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  • 19 Similar Profiles
Trypanosoma brucei brucei Medicine & Life Sciences
African Trypanosomiasis Medicine & Life Sciences
Drug Discovery Medicine & Life Sciences
Plasmodium falciparum Medicine & Life Sciences
Parasites Medicine & Life Sciences
Pharmaceutical Preparations Medicine & Life Sciences
Antimalarials Medicine & Life Sciences
Leishmania donovani Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1990 2018

2,4-Diamino-6-methylpyrimidines for the potential treatment of Chagas’ disease

Thomas, M. G., De Rycker, M., Cotillo Torrejon, I., Thomas, J., Riley, J., Spinks, D., Read, K. D., Miles, T. J., Gilbert, I. H. & Wyatt, P. G., 1 Oct 2018, In : Bioorganic & Medicinal Chemistry Letters. 28, 18, p. 3025-3030 6 p.

Research output: Contribution to journalArticle

Chagas Disease
Parasites
Nifurtimox
Trypanosoma cruzi
Screening
1 Citations

A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors

Harrison, J. R., Brand, S., Smith, V., Robinson, D. A., Thompson, S., Smith, A., Davies, K., Mok, N., Torrie, L. S., Collie, I., Hallyburton, I., Norval, S., Simeons, F. R. C., Stojanovski, L., Frearson, J. A., Brenk, R., Wyatt, P. G., Gilbert, I. H. & Read, K. D., 12 Sep 2018, In : Journal of Medicinal Chemistry. 61, 18, p. 8374–8389 16 p.

Research output: Contribution to journalArticle

Open Access
File
African Trypanosomiasis
Trypanosoma brucei brucei
Crystallography
Central Nervous System Diseases
Peripheral Nervous System

Anti-trypanosomal 8-hydroxyl naphthyridines are chelators of divalent transition metals

Wall, R., Moniz, S., Thomas, M., Norval, S., Ko, E. J., Marco, M., Miles, T. J., Gilbert, I., Horn, D., Fairlamb, A. & Wyllie, S., Aug 2018, In : Antimicrobial Agents and Chemotherapy. 62, 8, 15 p., e00235-18.

Research output: Contribution to journalArticle

Open Access
File
Naphthyridines
Chelating Agents
Hydroxyl Radical
Metals
Trypanosoma brucei brucei

Challenges and recent progress in drug discovery for tropical diseases

De Rycker, M., Baragaña, B., Duce, S. L. & Gilbert, I. H., 25 Jul 2018, In : Nature. 559, 7715, p. 498-506 9 p.

Research output: Contribution to journalReview article

Drug Discovery
Pharmaceutical Preparations
Communicable Diseases
Economics
Morbidity

Clinical and veterinary trypanocidal benzoxaboroles target CPSF3

Wall, R., Rico Vidal, E., Lukac, I., Zuccotto, F., Elg, S., Gilbert, I., Freund, Y. R., Alley, M. R. K., Field, M., Wyllie, S. & Horn, D., 18 Sep 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 38, p. 9616-9621 6 p.

Research output: Contribution to journalArticle

Open Access
File
Trypanosomiasis
Cleavage And Polyadenylation Specificity Factor
Clustered Regularly Interspaced Short Palindromic Repeats
Neglected Diseases
African Trypanosomiasis

Activities 2000 2000

  • 1 Participation in conference

13th International Conference on Antiviral Research

Ian Gilbert (Participant)
17 Apr 2000

Activity: Participating in or organising an event typesParticipation in conference

Press / Media

Automated design for Drug Discovery

Andrew Hopkins, Suzanne Norval, Jeremy Besnard, Laste Stojanovski, Richard Bickerton, Kevin Read & Ian Gilbert

13/12/12

1 item of media coverage

Press/Media: Research

Thesis

Synthetic strategies for potential trypanocides

Author: Capes, A., 2011

Supervisor: Gilbert, I. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

Target Identification and Mechanism of Action Studies in Folate Metabolism in Kinetoplastids

Author: Webster, L., 2014

Supervisor: Gilbert, I. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy