Keyphrases
Autophosphorylation
92%
Integrated Stress Response
92%
GCN2
63%
BRAF Inhibitor (BRAFi)
60%
Activating Transcription Factor 4 (ATF4)
60%
Paradoxical Activation
49%
CDDO-Me
46%
Heme-regulated Inhibitor
46%
Heme Binding
46%
Allosteric Activation
46%
General Control Nonderepressible 2
46%
ATP-competitive Inhibitors
46%
BACH1
46%
Natural Triterpenoids
46%
Direct Activation
46%
Structural Rearrangement
46%
Kinase Domain
23%
CDDO Derivatives
18%
Nuclear Factor Erythroid 2-related Factor 2 (Nrf2)
18%
Phosphorylation
17%
EIF2a
17%
EIF2
16%
Post-translational Modification
15%
Heterodimerization
15%
Cellular Stress
15%
Structural Mass Spectrometry
14%
Putative Drug Targets
13%
Small Molecules
10%
Heme Sensor
9%
Heme oxygenase-1 (HO-1)
9%
Transcription Factor
9%
Cellular Stress Response
9%
Hydrogen-deuterium Exchange Mass Spectrometry
9%
Erythroid Progenitors
9%
EIF2α Kinase
9%
Allosteric Interactions
9%
Mode of Inhibition
9%
Hemin
9%
Haem
9%
Tyrosine Phosphorylation
9%
Two-mode
9%
Neurodegeneration
9%
Biophysics
9%
Semi-systematic Review
7%
Pro-apoptosis
7%
Alpha Subunit
7%
Translation Initiation
7%
Stress-induced
7%
2-complex
7%
Pro-survival
7%
Biochemistry, Genetics and Molecular Biology
Kinase
100%
Phosphotransferase
100%
ATF4
92%
Autophosphorylation
92%
Adenosine Triphosphate
69%
Competitive Inhibition
46%
Mass Spectrometry
38%
RNA Translation
32%
Conformation
30%
Small Molecule
30%
Progenitor Cell
23%
Tyrosine Phosphorylation
23%
Cellular Stress Response
23%
Hydrogen/Deuterium Exchange Mass Spectrometry
23%
Biochemistry
23%
Posttranslational Modification
18%
Cell Stress
18%
Ponatinib
15%
Enzyme
15%
RNA Interference
11%
Concentration Response
11%
Recombinant
11%
Cell Survival
11%
Biological Target
11%
Initiation Factor
11%
Cell Death
11%
Unfolded Protein Response
11%
Nerve Cell Plasticity
9%
Activating Transcription Factor 4
9%
Cell Division
9%
Eukaryotic Initiation Factor
9%
Transcription Factors
9%
Translation Initiation
9%
Alpha Chain
9%
Pharmacology, Toxicology and Pharmaceutical Science
Bardoxolone
46%
Triterpenoid
46%
Initiation Factor 2
46%
Bardoxolone Methyl
46%
Adenosine Triphosphate
46%
Competitive Inhibitor
46%
Phosphotransferase
30%
Transcription Factors
28%
Activating Transcription Factor 4
23%
Messenger RNA
23%
Mesothelioma
15%
Malignant Neoplasm
15%
Ponatinib
15%
Heme Oxygenase 1
5%