Hundal, Hari

Professor

  • United Kingdom

1994 …2022
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Research Output 1994 2019

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Article
2019
100 Downloads (Pure)

CDK7 is a component of the integrated stress response regulating SNAT2 (SLC38A2)/System A adaptation in response to cellular amino acid deprivation

Stretton, C., Lipina, C., Hyde, R., Cwiklinski, E., Hoffmann, T. M., Taylor, P. M. & Hundal, H. S., 1 Jun 2019, In : Biochimica et Biophysica Acta. Molecular Cell Research. 1866, 6, p. 978-991 14 p.

Research output: Contribution to journalArticle

Open Access
File
Activating Transcription Factor 4
Amino Acids
Cyclin-Dependent Kinases
alvocidib
Phosphotransferases
4 Citations (Scopus)
62 Downloads (Pure)

GPR55 deficiency is associated with increased adiposity and impaired insulin signaling in peripheral metabolic tissues

Lipina, C., Walsh, S. K., Mitchell, S. E., Speakman, J. R., Wainwright, C. L. & Hundal, H., Jan 2019, In : FASEB Journal. 33, 1, p. 1299-1312 14 p.

Research output: Contribution to journalArticle

Open Access
File
Adiposity
G-Protein-Coupled Receptors
Insulin
Tissue
Insulin Resistance
1 Citation (Scopus)
71 Downloads (Pure)
Open Access
File
Skeletal Muscle Fibers
Insulin Resistance
Skeletal Muscle
Insulin
Muscle Cells
2018
2 Citations (Scopus)
68 Downloads (Pure)

Combined Hyperglycemia and Hyperinsulinemia-induced Insulin Resistance in Adipocytes is associated with Dual Signaling Defects mediated by PKC-ζ

Lu, H., Bogdanovic, E., Yu, Z., Cho, C., Liu, L., Ho, K., Guo, J., Yeung, L. S. N., Lehmann, R., Hundal, H. S., Giacca, A. & Fantus, I. G., 1 Apr 2018, In : Endocrinology. 159, 4, p. 1658-1677 20 p.

Research output: Contribution to journalArticle

Open Access
File
Hyperinsulinism
Adipocytes
Hyperglycemia
Insulin Resistance
Insulin
4 Citations (Scopus)
77 Downloads (Pure)

Effects of sodium and amino acid substrate availability upon the expression and stability of the SNAT2 (SLC38A2) amino acid transporter

Hoffmann, T., Cwiklinski, E., Shah, D., Stretton, C., Hyde, R., Taylor, P. & Hundal, H., 7 Feb 2018, In : Frontiers in Pharmacology. 9, p. 1-9 9 p., 63.

Research output: Contribution to journalArticle

Open Access
File
Amino Acid Transport Systems
Sodium
Amino Acids
Protein Stability
Neutral Amino Acids
2017
1 Citation (Scopus)

Michael John Rennie, MSc, PhD, FRSE, FHEA, 1946-2017: an appreciation of his work on protein metabolism in human muscle

Millward, D. J., Halliday, D., Hundal, H., Taylor, P., Atherton, P., Greenhaff, P. & Smith, K., Jul 2017, In : American Journal of Clinical Nutrition. 106, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

2016
13 Citations (Scopus)
67 Downloads (Pure)

CB1 receptor blockade counters age-induced insulin resistance and metabolic dysfunction

Lipina, C., Vaanholt, L. M., Davidova, A., Mitchell, S. E., Storey-Gordon, E., Hambly, C., Irving, A. J., Speakman, J. R. & Hundal, H. S. H., Apr 2016, In : Aging Cell. 15, 2, p. 325-335 11 p.

Research output: Contribution to journalArticle

Open Access
File
rimonabant
Cannabinoid Receptor CB1
Cannabinoid Receptors
Insulin Resistance
Adipose Tissue
5 Citations (Scopus)
231 Downloads (Pure)

Crumbs 3b promotes tight junctions in an ezrin-dependent manner in mammalian cells

Tilston-Lünel, A. M., Haley, K. E., Schlecht, N. F., Wang, Y., Chatterton, A. L. D., Moleirinho, S., Watson, A., Hundal, H. S., Prystowsky, M. B., Gunn-Moore, F. J. & Reynolds, P. A., Oct 2016, In : Journal of Molecular Cell Biology. 8, 5, p. 439-455 12 p.

Research output: Contribution to journalArticle

Open Access
File
Tight Junctions
Tight Junction Proteins
Alternative Splicing
Cell Adhesion
ezrin
14 Citations (Scopus)
66 Downloads (Pure)

Iron depletion suppresses mTORC1-directed signalling in intestinal Caco-2 cells via induction of REDD

Watson, A., Lipina, C., McArdle, H. J., Taylor, P. M. & Hundal, H., May 2016, In : Cellular Signalling. 28, 5, p. 412-424

Research output: Contribution to journalArticle

Open Access
File
Caco-2 Cells
Iron
DNA Damage
Protein Phosphatase 2
Intestinal Mucosa
20 Citations (Scopus)
82 Downloads (Pure)

Modulation of cellular redox homeostasis by the endocannabinoid system

Lipina, C. & Hundal, H. S., 27 Apr 2016, In : Open Biology. 6, 4, p. 1-10 10 p., 150276.

Research output: Contribution to journalArticle

Open Access
File
Endocannabinoids
Oxidation-Reduction
Homeostasis
Modulation
Reactive Oxygen Species
2015
19 Citations (Scopus)

Ganglioside GM3 as a gatekeeper of obesity-associated insulin resistance: evidence and mechanisms

Lipina, C. & Hundal, H. S., 24 Oct 2015, In : FEBS Letters. 589, 21, p. 3221-3227 7 p.

Research output: Contribution to journalArticle

G(M3) Ganglioside
Insulin Resistance
Obesity
Insulin
Glycosphingolipids
23 Citations (Scopus)
100 Downloads (Pure)

GSK3-mediated raptor phosphorylation supports amino acid-dependent Q2 mTORC1-directed signalling

Stretton, C., Hoffmann, T. M., Munson, M. J., Prescott, A., Taylor, P. M., Ganley, I. G. & Hundal, H., 1 Sep 2015, In : Biochemical Journal. 470, 2, p. 207-221

Research output: Contribution to journalArticle

Open Access
File
TOR Serine-Threonine Kinases
Glycogen Synthase Kinase 3
Phosphorylation
Sirolimus
Amino Acids
7 Citations (Scopus)

NEU3 sialidase as a marker of insulin sensitivity: Regulation by fatty acids

Lipina, C., Nardi, F., Grace, H. & Hundal, H. S., 1 Sep 2015, In : Cellular Signalling. 27, 9, p. 1742-1750 9 p.

Research output: Contribution to journalArticle

Neuraminidase
Insulin Resistance
Fatty Acids
Palmitates
Proteins
16 Citations (Scopus)

Proteasomal modulation of cellular SNAT2 (SLC38A2) abundance and function by unsaturated fatty acid availability

Nardi, F., Hoffmann, T. M., Stretton, C., Cwiklinski, E., Taylor, P. M. & Hundal, H. S., 27 Mar 2015, In : Journal of Biological Chemistry. 290, 13, p. 8173-8184 12 p.

Research output: Contribution to journalArticle

Unsaturated Fatty Acids
Ubiquitination
Fatty Acids
Modulation
Availability
2014
23 Citations (Scopus)

Carnosic acid stimulates glucose uptake in skeletal muscle cells via a PME-1/PP2A/PKB signalling axis

Lipina, C. & Hundal, H. S., Nov 2014, In : Cellular Signalling. 26, 11, p. 2343-2349 6 p.

Research output: Contribution to journalArticle

Protein Phosphatase 2
Muscle Cells
Skeletal Muscle
Glucose
Rosmarinus
18 Citations (Scopus)
81 Downloads (Pure)

Characterising the inhibitory actions of ceramide upon insulin signaling in different skeletal muscle cell models: a mechanistic insight

Mahfouz, R., Khoury, R., Blachnio-Zabielska, A., Turban, S., Loiseau, N., Lipina, C., Stretton, C., Bourron, O., Ferré, P., Foufelle, F., Hundal, H. S. & Hajduch, E., 24 Jul 2014, In : PLoS ONE. 9, 7, 9 p., e101865.

Research output: Contribution to journalArticle

Open Access
File
ceramides
Ceramides
mechanistic models
myocytes
Muscle Cells
14 Citations (Scopus)
99 Downloads (Pure)

Enhanced insulin sensitivity associated with provision of mono and polyunsaturated fatty acids in skeletal muscle cells involves counter modulation of PP2A

Nardi, F., Lipina, C., Magill, D., Hage Hassan, R., Hajduch, E., Gray, A. & Hundal, H. S., Mar 2014, In : PLoS ONE. 9, 3, 10 p., e92255.

Research output: Contribution to journalArticle

Open Access
File
Protein Phosphatase 2
phosphoprotein phosphatase
Unsaturated Fatty Acids
insulin resistance
myocytes
19 Citations (Scopus)
Endocannabinoids
Mitochondria
Homeostasis
Obesity
Physiological Phenomena
2013
25 Citations (Scopus)

Defining the role of DAG, mitochondrial function, and lipid deposition in palmitate-induced proinflammatory signaling and its counter-modulation by palmitoleate

Macrae, K., Stretton, C., Lipina, C., Blachnio-Zabielska, A., Baranowski, M., Gorski, J., Marley, A. & Hundal, H. S., Sep 2013, In : Journal of Lipid Research. 54, 9, p. 2366-2378 13 p.

Research output: Contribution to journalArticle

Palmitates
Diglycerides
Phosphatidylethanolamine Binding Protein
Modulation
Lipids
12 Citations (Scopus)

Mitochondrial Substrate Availability and its Role in Lipid-Induced Insulin Resistance and Proinflammatory Signalling in Skeletal Muscle

Lipina, C., Macrae, K., Suhm, T., Weigert, C., Blachnio-Zabielska, A., Baranowksi, M., Gorski, J., Burgess, K. & Hundal, H. S., Oct 2013, In : Diabetes. 62, 10, p. 3426-3436 11 p.

Research output: Contribution to journalArticle

Palmitates
Insulin Resistance
Skeletal Muscle
Deoxyglucose
Lipids
2012
56 Citations (Scopus)

Defining the contribution of AMP-activated protein kinase (AMPK) and protein kinase C (PKC) in regulation of glucose uptake by metformin in skeletal muscle cells

Turban, S., Stretton, C., Drouin, O., Green, C. J., Watson, M. L., Gray, A., Ross, F., Lantier, L., Viollet, B., Hardie, D. G., Marette, A. & Hundal, H. S., 8 Jun 2012, In : Journal of Biological Chemistry. 287, 24, p. 20088-20099 12 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Metformin
Muscle Cells
Protein Kinase C
Muscle
14 Citations (Scopus)

New vistas for treatment of obesity and diabetes? Endocannabinoid signalling and metabolism in the modulation of energy balance

Lipina, C., Rastedt, W., Irving, A. J. & Hundal, H. S., 1 Aug 2012, In : BioEssays. 34, 8, p. 681-691 11 p.

Research output: Contribution to journalArticle

Endocannabinoids
Medical problems
Energy balance
Metabolism
Obesity
2011
21 Citations (Scopus)

Chronic effects of palmitate overload on nutrient-induced insulin secretion and autocrine signalling in pancreatic MIN6 beta cells

Watson, M. L., Macrae, K., Marley, A. E. & Hundal, H. S., 5 Oct 2011, In : PLoS ONE. 6, 10, p. - 12 p., e25975.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor kappa B signalling in rat skeletal muscle cells by AMP-activated protein kinase

Green, C. J., Macrae, K., Fogarty, S., Hardie, D. G., Sakamoto, K. & Hundal, H. S., 15 Apr 2011, In : Biochemical Journal. 435, 2, p. 463-474 12 p.

Research output: Contribution to journalArticle

Erratum to: Sphingolipids: agents provocateurs in the pathogenesis of insulin resistance

Lipina, C. & Hundal, H. S., Nov 2011, In : Diabetologia. 54, 11, p. 2969 1 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

SNAT2 transceptor signalling via mTOR: a role in cell growth and proliferation?

Pinilla, J., Aledo, J. C., Cwiklinski, E., Hyde, R., Taylor, P. M. & Hundal, H. S., 1 Jun 2011, In : Frontiers in Bioscience (Elite Edition). E3, 4, p. 1289-1299 11 p.

Research output: Contribution to journalArticle

Cell proliferation
Cell growth
Cell Proliferation
Amino Acids
Growth
2010
20 Citations (Scopus)
3 Citations (Scopus)

Generation, validation and humanisation of a novel insulin resistant cell model

Logie, L., Ruiz-Alcaraz, A. J., Schofield, C. J., Hundal, H. S., Feuerstein, G. Z., Brady, J. D., Crowther, D., Tommasi, A. M., Grierson, C. E., Shepherd, B., Morris, A. D., Hansen, M. K., Pearson, E. & Sutherland, C., 1 Oct 2010, In : Biochemical Pharmacology. 80, 7, p. 1042-1049 8 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Mechanisms involved in the enhancement of mammalian target of rapamycin signalling and hypertrophy in skeletal muscle of myostatin-deficient mice

Lipina, C., Kendall, H., McPherron, A. C., Taylor, P. M. & Hundal, H. S., 3 Jun 2010, In : FEBS Letters. 584, 11, p. 2403-2408 6 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

Regulation of MAP Kinase-Directed Mitogenic and Protein Kinase B-Mediated Signaling by Cannabinoid Receptor Type 1 in Skeletal Muscle Cells

Lipina, C., Stretton, C., Hastings, S., Hundal, J. S., Mackie, K., Irving, A. J. & Hundal, H. S., Feb 2010, In : Diabetes. 59, 2, p. 375-385 11 p.

Research output: Contribution to journalArticle

2009
53 Citations (Scopus)

ABC50 promotes translation initiation in mammalian cells

Paytubi, S., Wang, X., Lam, Y. W., Izquierdo, L., Hunter, M. J., Jan, E., Hundal, H. S. & Proud, C. G., 4 Sep 2009, In : Journal of Biological Chemistry. 284, 36, p. 24061-24073 13 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Expression and modulation of TUB by insulin and thyroid hormone in primary rat and murine 3T3-L1 adipocytes

Stretton, C., Litherland, G. J., Moynihan, A., Hajduch, E. & Hundal, H. S., 25 Dec 2009, In : Biochemical and Biophysical Research Communications. 390, 4, p. 1328-1333 6 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)
45 Citations (Scopus)

Tertiary active transport of amino acids reconstituted by coexpression of System A and L transporters in Xenopus oocytes

Baird, F. E., Bett, K. J., MacLean, C., Tee, A. R., Hundal, H. S. & Taylor, P. M., Sep 2009, In : American Journal of Physiology, Endocrinology and Metabolism. 297, 3, p. E822-E829 8 p.

Research output: Contribution to journalArticle

2008
76 Citations (Scopus)

Targeting of PKC zeta and PKB to caveolin-enriched microdomains represents a crucial step underpinning the disruption in PKB-directed signalling by ceramide

Hajduch, E., Turban, S., Le Liepvre, X., Le Lay, S., Lipina, C., Dimopoulos, N., Dugail, I. & Hundal, H. S., 1 Mar 2008, In : Biochemical Journal. 410, p. 369-379 11 p.

Research output: Contribution to journalArticle

76 Citations (Scopus)

Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake

Green, C. J., Goransson, O., Kular, G. S., Leslie, N. R., Gray, A., Alessi, D. R., Sakamoto, K. & Hundal, H. S., 10 Oct 2008, In : Journal of Biological Chemistry. 283, 41, p. 27653-27667 15 p.

Research output: Contribution to journalArticle

2007
79 Citations (Scopus)

Distinct sensor pathways in the hierarchical control of SNAT2, a putative amino acid transceptor, by amino acid availability

Hyde, R., Cwiklinski, E. L., MacAulay, K., Taylor, P. M. & Hundal, H. S., 6 Jul 2007, In : Journal of Biological Chemistry. 282, 27, p. 19788-19798 11 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

The PPARdelta agonist, GW501516, promotes fatty acid oxidation but has no direct effect on glucose utilisation or insulin sensitivity in rat L6 skeletal muscle cells

Dimopoulos, N., Watson, M., Green, C. & Hundal, H. S., 2007, In : FEBS Letters. 581, 24, p. 4743-4748 6 p.

Research output: Contribution to journalArticle

PPAR delta
Muscle Cells
Muscle
Insulin Resistance
Rats
2006
25 Citations (Scopus)

Evidence for allosteric regulation of pH-sensitive System A (SNAT2) and System N (SNAT5) amino acid transporter activity involving a conserved histidine residue

Baird, F. E., Pinilla-Tenas, J. J., Ogilvie, W. L. J., Ganapathy, V., Hundal, H. S. & Taylor, P. M., 15 Jul 2006, In : Biochemical Journal. 397, 2, p. 369-375 7 p.

Research output: Contribution to journalArticle

Allosteric Regulation
Diethyl Pyrocarbonate
Amino Acid Transport Systems
Histidine
Amino Acids
19 Citations (Scopus)

Functional characterisation of the regulation of CAAT enhancer binding protein alpha by GSK-3 phosphorylation of Threonines 222/226

Liu, H. K., Perrier, S., Lipina, C., Finlay, D., McLauchlan, H., Hastie, C. J., Hundal, H. S., Sutherland, C. & Sutherland, C., 6 Apr 2006, In : BMC Molecular Biology. 7, p. - 12 p., 14.

Research output: Contribution to journalArticle

2005
21 Citations (Scopus)

A novel regulation of IRS1 (insulin receptor substrate-1) expression following short term insulin administration

Ruiz-Alcaraz, A. J., Liu, H-K., Cuthbertson, D. J., McManus, E. J., Akhtar, S., Lipina, C., Morris, A. D., Petrie, J. R., Hundal, H. S. & Sutherland, C., 1 Dec 2005, In : Biochemical Journal. 392, p. 345-352 8 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)

Ceramide down-regulates System A amino acid transport and protein synthesis in rat skeletal muscle cells

Hyde, R., Hajduch, E., Powell, D. J., Taylor, P. M. & Hundal, H. S., Mar 2005, In : FASEB Journal. 19, 3, p. 461-463 3 p.

Research output: Contribution to journalArticle

Ceramides
Muscle Cells
Muscle
Rats
Carrier Proteins
52 Citations (Scopus)

Constitutive activation of GSK3 down-regulates glycogen synthase abundance and glycogen deposition in rat skeletal muscle cells

MacAulay, K., Blair, A. S., Hajduch, E., Terashima, T., Baba, O., Sutherland, C. & Hundal, H. S., 11 Mar 2005, In : Journal of Biological Chemistry. 280, 10, p. 9509-9518 10 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Glycogen Synthase
Glycogen
Muscle Cells
Muscle
15 Citations (Scopus)

Insulin-stimulated glucose uptake does not require p38 mitogen-activated protein kinase in adipose tissue or skeletal muscle

Turban, S., Beardmore, V. A., Carr, J. M., Sakamoto, K., Hajduch, E., Arthur, J. S. C. & Hundal, H. S., Nov 2005, In : Diabetes. 54, 11, p. 3161-3168 8 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Adipose Tissue
Skeletal Muscle
Insulin
Glucose
2004
193 Citations (Scopus)

Intracellular ceramide synthesis and protein kinase Cζ activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells

Powell, D. J., Turban, S., Gray, A., Hajduch, E. & Hundal, H. S., 1 Sep 2004, In : Biochemical Journal. 382, 2, p. 619-629 11 p.

Research output: Contribution to journalArticle

Palmitates
Ceramides
Muscle Cells
Protein Kinase C
Muscle
2003
218 Citations (Scopus)

Amino acid transporters: roles in amino acid sensing and signalling in animal cells

Hyde, R., Taylor, P. M. & Hundal, H. S., 2003, In : Biochemical Journal. 373, 1, p. 1-18 18 p.

Research output: Contribution to journalArticle

213 Citations (Scopus)

Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism

Powell, D. J., Hajduch, E., Kular, G. & Hundal, H. S. H., 2003, In : Molecular and Cellular Biology. 23, 21, p. 7794-7808 15 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-akt
Phosphatidylinositols
Ceramides
Phosphotransferases
Insulin
2002
101 Citations (Scopus)

Intracellular sensing of amino acids in Xenopus laevis oocytes stimulates p70 S6 kinase in a target of rapamycin-dependent manner

Christie, G. R., Hajduch, E., Hundal, H. S., Proud, C. G. & Taylor, P. M., 22 Mar 2002, In : Journal of Biological Chemistry. 277, 12, p. 9952-9957 6 p.

Research output: Contribution to journalArticle

70-kDa Ribosomal Protein S6 Kinases
Xenopus laevis
Sirolimus
Oocytes
Amino Acids
2001
30 Citations (Scopus)

Mechanisms of glutamine transport in rat adipocytes and acute regulation by cell swelling

Ritchie, J. W. A., Baird, F. E., Christie, G. R., Stewart, A., Low, S. Y., Hundal, H. S. & Taylor, P. M., 2001, In : Cellular Physiology and Biochemistry. 11, 5, p. 259-270 12 p.

Research output: Contribution to journalArticle

2000
48 Citations (Scopus)

A role for the actin cytoskeleton in the hormonal and growth-factor-mediated activation of protein kinase B

Peyrollier, K., Hajduch, E., Gray, A., Litherland, G. J., Prescott, A. R., Leslie, N. R. & Hundal, H. S., 15 Dec 2000, In : Biochemical Journal. 352, 3, p. 617-622 6 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-akt
Phosphatidylinositols
Actin Cytoskeleton
Actins
Intercellular Signaling Peptides and Proteins