Projects per year
Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Dive into the research topics where Grahame Hardie is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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Defining the Role of the LKB1 - AMPK Signalling Pathway in Cancer and DNA Damage (Clinical PhD Programme: Dr Madhumita Dandapani)
Cantrell, D. (Investigator), Hardie, G. (Investigator), Lambert, J. (Investigator) & Marshall, S. (Investigator)
Project: Research
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Role of AMPK in Nutrient Sensing and in Cancer (Investigator Award Renewal)
Hardie, G. (Investigator)
1/10/17 → 31/03/24
Project: Research
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AMP-Activated Protein Kinase - A Tumour Suppressor that Opposes the Metabolic Changes in Proliferating Cells (Programme Grant)
Hardie, G. (Investigator)
1/01/13 → 30/09/18
Project: Research
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Non-canonical Pathways for Regulation of AMPK (Senior Investigator Award)
Hardie, G. (Investigator)
1/04/12 → 30/09/17
Project: Research
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Unraveling the Role of AMPK as a Hypothalamic Glucose-Sensor
Ashford, M. (Investigator), Hardie, G. (Investigator) & McCrimmon, R. (Investigator)
1/05/11 → 31/12/12
Project: Research
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Activity-dependent compartmentalization of dendritic mitochondria morphology through local regulation of fusion-fission balance in neurons in vivo
Virga, D. M., Hamilton, S., Osei, B., Morgan, A., Kneis, P., Zamponi, E., Park, N. J., Hewitt, V. L., Zhang, D., Gonzalez, K. C., Russell, F. M., Hardie, D. G., Prudent, J., Bloss, E., Losonczy, A., Polleux, F. (Lead / Corresponding author) & Lewis Jr, T. L. (Lead / Corresponding author), 8 Mar 2024, In: Nature Communications. 15, 1, p. 1-21 21 p., 2142.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)20 Downloads (Pure) -
AMP-activated protein kinase can be allosterically activated by ADP but AMP remains the key activating ligand
Hawley, S. A., Russell, F. M. & Hardie, D. G. (Lead / Corresponding author), Apr 2024, In: Biochemical Journal. 481, 8, p. 587-599 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Downloads (Pure) -
BAY-3827 and SBI-0206965: potent AMPK inhibitors that paradoxically increase Thr172 phosphorylation
Hawley, S. A., Russell, F. M., Ross, F. A. & Hardie, D. G. (Lead / Corresponding author), 1 Jan 2024, In: International Journal of Molecular Sciences. 25, 1, 21 p., 453.Research output: Contribution to journal › Article › peer-review
Open AccessFile57 Downloads (Pure) -
The pro-drug C13 activates AMPK by two distinct mechanisms
Freemantle, J. B., Shah, D., Lynch, D. M., Ciulli, A., Hundal, H. S. & Hardie, D. G. (Lead / Corresponding author), 2 Sept 2024, (E-pub ahead of print) In: The Biochemical journal.Research output: Contribution to journal › Article › peer-review
Open Access -
AMPK promotes lysosomal and mitochondrial biogenesis via folliculin: FNIP1
Freemantle, J. B. & Hardie, D. G. (Lead / Corresponding author), Oct 2023, In: Life Metabolism. 2, 5, 4 p., load027.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)71 Downloads (Pure)
Prizes
Activities
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The Conversation Article: Zombie caterpillar fungus may contain anti-cancer drug – but there are still questions to be answered
Hardie, G. (Contributor)
3 Mar 2020Activity: Other activity types › Public engagement and outreach - media article or participation
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The Conversation: AMPK: new research into cancer’s ‘good cop/bad cop’ protein could help develop more effective drugs
Hardie, G. (Contributor)
16 Aug 2019Activity: Other activity types › Public engagement and outreach - media article or participation
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IMPAKT 2010 Breast Cancer Conference
Hardie, D. G. (Keynote/plenary speaker)
8 May 2010Activity: Participating in or organising an event types › Participation in conference
Press/Media
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New research highlights benefits of old medicine
Hardie, D. G. & Morris, A. D.
3/05/12
1 item of Media coverage
Press/Media: Research