• 3503 Citations
  • 31 h-Index
1992 …2018
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Personal profile

Teaching

Dr Smith is lead for cancer-themed teaching in the School of Medicine. She is Module Manager for final year (Level 4) undergraduate Biological and Biomedical Sciences modules in Cancer Biology (BS42007) and Cancer Pharmacology and Treatment (BS42027), and module lead and member of the postgraduate MRes Cancer Biology programme team. Together with clinical colleagues Dr Michelle Ferguson and Dr Jonathan Berg, she also leads the BMSc Genetics, Cancer and Personalised Medicine programme for intercalating medical students. She additionally regularly supervises Year 1 MBChB SSC students and is an experienced supervsor of both laboratory-based, data analysis and science communication projects for undergraduate and postgraduate science and medical students. 

Biography

Dr Smith graduated from the University of Edinburgh with a BSc (Hons) degree in Chemistry and PhD in Medicine. Following a short Post-Doctoral Fellow position in the Department of Pathology, University of Edinburgh, she joined the newly created Biomedical Research Institute in the University of Dundee School of Medicine. Following an MRC-funded Post-Doctoral Fellowship in Dundee, she was invited to join the Department of Clinical Pharmacology, Uppsala University Hospital in Sweden as a visiting scientist, before returning to Dundee as Senior Scientist then Senior Lecturer. She is currently based in the Division of Cellular Medicine, where she is teaching lead for cancer-themed teaching and leads a translational research team working with clinical colleagues on novel approaches to personalise treatment and combat drug resistance in ovarian cancer.

Research interests

Translational studies on stratified medicine and drug resistance in ovarian and colorectal cancer. Biomarker discovery and collaborative "bench to bedside" cancer research.

Research

Dr Smith leads a translational research team, working collaboratively with clinical colleagues in oncology, surgery and pathology. We are particularly interested in understanding the molecular basis of drug resistance in common cancers, with current research focussing on ovarian and colorectal cancers, where the development of drug resistant disease frequently limits treatment response. We have created novel drug resistant cell line models which mimic typical clinical treatments, and have used these to identify key resistance modifiers including FGF and AKT-regulated signalling cascades which can be targeted in novel combination chemotherapy approaches. Our laboratory studies are complemented by longitudinal studies in drug sensitive and drug resistant cancer patients which focus both on target and biomarker discovery. Our research programme is currently supported by Medical Research Scotland, the Chief Scientist Office and local charities and we are fortunate to collaborate and share resources within the UK and with international colleagues.

Education/Academic qualification

Doctor of Philosophy, University of Edinburgh

Bachelor of Science, University of Edinburgh

Keywords

  • RM Therapeutics. Pharmacology
  • drug resistance
  • chemotherapy
  • ovarian cancer
  • colorectal cancer
  • stratified medicine
  • RZ Other systems of medicine
  • Cancer Biology
  • cancer research

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Research Output 1992 2018

Interaction between polymorphisms in aspirin metabolic pathways, regular aspirin use and colorectal cancer risk: A case-control study in unselected white European populations

Sheth, H. , Northwood, E. , Ulrich, C. M. , Scherer, D. , Elliott, F. , Barrett, J. H. , Forman, D. , Wolf, C. R. , Smith, G. , Jackson, M. S. , Santibanez-Koref, M. , Haile, R. , Casey, G. , Jenkins, M. , Win, A. K. , Hopper, J. L. , Marchand, L. L. , Lindor, N. M. , Thibodeau, S. N. , Potter, J. D. & 2 others Burn, J. & Bishop, D. T., 9 Feb 2018, In : PLoS ONE. 13, 2, p. 1-17 17 p., e0192223

Research output: Contribution to journalArticle

Open Access
File
aspirin
Metabolic Networks and Pathways
case-control studies
Polymorphism
colorectal neoplasms
23 Citations

ABCB1 (MDR1) induction defines a common resistance mechanism in paclitaxel- and olaparib-resistant ovarian cancer cells

Vaidyanathan, A., Sawers, L., Gannon, A-L., Chakravarty, P., Scott, A. L., Bray, S. E., Ferguson, M. J. & Smith, G., 9 Aug 2016, In : British Journal of Cancer. 115, p. 431-441 11 p.

Research output: Contribution to journalArticle

Open Access
File
Paclitaxel
Ovarian Neoplasms
Pharmaceutical Preparations
Doxorubicin
Verapamil
37 Citations

MicroRNA-224 is associated with colorectal cancer progression and response to 5-fluorouracil-based chemotherapy by KRAS-dependent and-independent mechanisms

Amankwatia, E. B., Chakravarty, P., Carey, F. A., Weidlich, S., Steele, R. J. C., Munro, A. J., Wolf, C. R. & Smith, G., 28 Apr 2015, In : British Journal of Cancer. 112, 9, p. 1480-1490 11 p.

Research output: Contribution to journalArticle

MicroRNAs
Fluorouracil
Colorectal Neoplasms
Adenoma
HCT116 Cells
10 Citations

Recurrent Coding Sequence Variation Explains only A Small Fraction of the Genetic Architecture of Colorectal Cancer

Timofeeva, M. N. , Kinnersley, B. , Farrington, S. M. , Whiffin, N. , Palles, C. , Svinti, V. , Lloyd, A. , Gorman, M. , Ooi, L. Y. , Hosking, F. , Barclay, E. , Zgaga, L. , Dobbins, S. , Martin, L. , Theodoratou, E. , Broderick, P. , Tenesa, A. , Smillie, C. , Grimes, G. , Hayward, C. & 41 others Campbell, A., Porteous, D., Deary, I. J., Harris, S. E., Northwood, E. L., Barrett, J. H., Smith, G., Wolf, R., Forman, D., Morreau, H., Ruano, D., Tops, C., Wijnen, J., Schrumpf, M., Boot, A., Vasen, H. F. A., Hes, F. J., Van Wezel, T., Franke, A., Lieb, W., Schafmayer, C., Hampe, J., Buch, S., Propping, P., Hemminki, K., Försti, A., Westers, H., Hofstra, R., Pinheiro, M., Pinto, C., Teixeira, M., Ruiz-Ponte, C., Fernández-Rozadilla, C., Carracedo, A., Castells, A., Castellví-Bel, S., Campbell, H., Bishop, D. T., Tomlinson, I. P. M., Dunlop, M. G. & Houlston, R. S., 10 Nov 2015, In : Scientific Reports. 5, 10 p., 16286

Research output: Contribution to journalArticle

Open Access
File
Colorectal Neoplasms
Genes
Exome
DNA Mismatch Repair
Nucleic Acid Regulatory Sequences
31 Citations

Glutathione S-transferase P1 (GSTP1) directly influences platinum drug chemosensitivity in ovarian tumour cell lines

Sawers, L., Ferguson, M. J., Ihrig, B. R., Young, H. C., Chakravarty, P., Wolf, C. R. & Smith, G., 9 Sep 2014, In : British Journal of Cancer. 111, 6, p. 1150-1158 9 p.

Research output: Contribution to journalArticle

Open Access
File
Transferases
Platinum
Tumor Cell Line
Ovarian Neoplasms
Glutathione

Activities 2001 2006

  • 5 Participation in conference

14th North American ISSX Meeting

Smith, G. (Participant)
22 Oct 200626 Oct 2006

Activity: Participating in or organising an eventParticipation in conference

Newcastle Pathology 2005: 3rd Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain and Ireland

Smith, G. (Participant)
5 Jul 20058 Jul 2005

Activity: Participating in or organising an eventParticipation in conference

British Society for Investigative Dermatology Annual Meeting

Smith, G. (Participant)
7 Apr 20039 Apr 2003

Activity: Participating in or organising an eventParticipation in conference

184th Meeting of the Pathological Society of Great Britain and Ireland

Smith, G. (Participant)
2 Jul 20025 Jul 2002

Activity: Participating in or organising an eventParticipation in conference

51st Annual Meeting of the American Society of Human Genetics

Smith, G. (Participant)
12 Oct 200116 Oct 2001

Activity: Participating in or organising an eventParticipation in conference

Press / Media

Gene helps predict which ovarian cancer sufferers will benefit most from chemotherapy

Gillian Smith, Michael Ng, C Simon Herrington, Michelle Ferguson & C Wolf

19/09/12

1 item of media coverage

Press/Media: Research

Thesis

microRNA expression in colorectal tumours: identification of novel mechanisms of gene regulation

Author: Amankwatia, E. B., 2014

Supervisor: Smith, G. (Supervisor) & Wolf, C. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File