Projects per year
Dr Smith is lead for cancer-themed teaching in the School of Medicine. She is Module Manager for final year (Level 4) undergraduate Biological and Biomedical Sciences modules in Cancer Biology (BS42007) and Cancer Pharmacology and Treatment (BS42027), and module lead and member of the postgraduate MRes Cancer Biology programme team. Together with clinical colleagues Dr Michelle Ferguson and Dr Jonathan Berg, she also leads the BMSc Genetics, Cancer and Personalised Medicine programme for intercalating medical students. She additionally regularly supervises Year 1 MBChB SSC students and is an experienced supervsor of both laboratory-based, data analysis and science communication projects for undergraduate and postgraduate science and medical students.
Dr Smith graduated from the University of Edinburgh with a BSc (Hons) degree in Chemistry and PhD in Medicine. Following a short Post-Doctoral Fellow position in the Department of Pathology, University of Edinburgh, she joined the newly created Biomedical Research Institute in the University of Dundee School of Medicine. Following an MRC-funded Post-Doctoral Fellowship in Dundee, she was invited to join the Department of Clinical Pharmacology, Uppsala University Hospital in Sweden as a visiting scientist, before returning to Dundee as Senior Scientist then Senior Lecturer. She is currently based in the Division of Cellular Medicine, where she is teaching lead for cancer-themed teaching and leads a translational research team working with clinical colleagues on novel approaches to personalise treatment and combat drug resistance in ovarian cancer.
Translational studies on stratified medicine and drug resistance in ovarian and colorectal cancer. Biomarker discovery and collaborative "bench to bedside" cancer research.
Dr Smith leads a translational research team, working collaboratively with clinical colleagues in oncology, surgery and pathology. We are particularly interested in understanding the molecular basis of drug resistance in common cancers, with current research focussing on ovarian and colorectal cancers, where the development of drug resistant disease frequently limits treatment response. We have created novel drug resistant cell line models which mimic typical clinical treatments, and have used these to identify key resistance modifiers including FGF and AKT-regulated signalling cascades which can be targeted in novel combination chemotherapy approaches. Our laboratory studies are complemented by longitudinal studies in drug sensitive and drug resistant cancer patients which focus both on target and biomarker discovery. Our research programme is currently supported by Medical Research Scotland, the Chief Scientist Office and local charities and we are fortunate to collaborate and share resources within the UK and with international colleagues.
Doctor of Philosophy, University of Edinburgh
Award Date: 1 Jan 1992
Bachelor of Science, University of Edinburgh
Award Date: 1 Jan 1988
- RM Therapeutics. Pharmacology
- drug resistance
- ovarian cancer
- colorectal cancer
- stratified medicine
- RZ Other systems of medicine
- Cancer Biology
- cancer research
Reversing Resistance - Development of Novel Combination Chemotherapy Approaches to Combat Drug Resistance in Ovarian Cancer
Ferguson, M. & Smith, G.
2/09/19 → 1/03/23
Characterisation of the Ovarian Cancer Stem Cell Niche - Targeting Stem Cell Biology to Combat Drug Resistance (NHS Tayside)
Ferguson, M., McMullen, W. & Smith, G.
1/06/18 → 1/12/21
A comparative pharmacokinetic study of PARP inhibitors demonstrates favorable properties for niraparib efficacy in preclinical tumor modelsSun, K., Mikule, K., Wang, Z., Poon, G., Vaidyanathan, A., Smith, G., Zhang, Z. Y., Hanke, J., Ramaswamy, S. & Wang, J., 14 Dec 2018, In : Oncotarget. 9, 98, p. 37080-37096 17 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile20 Citations (Scopus)184 Downloads (Pure)
Interaction between polymorphisms in aspirin metabolic pathways, regular aspirin use and colorectal cancer risk: A case-control study in unselected white European populationsSheth, H., Northwood, E., Ulrich, C. M., Scherer, D., Elliott, F., Barrett, J. H., Forman, D., Wolf, C. R., Smith, G., Jackson, M. S., Santibanez-Koref, M., Haile, R., Casey, G., Jenkins, M., Win, A. K., Hopper, J. L., Marchand, L. L., Lindor, N. M., Thibodeau, S. N., Potter, J. D. & 2 others, , 9 Feb 2018, In : PLoS ONE. 13, 2, p. 1-17 17 p., e0192223.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile2 Citations (Scopus)199 Downloads (Pure)
ABCB1 (MDR1) induction defines a common resistance mechanism in paclitaxel- and olaparib-resistant ovarian cancer cellsVaidyanathan, A., Sawers, L., Gannon, A-L., Chakravarty, P., Scott, A. L., Bray, S. E., Ferguson, M. J. & Smith, G., 9 Aug 2016, In : British Journal of Cancer. 115, p. 431-441 11 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile93 Citations (Scopus)358 Downloads (Pure)
MicroRNA-224 is associated with colorectal cancer progression and response to 5-fluorouracil-based chemotherapy by KRAS-dependent and-independent mechanismsAmankwatia, E. B., Chakravarty, P., Carey, F. A., Weidlich, S., Steele, R. J. C., Munro, A. J., Wolf, C. R. & Smith, G., 28 Apr 2015, In : British Journal of Cancer. 112, 9, p. 1480-1490 11 p.
Research output: Contribution to journal › Article › peer-review
Recurrent Coding Sequence Variation Explains only A Small Fraction of the Genetic Architecture of Colorectal CancerTimofeeva, M. N., Kinnersley, B., Farrington, S. M., Whiffin, N., Palles, C., Svinti, V., Lloyd, A., Gorman, M., Ooi, L. Y., Hosking, F., Barclay, E., Zgaga, L., Dobbins, S., Martin, L., Theodoratou, E., Broderick, P., Tenesa, A., Smillie, C., Grimes, G., Hayward, C. & 41 others, , 10 Nov 2015, In : Scientific Reports. 5, 10 p., 16286.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile15 Citations (Scopus)160 Downloads (Pure)
Erin Hardee (Organiser), Amy Cameron (Contributor), Ali Floyd (Contributor), Senga Robertson-Albertyn (Contributor), Claire Gorby (Contributor), Helge Dorfmueller (Contributor), Julia Marchingo (Contributor), Graham Christie (Contributor), Megan Bergkessel (Contributor), Mathew Jones (Contributor), Jorunn Bos (Contributor), Sarah McKim (Contributor), Piers Hemsley (Contributor), Davide Bulgarelli (Contributor), Edgar Huitema (Contributor), Christopher Henstridge (Contributor), Laureano de la Vega (Contributor), Ros Langston (Contributor), Amy Rogers (Contributor), Charlotte Proby (Contributor), Olga Semenova (Contributor), Carmen Escudero-Martinez (Contributor), Colin Henderson (Contributor), Gillian Smith (Contributor), Dominic Grussu (Contributor), Robin Pflughaupt (Contributor), Giulia Saredi (Contributor), Vanesa Alvarez (Contributor), Beatrice Colon (Contributor), Sharon Matthews (Contributor), Diana Gudynaite (Contributor), Sascha Roth (Contributor), Laura Casares Perez (Contributor), Hugh Nicholson (Contributor), Morven Shuttleworth (Contributor), Vasudha Tandon (Contributor), Richard Smith (Contributor), Rita Moreno Dorta (Contributor), Ryan Kwan (Contributor), Chidozie Ogbonnaya (Contributor), Ayman Banah (Contributor), Claire Ross (Contributor), Fiona Ramage (Contributor) & Xiong Weng (Contributor)27 Jul 2020 → 31 Jul 2020
Activity: Other activity types › Schools engagement
Matthew Jarron (Organiser), Amy Cameron (Organiser), Nicola Morrice (Contributor), Chim Lang (Contributor), Agathe Lermant (Contributor), Cara Nicholson (Contributor), Colin Henderson (Contributor), Ros Langston (Member), Laureano de la Vega (Member), Gillian Smith (Contributor), Daniella Cavellini (Contributor), Andrew Evans (Contributor), Jane Dickson (Contributor), Jacqueline Eccles (Contributor), Ola Epemolu (Contributor), Kevin Read (Contributor), Mattie Pawlowic (Contributor), Matthew Taylor (Contributor), Sarah McKim (Contributor), Henry McSorley (Contributor), Peter Mossey (Contributor), Susan Wyllie (Contributor), Niamh Nic Daeid (Contributor), Seaneen McDougall (Contributor), Ailsa Mackintosh (Contributor), Ali Floyd (Contributor), Catharine Goddard (Contributor), Li Kang (Contributor), James Gemmill (Contributor) & Rolf Black (Contributor)Nov 2020
Activity: Other activity types › Other
Colin Henderson (Organiser), Gillian Smith (Participant), Hugh Nicholson (Participant), Amber Mcwhirter (Participant), Sharon King (Participant), Susan Bray (Participant), Sally Chalmers (Participant), Daniella Cavellini (Participant), Susan Simpson (Participant), Yvonne Gormley (Participant), Lukas Markwalder (Participant), Agathe Lermant (Participant), Paul O'Mahoney (Participant), Kumara Dissanayake (Participant), Jill Belch (Participant), Amy Rogers (Participant), Suzanne Duce (Participant), Christopher Henstridge (Participant), Ros Langston (Participant), Fiona Hogarth (Participant), Jordan Napier (Participant), Annie Anderson (Participant), Fredrick Comerford (Participant), Frances Fuller-Pace (Participant), Lisa Crozier (Participant), Tania G. Frangova (Participant), Francisco Inesta-Vaquera (Participant), Marilia Henriques Cordeiro (Participant), Rebecca Barr (Participant), Andrea Corno (Participant), Roderick McLeod (Participant), Colin Murdoch (Participant) & Susan Storrier (Participant)21 Sep 2019
Activity: Participating in or organising an event types › Festival/Exhibition
Colin Henderson (Participant), Frances Fuller-Pace (Participant), Gillian Smith (Participant), Francisco Inesta-Vaquera (Participant), Susan Bray (Participant), Norman Pratt (Participant), Rosamund Langston (Participant), Suzanne Duce (Participant) & Hugh Nicholson (Participant)8 Sep 2018
Activity: Participating in or organising an event types › Festival/Exhibition
1 item of Media coverage