Barton, Geoffrey

Professor

  • United Kingdom

Accepting PhD Students

  • 19321 Citations
  • 58 h-Index
1987 …2024
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Research Output 1987 2019

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Article
2009
309 Citations (Scopus)

Filtering of deep sequencing data reveals the existence of abundant Dicer-dependent small RNAs derived from tRNAs

Cole, C., Sobala, A., Lu, C., Thatcher, S. R., Bowman, A., Brown, J. W. S., Green, P. J., Barton, G. J. & Hutvagner, G., Dec 2009, In : RNA: a Publication of the RNA Society. 15, 12, p. 2147-2160 14 p.

Research output: Contribution to journalArticle

129 Citations (Scopus)

Human miRNA Precursors with Box H/ACA snoRNA Features

Scott, M. S., Avolio, F., Ono, M., Lamond, A. I. & Barton, G. J., Sep 2009, In : PLoS Computational Biology. 5, 9, p. - 13 p., e1000507.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Identification of a glycosylphosphatidylinositol anchor-modifying beta 1-3 N-acetylglucosaminyl transferase in Trypanosoma brucei

Izquierdo, L., Nakanishi, M., Mehlert, A., Machray, G., Barton, G. J. & Ferguson, M. A. J., Jan 2009, In : Molecular Microbiology. 71, 2, p. 478-491 14 p.

Research output: Contribution to journalArticle

3322 Citations (Scopus)

Jalview Version 2-a multiple sequence alignment editor and analysis workbench

Waterhouse, A. M., Procter, J. B., Martin, D. M. A., Clamp, M. & Barton, G. J., 1 May 2009, In : Bioinformatics. 25, 9, p. 1189-1191 3 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Kinomer v. 1.0: a database of systematically classified eukaryotic protein kinases

Martin, D. M. A., Miranda-Saavedra, D. & Barton, G. J., 2009, In : Nucleic Acids Research. 37, Suppl. 1. Database issue, p. D244-D250 7 p.

Research output: Contribution to journalArticle

139 Citations (Scopus)

PIPs: human protein-protein interaction prediction database

McDowall, M. D., Scott, M. S. & Barton, G. J., Jan 2009, In : Nucleic Acids Research. 37, Suppl 1, p. D651-D656 6 p.

Research output: Contribution to journalArticle

311 Citations (Scopus)

System-wide changes to SUMO modifications in response to heat shock

Golebiowski, F., Matic, I., Tatham, M. H., Cole, C., Yin, Y., Nakamura, A., Cox, J., Barton, G. J., Mann, M. & Hay, R. T., 26 May 2009, In : Science Signaling. 2, 72, 12 p., ra24.

Research output: Contribution to journalArticle

2008
9 Citations (Scopus)

A comparison of SCOP and CATH with respect to domain-domain interactions

Jefferson, E. R., Walsh, T. P. & Barton, G. J., Jan 2008, In : Proteins: Structure, Function, and Bioinformatics. 70, 1, p. 54-62 9 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

A new family of transcription factors

Yamada, Y., Wang, H-Y., Fukuzawa, M., Barton, G. J. & Williams, J. G., 15 Sep 2008, In : Development. 135, 18, p. 3093-3101 9 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Genome analysis of the unicellular green alga Chlamydomonas reinhardtii indicates an ancient evolutionary origin for key pattern recognition and cell-signaling protein families

Wheeler, G. L., Miranda-Saavedra, D. & Barton, G. J., May 2008, In : Genetics. 179, 1, p. 193-197 5 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

ParCrys: a Parzen window density estimation approach to protein crystallization propensity prediction

Overton, I. M., Padovani, G., Girolami, M. A. & Barton, G. J., 1 Apr 2008, In : BMC Bioinformatics. 24, 7, p. 901-907 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

SCANPS: a web server for iterative protein sequence database searching by dynamic programing, with display in a hierarchical SCOP browser

Walsh, T. P., Webber, C., Searle, S., Sturrock, S. S. & Barton, G. J., Jul 2008, In : Nucleic Acids Research. 36, p. W25-W29 5 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Sequence alignment for molecular replacement

Barton, G. J., Jan 2008, In : Acta Crystallographica Section D: Biological Crystallography. 64, p. 25-32 8 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

TarO: a target optimisation system for structural biology

Overton, I. M., van Niekerk, C. A. J., Carter, L. G., Dawson, A., Martin, D. M. A., Cameron, S., McMahon, S. A., White, M. F., Hunter, W. N., Naismith, J. H. & Barton, G. J., Jul 2008, In : Nucleic Acids Research. 36, p. W190-W196 7 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

The contrasting properties of conservation and correlated phylogeny in protein functional residue prediction

Manning, J. R., Jefferson, E. R. & Barton, G. J., 25 Jan 2008, In : BMC Bioinformatics. 9, p. - 16 p., 51.

Research output: Contribution to journalArticle

1151 Citations (Scopus)

The Jpred 3 secondary structure prediction server

Cole, C., Barber, J. D. & Barton, G. J., Jul 2008, In : Nucleic Acids Research. 36, S2, p. W197-W201 5 p.

Research output: Contribution to journalArticle

2007
100 Citations (Scopus)

Classification and functional annotation of eukaryotic protein kinases

Miranda-Saavedra, D. & Barton, G. J., 2007, In : Proteins: Structure, Function, and Bioinformatics. 68, 4, p. 893-914 22 p.

Research output: Contribution to journalArticle

Protein Kinases
Libraries
Eukaryota
Protein-Tyrosine Kinases
Amoeba
455 Citations (Scopus)

Draft genome of the filarial nematode parasite Brugia malayi

Ghedin, E., Wang, S., Spiro, D., Caler, E., Zhao, Q., Crabtree, J., Allen, J. E., Delcher, A. L., Guiliano, D. B., Miranda-Saavedra, D., Angiuoli, S. V., Creasy, T., Amedeo, P., Haas, B., El-Sayed, N. M., Wortman, J. R., Feldblyum, T., Tallon, L., Schatz, M., Shumway, M. & 51 others, Koo, H., Salzberg, S. L., Schobel, S., Pertea, M., Pop, M., White, O., Barton, G. J., Carlow, C. K. S., Crawford, M. J., Daub, J., Dimmic, M. W., Estes, C. F., Foster, J. M., Ganatra, M., Gregory, W. F., Johnson, N. M., Jin, J., Komuniecki, R., Korf, I., Kumar, S., Laney, S., Li, B-W., Li, W., Lindblom, T. H., Lustigman, S., Ma, D., Maina, C. V., Martin, D. M. A., McCarter, J. P., McReynolds, L., Mitreva, M., Nutman, T. B., Parkinson, J., Peregrín-Alvarez, J. M., Poole, C., Ren, Q., Saunders, L., Sluder, A. E., Smith, K., Stanke, M., Unnasch, T. R., Ware, J., Wei, A. D., Weil, G., Williams, D. J., Zhang, Y., Williams, S. A., Fraser-Liggett, C., Slatko, B., Blaxter, M. L. & Scott, A. L., 21 Sep 2007, In : Science. 317, 5845, p. 1756-1760 5 p.

Research output: Contribution to journalArticle

Brugia malayi
Parasites
Ocular Onchocerciasis
Elephantiasis
Genome
516 Citations (Scopus)

Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis

Carlton, J. M., Hirt, R. P., Silva, J. C., Delcher, A. L., Schatz, M., Zhao, Q., Wortman, J. R., Bidwell, S. L., Alsmark, U. C. M., Besteiro, S., Sicheritz-Ponten, T., Noel, C. J., Dacks, J. B., Foster, P. G., Simillion, C., Van de Peer, Y., Miranda-Saavedra, D., Barton, G. J., Westrop, G. D., Muller, S. & 45 others, Dessi, D., Fiori, P. L., Ren, Q., Paulsen, I., Zhang, H., Bastida-Corcuera, F. D., Simoes-Barbosa, A., Brown, M. T., Hayes, R. D., Mukherjee, M., Okumura, C. Y., Schneider, R., Smith, A. J., Vanacova, S., Villalvazo, M., Haas, B. J., Pertea, M., Feldblyum, T. V., Utterback, T. R., Shu, C-L., Osoegawa, K., Jong, P. J. D., Hrdy, I., Horvathova, L., Zubacova, Z., Dolezal, P., Malik, S-B., Logsdon, J. M., Henze, K., Gupta, A., Wang, C. C., Dunne, R. L., Upcroft, J. A., Upcroft, P., White, O., Salzberg, S. L., Tang, P., Chiu, C-H., Lee, Y-S., Embley, T. M., Coombs, G. H., Mottram, J. C., Tachezy, J., Fraser-Liggett, C. M. & Johnson, P. J., 2007, In : Science. 315, 5809, p. 207-212 6 p.

Research output: Contribution to journalArticle

Trichomonas vaginalis
Genome
Horizontal Gene Transfer
DNA Transposable Elements
Gene Amplification
4 Citations (Scopus)

Expression, purification, crystallization, data collection and preliminary biochemical characterization of methicillin-resistant Staphylococcus aureus Sar2028, an aspartate/tyrosine/phenylalanine pyridoxal-5'-phosphate-dependent aminotransferase

Seetharamappa, J., Oke, M., Liu, H., McMahon, S. A., Johnson, K. A., Carter, L., Dorward, M., Zawadzki, M., Overton, I. M., van Niekirk, C. A. J., Graham, S., Botting, C. H., Taylor, G. L., White, M. F., Barton, G. J., Coote, P. J. & Naismith, J. H., 1 May 2007, In : Acta Crystallographica F-Structural Biology and Crystallization Communications. 63, Pt 5, p. 452-6 5 p.

Research output: Contribution to journalArticle

aspartates
Methicillin
Pyridoxal Phosphate
phenylalanine
staphylococcus
88 Citations (Scopus)

Probabilistic prediction and ranking of human protein-protein interactions

Scott, M. S. & Barton, G. J., 2007, In : BMC Bioinformatics. 8, p. 239 1 p.

Research output: Contribution to journalArticle

Protein-protein Interaction
Ranking
Proteins
Prediction
Interaction
4 Citations (Scopus)

Purification, crystallization and data collection of methicillin-resistant Staphylococcus aureus Sar2676, a pantothenate synthetase

Seetharamappa, J., Oke, M., Liu, H., McMahon, S. A., Johnson, K. A., Carter, L., Dorward, M., Zawadzki, M., Overton, I. M., Van Niekirk, C. A. J., Graham, S., Botting, C. H., Taylor, G. L., White, M. F., Barton, G. J., Coote, P. J. & Naismith, J. H., 5 May 2007, In : Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 63, 6, p. 488-491 4 p.

Research output: Contribution to journalArticle

pantothenate synthetase
Methicillin
staphylococcus
Methicillin-Resistant Staphylococcus aureus
Crystallization
46 Citations (Scopus)

SNAPPI-DB: a database and API of structures, iNterfaces and alignments for protein-protein interactions

Jefferson, E. R., Walsh, T. P., Roberts, T. J. & Barton, G. J., 2007, In : Nucleic Acids Research. 35, Database issue, p. D580-D589 10 p.

Research output: Contribution to journalArticle

Databases
Proteins
Quaternary Protein Structure
Protein Databases
47 Citations (Scopus)

The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe

Miranda-Saavedra, D., Stark, M. J. R., Packer, J. C., Vivares, C. P., Doerig, C. & Barton, G. J., 2007, In : BMC Genomics. 8, 309.

Research output: Contribution to journalArticle

Unclassified Microsporidia
Encephalitozoon cuniculi
Schizosaccharomyces
Eukaryota
Protein Kinases
70 Citations (Scopus)

The Structure of Serine Palmitoyltransferase; Gateway to Sphingolipid Biosynthesis

Yard, B. A., Carter, L. G., Johnson, K. A., Overton, I. M., Dorward, M., Liu, H., McMahon, S. A., Oke, M., Puech, D., Barton, G. J., Naismith, J. H. & Campopiano, D. J., 27 Jul 2007, In : Journal of Molecular Biology. 370, 5, p. 870-886 17 p.

Research output: Contribution to journalArticle

Serine C-Palmitoyltransferase
Sphingolipids
Glycosphingolipids
Catalytic Domain
Enzymes
2006
44 Citations (Scopus)

A normalised scale for structural genomics target ranking: the OB-Score

Overton, I. M. & Barton, G. J., 10 Jul 2006, In : FEBS Letters. 580, 16, p. 4005-4009 5 p.

Research output: Contribution to journalArticle

Isoelectric Point
Hydrophobicity
Genomics
Hydrophobic and Hydrophilic Interactions
Diffraction
21 Citations (Scopus)

Biological units and their effect upon the properties and prediction of protein–protein interactions

Jefferson, E. R., Walsh, T. P. & Barton, G. J., 2006, In : Journal of Molecular Biology. 364, 5, p. 1118-1129 12 p.

Research output: Contribution to journalArticle

Quaternary Protein Structure
Databases
Proteins
Protein Databases
336 Citations (Scopus)

Emerging roles of pseudokinases

Boudeau, J., Miranda-Saavedra, D., Barton, G. J. & Alessi, D. R., Sep 2006, In : Trends in Cell Biology. 16, 9, p. 443-452 10 p.

Research output: Contribution to journalArticle

Phosphotransferases
Myeloproliferative Disorders
Amino Acid Substitution
Protein-Tyrosine Kinases
Proteins
395 Citations (Scopus)
79 Downloads (Pure)

Identification of multiple distinct Snf2 subfamilies with conserved structural motifs

Flaus, A., Martin, D. M. A., Barton, G. J. & Owen-Hughes, T., 2006, In : Nucleic Acids Research. 34, 10, p. 2887-905 19 p.

Research output: Contribution to journalArticle

File
Eukaryota
Proteins
Genome
Chromatin Assembly and Disassembly
Conserved Sequence
34 Citations (Scopus)
161 Downloads (Pure)

MACSIMS: multiple alignment of complete sequences information management system

Thompson, J. D., Muller, A., Waterhouse, A., Procter, J., Barton, G. J., Plewniak, F. & Poch, O., 2006, In : BMC Bioinformatics. 7, p. 318

Research output: Contribution to journalArticle

Open Access
File
Management Information Systems
Information Management
Sequence Alignment
Information management
Alignment
34 Citations (Scopus)
50 Downloads (Pure)

Quantification of the variation in percentage identity for protein sequence alignments

Raghava, G. P. S. & Barton, G. J., 2006, In : BMC Bioinformatics. 7, p. 415

Research output: Contribution to journalArticle

Open Access
File
Sequence Alignment
Protein Sequence
Quantification
Percentage
Proteins
2004
66 Citations (Scopus)

E-MSD: an integrated data resource for bioinformatics

Golovin, A., Oldfield, T. J., Tate, J. G., Velankar, S., Barton, G. J., Boutselakis, H., Dimitropoulos, D., Fillon, J., Ionides, J. M. C., John, M., Keller, P. A., Krissinel, E., McNeil, P., Naim, A., Newman, R., Pajon, A., Pineda, J., Rachedi, A., Copeland, J., Sitnov, A. & 7 others, Sobhany, S., Suarez-Uruena, A., Swaminathan, G. J., Tagari, M., Tromm, S., Vranken, W. & Henrick, K., 1 Jan 2004, In : Nucleic Acids Research. 32, Database issue, p. D211-6

Research output: Contribution to journalArticle

Computational Biology
Databases
Secondary Protein Structure
Atlases
Proteins
181 Citations (Scopus)
19 Downloads (Pure)

GOtcha: a new method for prediction of protein function assessed by the annotation of seven genomes

Martin, D. M. A., Berriman, M. & Barton, G. J., 18 Nov 2004, In : BMC Bioinformatics. 5, 17 p., 178.

Research output: Contribution to journalArticle

Open Access
File
Gene Ontology
Annotation
Genome
Genes
Proteins
1102 Citations (Scopus)

The Jalview Java alignment editor

Clamp, M., Cuff, J., Searle, S. M. & Barton, G. J., 12 Feb 2004, In : Bioinformatics. 20, 3, p. 426-427 2 p.

Research output: Contribution to journalArticle

Multiple Sequence Alignment
Sequence Alignment
Java
Alignment
Protein Sequence
2003
4 Citations (Scopus)

Increased coverage obtained by combination of methods for protein sequence database searching

Webber, C. & Barton, G. J., 22 Jul 2003, In : Bioinformatics. 19, 11, p. 1397-1403 7 p.

Research output: Contribution to journalArticle

Protein Databases
Protein Sequence
Dynamic programming
Coverage
Proteins
138 Citations (Scopus)
65 Downloads (Pure)

OXBench: a benchmark for evaluation of protein multiple sequence alignment accuracy

Raghava, G. P. S., Searle, S. M. J., Audley, P. C., Barber, J. D. & Barton, G. J., 10 Oct 2003, In : BMC Bioinformatics. 4, 23 p., 47.

Research output: Contribution to journalArticle

Open Access
File
Benchmarking
Multiple Sequence Alignment
Sequence Alignment
Alignment
Benchmark
1 Citation (Scopus)

Visual representation of database search results: the RHIMS Plot

Martin, D. M. A., Hill, P., Barton, G. J. & Flavell, A. J., 22 May 2003, In : Bioinformatics. 19, 8, p. 1037-1038 2 p.

Research output: Contribution to journalArticle

Servers
Software
Visualization
Databases
Data Mining
2001
46 Citations (Scopus)

3Dee: a database of protein structural domains

Siddiqui, A. S., Dengler, U. & Barton, G. J., Feb 2001, In : Bioinformatics. 17, 2, p. 200-1 2 p.

Research output: Contribution to journalArticle

Databases
Proteins
Protein
World Wide Web
Internet
31 Citations (Scopus)

Estimation of P-values for global alignments of protein sequences

Webber, C. & Barton, G. J., Dec 2001, In : Bioinformatics. 17, 12, p. 1158-1167 10 p.

Research output: Contribution to journalArticle

Z-score
Sequence Alignment
Protein Sequence
Alignment
Proteins
26 Citations (Scopus)

Protein structural domains: analysis of the 3Dee domains database

Dengler, U., Siddiqui, A. S. & Barton, G. J., 15 Feb 2001, In : Proteins: Structure, Function, and Bioinformatics. 42, 3, p. 332-344 13 p.

Research output: Contribution to journalArticle

Databases
Proteins
Protein Domains
Internet
World Wide Web
2000
602 Citations (Scopus)

Application of multiple sequence alignment profiles to improve protein secondary structure prediction

Cuff, J. A. & Barton, G. J., 15 Aug 2000, In : Proteins: Structure, Function, and Bioinformatics. 40, 3, p. 502-511 10 p.

Research output: Contribution to journalArticle

Secondary Protein Structure
Sequence Alignment
Proteins
Computer program listings
Servers
11 Citations (Scopus)

ProtEST: protein multiple sequence alignments from expressed sequence tags

Cuff, J. A., Birney, E., Clamp, M. E. & Barton, G. J., Feb 2000, In : Bioinformatics. 16, 2, p. 111-6 6 p.

Research output: Contribution to journalArticle

Multiple Sequence Alignment
Sequence Alignment
Expressed Sequence Tags
Proteins
Protein
1999
478 Citations (Scopus)

Evaluation and improvement of multiple sequence methods for protein secondary structure prediction

Cuff, J. A. & Barton, G. J., 1 Mar 1999, In : Proteins: Structure, Function, and Bioinformatics. 34, 4, p. 508-19 12 p.

Research output: Contribution to journalArticle

Secondary Protein Structure
Proteins
World Wide Web
Web services
Sequence Alignment
1998
12 Citations (Scopus)

Deposition of macromolecular structures

Keller, P. A., Henrick, K., McNeil, P., Moodie, S. & Barton, G. J., 1 Nov 1998, In : Acta Crystallographica Section D: Biological Crystallography. 54, 6, no. 1, p. 1105-1108 4 p.

Research output: Contribution to journalArticle

876 Citations (Scopus)

JPred: a consensus secondary structure prediction server

Cuff, J. A., Clamp, M. E., Siddiqui, A. S., Finlay, M. & Barton, G. J., 1998, In : Bioinformatics. 14, 10, p. 892-3 2 p.

Research output: Contribution to journalArticle

Structure Prediction
Secondary Structure
Servers
Server
Secondary Protein Structure
10 Citations (Scopus)

Protein sequence alignment techniques

Barton, G. J., 1 Nov 1998, In : Acta Crystallographica Section D: Biological Crystallography. 54, 6, no. 1, p. 1139-1146 8 p.

Research output: Contribution to journalArticle

Sequence Alignment
Protein Sequence Analysis
Proteins
Research Design
1996
20 Citations (Scopus)

Conservation of amino acids in multiple alignments: aspartic acid has unexpected conservation

Fiser, A., Simon, I. & Barton, G. J., 18 Nov 1996, In : FEBS Letters. 397, 2-3, p. 225-229 5 p.

Research output: Contribution to journalArticle

Aspartic Acid
Conservation
Amino Acids
Sequence Alignment
Viperidae
60 Citations (Scopus)

Identification of functional residues and secondary structure from protein multiple sequence alignment

Livingstone, C. D. & Barton, G. J., 1996, In : Methods in Enzymology. 266, p. 497-512 16 p.

Research output: Contribution to journalArticle

Secondary Protein Structure
Sequence Alignment
Proteins
Conservation
114 Citations (Scopus)

Protein fold recognition by mapping predicted secondary structures

Russell, R. B., Copley, R. R. & Barton, G. J., 14 Jun 1996, In : Journal of Molecular Biology. 259, 3, p. 349-365 17 p.

Research output: Contribution to journalArticle

Proteins
Imino Acids
Phosphotyrosine
Sequence Alignment
von Willebrand Factor
1995
143 Citations (Scopus)

Continuous and discontinuous domains: an algorithm for the automatic generation of reliable protein domain definitions

Siddiqui, A. S. & Barton, G. J., May 1995, In : Protein Science. 4, 5, p. 872-84 13 p.

Research output: Contribution to journalArticle

Proteins
Protein Databases
Molecular graphics
Databases
Protein Domains