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Dorfmueller, Helge

Dr

20062021
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  • 7 Similar Profiles
Glucosamine 6-Phosphate N-Acetyltransferase Medicine & Life Sciences
Enzymes Medicine & Life Sciences
Chitin Synthase Medicine & Life Sciences
Bacterial Structures Medicine & Life Sciences
Rhamnose Medicine & Life Sciences
Acetylglucosamine Medicine & Life Sciences
Acetyltransferases Medicine & Life Sciences
Chitin Medicine & Life Sciences

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Projects 2015 2021

Exploration of Biosynthetic Carbohydrates as Vaccine Candidates for Streptococcus Pyogenes

Dorfmueller, H.

1/07/18 → 30/06/20

Project: Research

Functional and Structural Studies of the Streptococcal Virulence Factor Group A Carbohydrate Biosynthesis Pathway (Sir Henry Dale Fellowship)

Dorfmueller, H.

Wellcome Trust

1/04/16 → 31/03/21

Project: Research

Towards the Discovery of Chemical Tools to Prevent Human Infection Caused by Pathogenic Streptococcus Pyogenes

Dorfmueller, H.

1/10/15 → 30/09/16

Project: Research

Research Output 2006 2019

4 Downloads (Pure)

Streptococcal dTDP-L-rhamnose biosynthesis enzymes: functional characterization and lead compound identification

van der Beek, S. L., Zorzoli, A., Çanak, E., Chapman, R. N., Lucas, K., Meyer, B. H., Evangelopoulos, D., de Carvalho, L. P. S., Boons, G-J., Dorfmueller, H. C. & van Sorge, N. M., 1 Jan 2019, In : Molecular Microbiology. 14 p.

Research output: Contribution to journal › Article

Open Access
File
Rhamnose
Enzymes
Streptococcus mutans
Mycobacterium tuberculosis
Interferometry
18 Citations (Scopus)
32 Downloads (Pure)

A structural and biochemical model of processive chitin synthesis

Dorfmueller, H. C., Ferenbach, A. T., Borodkin, V. S. & van Aalten, D. M. F., 15 Aug 2014, In : Journal of Biological Chemistry. 289, p. 23020-23028 9 p.

Research output: Contribution to journal › Article

Open Access
File
Chitin Synthase
Chitin
Structural Models
Fungal Structures
Glycosyltransferases
20 Citations (Scopus)

Bisubstrate UDP-peptide conjugates as human O-GlcNAc transferase inhibitors

Borodkin, V. S., Schimpl, M., Gundogdu, M., Rafie, K., Dorfmueller, H. C., Robinson, D. A. & van Aalten, D. M. F., 1 Feb 2014, In : Biochemical Journal. 457, 3, p. 497-502 6 p.

Research output: Contribution to journal › Article

Uridine Diphosphate
Peptides
Cytology
Substrates
Serine
22 Citations (Scopus)

Structure of a bacterial putative acetyltransferase defines the fold of the human O-GlcNAcase C-terminal domain

Rao, F. V., Schüttelkopf, A. W., Dorfmueller, H. C., Ferenbach, A. T., Navratilova, I. & van Aalten, D. M. F., 2 Oct 2013, In : Open Biology. 3, 130021.

Research output: Contribution to journal › Article

Bacterial Structures
Acetyltransferases
Acetyl Coenzyme A
Histone Acetyltransferases
Mutagenesis
11 Citations (Scopus)

Structural and biochemical characterization of a trapped coenzyme a adduct of Caenorhabditis elegans glucosamine-6-phosphate N-acetyltransferase 1

Dorfmueller, H. C., Fang, W., Rao, F. V., Blair, D. E., Attrill, H. & van Aalten, D. M. F., 2012, In : Acta Crystallographica Section D: Biological Crystallography. 68, 8, p. 1019-1029 11 p.

Research output: Contribution to journal › Article

Glucosamine 6-Phosphate N-Acetyltransferase
Coenzymes
Caenorhabditis elegans
Cysteine
Phosphates