Barton, Geoffrey

Professor

  • United Kingdom

  • 20339 Citations
  • 58 h-Index
1987 …2024

Research output per year

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Research Output

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2010

The Scottish Structural Proteomics Facility: targets, methods and outputs

Oke, M., Carter, L. G., Johnson, K. A., Liu, H., McMahon, S. A., Yan, X., Kerou, M., Weikart, N. D., Kadi, N., Sheikh, M. A., Schmelz, S., Dorward, M., Zawadzki, M., Cozens, C., Falconer, H., Powers, H., Overton, I. M., van Niekerk, C. A. J., Peng, X., Patel, P. & 11 others, Garrett, R. A., Prangishvili, D., Botting, C. H., Coote, P. J., Dryden, D. T. F., Barton, G. J., Schwarz-Linek, U., Challis, G. L., Taylor, G. L., White, M. F. & Naismith, J. H., 2010, In : Journal of Structural and Functional Genomics. 11, 2, p. 167-80 14 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)
2009

Distinct donor and acceptor specificities of Trypanosoma brucei oligosaccharyltransferases

Izquierdo, L., Schulz, B. L., Rodrigues, J. A., Guther, M. L. S., Procter, J. B., Barton, G. J., Aebi, M. & Ferguson, M. A. J., 2 Sep 2009, In : EMBO Journal. 28, 17, p. 2650-2661 12 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

Filtering of deep sequencing data reveals the existence of abundant Dicer-dependent small RNAs derived from tRNAs

Cole, C., Sobala, A., Lu, C., Thatcher, S. R., Bowman, A., Brown, J. W. S., Green, P. J., Barton, G. J. & Hutvagner, G., Dec 2009, In : RNA: a Publication of the RNA Society. 15, 12, p. 2147-2160 14 p.

Research output: Contribution to journalArticle

333 Citations (Scopus)

Human miRNA Precursors with Box H/ACA snoRNA Features

Scott, M. S., Avolio, F., Ono, M., Lamond, A. I. & Barton, G. J., Sep 2009, In : PLoS Computational Biology. 5, 9, p. - 13 p., e1000507.

Research output: Contribution to journalArticle

134 Citations (Scopus)

Identification of a glycosylphosphatidylinositol anchor-modifying beta 1-3 N-acetylglucosaminyl transferase in Trypanosoma brucei

Izquierdo, L., Nakanishi, M., Mehlert, A., Machray, G., Barton, G. J. & Ferguson, M. A. J., Jan 2009, In : Molecular Microbiology. 71, 2, p. 478-491 14 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Jalview Version 2-a multiple sequence alignment editor and analysis workbench

Waterhouse, A. M., Procter, J. B., Martin, D. M. A., Clamp, M. & Barton, G. J., 1 May 2009, In : Bioinformatics. 25, 9, p. 1189-1191 3 p.

Research output: Contribution to journalArticle

3713 Citations (Scopus)

Kinomer v. 1.0: a database of systematically classified eukaryotic protein kinases

Martin, D. M. A., Miranda-Saavedra, D. & Barton, G. J., 2009, In : Nucleic Acids Research. 37, Suppl. 1. Database issue, p. D244-D250 7 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

PIPs: human protein-protein interaction prediction database

McDowall, M. D., Scott, M. S. & Barton, G. J., Jan 2009, In : Nucleic Acids Research. 37, Suppl 1, p. D651-D656 6 p.

Research output: Contribution to journalArticle

146 Citations (Scopus)

System-wide changes to SUMO modifications in response to heat shock

Golebiowski, F., Matic, I., Tatham, M. H., Cole, C., Yin, Y., Nakamura, A., Cox, J., Barton, G. J., Mann, M. & Hay, R. T., 26 May 2009, In : Science Signaling. 2, 72, 12 p., ra24.

Research output: Contribution to journalArticle

327 Citations (Scopus)
2008

A comparison of SCOP and CATH with respect to domain-domain interactions

Jefferson, E. R., Walsh, T. P. & Barton, G. J., Jan 2008, In : Proteins: Structure, Function, and Bioinformatics. 70, 1, p. 54-62 9 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

A new family of transcription factors

Yamada, Y., Wang, H-Y., Fukuzawa, M., Barton, G. J. & Williams, J. G., 15 Sep 2008, In : Development. 135, 18, p. 3093-3101 9 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Genome analysis of the unicellular green alga Chlamydomonas reinhardtii indicates an ancient evolutionary origin for key pattern recognition and cell-signaling protein families

Wheeler, G. L., Miranda-Saavedra, D. & Barton, G. J., May 2008, In : Genetics. 179, 1, p. 193-197 5 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

ParCrys: a Parzen window density estimation approach to protein crystallization propensity prediction

Overton, I. M., Padovani, G., Girolami, M. A. & Barton, G. J., 1 Apr 2008, In : BMC Bioinformatics. 24, 7, p. 901-907 7 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

SCANPS: a web server for iterative protein sequence database searching by dynamic programing, with display in a hierarchical SCOP browser

Walsh, T. P., Webber, C., Searle, S., Sturrock, S. S. & Barton, G. J., Jul 2008, In : Nucleic Acids Research. 36, p. W25-W29 5 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Sequence alignment for molecular replacement

Barton, G. J., Jan 2008, In : Acta Crystallographica Section D: Biological Crystallography. 64, p. 25-32 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

TarO: a target optimisation system for structural biology

Overton, I. M., van Niekerk, C. A. J., Carter, L. G., Dawson, A., Martin, D. M. A., Cameron, S., McMahon, S. A., White, M. F., Hunter, W. N., Naismith, J. H. & Barton, G. J., Jul 2008, In : Nucleic Acids Research. 36, p. W190-W196 7 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

The contrasting properties of conservation and correlated phylogeny in protein functional residue prediction

Manning, J. R., Jefferson, E. R. & Barton, G. J., 25 Jan 2008, In : BMC Bioinformatics. 9, p. - 16 p., 51.

Research output: Contribution to journalArticle

26 Citations (Scopus)

The Jpred 3 secondary structure prediction server

Cole, C., Barber, J. D. & Barton, G. J., Jul 2008, In : Nucleic Acids Research. 36, S2, p. W197-W201 5 p.

Research output: Contribution to journalArticle

1171 Citations (Scopus)
2007

Classification and functional annotation of eukaryotic protein kinases

Miranda-Saavedra, D. & Barton, G. J., 2007, In : Proteins: Structure, Function, and Bioinformatics. 68, 4, p. 893-914 22 p.

Research output: Contribution to journalArticle

103 Citations (Scopus)

Draft genome of the filarial nematode parasite Brugia malayi

Ghedin, E., Wang, S., Spiro, D., Caler, E., Zhao, Q., Crabtree, J., Allen, J. E., Delcher, A. L., Guiliano, D. B., Miranda-Saavedra, D., Angiuoli, S. V., Creasy, T., Amedeo, P., Haas, B., El-Sayed, N. M., Wortman, J. R., Feldblyum, T., Tallon, L., Schatz, M., Shumway, M. & 51 others, Koo, H., Salzberg, S. L., Schobel, S., Pertea, M., Pop, M., White, O., Barton, G. J., Carlow, C. K. S., Crawford, M. J., Daub, J., Dimmic, M. W., Estes, C. F., Foster, J. M., Ganatra, M., Gregory, W. F., Johnson, N. M., Jin, J., Komuniecki, R., Korf, I., Kumar, S., Laney, S., Li, B-W., Li, W., Lindblom, T. H., Lustigman, S., Ma, D., Maina, C. V., Martin, D. M. A., McCarter, J. P., McReynolds, L., Mitreva, M., Nutman, T. B., Parkinson, J., Peregrín-Alvarez, J. M., Poole, C., Ren, Q., Saunders, L., Sluder, A. E., Smith, K., Stanke, M., Unnasch, T. R., Ware, J., Wei, A. D., Weil, G., Williams, D. J., Zhang, Y., Williams, S. A., Fraser-Liggett, C., Slatko, B., Blaxter, M. L. & Scott, A. L., 21 Sep 2007, In : Science. 317, 5845, p. 1756-1760 5 p.

Research output: Contribution to journalArticle

468 Citations (Scopus)

Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis

Carlton, J. M., Hirt, R. P., Silva, J. C., Delcher, A. L., Schatz, M., Zhao, Q., Wortman, J. R., Bidwell, S. L., Alsmark, U. C. M., Besteiro, S., Sicheritz-Ponten, T., Noel, C. J., Dacks, J. B., Foster, P. G., Simillion, C., Van de Peer, Y., Miranda-Saavedra, D., Barton, G. J., Westrop, G. D., Muller, S. & 45 others, Dessi, D., Fiori, P. L., Ren, Q., Paulsen, I., Zhang, H., Bastida-Corcuera, F. D., Simoes-Barbosa, A., Brown, M. T., Hayes, R. D., Mukherjee, M., Okumura, C. Y., Schneider, R., Smith, A. J., Vanacova, S., Villalvazo, M., Haas, B. J., Pertea, M., Feldblyum, T. V., Utterback, T. R., Shu, C-L., Osoegawa, K., Jong, P. J. D., Hrdy, I., Horvathova, L., Zubacova, Z., Dolezal, P., Malik, S-B., Logsdon, J. M., Henze, K., Gupta, A., Wang, C. C., Dunne, R. L., Upcroft, J. A., Upcroft, P., White, O., Salzberg, S. L., Tang, P., Chiu, C-H., Lee, Y-S., Embley, T. M., Coombs, G. H., Mottram, J. C., Tachezy, J., Fraser-Liggett, C. M. & Johnson, P. J., 2007, In : Science. 315, 5809, p. 207-212 6 p.

Research output: Contribution to journalArticle

538 Citations (Scopus)

Expression, purification, crystallization, data collection and preliminary biochemical characterization of methicillin-resistant Staphylococcus aureus Sar2028, an aspartate/tyrosine/phenylalanine pyridoxal-5'-phosphate-dependent aminotransferase

Seetharamappa, J., Oke, M., Liu, H., McMahon, S. A., Johnson, K. A., Carter, L., Dorward, M., Zawadzki, M., Overton, I. M., van Niekirk, C. A. J., Graham, S., Botting, C. H., Taylor, G. L., White, M. F., Barton, G. J., Coote, P. J. & Naismith, J. H., 1 May 2007, In : Acta Crystallographica F-Structural Biology and Crystallization Communications. 63, Pt 5, p. 452-6 5 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Probabilistic prediction and ranking of human protein-protein interactions

Scott, M. S. & Barton, G. J., 2007, In : BMC Bioinformatics. 8, p. 239 1 p.

Research output: Contribution to journalArticle

95 Citations (Scopus)

Purification, crystallization and data collection of methicillin-resistant Staphylococcus aureus Sar2676, a pantothenate synthetase

Seetharamappa, J., Oke, M., Liu, H., McMahon, S. A., Johnson, K. A., Carter, L., Dorward, M., Zawadzki, M., Overton, I. M., Van Niekirk, C. A. J., Graham, S., Botting, C. H., Taylor, G. L., White, M. F., Barton, G. J., Coote, P. J. & Naismith, J. H., 5 May 2007, In : Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 63, 6, p. 488-491 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

SNAPPI-DB: a database and API of structures, iNterfaces and alignments for protein-protein interactions

Jefferson, E. R., Walsh, T. P., Roberts, T. J. & Barton, G. J., 2007, In : Nucleic Acids Research. 35, Database issue, p. D580-D589 10 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe

Miranda-Saavedra, D., Stark, M. J. R., Packer, J. C., Vivares, C. P., Doerig, C. & Barton, G. J., 2007, In : BMC Genomics. 8, 309.

Research output: Contribution to journalArticle

48 Citations (Scopus)

The Structure of Serine Palmitoyltransferase; Gateway to Sphingolipid Biosynthesis

Yard, B. A., Carter, L. G., Johnson, K. A., Overton, I. M., Dorward, M., Liu, H., McMahon, S. A., Oke, M., Puech, D., Barton, G. J., Naismith, J. H. & Campopiano, D. J., 27 Jul 2007, In : Journal of Molecular Biology. 370, 5, p. 870-886 17 p.

Research output: Contribution to journalArticle

76 Citations (Scopus)
2006

A normalised scale for structural genomics target ranking: the OB-Score

Overton, I. M. & Barton, G. J., 10 Jul 2006, In : FEBS Letters. 580, 16, p. 4005-4009 5 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Biological units and their effect upon the properties and prediction of protein–protein interactions

Jefferson, E. R., Walsh, T. P. & Barton, G. J., 2006, In : Journal of Molecular Biology. 364, 5, p. 1118-1129 12 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Emerging roles of pseudokinases

Boudeau, J., Miranda-Saavedra, D., Barton, G. J. & Alessi, D. R., Sep 2006, In : Trends in Cell Biology. 16, 9, p. 443-452 10 p.

Research output: Contribution to journalArticle

352 Citations (Scopus)

Identification of multiple distinct Snf2 subfamilies with conserved structural motifs

Flaus, A., Martin, D. M. A., Barton, G. J. & Owen-Hughes, T., 2006, In : Nucleic Acids Research. 34, 10, p. 2887-905 19 p.

Research output: Contribution to journalArticle

File
407 Citations (Scopus)
141 Downloads (Pure)

MACSIMS: multiple alignment of complete sequences information management system

Thompson, J. D., Muller, A., Waterhouse, A., Procter, J., Barton, G. J., Plewniak, F. & Poch, O., 2006, In : BMC Bioinformatics. 7, p. 318

Research output: Contribution to journalArticle

Open Access
File
34 Citations (Scopus)
209 Downloads (Pure)

Quantification of the variation in percentage identity for protein sequence alignments

Raghava, G. P. S. & Barton, G. J., 2006, In : BMC Bioinformatics. 7, p. 415

Research output: Contribution to journalArticle

Open Access
File
38 Citations (Scopus)
88 Downloads (Pure)
2004

E-MSD: an integrated data resource for bioinformatics

Golovin, A., Oldfield, T. J., Tate, J. G., Velankar, S., Barton, G. J., Boutselakis, H., Dimitropoulos, D., Fillon, J., Ionides, J. M. C., John, M., Keller, P. A., Krissinel, E., McNeil, P., Naim, A., Newman, R., Pajon, A., Pineda, J., Rachedi, A., Copeland, J., Sitnov, A. & 7 others, Sobhany, S., Suarez-Uruena, A., Swaminathan, G. J., Tagari, M., Tromm, S., Vranken, W. & Henrick, K., 1 Jan 2004, In : Nucleic Acids Research. 32, Database issue, p. D211-6

Research output: Contribution to journalArticle

66 Citations (Scopus)

GOtcha: a new method for prediction of protein function assessed by the annotation of seven genomes

Martin, D. M. A., Berriman, M. & Barton, G. J., 18 Nov 2004, In : BMC Bioinformatics. 5, 17 p., 178.

Research output: Contribution to journalArticle

Open Access
File
183 Citations (Scopus)
52 Downloads (Pure)

The Jalview Java alignment editor

Clamp, M., Cuff, J., Searle, S. M. & Barton, G. J., 12 Feb 2004, In : Bioinformatics. 20, 3, p. 426-427 2 p.

Research output: Contribution to journalArticle

1119 Citations (Scopus)
2003

Increased coverage obtained by combination of methods for protein sequence database searching

Webber, C. & Barton, G. J., 22 Jul 2003, In : Bioinformatics. 19, 11, p. 1397-1403 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

OXBench: a benchmark for evaluation of protein multiple sequence alignment accuracy

Raghava, G. P. S., Searle, S. M. J., Audley, P. C., Barber, J. D. & Barton, G. J., 10 Oct 2003, In : BMC Bioinformatics. 4, 23 p., 47.

Research output: Contribution to journalArticle

Open Access
File
148 Citations (Scopus)
102 Downloads (Pure)

Visual representation of database search results: the RHIMS Plot

Martin, D. M. A., Hill, P., Barton, G. J. & Flavell, A. J., 22 May 2003, In : Bioinformatics. 19, 8, p. 1037-1038 2 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2001

3Dee: a database of protein structural domains

Siddiqui, A. S., Dengler, U. & Barton, G. J., Feb 2001, In : Bioinformatics. 17, 2, p. 200-1 2 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Estimation of P-values for global alignments of protein sequences

Webber, C. & Barton, G. J., Dec 2001, In : Bioinformatics. 17, 12, p. 1158-1167 10 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Protein structural domains: analysis of the 3Dee domains database

Dengler, U., Siddiqui, A. S. & Barton, G. J., 15 Feb 2001, In : Proteins: Structure, Function, and Bioinformatics. 42, 3, p. 332-344 13 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2000

Application of multiple sequence alignment profiles to improve protein secondary structure prediction

Cuff, J. A. & Barton, G. J., 15 Aug 2000, In : Proteins: Structure, Function, and Bioinformatics. 40, 3, p. 502-511 10 p.

Research output: Contribution to journalArticle

613 Citations (Scopus)

ProtEST: protein multiple sequence alignments from expressed sequence tags

Cuff, J. A., Birney, E., Clamp, M. E. & Barton, G. J., Feb 2000, In : Bioinformatics. 16, 2, p. 111-6 6 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
1999

Evaluation and improvement of multiple sequence methods for protein secondary structure prediction

Cuff, J. A. & Barton, G. J., 1 Mar 1999, In : Proteins: Structure, Function, and Bioinformatics. 34, 4, p. 508-19 12 p.

Research output: Contribution to journalArticle

485 Citations (Scopus)
1998

Deposition of macromolecular structures

Keller, P. A., Henrick, K., McNeil, P., Moodie, S. & Barton, G. J., 1 Nov 1998, In : Acta Crystallographica Section D: Biological Crystallography. 54, 6, no. 1, p. 1105-1108 4 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

JPred: a consensus secondary structure prediction server

Cuff, J. A., Clamp, M. E., Siddiqui, A. S., Finlay, M. & Barton, G. J., 1998, In : Bioinformatics. 14, 10, p. 892-3 2 p.

Research output: Contribution to journalArticle

882 Citations (Scopus)

Protein sequence alignment techniques

Barton, G. J., 1 Nov 1998, In : Acta Crystallographica Section D: Biological Crystallography. 54, 6, no. 1, p. 1139-1146 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
1996

Conservation of amino acids in multiple alignments: aspartic acid has unexpected conservation

Fiser, A., Simon, I. & Barton, G. J., 18 Nov 1996, In : FEBS Letters. 397, 2-3, p. 225-229 5 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Identification of functional residues and secondary structure from protein multiple sequence alignment

Livingstone, C. D. & Barton, G. J., 1996, In : Methods in Enzymology. 266, p. 497-512 16 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)