Hardie, Grahame

Zong, Y., Zhang, C-S., Li, M., Wang, W., Wang, Z., Hawley, S. A., Ma, T., Feng, J-W., Tian, X., Qi, Q., Wu, Y-Q., Zhang, C., Ye, Z., Lin, S-Y., Piao, H-L., Hardie, D. G. & Lin, S-C., 4 Apr 2019, In : Cell Research. 29, p. 460-473 14 p.

Research output: Contribution to journal › Article

AMP-Activated Protein Kinases

Adenosine Monophosphate

Food

Mitochondrial Dynamics

Lysosomes

41 Downloads (Pure)

Phenformin, but not metformin, delays development of T-cell acute lymphoblastic leukemia/lymphoma via cell-autonomous AMPK activation

Vara Ciruelos, D., Dandapani, M., Russell, F., Grzes, K. M., Atrih, A., Foretz, M., Viollet, B., Lamont, D., Cantrell, D. & Hardie, G., 16 Apr 2019, In : Cell Reports. 27, 3, p. 690-698.e4

Research output: Contribution to journal › Article

Open Access

File

Phenformin

AMP-Activated Protein Kinases

T-cells

Metformin

Precursor Cell Lymphoblastic Leukemia-Lymphoma

7 Downloads (Pure)

The strange case of AMPK and cancer: Dr Jekyll or Mr Hyde? †

Vara-Ciruelos, D., Russell, F. M. & Hardie, D. G., 10 Jul 2019, In : Open Biology. 9, 7, p. 1-21 21 p., 190099.

Research output: Contribution to journal › Article

Open Access

File

AMP-Activated Protein Kinases

Adenosine Monophosphate

Neoplasms

Tumors

DNA Damage

1 Citation (Scopus)

16 Downloads (Pure)

Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK

Li, M., Zhang, C-S., Zong, Y., Feng, J-W., Ma, T., Hu, M., Lin, Z., Li, X., Xie, C., Wu, Y., Jiang, D., Li, Y., Zhang, C., Tian, X., Wang, W., Yang, Y., Chen, J., Cui, J., Wu, Y-Q., Chen, X. & 11 others, Liu, Q-F., Wu, J., Lin, S-Y., Ye, Z., Liu, Y., Piao, H-L., Yu, L., Zhou, Z., Xie, X-S., Hardie, D. G. & Lin, S-C., 3 Sep 2019, In : Cell Metabolism. 30, 3, p. 508-524.e12 17 p.

Research output: Contribution to journal › Article

Open Access

File

Transient Receptor Potential Channels

Fructose-Bisphosphate Aldolase

AMP-Activated Protein Kinases

Glucose

Endoplasmic Reticulum

99 Citations (Scopus)

140 Downloads (Pure)

AMPK: Sensing Glucose as well as Cellular Energy Status

Lin, S-C. & Hardie, D., 6 Feb 2018, In : Cell Metabolism. 27, 2, p. 299-313 15 p.

Research output: Contribution to journal › Review article

Open Access

File

AMP-Activated Protein Kinases

Glucose

Adenosine Triphosphatases

Fructose-Bisphosphate Aldolase

Adenosine Triphosphate

Activities 2010 2010

1 Participation in conference

IMPAKT 2010 Breast Cancer Conference

David Grahame Hardie (Keynote/plenary speaker)

8 May 2010

Activity: Participating in or organising an event types › Participation in conference

Press / Media

New research highlights benefits of old medicine

David Grahame Hardie & Andrew D. Morris

3/05/12

1 item of Media coverage

Press/Media: Research

Thesis

Canonical and non-canonical regulation of AMP-activated protein kinase

Author: Auciello, F. R., 2015

Supervisor: Hardie, D. (Supervisor)

Student thesis: Doctoral Thesis › Doctor of Philosophy

File

Regulation and role of the LKB1-AMPK pathway

Author: Gowans, G. J., 2014

Supervisor: Hardie, D. (Supervisor)

Student thesis: Doctoral Thesis › Doctor of Philosophy

File

The AMPK signalling pathway in cancer and DNA damage

Author: Dandapani, M., 2013

Supervisor: Hardie, D. (Supervisor)

Student thesis: Doctoral Thesis › Doctor of Philosophy

File