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Moraga Gonzalez, Ignacio

Dr

20162022

Research output per year

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Projects

Mapping Cytokine Signalling Networks using Engineered Surrogate Ligands (ERC Starting Grant)

Crocker, P. & Moraga Gonzalez, I.

COMMISSION OF THE EUROPEAN COMMUNITIES

1/04/17 → 31/03/22

Project: Research

Mapping Cytokine Signalling Networks using Engineered Surrogate Ligands (Sir Henry Dale Fellowship)

Crocker, P. & Moraga Gonzalez, I.

Wellcome Trust

1/09/16 → 31/08/21

Project: Research

Research Output

Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

Wilmes, S., Hafer, M., Vuorio, J., Tucker, J. A., Winkelmann, H., Löchte, S., Stanly, T. A., Pulgar Prieto, K. D., Poojari, C., Sharma, V., Richter, C. P., Kurre, R., Hubbard, S. R., Garcia, K. C., Moraga, I., Vattulainen, I., Hitchcock, I. S. & Piehler, J., 7 Feb 2020, In : Science. 367, 6478, p. 643-652 10 p.

Research output: Contribution to journal › Article

    • Kinetics of cytokine receptor trafficking determine signaling and functional selectivity

    Martinez-Fabregas, J., Wilmes, S., Wang, L., Hafer, M., Pohler, E., Lokau, J., Garbers, C., Cozzani, A., Piehler, J., Kazemian, M., Mitra, S. & Moraga Gonzalez, I., 27 Nov 2019, In : eLife. 8, p. 1-32 32 p., e49314.

    Research output: Contribution to journal › Article

    Open Access
    File
    • 31 Downloads (Pure)

    Loss of Adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22

    Chen, Y., Vandereyken, M., Newton, I., Moraga Gonzalez, I., Nathke, I. & Swamy, M., 26 Nov 2019, In : PLoS Biology. 17, 11, p. 1-23 23 p., e3000540.

    Research output: Contribution to journal › Article

    Open Access
    File
    • 38 Downloads (Pure)

    Mapping determinants of cytokine signaling via protein engineering

    Gorby, C., Martinez-Fabregas, J., Wilmes, S. & Moraga Gonzalez, I., 27 Sep 2018, In : Frontiers in Immunology. 9, 9 p., 2143.

    Research output: Contribution to journal › Review article

    Open Access
    File
    • 1 Citation (Scopus)
    133 Downloads (Pure)

    Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers

    Moraga, I., Spangler, J. B., Mendoza, J. L., Gakovic, M., Wehrman, T. S., Krutzik, P. & Garcia, K. C., 12 May 2017, In : eLife. 6, e22882.

    Research output: Contribution to journal › Article

    Open Access
    File
    • 13 Citations (Scopus)
    117 Downloads (Pure)