Smith, Gillian

Dr

  • 3611 Citations
  • 32 h-Index
1992 …2022
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Research Output 1992 2018

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Article
2018
4 Citations (Scopus)
60 Downloads (Pure)

A comparative pharmacokinetic study of PARP inhibitors demonstrates favorable properties for niraparib efficacy in preclinical tumor models

Sun, K., Mikule, K., Wang, Z., Poon, G., Vaidyanathan, A., Smith, G., Zhang, Z. Y., Hanke, J., Ramaswamy, S. & Wang, J., 14 Dec 2018, In : Oncotarget. 9, 98, p. 37080-37096 17 p.

Research output: Contribution to journalArticle

Open Access
File
Pharmacokinetics
Neoplasms
Cell Membrane Permeability
niraparib
Poly(ADP-ribose) Polymerase Inhibitors
2 Citations (Scopus)
123 Downloads (Pure)

Interaction between polymorphisms in aspirin metabolic pathways, regular aspirin use and colorectal cancer risk: A case-control study in unselected white European populations

Sheth, H., Northwood, E., Ulrich, C. M., Scherer, D., Elliott, F., Barrett, J. H., Forman, D., Wolf, C. R., Smith, G., Jackson, M. S., Santibanez-Koref, M., Haile, R., Casey, G., Jenkins, M., Win, A. K., Hopper, J. L., Marchand, L. L., Lindor, N. M., Thibodeau, S. N., Potter, J. D. & 2 others, Burn, J. & Bishop, D. T., 9 Feb 2018, In : PLoS ONE. 13, 2, p. 1-17 17 p., e0192223.

Research output: Contribution to journalArticle

Open Access
File
aspirin
Metabolic Networks and Pathways
case-control studies
Polymorphism
colorectal neoplasms
2016
40 Citations (Scopus)
187 Downloads (Pure)

ABCB1 (MDR1) induction defines a common resistance mechanism in paclitaxel- and olaparib-resistant ovarian cancer cells

Vaidyanathan, A., Sawers, L., Gannon, A-L., Chakravarty, P., Scott, A. L., Bray, S. E., Ferguson, M. J. & Smith, G., 9 Aug 2016, In : British Journal of Cancer. 115, p. 431-441 11 p.

Research output: Contribution to journalArticle

Open Access
File
Paclitaxel
Ovarian Neoplasms
Pharmaceutical Preparations
Doxorubicin
Verapamil
2015
42 Citations (Scopus)

MicroRNA-224 is associated with colorectal cancer progression and response to 5-fluorouracil-based chemotherapy by KRAS-dependent and-independent mechanisms

Amankwatia, E. B., Chakravarty, P., Carey, F. A., Weidlich, S., Steele, R. J. C., Munro, A. J., Wolf, C. R. & Smith, G., 28 Apr 2015, In : British Journal of Cancer. 112, 9, p. 1480-1490 11 p.

Research output: Contribution to journalArticle

MicroRNAs
Fluorouracil
Colorectal Neoplasms
Adenoma
HCT116 Cells
12 Citations (Scopus)
78 Downloads (Pure)

Recurrent Coding Sequence Variation Explains only A Small Fraction of the Genetic Architecture of Colorectal Cancer

Timofeeva, M. N., Kinnersley, B., Farrington, S. M., Whiffin, N., Palles, C., Svinti, V., Lloyd, A., Gorman, M., Ooi, L. Y., Hosking, F., Barclay, E., Zgaga, L., Dobbins, S., Martin, L., Theodoratou, E., Broderick, P., Tenesa, A., Smillie, C., Grimes, G., Hayward, C. & 41 others, Campbell, A., Porteous, D., Deary, I. J., Harris, S. E., Northwood, E. L., Barrett, J. H., Smith, G., Wolf, R., Forman, D., Morreau, H., Ruano, D., Tops, C., Wijnen, J., Schrumpf, M., Boot, A., Vasen, H. F. A., Hes, F. J., Van Wezel, T., Franke, A., Lieb, W., Schafmayer, C., Hampe, J., Buch, S., Propping, P., Hemminki, K., Försti, A., Westers, H., Hofstra, R., Pinheiro, M., Pinto, C., Teixeira, M., Ruiz-Ponte, C., Fernández-Rozadilla, C., Carracedo, A., Castells, A., Castellví-Bel, S., Campbell, H., Bishop, D. T., Tomlinson, I. P. M., Dunlop, M. G. & Houlston, R. S., 10 Nov 2015, In : Scientific Reports. 5, 10 p., 16286.

Research output: Contribution to journalArticle

Open Access
File
Colorectal Neoplasms
Genes
Exome
DNA Mismatch Repair
Nucleic Acid Regulatory Sequences
2014
38 Citations (Scopus)
100 Downloads (Pure)

Glutathione S-transferase P1 (GSTP1) directly influences platinum drug chemosensitivity in ovarian tumour cell lines

Sawers, L., Ferguson, M. J., Ihrig, B. R., Young, H. C., Chakravarty, P., Wolf, C. R. & Smith, G., 9 Sep 2014, In : British Journal of Cancer. 111, 6, p. 1150-1158 9 p.

Research output: Contribution to journalArticle

Open Access
File
Platinum
Glutathione Transferase
Tumor Cell Line
Pharmaceutical Preparations
Ovarian Neoplasms
2013
7 Citations (Scopus)

Cytochrome P450 CYP1B1 interacts with 8-methoxypsoralen (8-MOP) and influences psoralen-ultraviolet (PUVA) sensitivity

Deeni, Y. Y., Ibbotson, S. H., Woods, J. A., Wolf, C. R. & Smith, G., 2013, In : PLoS ONE. 8, 9, e75494.

Research output: Contribution to journalArticle

psoralen
methoxsalen
Methoxsalen
Ficusin
cytochrome P-450
2012
16 Citations (Scopus)
15 Citations (Scopus)

Glutathione S-transferase genotype is associated with sensitivity to psoralen-ultraviolet A photochemotherapy

Ibbotson, S. H., Dawe, R. S., Dinkova-Kostova, A. T., Weidlich, S., Farr, P. M., Ferguson, J., Wolf, C. R. & Smith, G., Feb 2012, In : British Journal of Dermatology. 166, 2, p. 380-388 9 p.

Research output: Contribution to journalArticle

Ficusin
Photochemotherapy
Glutathione Transferase
Genotype
Methoxsalen
13 Citations (Scopus)

Individuality in FGF1 expression significantly influences platinum resistance and progression-free survival in ovarian cancer

Smith, G., Ng, M. T. H., Shepherd, L., Herrington, C. S., Gourley, C., Ferguson, M. & Wolf, C. R., 9 Oct 2012, In : British Journal of Cancer. 107, 8, p. 1327-1336 10 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 1
Platinum
Individuality
Ovarian Neoplasms
Disease-Free Survival
2011
8 Citations (Scopus)
20 Citations (Scopus)

Pyrosequencing-based methods reveal marked inter-individual differences in oncogene mutation burden in human colorectal tumours

Weidlich, S., Walsh, K., Crowther, D., Burczynski, M. E., Feuerstein, G., Carey, F., Steele, R. J. C., Wolf, C. R., Miele, G. & Smith, G., 12 Jul 2011, In : British Journal of Cancer. 105, 2, p. 246-254 9 p.

Research output: Contribution to journalArticle

2010
111 Citations (Scopus)

Activating K-Ras mutations outwith 'hotspot' codons in sporadic colorectal tumours: implications for personalised cancer medicine

Smith, G., Bounds, R., Wolf, H., Steele, R., Carey, F. & Wolf, R., 16 Feb 2010, In : British Journal of Cancer. 102, 4, p. 693-703 11 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Polymorphisms in xenobiotic metabolizing enzymes and diet influence colorectal adenoma risk

Northwood, E. L., Elliott, F., Forman, D., Barrett, J. H., Wilkie, M. J. V., Carey, F. A., Steele, R. J. C., Wolf, R., Bishop, T. & Smith, G., 2010, In : Pharmacogenetics and Genomics. 20, 5, p. 315-326 12 p.

Research output: Contribution to journalArticle

2009
31 Citations (Scopus)

Genetic Variants in XRCC2: New Insights Into Colorectal Cancer Tumorigenesis

Curtin, K., Lin, W-Y., George, R., Katory, M., Shorto, J., Cannon-Albright, L. A., Smith, G., Bishop, D. T., Cox, A., Camp, N. J. & Colorectal Canc Study Grp, Sep 2009, In : Cancer Epidemiology, Biomarkers & Prevention. 18, 9, p. 2476-2484 9 p.

Research output: Contribution to journalArticle

Glutathione S-transferase M1 genotype is associated with erythemal sensitivity to narrowband ultraviolet B in patients with psoriasis

Ibbotson, S. H., Weidlich, S., Ferguson, J., Wolf, R., Dawe, R. S. & Smith, G., Apr 2009, In : British Journal of Dermatology. 160, 4, p. 928-928 1 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)

Polymorphisms in the SLC6A4 and HTR2A genes influence treatment outcome following antidepressant therapy

Wilkie, M. J. V., Smith, G., Day, R., Matthews, K., Smith, D., Blackwood, D., Reid, I. C. & Wolf, R., 2009, In : Pharmacogenomics Journal. 9, 1, p. 61-70 10 p.

Research output: Contribution to journalArticle

2008
22 Citations (Scopus)

Methylene tetrahydrofolate reductase genotype modifies the chemopreventive effect of folate in colorectal adenoma, but not colorectal cancer

Lightfoot, T. J., Barrett, J. H., Bishop, T., Northwood, E. L., Smith, G., Wilkie, M. J. V., Steele, R. J. C., Carey, F. A., Key, T. J., Wolf, R. & Forman, D., Sep 2008, In : Cancer Epidemiology, Biomarkers & Prevention. 17, 9, p. 2421-2430 10 p.

Research output: Contribution to journalArticle

2007
72 Citations (Scopus)

A splice site polymorphism in the G-protein beta subunit influences antidepressant efficacy in depression

Wilkie, M. J. V., Smith, D., Reid, I. C., Day, R. K., Matthews, K., Wolf, R., Blackwood, D. & Smith, G., Mar 2007, In : Pharmacogenetics and Genomics. 17, 3, p. 207-215 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Can dietary furanocoumarin ingestion enhance the erythemal response during high-dose UVA1 therapy?

Beattie, P. E., Wilkie, M. J. V., Smith, G., Ferguson, J. & Ibbotson, S., Jan 2007, In : Journal of the American Academy of Dermatology. 56, 1, p. 84-87 4 p.

Research output: Contribution to journalArticle

Ficusin
Pastinaca
Eating
Phototoxic Dermatitis
Skin
13 Citations (Scopus)

Melanocortin 1 receptor (MC1R) genotype influences erythemal sensitivity to psoralen-ultraviolet A photochemotherapy

Smith, G., Wilkie, M. J. V., Deeni, Y. Y., Farr, P. M., Ferguson, J., Wolf, C. R. & Ibbotson, S. H., Dec 2007, In : British Journal of Dermatology. 157, 6, p. 1230-4 5 p.

Research output: Contribution to journalArticle

Receptor, Melanocortin, Type 1
Ficusin
Photochemotherapy
Genotype
Skin Neoplasms
2006
24 Citations (Scopus)

Chromosomal changes in colorectal adenomas: relationship to gene mutations and potential for clinical utility

Leslie, A., Stewart, A., Baty, D. U., Mechan, D., McGreavey, L., Smith, G., Wolf, C. R., Sales, M., Pratt, N. R., Steele, R. J. C. & Carey, F. A., Feb 2006, In : Genes, Chromosomes and Cancer. 45, 2, p. 126-135 10 p.

Research output: Contribution to journalArticle

Adenoma
Chromosome Aberrations
Mutation
Genes
Adenocarcinoma
38 Citations (Scopus)

Regulation of cutaneous drug-metabolizing enzymes and cytoprotective gene expression by topical drugs in human skin in vivo

Smith, G., Ibbotson, S. H., Comrie, M. M., Dawe, R. S., Bryden, A., Ferguson, J. & Wolf, C. R., 2006, In : British Journal of Dermatology. 155, 2, p. 275-81 7 p.

Research output: Contribution to journalArticle

Drug and Narcotic Control
Gene Expression
Skin
Enzymes
Pharmaceutical Preparations
2005
49 Citations (Scopus)

No evidence that polymorphisms in CYP2C8, CYP2C9, UGT1A6, PPAR[delta] and PPAR[gamma] act as modifiers of the protective effect of regular NSAID use on the risk of colorectal carcinoma

McGreavey, L. E., Turner, F., Smith, G., Boylan, K., Bishop, D. T., Forman, D., Wolf, C. R. & Barrett, J. H., 2005, In : Pharmacogenetics and Genomics. 15, 10, p. 713-721 9 p.

Research output: Contribution to journalArticle

153 Citations (Scopus)

The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma

Conlin, A., Smith, G., Carey, F. A., Wolf, C. R. & Steele, R. J. C., 2005, In : Gut. 54, 9, p. 1283-1286 4 p.

Research output: Contribution to journalArticle

Adenomatous Polyposis Coli
Colorectal Neoplasms
Mutation
Genes
Carcinogenesis
2004
27 Citations (Scopus)

No association of polymorphisms in CYP17, CYP19, and HSD17-B1 with plasma estradiol concentrations in 1,090 British women

Travis, R. C., Churchman, M., Edwards, S. A., Smith, G., Verkasalo, P. K., Wolf, C. R., Wolf, H. & Key, T. J., 2004, In : Cancer Epidemiology, Biomarkers & Prevention. 13, 12, p. 2282-4 3 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Phenotyping of N-acetyltransferase type 2 by caffeine from uncontrolled dietary exposure

Jetter, A., Kinzig-Schippers, M., Illauer, M., Hermann, R., Erb, K., Borlak, J., Wolf, H., Smith, G., Cascorbi, I., Sorgel, F. & Fuhr, U., 2004, In : European Journal of Clinical Pharmacology. 60, 1, p. 17-21 5 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

Vegetable, fruit and meat consumption and potential risk modifying genes in relation to colorectal cancer

Turner, F., Smith, G., Sachse, C., Lightfoot, T., Garner, R. C., Wolf, C. R., Forman, D., Bishop, D. T., Barrett, J. H. & Colorectal Cancer Study Group, 1 Nov 2004, In : International Journal of Cancer. 112, 2, p. 259-264 6 p.

Research output: Contribution to journalArticle

2003
113 Citations (Scopus)

Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases

Smith, G., Wolf, C. R., Deeni, Y. Y., Dawe, R. S., Evans, A. T., Comrie, M. M., Ferguson, J. & Ibbotson, S. H., 2003, In : Lancet. 361, 9366, p. 1336-1343 8 p.

Research output: Contribution to journalArticle

Psoriasis
Skin Diseases
Individuality
Cytochrome P-450 Enzyme System
Skin
89 Citations (Scopus)

Investigation of interaction between N-acetyltransferase 2 and heterocyclic amines as potential risk factors for colorectal cancer

Barrett, J. H., Smith, G., Waxman, R., Gooderham, N., Lightfoot, T., Garner, R. C., Augustsson, K., Wolf, C. R., Bishop, D. T. & Forman, D., 2003, In : Carcinogenesis. 24, 2, p. 275-282 8 p.

Research output: Contribution to journalArticle

Acetyltransferases
Meat
Amines
Colorectal Neoplasms
Smoking
69 Citations (Scopus)

Mutations of APC, K-ras, and p53 are associated with specific chromosomal aberrations in colorectal adenocarcinomas

Leslie, A., Pratt, N. R., Gillespie, K., Sales, M., Kernohan, N. M., Smith, G., Wolf, C. R., Carey, F. A. & Steele, R. J. C., Aug 2003, In : Cancer Research. 63, 15, p. 4656-4661 6 p.

Research output: Contribution to journalArticle

Chromosome Aberrations
Adenocarcinoma
Mutation
Comparative Genomic Hybridization
Genes
142 Citations (Scopus)

Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism

Sachse, C., Bhambra, U., Smith, G., Lightfoot, T. J., Barrett, J. H., Scollay, J., Garner, R. C., Boobis, A. R., Wolf, C. R., Gooderham, N. J. & Colorectal Cancer Study Group, 2003, In : British Journal of Clinical Pharmacology. 55, 1, p. 68-76 9 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP1A2
Linkage Disequilibrium
Caffeine
Gene Frequency
Cytochrome P-450 Enzyme System
48 Citations (Scopus)
Polymerase chain reaction
Transcription
Psoriasis
Ultraviolet radiation
Reverse Transcription
2002
248 Citations (Scopus)

A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer

Sachse, C., Smith, G., Wilkie, M. J. V., Barrett, J. H., Waxman, R., Sullivan, F., Forman, D., Bishop, D. T., Wolf, C. R. & Colorectal Cancer Study Group, Nov 2002, In : Carcinogenesis. 23, 11, p. 1839-49 11 p.

Research output: Contribution to journalArticle

Carcinogens
Colorectal Neoplasms
Amines
Cytochrome P-450 CYP1A1
Polycyclic Aromatic Hydrocarbons
14 Citations (Scopus)

Factors influencing the cellular accumulation of SN-38 and camptothecin

Cummings, J., Boyd, G., Macpherson, J. S., Wolf, H., Smith, G., Smyth, J. F. & Jodrell, D. I., 2002, In : Cancer Chemotherapy and Pharmacology. 49, 3, p. 194-200 7 p.

Research output: Contribution to journalArticle

327 Citations (Scopus)

Mutations in APC, Kirsten-ras, and p53—alternative genetic pathways to colorectal cancer

Smith, G., Carey, F. A., Beattie, J., Wilkie, M. J. V., Lightfoot, T. J., Coxhead, J., Garner, R. C., Steele, R. J. C. & Wolf, C. R., 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 14, p. 9433-9438 6 p.

Research output: Contribution to journalArticle

Adenomatous Polyposis Coli
Colorectal Neoplasms
Mutation
Neoplasms
Genetic Models
2001
63 Citations (Scopus)

Detection of cytochrome P450 mRNA transcripts in prostate samples by RT-PCR

Finnström, N., Bjelfman, C., Söderström, T. G., Smith, G., Egevad, L., Norlén, B. J., Wolf, C. R. & Rane, A., 2001, In : European Journal of Clinical Investigation. 31, 10, p. 880-886 7 p.

Research output: Contribution to journalArticle

Cytochrome P-450 Enzyme System
Prostate
Polymerase Chain Reaction
Oxygenases
Messenger RNA
2000
20 Citations (Scopus)

Evidence that serine 304 is not a key ligand-binding residue in the active site of cytochrome P450 2D6

Ellis, S. W., Hayhurst, G. P., Lightfoot, T., Smith, G., Harlow, J., Rowland-Yeo, K., Larsson, C., Mahling, J., Lim, C. K., Wolf, C. R., Blackburn, M. G., Lennard, M. S. & Tucker, G. T., 2000, In : Biochemical Journal. 345 , 3, p. 565-571 7 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2D6
Metoprolol
Serine
Catalytic Domain
Ligands
209 Citations (Scopus)

Pharmacogenetics

Wolf, C. R., Smith, G. & Smith, R. L., 2000, In : British Medical Journal. 320, 7240, p. 987-90 4 p.

Research output: Contribution to journalArticle

1999
92 Citations (Scopus)

Pharmacogenetics

Wolf, C. R. & Smith, G., 1999, In : British Medical Bulletin. 55, 2, p. 366-86 21 p.

Research output: Contribution to journalArticle

Pharmacogenetics
Cytochrome P-450 CYP2D6
Drug-Related Side Effects and Adverse Reactions
Pharmaceutical Preparations
Drug Prescriptions
1998
56 Citations (Scopus)

Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity

Smith, G., Modi, S., Pillai, I., Lian, L-Y., Sutcliffe, M. J., Pritchard, M. P., Friedberg, T., Roberts, G. C. K. & Wolf, C. R., 1998, In : Biochemical Journal. 331 , 3, p. 783-792 10 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2D6
Substrate Specificity
Mixed Function Oxygenases
Testosterone
Substrates
103 Citations (Scopus)

Molecular genetics of the human cytochrome P450 monooxygenase superfamily

Smith, G., Stubbins, M. J., Harries, L. W. & Wolf, C. R., 1998, In : Xenobiotica. 28, 12, p. 1129-1165 37 p.

Research output: Contribution to journalArticle

1996
44 Citations (Scopus)

Active-site topologies of human CYP2D6 and its aspartate-301 → glutamate, asparagine, and glycine mutants

Mackman, R., Tschirret-Guth, R. A., Smith, G., Hayhurst, G. P., Ellis, S. W., Lennard, M. S., Tucker, G. T., Wolf, C. R. & Ortiz de Montellano, P. R., 1996, In : Archives of Biochemistry and Biophysics. 331, 1, p. 134-140 7 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2D6
Asparagine
Aspartic Acid
Glycine
Glutamic Acid
271 Citations (Scopus)

Genetic analysis of the human cytochrome P450 CYP2C9 locus

Stubbins, M. J., Harries, L. W., Smith, G., Tarbit, M. H. & Wolf, C. R., 1996, In : Pharmacogenetics. 6, 5, p. 429-39 11 p.

Research output: Contribution to journalArticle

Medical Genetics
Cytochrome P-450 Enzyme System
Gene Frequency
Cytochrome P-450 CYP2C9
Alleles
1995
264 Citations (Scopus)

Metabolic polymorphisms and cancer susceptibility

Smith, G., Stanley, L. A., Sim, E., Strange, R. C. & Wolf, C. R., 1995, In : Cancer Surveys. 25, p. 27-65 39 p.

Research output: Contribution to journalArticle

Poisons
Carcinogens
Enzymes
Neoplasms
Environmental Exposure
1994
87 Citations (Scopus)

Genetic polymorphisms in xenobiotic metabolism

Smith, C. A. D., Smith, G. & Wolf, C. R., 1994, In : European Journal of Cancer. 30, 13, p. 1921-35 15 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
1993
38 Citations (Scopus)

1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene, an extremely potent modulator of mouse hepatic cytochrome P-450 gene expression.

Smith, G., Henderson, C. J., WHITE, R., Parker, M. G., Bars, R. G. & Wolf, C. R., 1 Feb 1993, In : Biochemical Journal. 289, 3, p. 807-813 7 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Autoantibodies to hepatic microsomal carboxylesterase in halothane hepatitis

Smith, G. C. M., Wolf, C. R., Kenna, J. G., Harrison, D. J. & Tew, D., 1993, In : Lancet. 342, 8877, p. 963-4 2 p.

Research output: Contribution to journalArticle

Carboxylesterase
Autoantibodies
Liver
Halothane
Liver Diseases
40 Citations (Scopus)
Cytochrome P-450 CYP3A
Endoplasmic Reticulum
Anticonvulsants
Autoantibodies
Cytochrome P-450 Enzyme System