Sapkota, Gopal

Professor

Professor & Disease Signalling, MRC PPU

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4 Active

Determining the ligase and DUB landscape of mitochondrial and alpha-synuclein turnover
Ganley, I., Sapkota, G. & Virdee, S.
1/12/20 → 30/11/22
Project: Research
Investigating the Druggability of Undruggable Targets Using the Affinity Directed Protein Missile System (AdPROM) in Neurodegenerative Disorders
Muqit, M. & Sapkota, G.
10/09/18 → 9/09/21
Project: Research
Novel PROTAC-based Chemical Biology Approaches to Induced Protein Knockdown Across the Proteome (PhD Studentship - with Boehringer Ingelheim)
Ciulli, A. & Sapkota, G.
3/09/18 → 2/09/22
Project: Research
MRC QQR
Alessi, D., Davies, P., Ganley, I., Kulathu, Y., Labib, K., Rouse, J., Rousseau, A., Sapkota, G., Virdee, S. & Walden, H.
Medical Research Council
1/04/18 → 31/03/23
Project: Research

44 Article
4 Review article
2 Chapter (peer-reviewed)

FAM83F regulates canonical Wnt signalling through an interaction with CK1α
Dunbar, K., Jones, R. A., Dingwell, K., Macartney, T. J., Smith, J. C. & Sapkota, G., Feb 2021, In: Life Science Alliance. 4, 2, 17 p., e202000805.
Research output: Contribution to journal › Article › peer-review

Open Access
File
1 Citation (Scopus)

45 Downloads (Pure)
IMiDs induce FAM83F degradation via an interaction with CK1α to attenuate Wnt signalling
Dunbar, K., Macartney, T. J. & Sapkota, G., Feb 2021, In: Life Science Alliance. 4, 2, 17 p., e202000804.
Research output: Contribution to journal › Article › peer-review

Open Access
File
72 Downloads (Pure)
Characterisation of the biochemical and cellular roles of native and pathogenic amelogenesis imperfecta mutants of FAM83H
Tachie-Menson, T., Gázquez-Gutiérrez, A., Fulcher, L., Macartney, T., Wood, N., Varghese, J., Gourlay, R., Filipe Soares, R. & Sapkota, G., Aug 2020, In: Cellular Signalling. 72, p. 1-17 17 p., 109632.
Research output: Contribution to journal › Article › peer-review

Open Access
File
3 Citations (Scopus)

56 Downloads (Pure)
Functions and regulation of the serine/threonine protein kinase CK1 family: moving beyond promiscuity
Fulcher, L. J. & Sapkota, G. P., Dec 2020, In: Biochemical Journal. 477, 23, p. 4603-4621 19 p.
Research output: Contribution to journal › Review article › peer-review

Open Access
File
2 Citations (Scopus)

41 Downloads (Pure)
Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System
Simpson, L. M., Macartney, T. J., Nardin, A., Fulcher, L. J., Röth, S., Testa, A., Maniaci, C., Ciulli, A., Ganley, I. G. & Sapkota, G. P., 17 Sep 2020, In: Cell Chemical Biology. 27, 9, p. 1164-1180.e5 17 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
2 Citations (Scopus)

21 Downloads (Pure)