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Sapkota, Gopal

Dr

 https://orcid.org/0000-0001-9931-3338

  • United Kingdom

20002023
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  • 5 Similar Profiles
Phosphorylation Chemical Compounds
Bone Morphogenetic Proteins Medicine & Life Sciences
Protein Kinases Medicine & Life Sciences
Casein Kinase I Medicine & Life Sciences
Proteins Medicine & Life Sciences
Peutz-Jeghers Syndrome Medicine & Life Sciences
Phosphotransferases Medicine & Life Sciences
Clustered Regularly Interspaced Short Palindromic Repeats Medicine & Life Sciences

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Projects 2018 2023

Investigating the Druggability of Undruggable Targets Using the Affinity Directed Protein Missile System (AdPROM) in Neurodegenerative Disorders

Muqit, M. & Sapkota, G.

10/09/18 → 9/09/21

Project: Research

Novel PROTAC-based Chemical Biology Approaches to Induced Protein Knockdown Across the Proteome (PhD Studentship - with Boehringer Ingelheim)

Ciulli, A. & Sapkota, G.

3/09/18 → 2/09/22

Project: Research

MRC QQR

Alessi, D., Davies, P., Ganley, I., Kulathu, Y., Labib, K., Rouse, J., Rousseau, A., Sapkota, G., Virdee, S. & Walden, H.

Medical Research Council

1/04/18 → 31/03/23

Project: Research

Research Output 2000 2018

  • 36 Article
  • 2 Chapter (peer-reviewed)
  • 1 Review article
1 Citation (Scopus)

Characterization of Protein Complexes Using Chemical Cross-Linking Coupled Electrospray Mass Spectrometry

Cummins, T. D. & Sapkota, G. P., 1 Jan 2018, Tissue Proteomics: Methods and Protocols. Sarwal, M. & Sigel, T. (eds.). New York: Humana Press, Vol. 1788. p. 43-61 19 p. (Methods in Molecular Biology; vol. 1788).

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed)

Mass Spectrometry
Green Fluorescent Proteins
Proteomics
Proteins
Tetracycline

Generation of endogenous BMP transcriptional reporter cells through CRISPR/Cas9 genome editing

Hutchinson, L. D., Bozatzi, P., Macartney, T. & Sapkota, G. P., 2018, Bone Morphogenetic Proteins: Methods and Protocols. Rogers, M. B. (ed.). New York: Humana Press, Vol. 1891. p. 29-35 7 p. (Methods in Molecular Biology (Clifton, N.J.); vol. 1891).

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed)

Clustered Regularly Interspaced Short Palindromic Repeats
Bone Morphogenetic Proteins
Chromatin
Complementary DNA
Firefly Luciferases
39 Downloads (Pure)

PAWS1controls cytoskeletal dynamics and cell migration through association with the SH3 adaptor CD2AP

Cummins, T. D., Wu, K. Z. L., Bozatzi, P., Dingwell, K. S., Macartney, T. J., Wood, N. T., Varghese, J., Gourlay, R., Campbell, D. G., Prescott, A., Griffis, E., Smith, J. C. & Sapkota, G. P., 10 Jan 2018, In : Journal of Cell Science. 131, 1, p. 1-12 12 p., jcs202390.

Research output: Contribution to journal › Article

Open Access
File
Cell Movement
Actins
Clustered Regularly Interspaced Short Palindromic Repeats
Focal Adhesions
Osteosarcoma
4 Citations (Scopus)
34 Downloads (Pure)

PAWS1 controls Wnt signalling through association with casein kinase 1α

Bozatzi, P., Dingwell, K. S., Wu, K. Z. L., Cooper, F., Cummins, T. D., Hutchinson, L. D., Vogt, J., Wood, N. T., Macartney, T. J., Varghese, J., Gourlay, R., Campbell, D. G., Smith, J. C. & Sapkota, G. P., 1 Apr 2018, In : EMBO Reports. 19, 4, p. 1-18 18 p., e44807.

Research output: Contribution to journal › Article

Open Access
File
Casein Kinase I
Xenopus
Embryonic Structures
Wnt Signaling Pathway
Osteosarcoma
8 Citations (Scopus)
34 Downloads (Pure)

TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition

Ramachandran, A., Vizan, P., Das, D., Chakravarty, P., Vogt, J., Rogers, K. W., Müller, P., Hinck, A. P., Sapkota, G. P. & Hill, C. S., 29 Jan 2018, In : eLife. 7, p. 1-29 29 p., e31756.

Research output: Contribution to journal › Article

Open Access
File
Epithelial-Mesenchymal Transition
Transforming Growth Factors
Chemical activation
Phosphorylation
Transcriptome

Thesis

Dissecting the molecular mechanisms of the TGF-ß/BMP signal transduction pathways : mapping new players and critically assessing established tools

Author: Vogt, J., 2013

Supervisor: Sapkota, G. (Supervisor)

Student thesis: Doctoral Thesis › Doctor of Philosophy

File

Elucidating the biological function of the uncharacterised protein FAM83G/PAWS1: Role in Wnt signalling through its interaction with Caseine Kinase 1α

Author: Bozatzi, P., 2018

Supervisor: Sapkota, G. (Supervisor)

Student thesis: Doctoral Thesis › Doctor of Philosophy

The regulation of TGFβ/BMP signalling by deubiquitylating enzymes

Author: Herhaus, L., 2014

Supervisor: Sapkota, G. (Supervisor)

Student thesis: Doctoral Thesis › Doctor of Philosophy

File