf2-related nucleosome-spacing enzymes in genome-wide nucleosome organization

Gkikopoulos, T., Schofield, P., Singh, V., Pinskaya, M., Mellor, J., Smolle, M., Workman, J. L., Barton, G. J. & Owen-Hughes, T., 23 Sep 2011, In : Science. 333, 6050, p. 1758-1760 3 p.

Research output: Contribution to journalArticle

174 Citations (Scopus)

Computational approaches to selecting and optimising targets for structural biology

Overton, I. M. & Barton, G. J., Sep 2011, In : Journal of Neuroscience Methods. 55, 1, p. 311 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Global network analysis of drug tolerance, mode of action and virulence in methicillin-resistant S. aureus

Overton, I. M., Graham, S., Gould, K. A., Hinds, J., Botting, C. H., Shirran, S., Barton, G. J. & Coote, P. J., 12 May 2011, In : BMC Systems Biology. 5, p. - 16 p., 68.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Identification of human miRNA precursors that resemble box C/D snoRNAs

Ono, M., Scott, M. S., Yamada, K., Avolio, F., Barton, G. J. & Lamond, A. I., May 2011, In : Nucleic Acids Research. 39, 9, p. 3879-3891 13 p.

Research output: Contribution to journalArticle

95 Citations (Scopus)

Java bioinformatics analysis web services for multiple sequence alignment-JABAWS:MSA

Troshin, P. V., Procter, J. B. & Barton, G. J., 15 Jul 2011, In : BMC Bioinformatics. 27, 14, p. 2001-2002 2 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

NoD: a Nucleolar localization sequence detector for eukaryotic and viral proteins

Scott, M. S., Troshin, P. V. & Barton, G. J., 3 Aug 2011, In : BMC Bioinformatics. 12, p. - 7 p., 317.

Research output: Contribution to journalArticle

67 Citations (Scopus)

PIMS sequencing extension: a laboratory information management system for DNA sequencing facilities

Troshin, P. V., Postis, V. L. G., Ashworth, D., Baldwin, S. A., McPherson, M. J. & Barton, G. J., 7 Mar 2011, In : BMC Research Notes. 4, 9 p., 48.

Research output: Contribution to journalArticle

5 Citations (Scopus)

PNAC: a protein nucleolar association classifier

Scott, M. S., Boisvert, F-M., Lamond, A. I. & Barton, G. J., 27 Jan 2011, In : BMC Genomics. 12, p. - 14 p., 74.

Research output: Contribution to journalArticle

7 Citations (Scopus)

The SWI/SNF complex acts to constrain distribution of the centromeric histone variant Cse4

Gkikopoulos, T., Singh, V., Tsui, K., Awad, S., Renshaw, M. J., Scholfield, P., Barton, G. J., Nislow, C., Tanaka, T. U. & Owen-Hughes, T., 18 May 2011, In : EMBO Journal. 30, 10, p. 1919-1927 9 p.

Research output: Contribution to journalArticle

Open Access
File
33 Citations (Scopus)
136 Downloads (Pure)

XANNpred: Neural nets that predict the propensity of a protein to yield diffraction-quality crystals

Overton, I. M., van Niekerk, C. A. J. & Barton, G. J., Apr 2011, In : Proteins: Structure, Function, and Bioinformatics. 79, 4, p. 1027-1033 7 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2010

Analysis of Human Small Nucleolar RNAs (snoRNA) and the Development of snoRNA Modulator of Gene Expression Vectors

Ono, M., Yamada, K., Avolio, F., Scott, M. S., van Koningsbruggen, S., Barton, G. J. & Lamond, A. I., 1 May 2010, In : Molecular Biology of the Cell. 21, 9, p. 1569-1584 16 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Characterization and prediction of protein nucleolar localization sequences

Scott, M. S., Boisvert, F-M., McDowall, M. D., Lamond, A. I. & Barton, G. J., Nov 2010, In : Nucleic Acids Research. 38, 21, p. 7388-7399 12 p.

Research output: Contribution to journalArticle

91 Citations (Scopus)

High-resolution whole-genome sequencing reveals that specific Chromatin Domains from most human chromosomes associate with nucleoli

van Koningsbruggen, S., Gierlinski, M., Schofield, P., Martin, D., Barton, G. J., Ariyurek, Y., den Dunnen, J. T. & Lamond, A. I., 1 Nov 2010, In : Molecular Biology of the Cell. 21, 21, p. 3735-3748 14 p.

Research output: Contribution to journalArticle

164 Citations (Scopus)

Regulation of the miR-212/132 locus by MSK1 and CREB in response to neurotrophins

Remenyi, J., Hunter, C. J., Cole, C., Ando, H., Impey, S., Monk, C. E., Martin, K. J., Barton, G. J., Hutvagner, G. & Arthur, J. S. C., 1 Jun 2010, In : Biochemical Journal. 428, 2, p. 281-291 11 p.

Research output: Contribution to journalArticle

152 Citations (Scopus)