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Sapkota, Gopal

Dr

  • Scientific Programme Leader (MRC), MRC PPU
 https://orcid.org/0000-0001-9931-3338

  • United Kingdom

20002023

Research output per year

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Projects

Investigating the Druggability of Undruggable Targets Using the Affinity Directed Protein Missile System (AdPROM) in Neurodegenerative Disorders

Muqit, M. & Sapkota, G.

10/09/18 → 9/09/21

Project: Research

Novel PROTAC-based Chemical Biology Approaches to Induced Protein Knockdown Across the Proteome (PhD Studentship - with Boehringer Ingelheim)

Ciulli, A. & Sapkota, G.

3/09/18 → 2/09/22

Project: Research

MRC QQR

Alessi, D., Davies, P., Ganley, I., Kulathu, Y., Labib, K., Rouse, J., Rousseau, A., Sapkota, G., Virdee, S. & Walden, H.

Medical Research Council

1/04/18 → 31/03/23

Project: Research

Research Output

  • 39 Article
  • 3 Review article
  • 2 Chapter (peer-reviewed)

Mitotic kinase anchoring proteins: the navigators of cell division

Fulcher, L. & Sapkota, G., 12 Feb 2020, In : Cell Cycle. 20 p.

Research output: Contribution to journal › Review article

    • Salt-inducible kinases (SIKs) regulate TGFβ-mediated transcriptional and apoptotic responses

    Hutchinson, L. D., Darling, N. J., Nicolaou, S., Gori, L., Squair, D. R., Cohen, P., Hill, C. S. & Sapkota, G. P., 22 Jan 2020, In : Cell Death and Disease. 11, p. 1-17 17 p., 49.

    Research output: Contribution to journal › Article

    Open Access
    File
    • 27 Downloads (Pure)

    Advances in targeted degradation of endogenous proteins

    Roth, S., Fulcher, L. & Sapkota, G., 27 Apr 2019, In : Cellular and Molecular Life Sciences. 76, 14, p. 2761-2777 17 p.

    Research output: Contribution to journal › Review article

    Open Access
    File
    • 5 Citations (Scopus)
    256 Downloads (Pure)

    FAM83D directs protein kinase CK1α to the mitotic spindle for proper spindle positioning

    Fulcher, L. J., He, Z., Mei, L., Macartney, T. J., Wood, N. T., Prescott, A. R., Whigham, A., Varghese, J., Gourlay, R., Ball, G., Clarke, R., Campbell, D., Maxwell, C. A. & Sapkota, G. P., 24 Jul 2019, In : EMBO Reports. p. 1-19 19 p., e47495.

    Research output: Contribution to journal › Article

    Open Access
    File
    • 3 Citations (Scopus)
    77 Downloads (Pure)

    Pathogenic FAM83g palmoplantar keratoderma mutations inhibit the PAWS1: Ck1α association and attenuate wnt signalling

    Wu, K. Z. L., Jones, R. A., Tachie-Menson, T., Macartney, T. J., Wood, N. T., Varghese, J., Gourlay, R., Soares, R. F., Smith, J. C. & Sapkota, G. P., 9 Sep 2019, In : Wellcome Open Research. 4, p. 1-18 18 p., 133.

    Research output: Contribution to journal › Article

    Open Access
    File
    • 53 Downloads (Pure)

    Thesis

    Dissecting the molecular mechanisms of the TGF-ß/BMP signal transduction pathways : mapping new players and critically assessing established tools

    Author: Vogt, J., 2013

    Supervisor: Sapkota, G. (Supervisor)

    Student thesis: Doctoral Thesis › Doctor of Philosophy

    File

    Elucidating the biological function of the uncharacterised protein FAM83G/PAWS1: Role in Wnt signalling through its interaction with Caseine Kinase 1α

    Author: Bozatzi, P., 2018

    Supervisor: Sapkota, G. (Supervisor)

    Student thesis: Doctoral Thesis › Doctor of Philosophy

    Identification and characterisation of FAM83 proteins as key regulators of CK1 protein kinases in cells: FAM83D recruits CK1α to the mitotic spindle for proper spindle positioning

    Author: Fulcher, L. J., 2019

    Supervisor: Sapkota, G. (Supervisor) & Ganley, I. (Supervisor)

    Student thesis: Doctoral Thesis › Doctor of Philosophy

    File

    Identification of novel protein kinase regulators of TGFβ signalling

    Author: Hutchinson, L., 2019

    Supervisor: Sapkota, G. (Supervisor)

    Student thesis: Doctoral Thesis › Doctor of Philosophy

    File

    Investigating FAM83H, a protein mutated in Amelogenesis Imperfecta

    Author: Tachie-Menson, T., 2020

    Supervisor: Sapkota, G. (Supervisor)

    Student thesis: Doctoral Thesis › Doctor of Philosophy