Smith, Gillian

Dr

  • 3647 Citations
  • 32 h-Index
1992 …2022
If you made any changes in Pure these will be visible here soon.

Research Output 1992 2018

2018
6 Citations (Scopus)
81 Downloads (Pure)

A comparative pharmacokinetic study of PARP inhibitors demonstrates favorable properties for niraparib efficacy in preclinical tumor models

Sun, K., Mikule, K., Wang, Z., Poon, G., Vaidyanathan, A., Smith, G., Zhang, Z. Y., Hanke, J., Ramaswamy, S. & Wang, J., 14 Dec 2018, In : Oncotarget. 9, 98, p. 37080-37096 17 p.

Research output: Contribution to journalArticle

Open Access
File
Pharmacokinetics
Neoplasms
Cell Membrane Permeability
niraparib
Poly(ADP-ribose) Polymerase Inhibitors
2 Citations (Scopus)
134 Downloads (Pure)

Interaction between polymorphisms in aspirin metabolic pathways, regular aspirin use and colorectal cancer risk: A case-control study in unselected white European populations

Sheth, H., Northwood, E., Ulrich, C. M., Scherer, D., Elliott, F., Barrett, J. H., Forman, D., Wolf, C. R., Smith, G., Jackson, M. S., Santibanez-Koref, M., Haile, R., Casey, G., Jenkins, M., Win, A. K., Hopper, J. L., Marchand, L. L., Lindor, N. M., Thibodeau, S. N., Potter, J. D. & 2 others, Burn, J. & Bishop, D. T., 9 Feb 2018, In : PLoS ONE. 13, 2, p. 1-17 17 p., e0192223.

Research output: Contribution to journalArticle

Open Access
File
aspirin
Metabolic Networks and Pathways
case-control studies
Polymorphism
colorectal neoplasms
2016
49 Citations (Scopus)
229 Downloads (Pure)

ABCB1 (MDR1) induction defines a common resistance mechanism in paclitaxel- and olaparib-resistant ovarian cancer cells

Vaidyanathan, A., Sawers, L., Gannon, A-L., Chakravarty, P., Scott, A. L., Bray, S. E., Ferguson, M. J. & Smith, G., 9 Aug 2016, In : British Journal of Cancer. 115, p. 431-441 11 p.

Research output: Contribution to journalArticle

Open Access
File
Paclitaxel
Ovarian Neoplasms
Pharmaceutical Preparations
Doxorubicin
Verapamil
2015
43 Citations (Scopus)

MicroRNA-224 is associated with colorectal cancer progression and response to 5-fluorouracil-based chemotherapy by KRAS-dependent and-independent mechanisms

Amankwatia, E. B., Chakravarty, P., Carey, F. A., Weidlich, S., Steele, R. J. C., Munro, A. J., Wolf, C. R. & Smith, G., 28 Apr 2015, In : British Journal of Cancer. 112, 9, p. 1480-1490 11 p.

Research output: Contribution to journalArticle

MicroRNAs
Fluorouracil
Colorectal Neoplasms
Adenoma
HCT116 Cells
15 Citations (Scopus)
97 Downloads (Pure)

Recurrent Coding Sequence Variation Explains only A Small Fraction of the Genetic Architecture of Colorectal Cancer

Timofeeva, M. N., Kinnersley, B., Farrington, S. M., Whiffin, N., Palles, C., Svinti, V., Lloyd, A., Gorman, M., Ooi, L. Y., Hosking, F., Barclay, E., Zgaga, L., Dobbins, S., Martin, L., Theodoratou, E., Broderick, P., Tenesa, A., Smillie, C., Grimes, G., Hayward, C. & 41 others, Campbell, A., Porteous, D., Deary, I. J., Harris, S. E., Northwood, E. L., Barrett, J. H., Smith, G., Wolf, R., Forman, D., Morreau, H., Ruano, D., Tops, C., Wijnen, J., Schrumpf, M., Boot, A., Vasen, H. F. A., Hes, F. J., Van Wezel, T., Franke, A., Lieb, W., Schafmayer, C., Hampe, J., Buch, S., Propping, P., Hemminki, K., Försti, A., Westers, H., Hofstra, R., Pinheiro, M., Pinto, C., Teixeira, M., Ruiz-Ponte, C., Fernández-Rozadilla, C., Carracedo, A., Castells, A., Castellví-Bel, S., Campbell, H., Bishop, D. T., Tomlinson, I. P. M., Dunlop, M. G. & Houlston, R. S., 10 Nov 2015, In : Scientific Reports. 5, 10 p., 16286.

Research output: Contribution to journalArticle

Open Access
File
Colorectal Neoplasms
Genes
Exome
DNA Mismatch Repair
Nucleic Acid Regulatory Sequences
2014
39 Citations (Scopus)
128 Downloads (Pure)

Glutathione S-transferase P1 (GSTP1) directly influences platinum drug chemosensitivity in ovarian tumour cell lines

Sawers, L., Ferguson, M. J., Ihrig, B. R., Young, H. C., Chakravarty, P., Wolf, C. R. & Smith, G., 9 Sep 2014, In : British Journal of Cancer. 111, 6, p. 1150-1158 9 p.

Research output: Contribution to journalArticle

Open Access
File
Platinum
Glutathione Transferase
Tumor Cell Line
Pharmaceutical Preparations
Ovarian Neoplasms
2013
8 Citations (Scopus)

Cytochrome P450 CYP1B1 interacts with 8-methoxypsoralen (8-MOP) and influences psoralen-ultraviolet (PUVA) sensitivity

Deeni, Y. Y., Ibbotson, S. H., Woods, J. A., Wolf, C. R. & Smith, G., 2013, In : PLoS ONE. 8, 9, e75494.

Research output: Contribution to journalArticle

psoralen
methoxsalen
Methoxsalen
Ficusin
cytochrome P-450
2012
16 Citations (Scopus)
16 Citations (Scopus)

Glutathione S-transferase genotype is associated with sensitivity to psoralen-ultraviolet A photochemotherapy

Ibbotson, S. H., Dawe, R. S., Dinkova-Kostova, A. T., Weidlich, S., Farr, P. M., Ferguson, J., Wolf, C. R. & Smith, G., Feb 2012, In : British Journal of Dermatology. 166, 2, p. 380-388 9 p.

Research output: Contribution to journalArticle

Ficusin
Photochemotherapy
Glutathione Transferase
Genotype
Methoxsalen
13 Citations (Scopus)

Individuality in FGF1 expression significantly influences platinum resistance and progression-free survival in ovarian cancer

Smith, G., Ng, M. T. H., Shepherd, L., Herrington, C. S., Gourley, C., Ferguson, M. & Wolf, C. R., 9 Oct 2012, In : British Journal of Cancer. 107, 8, p. 1327-1336 10 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 1
Platinum
Individuality
Ovarian Neoplasms
Disease-Free Survival
2011
8 Citations (Scopus)
21 Citations (Scopus)

Pyrosequencing-based methods reveal marked inter-individual differences in oncogene mutation burden in human colorectal tumours

Weidlich, S., Walsh, K., Crowther, D., Burczynski, M. E., Feuerstein, G., Carey, F., Steele, R. J. C., Wolf, C. R., Miele, G. & Smith, G., 12 Jul 2011, In : British Journal of Cancer. 105, 2, p. 246-254 9 p.

Research output: Contribution to journalArticle

2010

Activating K-Ras mutations outwith "hotspot" codons in sporadic colorectal tumours: implications for personalised cancer medicine

Smith, G., Bounds, R., Wolf, H., Pratt, N., Carey, F., Steele, R. & Wolf, C., Sep 2010, In : Journal of Pathology. 222, S1, p. S12-S12 1 p.

Research output: Contribution to journalMeeting abstract

113 Citations (Scopus)

Activating K-Ras mutations outwith 'hotspot' codons in sporadic colorectal tumours: implications for personalised cancer medicine

Smith, G., Bounds, R., Wolf, H., Steele, R., Carey, F. & Wolf, R., 16 Feb 2010, In : British Journal of Cancer. 102, 4, p. 693-703 11 p.

Research output: Contribution to journalArticle

Glutathione S-transferase M1 (GSTM1) genotype is associated with serum 8-MOP concentration and PUVA sensitivity

Ibbotson, S. H., Dawe, R. S., Weidlich, S., Dinkova-Kostova, A. T., Farr, P. M., Ferguson, J., Wolf, C. R. & Smith, G., Apr 2010, In : British Journal of Dermatology. 162, 4, p. 941-941 1 p.

Research output: Contribution to journalMeeting abstract

39 Citations (Scopus)

Polymorphisms in xenobiotic metabolizing enzymes and diet influence colorectal adenoma risk

Northwood, E. L., Elliott, F., Forman, D., Barrett, J. H., Wilkie, M. J. V., Carey, F. A., Steele, R. J. C., Wolf, R., Bishop, T. & Smith, G., 2010, In : Pharmacogenetics and Genomics. 20, 5, p. 315-326 12 p.

Research output: Contribution to journalArticle

2009
31 Citations (Scopus)

Genetic Variants in XRCC2: New Insights Into Colorectal Cancer Tumorigenesis

Curtin, K., Lin, W-Y., George, R., Katory, M., Shorto, J., Cannon-Albright, L. A., Smith, G., Bishop, D. T., Cox, A., Camp, N. J. & Colorectal Canc Study Grp, Sep 2009, In : Cancer Epidemiology, Biomarkers & Prevention. 18, 9, p. 2476-2484 9 p.

Research output: Contribution to journalArticle

Glutathione S-transferase M1 genotype is associated with erythemal sensitivity to narrowband ultraviolet B in patients with psoriasis

Ibbotson, S. H., Weidlich, S., Ferguson, J., Wolf, R., Dawe, R. S. & Smith, G., Apr 2009, In : British Journal of Dermatology. 160, 4, p. 928-928 1 p.

Research output: Contribution to journalArticle

75 Citations (Scopus)

Polymorphisms in the SLC6A4 and HTR2A genes influence treatment outcome following antidepressant therapy

Wilkie, M. J. V., Smith, G., Day, R., Matthews, K., Smith, D., Blackwood, D., Reid, I. C. & Wolf, R., 2009, In : Pharmacogenomics Journal. 9, 1, p. 61-70 10 p.

Research output: Contribution to journalArticle

2008

DUSP6/MKP-3 expression and K-ras mutation in colorectal cancer

Conlin, A., Smith, G., Steele, R. J. C. & Wolf, C. R., Mar 2008, In : Gut. 57, Supplement 1, p. A134-A134 1 p., 350.

Research output: Contribution to journalBook/Film/Article review

22 Citations (Scopus)

Methylene tetrahydrofolate reductase genotype modifies the chemopreventive effect of folate in colorectal adenoma, but not colorectal cancer

Lightfoot, T. J., Barrett, J. H., Bishop, T., Northwood, E. L., Smith, G., Wilkie, M. J. V., Steele, R. J. C., Carey, F. A., Key, T. J., Wolf, R. & Forman, D., Sep 2008, In : Cancer Epidemiology, Biomarkers & Prevention. 17, 9, p. 2421-2430 10 p.

Research output: Contribution to journalArticle

2007
72 Citations (Scopus)

A splice site polymorphism in the G-protein beta subunit influences antidepressant efficacy in depression

Wilkie, M. J. V., Smith, D., Reid, I. C., Day, R. K., Matthews, K., Wolf, R., Blackwood, D. & Smith, G., Mar 2007, In : Pharmacogenetics and Genomics. 17, 3, p. 207-215 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Can dietary furanocoumarin ingestion enhance the erythemal response during high-dose UVA1 therapy?

Beattie, P. E., Wilkie, M. J. V., Smith, G., Ferguson, J. & Ibbotson, S., Jan 2007, In : Journal of the American Academy of Dermatology. 56, 1, p. 84-87 4 p.

Research output: Contribution to journalArticle

Ficusin
Pastinaca
Eating
Phototoxic Dermatitis
Skin
13 Citations (Scopus)

Melanocortin 1 receptor (MC1R) genotype influences erythemal sensitivity to psoralen-ultraviolet A photochemotherapy

Smith, G., Wilkie, M. J. V., Deeni, Y. Y., Farr, P. M., Ferguson, J., Wolf, C. R. & Ibbotson, S. H., Dec 2007, In : British Journal of Dermatology. 157, 6, p. 1230-4 5 p.

Research output: Contribution to journalArticle

Receptor, Melanocortin, Type 1
Ficusin
Photochemotherapy
Genotype
Skin Neoplasms
2006
24 Citations (Scopus)

Chromosomal changes in colorectal adenomas: relationship to gene mutations and potential for clinical utility

Leslie, A., Stewart, A., Baty, D. U., Mechan, D., McGreavey, L., Smith, G., Wolf, C. R., Sales, M., Pratt, N. R., Steele, R. J. C. & Carey, F. A., Feb 2006, In : Genes, Chromosomes and Cancer. 45, 2, p. 126-135 10 p.

Research output: Contribution to journalArticle

Adenoma
Chromosome Aberrations
Mutation
Genes
Adenocarcinoma

Genetic factors associated with the aetiology and treatment of colorectal cancer

Wolf, C. R., Steele, R. J. C., Carey, F. A., Pratt, N. D., Bishop, D. T., Barrett, J. H., Forman, D. & Smith, G., 1 Sep 2006, In : Toxicology. 226, 1, p. 14-14 1 p.

Research output: Contribution to journalMeeting abstract

Identification of CYP2S1 ligands

Dickmann, L. J., Deeni, Y., Smith, G. & Wolf, C. R., 2006.

Research output: Contribution to conferenceAbstract

Identification of CYP2S1 ligands

Dickmann, L. J., Deeni, Y., Smith, G. & Wolf, C. R., 2006, In : Drug Metabolism Reviews. 38, Suppl., p. 56-56 1 p.

Research output: Contribution to journalMeeting abstract

1 Citation (Scopus)

Inter- and intrasubject variation in cytoprotective gene expression in patients with psoriasis

Smith, G., Hearn, R., Wolf, C. R., Ferguson, J. & Ibbotson, S. H., Jul 2006, In : British Journal of Dermatology. 155, 1, p. 254-254 1 p., P26.

Research output: Contribution to journalMeeting abstract

Melanocortin 1 receptor genotype influences erythemal sensitivity and treatment response in patients undergoing psoralen plus ultraviolet A treatment

Smith, G., Wilkie, M. J. V., Deeni, Y. Y., Ferguson, J., Wolf, C. R. & Ibbotson, S. H., Jul 2006, In : British Journal of Dermatology. 155, 1, p. 240-240 1 p., O15.

Research output: Contribution to journalMeeting abstract

39 Citations (Scopus)

Regulation of cutaneous drug-metabolizing enzymes and cytoprotective gene expression by topical drugs in human skin in vivo

Smith, G., Ibbotson, S. H., Comrie, M. M., Dawe, R. S., Bryden, A., Ferguson, J. & Wolf, C. R., 2006, In : British Journal of Dermatology. 155, 2, p. 275-81 7 p.

Research output: Contribution to journalArticle

Drug and Narcotic Control
Gene Expression
Skin
Enzymes
Pharmaceutical Preparations
2005
15 Citations (Scopus)

Mutation and tissue microarray analysis of tumour suppressor genes and cell cycle-related proteins in colorectal cancer

Robertson, K. E., Conlin, A., Miller, J., Smith, G., Steele, R. J. C., Wolf, C. R., Levison, D. A. & Carey, F. A., 2005, In : Journal of Pathology. 207, Suppl. 1, p. 43-43 1 p.

Research output: Contribution to journalMeeting abstract

Mutation and tissue microarray analysis of tumour suppressor genes and cell cycle-related proteins in colorectal cancer

Robertson, K. E., Conlin, A., Miller, J., Smith, G., Steele, R. J. C., Wolf, C. R., Levison, D. A. & Carey, F. A., 2005.

Research output: Contribution to conferenceAbstract

49 Citations (Scopus)

No evidence that polymorphisms in CYP2C8, CYP2C9, UGT1A6, PPAR[delta] and PPAR[gamma] act as modifiers of the protective effect of regular NSAID use on the risk of colorectal carcinoma

McGreavey, L. E., Turner, F., Smith, G., Boylan, K., Bishop, D. T., Forman, D., Wolf, C. R. & Barrett, J. H., 2005, In : Pharmacogenetics and Genomics. 15, 10, p. 713-721 9 p.

Research output: Contribution to journalArticle

155 Citations (Scopus)

The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma

Conlin, A., Smith, G., Carey, F. A., Wolf, C. R. & Steele, R. J. C., 2005, In : Gut. 54, 9, p. 1283-1286 4 p.

Research output: Contribution to journalArticle

Adenomatous Polyposis Coli
Colorectal Neoplasms
Mutation
Genes
Carcinogenesis
2004
27 Citations (Scopus)

No association of polymorphisms in CYP17, CYP19, and HSD17-B1 with plasma estradiol concentrations in 1,090 British women

Travis, R. C., Churchman, M., Edwards, S. A., Smith, G., Verkasalo, P. K., Wolf, C. R., Wolf, H. & Key, T. J., 2004, In : Cancer Epidemiology, Biomarkers & Prevention. 13, 12, p. 2282-4 3 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Phenotyping of N-acetyltransferase type 2 by caffeine from uncontrolled dietary exposure

Jetter, A., Kinzig-Schippers, M., Illauer, M., Hermann, R., Erb, K., Borlak, J., Wolf, H., Smith, G., Cascorbi, I., Sorgel, F. & Fuhr, U., 2004, In : European Journal of Clinical Pharmacology. 60, 1, p. 17-21 5 p.

Research output: Contribution to journalArticle

Regulation of cytochrome P450 CYP2S1 in human skin by UVR and topical drugs used to treat psoriasis

Smith, G., Deeni, Y. Y., Dawe, R. S., Evans, A. T., Ferguson, J., Wolf, C. R. & Ibbotson, S. H., Aug 2004, In : Drug Metabolism Reviews. 36, Supplement 1, p. 181-181 1 p., 363.

Research output: Contribution to journalMeeting abstract

57 Citations (Scopus)

Vegetable, fruit and meat consumption and potential risk modifying genes in relation to colorectal cancer

Turner, F., Smith, G., Sachse, C., Lightfoot, T., Garner, R. C., Wolf, C. R., Forman, D., Bishop, D. T., Barrett, J. H. & Colorectal Cancer Study Group, 1 Nov 2004, In : International Journal of Cancer. 112, 2, p. 259-264 6 p.

Research output: Contribution to journalArticle

2003
114 Citations (Scopus)

Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases

Smith, G., Wolf, C. R., Deeni, Y. Y., Dawe, R. S., Evans, A. T., Comrie, M. M., Ferguson, J. & Ibbotson, S. H., 2003, In : Lancet. 361, 9366, p. 1336-1343 8 p.

Research output: Contribution to journalArticle

Psoriasis
Skin Diseases
Individuality
Cytochrome P-450 Enzyme System
Skin
32 Citations (Scopus)

Cytochrome P450 CYP2S1 expression in human skin: individuality in regulation by therapeutic agents for psoriasis and other skin diseases

Smith, G., Deeni, Y. Y., Dawe, R. S., Comrie, M. M., Wolf, C. R., Ferguson, J. & Ibbotson, S. H., Apr 2003, In : British Journal of Dermatology. 148, 4, p. 853-853 1 p., O16.

Research output: Contribution to journalMeeting abstract

90 Citations (Scopus)

Investigation of interaction between N-acetyltransferase 2 and heterocyclic amines as potential risk factors for colorectal cancer

Barrett, J. H., Smith, G., Waxman, R., Gooderham, N., Lightfoot, T., Garner, R. C., Augustsson, K., Wolf, C. R., Bishop, D. T. & Forman, D., 2003, In : Carcinogenesis. 24, 2, p. 275-282 8 p.

Research output: Contribution to journalArticle

Acetyltransferases
Meat
Amines
Colorectal Neoplasms
Smoking
69 Citations (Scopus)

Mutations of APC, K-ras, and p53 are associated with specific chromosomal aberrations in colorectal adenocarcinomas

Leslie, A., Pratt, N. R., Gillespie, K., Sales, M., Kernohan, N. M., Smith, G., Wolf, C. R., Carey, F. A. & Steele, R. J. C., Aug 2003, In : Cancer Research. 63, 15, p. 4656-4661 6 p.

Research output: Contribution to journalArticle

Chromosome Aberrations
Adenocarcinoma
Mutation
Comparative Genomic Hybridization
Genes
142 Citations (Scopus)

Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism

Sachse, C., Bhambra, U., Smith, G., Lightfoot, T. J., Barrett, J. H., Scollay, J., Garner, R. C., Boobis, A. R., Wolf, C. R., Gooderham, N. J. & Colorectal Cancer Study Group, 2003, In : British Journal of Clinical Pharmacology. 55, 1, p. 68-76 9 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP1A2
Linkage Disequilibrium
Caffeine
Gene Frequency
Cytochrome P-450 Enzyme System
50 Citations (Scopus)
Polymerase chain reaction
Transcription
Psoriasis
Ultraviolet radiation
Reverse Transcription

Topical coal tar and all-trans retinoic acid modulate drug metabolising gene expression in human skin in vivo

Ibbotson, S. H., Smith, G., Sawe, R. S., Comrie, M. M., Bryden, A., Wolf, C. E. & Ferguson, J., 2003.

Research output: Contribution to conferencePoster

Topical coal tar and all-trans retinoic acid modulate drug metabolising gene expression in human skin in vivo

Ibbotson, S. H., Smith, G., Sawe, R. S., Comrie, M. M., Bryden, A., Wolf, C. E. & Ferguson, J., 2003, In : British Journal of Dermatology. 148, 4, p. 861-861 1 p., P15.

Research output: Contribution to journalMeeting abstract

2002
248 Citations (Scopus)

A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer

Sachse, C., Smith, G., Wilkie, M. J. V., Barrett, J. H., Waxman, R., Sullivan, F., Forman, D., Bishop, D. T., Wolf, C. R. & Colorectal Cancer Study Group, Nov 2002, In : Carcinogenesis. 23, 11, p. 1839-49 11 p.

Research output: Contribution to journalArticle

Carcinogens
Colorectal Neoplasms
Amines
Cytochrome P-450 CYP1A1
Polycyclic Aromatic Hydrocarbons

Chromosomal abnormality and gene mutation in sporadic colorectal cancer

Leslie, A., Smith, G., Pratt, N. R., Carey, F. A., Wolf, C. R. & Steele, R. J. C., 2002, In : British Journal of Surgery. 89, 5, p. 663-664 2 p.

Research output: Contribution to journalMeeting abstract

Expression and regulation of cytoprotective genes by ultraviolet radiation in skin of patients with psoriasis

Smith, G., Dawe, R. S., Evans, A. T., Comrie, M. M., Ferguson, J., Wolf, C. R. & Ibbotson, S. H., Sep 2002, In : Journal of Investigative Dermatology. 119, 3, p. 740-740 1 p., 166.

Research output: Contribution to journalMeeting abstract