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Moraga Gonzalez, Ignacio

Dr

20162022
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Fingerprint Dive into the research topics where Ignacio Moraga Gonzalez is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 21 Similar Profiles
Cytokine Receptors Medicine & Life Sciences
Cytokines Medicine & Life Sciences
Ligands Medicine & Life Sciences
Dimers Chemical Compounds
Protein Engineering Medicine & Life Sciences
Adenomatous Polyposis Coli Medicine & Life Sciences
Dimerization Medicine & Life Sciences
Interleukins Medicine & Life Sciences

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Projects 2016 2022

Mapping Cytokine Signalling Networks using Engineered Surrogate Ligands (ERC Starting Grant)

Crocker, P. & Moraga Gonzalez, I.

COMMISSION OF THE EUROPEAN COMMUNITIES

1/04/17 → 31/03/22

Project: Research

Mapping Cytokine Signalling Networks using Engineered Surrogate Ligands (Sir Henry Dale Fellowship)

Crocker, P. & Moraga Gonzalez, I.

Wellcome Trust

1/09/16 → 31/08/21

Project: Research

Research Output 2017 2020

Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

Wilmes, S., Hafer, M., Vuorio, J., Tucker, J. A., Winkelmann, H., Löchte, S., Stanly, T. A., Pulgar Prieto, K. D., Poojari, C., Sharma, V., Richter, C. P., Kurre, R., Hubbard, S. R., Garcia, K. C., Moraga, I., Vattulainen, I., Hitchcock, I. S. & Piehler, J., 7 Feb 2020, In : Science. 367, 6478, p. 643-652 10 p.

Research output: Contribution to journal › Article

Open Access
Cytokine Receptors
Dimerization
Janus Kinase 2
Mutation
Ligands
14 Downloads (Pure)

Kinetics of cytokine receptor trafficking determine signaling and functional selectivity

Martinez-Fabregas, J., Wilmes, S., Wang, L., Hafer, M., Pohler, E., Lokau, J., Garbers, C., Cozzani, A., Piehler, J., Kazemian, M., Mitra, S. & Moraga Gonzalez, I., 27 Nov 2019, In : eLife. 8, p. 1-32 32 p., e49314.

Research output: Contribution to journal › Article

Open Access
File
Cytokine Receptors
Kinetics
Interleukin-6
Cytokines
Th17 Cells
22 Downloads (Pure)

Loss of Adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22

Chen, Y., Vandereyken, M., Newton, I., Moraga Gonzalez, I., Nathke, I. & Swamy, M., 26 Nov 2019, In : PLoS Biology. 17, 11, p. 1-23 23 p., e3000540.

Research output: Contribution to journal › Article

Open Access
File
Adenomatous Polyposis Coli
interleukins
epithelial cells
cytokines
Epithelial Cells
1 Citation (Scopus)
116 Downloads (Pure)

Mapping determinants of cytokine signaling via protein engineering

Gorby, C., Martinez-Fabregas, J., Wilmes, S. & Moraga Gonzalez, I., 27 Sep 2018, In : Frontiers in Immunology. 9, 9 p., 2143.

Research output: Contribution to journal › Review article

Open Access
File
Protein Engineering
Cytokines
Ligands
Janus Kinases
Cytokine Receptors
12 Citations (Scopus)
101 Downloads (Pure)

Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers

Moraga, I., Spangler, J. B., Mendoza, J. L., Gakovic, M., Wehrman, T. S., Krutzik, P. & Garcia, K. C., 12 May 2017, In : eLife. 6, e22882.

Research output: Contribution to journal › Article

Open Access
File
Dimers
Intercellular Signaling Peptides and Proteins
Cytokine Receptors
Cytokines
Ligands