Projects per year
Dr Graham Rena's undergraduate BSc studies were at University of Bristol, followed by Ph.D. studies with Professor Miles Houslay FRSE at the University of Glasgow and postdoctoral work with Professor Sir Philip Cohen FRS, FRSE at the University of Dundee. Graham was a Caledonian Research Foundation Fellow between 2004 and 2007 before staying on to take up a permanent lectureship at the University of Dundee. Graham has been a contributing author on over 30 peer-reviewed publications. The key area of current research is drug repurposing, particularly including recent key insights into metformin action. Graham’s research has attracted grant funding from MRC, BHF Diabetes UK as well as other major funders. Graham enjoys teaching, particularly including innovative international teaching activities in Kuwait.
Repurposing metformin, studies from cells to patients
A major recent focus has been metformin, which is the gold-standard treatment of insulin resistance in type 2 diabetes. Collaborative work particularly with Prof Chim Lang has included investigation of anti-inflammatory effects of the drug, which are likely to contribute towards cardioprotective effects in patients, irrespective of diabetes status. This insight provides an easily understood rationale for further testing of non-diabetic cardiovascular patient groups that may benefit from metformin and has been published in high impact journals (Circulation and Circulation Research)
Lectures and conferences
2018 European Heart Failure Association annual meeting Vienna
2017 “Metformin: heart failure drug?” Translational Research Workshop, Brussels, Belgium
2017 12th Annual Winter Research Meeting of the Heart Failure Association and Working Group on Myocardial Function of the European Society of Cardiology, Les Diablerets, Switzerland
2016 Danish Technical University, Lyngby, Denmark
PRIZE: Best Manuscript Award at Circulation Research editorial board dinner in New Orleans, November 2016.
M.Sc. Dissertation Lead, Quantitative (Kuwait, Dasman Diabetes Institute)
The MSc makes use of modern approaches, including for example a recently generated virtual poster room (see separate picture)
Life Sciences Teaching: Regulatory Physiology and Pharmacology
Medical School Teaching: BMSc Diabetes and Metabolic Disorders
- RM Therapeutics. Pharmacology
1/09/19 → 31/08/22
1/03/19 → 28/02/21
Role of Purinergic Signalling and Intracellular Nucleotide Sensing in Metformin Action (PhD Studentship)
Beall, C. & Rena, G.
1/09/15 → 31/08/18
15/11/14 → 14/11/17
In a cohort of individuals with type 2 diabetes using the drug sulfasalazine, HbA1c lowering is associated with haematological changesN'Dow, S. M. S., Donnelly, L. A., Pearson, E. R. & Rena, G., 25 Nov 2020, In : Diabetic Medicine. e14463.
Research output: Contribution to journal › Article › peer-review
Rena, G. & Viollet, B., 6 Dec 2019, In : Frontiers in endocrinology. 10, p. 1-3 3 p., 851.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile1 Citation (Scopus)56 Downloads (Pure)
Iskandar, Z., Mordi, I., Yeow, C., Neaogoie, A., Rena, G., Chew, S. & Lang, C., 26 Aug 2019, In : Journal of Diabetes and Treatment. 4, 2, 4 p.
Research output: Contribution to journal › Editorial › peer-reviewOpen AccessFile106 Downloads (Pure)
Scientific Business Abstracts of the 113th Annual Meeting of the Association of Physicians of Great Britain and IrelandDeciphering Developmental Disorders (DDD) Study, Cacciottolo, T. M., Perikari, A., van der Klaauw, A., Henning, E., Stadler, L. K. J., Keogh, J., Farooqi, I. S., Tenin, G., Keavney, B., Ryan, E., Budd, R., Bewley, M., Coelho, P., Rumsey, W., Sanchez, Y., McCafferty, J., Dockrell, D., Walmsley, S., Whyte, M. & 31 others, , 5 Sep 2019, In : QJM : an International Journal of Medicine. 112, 9, p. 724-729 6 p., 9.
Research output: Contribution to journal › Meeting abstract › peer-review
Heart failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure Association-European Society of CardiologyMaack, C., Lehrke, M., Backs, J., Heinzel, F. R., Hulot, J-S., Marx, N., Paulus, W. J., Rossignol, P., Taegtmeyer, H., Bauersachs, J., Bayes-Genis, A., Brutsaert, D., Bugger, H., Clarke, K., Cosentino, F., De Keulenaer, G., Dei Cas, A., González, A., Huelsmann, M., Iaccarino, G. & 15 others, , 21 Dec 2018, In : European Heart Journal. 39, 48, p. 4243-4254 12 p., ehy596.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile66 Citations (Scopus)274 Downloads (Pure)
Graham Rena (Participant)10 Sep 2008
Activity: Participating in or organising an event types › Participation in conference