Rena, Graham

Dr

  • 3304 Citations
  • 23 h-Index
1995 …2022

Research output per year

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Personal profile

Research interests

Biography

Dr Graham Rena's undergraduate BSc studies were at University of Bristol, followed by Ph.D. studies with Professor Miles Houslay FRSE at the University of Glasgow and postdoctoral work with Professor Sir Philip Cohen FRS, FRSE at the University of Dundee. Graham was a Caledonian Research Foundation Fellow between 2004 and 2007 before staying on to take up a permanent lectureship at the University of Dundee. Graham has been a contributing author on over 30 peer-reviewed publications. The key area of current research is drug repurposing, particularly including recent key insights into metformin action. Graham’s research has attracted grant funding from MRC, BHF Diabetes UK as well as other major funders. Graham enjoys teaching, particularly including innovative international teaching activities in Kuwait.

Research

Repurposing metformin, studies from cells to patients

A major recent focus has been metformin, which is the gold-standard treatment of insulin resistance in type 2 diabetes. Collaborative work particularly with Prof Chim Lang has included investigation of anti-inflammatory effects of the drug, which are likely to contribute towards cardioprotective effects in patients, irrespective of diabetes status. This insight provides an easily understood rationale for further testing of non-diabetic cardiovascular patient groups that may benefit from metformin and has been published in high impact journals (Circulation and Circulation Research)

Lectures and conferences

2018 European Heart Failure Association annual meeting Vienna

2017 “Metformin: heart failure drug?” Translational Research Workshop, Brussels, Belgium

2017 12th Annual Winter Research Meeting of the Heart Failure Association and Working Group on Myocardial Function of the European Society of Cardiology, Les Diablerets, Switzerland

2016 Danish Technical University, Lyngby, Denmark

Impact

PRIZE: Best Manuscript Award at Circulation Research editorial board dinner in New Orleans, November 2016.

Teaching

M.Sc. Dissertation Lead, Quantitative (Kuwait, Dasman Diabetes Institute)

The MSc makes use of modern approaches, including for example a recently generated virtual poster room (see separate picture) 

Life Sciences Teaching: Regulatory Physiology and Pharmacology

Medical School Teaching: BMSc Diabetes and Metabolic Disorders

 

Keywords

  • RM Therapeutics. Pharmacology
  • Diabetes
  • Cardiovascular

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Projects

Research Output

Editorial: Metformin: Beyond Diabetes

Bost, F., Rena, G. & Viollet, B., 6 Dec 2019, In : Frontiers in endocrinology. 10, p. 1-3 3 p., 851.

Research output: Contribution to journalArticle

Open Access
File
35 Downloads (Pure)

Metformin and its Potential for Heart Failure with Preserved Ejection Fraction

Mohan, P., Iskandar, Z., Mordi, I., Yeow, C., Neaogoie, A., Rena, G., Chew, S. & Lang, C., 26 Aug 2019, In : Journal of Diabetes and Treatment. 4, 2, 4 p.

Research output: Contribution to journalEditorial

Open Access
File
71 Downloads (Pure)

Scientific Business Abstracts of the 113th Annual Meeting of the Association of Physicians of Great Britain and Ireland

Deciphering Developmental Disorders (DDD) Study, Cacciottolo, T. M., Perikari, A., van der Klaauw, A., Henning, E., Stadler, L. K. J., Keogh, J., Farooqi, I. S., Tenin, G., Keavney, B., Ryan, E., Budd, R., Bewley, M., Coelho, P., Rumsey, W., Sanchez, Y., McCafferty, J., Dockrell, D., Walmsley, S., Whyte, M. & 31 others, Liu, Y., Choy, M-K., Tenin, G., Abraham, S., Black, G., Keavney, B., Watkins, S., Robertson, K., Collison, D., Rush, C., Marshall, J., McGowan, R., Fraser, R., Gandhi, S., Cooper, C., Howden, A., Hukelmann, J. L., Cantrell, D. A., Mordi, I., Forteath, C., Wong, A., Mohan, M., Palmer, C., Doney, A., Rena, G., Lang, C., Gray, E. H., Williams, R., Williams, S., Hughes, J. & Davies, J., 5 Sep 2019, In : QJM : an International Journal of Medicine. 112, 9, p. 724-729 6 p., 9.

Research output: Contribution to journalMeeting abstract

  • Heart failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure Association-European Society of Cardiology

    Maack, C., Lehrke, M., Backs, J., Heinzel, F. R., Hulot, J-S., Marx, N., Paulus, W. J., Rossignol, P., Taegtmeyer, H., Bauersachs, J., Bayes-Genis, A., Brutsaert, D., Bugger, H., Clarke, K., Cosentino, F., De Keulenaer, G., Dei Cas, A., González, A., Huelsmann, M., Iaccarino, G. & 15 others, Lunde, I. G., Lyon, A. R., Pollesello, P., Rena, G., Riksen, N. P., Rosano, G., Staels, B., van Laake, L. W., Wanner, C., Farmakis, D., Filippatos, G., Ruschitzka, F., Seferovic, P., de Boer, R. A. & Heymans, S., 21 Dec 2018, In : European Heart Journal. 39, 48, p. 4243-4254 12 p., ehy596.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 54 Citations (Scopus)
    177 Downloads (Pure)

    Metformin selectively targets redox control of complex I energy transduction

    Cameron, A., Logie, L., Patel, K., Erhardt, S., Bacon, S., Middleton, P., Harthill, J., Forteath, C., Coats, J., Kerr, C., Curry, H., Stewart, D., Sakamoto, K., Repiščák, P., Paterson, M. J., Hassinen, I., McDougall, G. & Rena, G., Apr 2018, In : Redox Biology. 14, p. 187-197 11 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 50 Citations (Scopus)
    156 Downloads (Pure)

    Prizes

    Circulation Research Best Manuscript Award 2016

    Rena, Graham (Recipient), 13 Nov 2016

    Prize: Prize (including medals and awards)

    The Rank Prize Funds Nutrition Committee Prize

    Rena, Graham (Recipient), 20 May 2002

    Prize: Prize (including medals and awards)

    Activities

    • 4 Participation in conference

    Diabetes UK Professional Conference 2013

    Graham Rena (Participant)

    13 Mar 201315 Mar 2013

    Activity: Participating in or organising an event typesParticipation in conference

    Diabetes UK Professional Conference 2012

    Graham Rena (Participant)

    7 Mar 20129 Mar 2012

    Activity: Participating in or organising an event typesParticipation in conference

    44th General Assembly of the European Association for the Study of Diabetes

    Graham Rena (Participant)

    10 Sep 2008

    Activity: Participating in or organising an event typesParticipation in conference

    676th Biochemical Society Meeting

    Graham Rena (Participant)

    8 Apr 200210 Apr 2002

    Activity: Participating in or organising an event typesParticipation in conference

    Press / Media

    Diabetic drug may offer benefits in heart failure

    Chim C. Lang & Graham Rena

    2/07/12

    1 item of Media coverage

    Press/Media: Research

    Thesis

    Investigation of plant derived compounds mediating cell signalling effectson FOXO1a and AMPK

    Author: Bacon, S., 2012

    Supervisor: Rena, N. (Supervisor) & McDougall, G. (External person) (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    The Role of Amino Acid Transport in the Regulation of mTORC1 by Metformin

    Author: Forteath, C. D., 2017

    Supervisor: Rena, N. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy