Leigh, Irene

Professor

  • 6201 Citations
  • 32 h-Index
1989 …2020

Research output per year

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Research Output

2020

The Identification of Potential Therapeutic Targets for Cutaneous Squamous Cell Carcinoma

McHugh, A., Fernandes, K., Chinner, N., Ibrahim, A. F. M., Garg, A. K., Boag, G., Hepburn, L. A., Proby, C. M., Leigh, I. M. & Saville, M. K., Jun 2020, In : Journal of Investigative Dermatology. 140, 6, p. 1154-1165.e5 17 p.

Research output: Contribution to journalArticle

Open Access
File
65 Downloads (Pure)
2019

A Unique Panel of Patient-Derived Cutaneous Squamous Cell Carcinoma Cell Lines Provides a Preclinical Pathway for Therapeutic Testing

Hassan, S., Purdie, K. J., Wang, J., Harwood, C. A., Proby, C. M., Pourreyron, C., Mladkova, N., Nagano, A., Dhayade, S., Athineos, D., Caley, M., Mannella, V., Blyth, K., Inman, G. J. & Leigh, I. M., 12 Jul 2019, In : International Journal of Molecular Sciences. 20, 14, p. 1-26 26 p., 3428.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
82 Downloads (Pure)

Azathioprine: friend or foe?

Leigh, I. M., Proby, C. M., Inman, G. J. & Harwood, C. A., May 2019, In : British Journal of Dermatology. 180, 5, p. 961-963 3 p.

Research output: Contribution to journalEditorial

1 Citation (Scopus)

Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model

Kalin, J. H., Eroglu, A., Liu, H., Holtzclaw, W. D., Leigh, I., Proby, C. M., Fahey, J. W., Cole, P. A. & Dinkova-Kostova, A. T., 13 Mar 2019, In : PLoS ONE. 14, 3, p. 1-13 13 p., e0213095.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
110 Downloads (Pure)
2018

Nationwide Incidence of Metastatic Cutaneous Squamous Cell Carcinoma in England

Venables, Z. C., Autier, P., Nijsten, T., Wong, K. F., Langan, S. M., Rous, B., Broggio, J., Harwood, C., Henson, K., Proby, C. M., Rashbass, J. & Leigh, I. M., 28 Nov 2018, In : JAMA Dermatology. 153, 3, p. 298-306 9 p.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
191 Downloads (Pure)

Preclinical comparison of proteasome and ubiquitin E1 enzyme inhibitors in cutaneous squamous cell carcinoma: the identification of mechanisms of differential sensitivity

McHugh, A., Fernandes, K., South, A., Mellerio, J. E., Salas-Alanis, J. C., Proby, C., Leigh, I. & Saville, M., 17 Apr 2018, In : Oncotarget. 9, p. 20265-20281 17 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
147 Downloads (Pure)

Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma

Rose, A. M., Spender, L. C., Stephen, C., Mitchell, A., Rickaby, W., Bray, S., Evans, A. T., Dayal, J., Purdie, K. J., Harwood, C. A., Proby, C. M., Leigh, I. M., Coates, P. J. . & Inman, G. J., 6 Mar 2018, In : Oncotarget. 9, 18, p. 14552-14566 15 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
184 Downloads (Pure)

Targeting the spliceosome for cutaneous squamous cell carcinoma therapy: a role for c-MYC and wild-type p53 in determining the degree of tumour selectivity

Hepburn, L., McHugh, A., Fernandes, K., Boag, G., Proby, C., Leigh, I. & Saville, M., 1 May 2018, In : Oncotarget. 9, 33, p. 23029-23046 18 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
126 Downloads (Pure)

The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature

Inman, G. J., Wang, J., Nagano, A., Alexandrov, L. B., Purdie, K. J., Taylor, R. G., Sherwood, V., Thomson, J., Hogan, S., Spender, L. C., South, A. P., Stratton, M., Chelala, C., Harwood, C. A., Proby, C. M. & Leigh, I. M., 10 Sep 2018, In : Nature Communications. 9, 1, p. 1-14 14 p., 3667.

Research output: Contribution to journalArticle

Open Access
File
37 Citations (Scopus)
144 Downloads (Pure)

The Role of Human Papillomaviruses and Polyomaviruses in BRAF-Inhibitor Induced Cutaneous Squamous Cell Carcinoma and Benign Squamoproliferative Lesions

Purdie, K. J., Proby, C. M., Rizvi, H., Griffin, H., Doorbar, J., Sommerlad, M., Feltkamp, M. C., Van der Meijden, E., Inman, G. J., South, A. P., Leigh, I. M. & Harwood, C. A., 14 Aug 2018, In : Frontiers in Microbiology. 9, 16 p., 1806.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
133 Downloads (Pure)
2017

Genomic analysis of atypical fibroxanthoma

Lai, K., Harwood, C. A., Purdie, K. J., Proby, C. M., Leigh, I. M., Ravi, N., Mully, T. W., Brooks, L., Sandoval, P. M., Rosenblum, M. D. & Arron, S. T., 15 Nov 2017, In : PLoS ONE. 12, 11, p. 1-15 15 p., e0188272.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
221 Downloads (Pure)

Keratinocyte skin cancers in the spotlight

Nijsten, T. & Leigh, I. M., 18 Aug 2017, In : British Journal of Dermatology. 177, 2, p. 334-335 2 p.

Research output: Contribution to journalEditorial

1 Citation (Scopus)

Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16

Maruthappu, T., Chikh, A., Fell, B., Delaney, P. J., Brooke, M. A., Levet, C., Moncada-Pazos, A., Ishida-Yamamoto, A., Blaydon, D., Waseem, A., Leigh, I. M., Freeman, M. & Kelsell, D. P., 27 Jan 2017, In : Nature Communications. 8, p. 1-11 11 p., 14174.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
164 Downloads (Pure)
2016

CREBBP mutation in human cutaneous squamous cell carcinoma

Watt, S. A., Purdie, K. J., den Breems, N. Y., Dimon, M., Tucker, S., Arron, S. T., Mchugh, A., Xue, D. J., Dayal, J. H. S., Harwood, C. A., Leigh, I. M., Proby, C. M. & South, A. P., Aug 2016, In : Experimental Dermatology. 25, 8, p. 650-651 2 p.

Research output: Contribution to journalLetter

Open Access
File
3 Citations (Scopus)
119 Downloads (Pure)

Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma

Cammareri, P., Rose, A., Vincent, D. F., Wang, J., Nagano, A., Libertini, S., Ridgway, R. A., Athineos, D., Coates, P. J. ., McHugh, A., Pourreyron, C., Dayal, J., Larsson, J., Weidlich, S., Spender, L., Sapkota, G., Purdie, K. J., Proby, C., Harwood, C. A., Leigh, I. & 9 others, Clevers, H., Barker, N., Karlsson, S., Pritchard, C., Marais, R., Chelala, C., South, A., Sansom, O. J. & Inman, G., 25 Aug 2016, In : Nature Communications. 7, p. 1-7 7 p., 12493.

Research output: Contribution to journalArticle

Open Access
File
43 Citations (Scopus)
127 Downloads (Pure)

MEK is a therapeutic and chemopreventative target in squamous cell carcinoma

Adelmann, C. H., Truong, K. A., Liang, R. J., Bansal, V., Gandee, L., Saporito, R., Lee, W., Du, L., Nicholas, C., Napoli, M., Mino, B., South, A. P., Proby, C. M., Leigh, I. M., Coarfa, C., Flores, E. R. & Tsai, K. Y., Sep 2016, In : Journal of Investigative Dermatology. 136, 9, p. 1920-1924 5 p.

Research output: Contribution to journalLetter

Open Access
File
4 Citations (Scopus)
172 Downloads (Pure)

The European Union's investment and future role in dermatologic research

Leigh, I. M., Jul 2016, In : Journal of Investigative Dermatology. 136, 7, p. 1307-1310 4 p.

Research output: Contribution to journalEditorial

WNT Signaling in Cutaneous Squamous Cell Carcinoma: A Future Treatment Strategy?

Sherwood, V. & Leigh, I., Sep 2016, In : Journal of Investigative Dermatology. 136, 9, p. 1760-1767 8 p.

Research output: Contribution to journalReview article

Open Access
File
7 Citations (Scopus)
187 Downloads (Pure)
2015

Lysyl hydroxylase 3 localizes to epidermal basement membrane and Is reduced in patients with Recessive Dystrophic Epidermolysis Bullosa

Watt, S. A., Dayal, J. H. S., Wright, S., Riddle, M., Pourreyron, C., McMillan, J. R., Kimble, R. M., Prisco, M., Gartner, U., Warbrick, E., McLean, W. H. I., Leigh, I. M., McGrath, J. A., Salas-Alanis, J. C., Tolar, J. & South, A. P., 18 Sep 2015, In : PLoS ONE. 10, 9, 15 p., e0137639.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
178 Downloads (Pure)

Novel CARD11 mutations in human cutaneous squamous cell carcinoma lead to aberrant NF-κB regulation

Watt, S. A., Purdie, K. J., den Breems, N. Y., Dimon, M., Arron, S. T., McHugh, A. T., Xue, D. J., Dayal, J. H. S., Proby, C. M., Harwood, C. A., Leigh, I. M. & South, A. P., Sep 2015, In : American Journal of Pathology. 185, 9, p. 2354-2363 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2014

High levels of type VII collagen expression in RDEB cSCC keratinocytes increases PI3K and MAPK signalling, cell migration and invasion

Pourreyron, C., Chen, M., McGrath, J. A., Salas-Alanis, J. C., South, A. P. & Leigh, I. M., 2014, In : British Journal of Dermatology. 170, 6, p. 1256-1265 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Inherited epidermolysis bullosa: updated recommendations on diagnosis and classification

Fine, J-D., Bruckner-Tuderman, L., Eady, R. A. J., Bauer, E. A., Bauer, J. W., Has, C., Heagerty, A., Hintner, H., Hovnanian, A., Jonkman, M. F., Leigh, I., Marinkovich, M. P., Martinez, A. E., McGrath, J. A., Mellerio, J. E., Moss, C., Murrell, D. F., Shimizu, H., Uitto, J., Woodley, D. & 1 others, Zambruno, G., Jun 2014, In : Journal of the American Academy of Dermatology. 70, 6, p. 1103-1126 24 p.

Research output: Contribution to journalArticle

449 Citations (Scopus)

NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis

South, A. P., Purdie, K. J., Watt, S. A., Haldenby, S., den Breems, N., Dimon, M., Arron, S. T., Kluk, M. J., Aster, J. C., McHugh, A., Xue, D. J., Dayal, J. H. S., Robinson, K. S., Rizvi, S. M. H., Proby, C. M., Harwood, C. A. & Leigh, I. M., Oct 2014, In : Journal of Investigative Dermatology. 134, 10, p. 2630-2638 9 p.

Research output: Contribution to journalArticle

142 Citations (Scopus)

Progress in skin cancer: the U.K. experience

Leigh, I. M., Sep 2014, In : British Journal of Dermatology. 171, 3, p. 443-445 3 p.

Research output: Contribution to journalEditorial

10 Citations (Scopus)

Type VII collagen regulates expression of OATP1B3, promotes front-to-rear polarity and increases structural organisation in 3D spheroid cultures of RDEB tumour keratinocytes

Dayal, J. H. S., Cole, C. L., Pourreyron, C., Watt, S. A., Lim, Y. Z., Salas-Alanis, J. C., Murrell, D. F., McGrath, J. A., Stieger, B., Jahoda, C., Leigh, I. M. & South, A. P., 15 Feb 2014, In : Journal of Cell Science. 127, 4, p. 740-751 12 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2013

A surveillance model for skin cancer in organ transplant recipients: A 22-year prospective study in an ethnically diverse population

Harwood, C. A., Mesher, D., McGregor, J. M., Mitchell, L., Leedham-Green, M., Raftery, M., Cerio, R., Leigh, I. M., Sasieni, P. & Proby, C. M., Jan 2013, In : American Journal of Transplantation. 13, 1, p. 119-129 11 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)

A two gene serum epigenetic signature detects metastatic melanoma with high sensitivity and specificity

Wang, H., McHugh, A., Matin, R., Fleming, C., Leigh, I., Harwood, C., Inman, G., Crook, T. & Proby, C., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S235 1 p., 1379.

Research output: Contribution to journalMeeting abstract

Cutaneous SCC and the RAS controversy

McHugh, A. T., Purdie, K., Pourreyron, C., Watt, S., Rose, A., Leigh, I., Harwood, C., South, A. & Proby, C., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S66 1 p., 386.

Research output: Contribution to journalMeeting abstract

Cutaneous squamous cell carcinoma carries the highest burden of mutation of any human tumor type and harbors prevalent mutations in CARD11 and CREBBP

South, A. P., Watt, S. A., Purdie, K. J., Proby, C. M., Harwood, C. A. & Leigh, I. M., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S72 1 p., 427.

Research output: Contribution to journalMeeting abstract

Cutaneous squamous cell carcinoma derived cell lines are more sensitive to the proteasome inhibitor bortezomib than normal skin cells

Koerver, L., Tura, Z. H., Leigh, I. M., South, A. P. & Saville, M. K., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S183 1 p.

Research output: Contribution to journalMeeting abstract

Depletion of MRG-binding protein invokes TIP60 histone acetyltransferase-dependent apoptosis in cutaneous squamous cell carcinoma cells

Watt, S. A., Arrand, K., Leigh, I. M. & South, A. P., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S71 1 p., 416.

Research output: Contribution to journalMeeting abstract

Expression microarray analysis identifies key processes in the transition from actinic keratosis to cutaneous squamous cell carcinoma

Lambert, S. R., Mladkova, N., Gulati, A., Hamoudi, R., Purdie, K. J., Cerio, R., Leigh, I. M., Proby, C. M. & Harwood, C. A., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S67 1 p., 393.

Research output: Contribution to journalMeeting abstract

Gauging NOTCH1 activation in cancer using immunohistochemistry

Kluk, M. J., Ashworth, T., Wang, H., Knoechel, B., Mason, E. F., Morgan, E. A., Dorfman, D., Pinkus, G., Weigert, O., Hornick, J. L., Chirieac, L. R., Hirsch, M., Oh, D. J., South, A. P., Leigh, I. M., Pourreyron, C., Cassidy, A. J., DeAngelo, D. J., Weinstock, D. M., Krop, I. E. & 10 others, Dillon, D., Brock, J. E., Lazar, A. J. F., Peto, M., Cho, R. J., Stoeck, A., Haines, B. B., Sathayanrayanan, S., Rodig, S. & Aster, J. C., 2013, In : PLoS ONE. 8, 6, 14 p., e67306.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Immunohistochemical assessment of MRG-binding protein and polo-like kinase 1 over-expression in human cutaneous SCC

Harkins, C., Watt, S. A., Pourreyron, C., Leigh, I. M., Proby, C. M. & South, A. P., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S70 1 p., 414.

Research output: Contribution to journalMeeting abstract

Key differences identified between actinic keratosis and cutaneous squamous cell carcinoma by transcriptome profiling

Lambert, S. R., Mladkova, N., Gulati, A., Hamoudi, R., Purdie, K., Cerio, R., Leigh, I., Proby, C. & Harwood, C. A., 21 Jan 2013, In : British Journal of Cancer. 110, 2, p. 520-529 10 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Methylated tissue factor pathway inhibitor 2 (TFPI2) DNA in serum is a biomarker of metastatic melanoma

Nigro, C. L., Wang, H., McHugh, A., Lattanzio, L., Matin, R., Harwood, C., Syed, N., Hatzimichael, E., Briasoulis, E., Merlano, M., Evans, A., Thompson, A., Leigh, I., Fleming, C., Inman, G. J., Proby, C. & Crook, T., May 2013, In : Journal of Investigative Dermatology. 133, 5, p. 1278-1285 8 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

MMP1, 2 and 7 but not 9 or 13 promote cutaneous SCC keratinocyte invasion and migration

Pourreyron, C., Pautu, V., Simons, M. R., Proby, C. M., Leigh, I. M. & South, A. P., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S156 1 p., 917.

Research output: Contribution to journalMeeting abstract

Mutant p53 in cutaneous squamous cell carcinoma

Saundh, H., Leigh, I. M., South, A. P. & Saville, M. K., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S70 1 p., 413.

Research output: Contribution to journalMeeting abstract

Mutations in AQP5, encoding a water-channel protein, cause autosomal-dominant diffuse nonepidermolytic palmoplantar keratoderma

Blaydon, D. C., Lind, L. K., Plagnol, V., Linton, K. J., Smith, F. J. D., Wilson, N. J., McLean, W. H. I., Munro, C. S., South, A. P., Leigh, I. M., O'Toole, E. A., Lundström, A. & Kelsell, D. P., 8 Aug 2013, In : American Journal of Human Genetics. 93, 2, p. 330-335 6 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

RNAi depletion of PRSS21 in cutaneous squamous cell carcinoma keratinocytes induces maspin dependent apoptosis

Robinson, K. S., Watt, S. A., Leigh, I. M. & South, A. P., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S72 1 p., 423.

Research output: Contribution to journalMeeting abstract

The development of cutaneous squamous lesions in patients treated with vemurafenib: a possible role for human papillomavirus in addition to activated RAS

Purdie, K., South, A., Sommerlad, M., Leigh, I., Proby, C. & Harwood, C., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S61 1 p., 357.

Research output: Contribution to journalMeeting abstract

Type VII collagen regulates front-to-rear polarity in primary cutaneous squamous cell carcinoma keratinocytes

Dayal, J. H., Pourreyron, C., Watt, S. A., Leigh, I. M. & South, A. P., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S157 1 p., 921.

Research output: Contribution to journalMeeting abstract

2012

A quantitative molecular diagnostic system for predicting progression of vulval intraepithelial neoplasia to invasive squamous cell carcinoma

Purdie, K., Gibbon, K., Proby, C., Leigh, I., Harwood, C. & Teh, T., Apr 2012, In : British Journal of Dermatology. 166, 4, p. e29-e29 1 p., P-1.

Research output: Contribution to journalArticle

37 Citations (Scopus)

ARNT controls the expression of epidermal differentiation genes through HDAC- and EGFR-dependent pathways

Robertson, E. D., Weir, L., Romanowska, M., Leigh, I. M. & Panteleyev, A. A., 15 Jul 2012, In : Journal of Cell Science. 125, 14, p. 3320-3332 13 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Dermal matrix composition promotes development of aggressive squamous cell carcinoma in recessive dystrophic epidermolysis bullosa

Ng, Y., Pourreyron, C., Salas-Alanis, J., Cepeda-Valdes, R., Yan, W., Wright, S., Chen, M., Hogg, F., McGrath, J., Murrell, D., Leigh, I., Lane, E. & South, A., May 2012, In : Journal of Investigative Dermatology. 132, p. S20-S20 1 p.

Research output: Contribution to journalArticle

Exome level sequencing identifies candidate genes mutated in cutaneous squamous cell carcinoma progression

South, A. P., Purdie, K. J., Watt, S. A., Harwood, C. A., Proby, C. & Leigh, I. M., Sep 2012, In : Journal of Investigative Dermatology. 132, p. S37-S37 1 p.

Research output: Contribution to journalMeeting abstract

Expression of activated NOTCH1 induces terminal differentiation in squamous cell carcinoma keratinocytes

Robinson, K. S., Purdie, K. J., Cho, R. J., Aster, J. C., Leigh, I. M. & South, A. P., Sep 2012, In : Journal of Investigative Dermatology. 132, p. S40-S40 1 p.

Research output: Contribution to journalMeeting abstract

9 Citations (Scopus)

Fibroblast-derived dermal matrix drives development of aggressive cutaneous squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa

Ng, Y-Z., Pourreyron, C., Salas-Alanis, J. C., Dayal, J. H. S., Cepeda-Valdes, R., Yan, W., Wright, S., Chen, M., Fine, J-D., Hogg, F. J., McGrath, J. A., Murrell, D. F., Leigh, I. M., Lane, E. B. & South, A. P., 2012, In : Cancer Research. 72, 14, p. 3522-3534 13 p.

Research output: Contribution to journalArticle

71 Citations (Scopus)

Metastatic cutaneous squamous cell carcinoma shows frequent deletion in the protein tyrosine phosphatase receptor Type D gene

Lambert, S. R., Harwood, C. A., Purdie, K. J., Gulati, A., Matin, R. N., Romanowska, M., Cerio, R., Kelsell, D. P., Leigh, I. M. & Proby, C. M., 2012, In : International Journal of Cancer. 131, 3, p. E216-E226

Research output: Contribution to journalArticle

12 Citations (Scopus)

Next-generation sequencing identifies Notch receptors as integral tumor suppressors in cutaneous and lung squamous cell carcinomas

Wang, N. J., Sanborn, Z., Arnett, K. L., Bayston, L. J., Liao, W., Proby, C. M., Leigh, I. M., Gordon, P. B., Sharma, M., North, J. P., Vemula, S. S., Mauro, T. M., Neuhaus, I. M., LeBoit, P. E., Kwok, P., Arron, S. T., Bale, A. E., Haussler, D., Cleaver, J. E., Gray, J. W. & 5 others, Spellman, P. T., South, A. P., Aster, J. C., Blacklow, S. C. & Cho, R. J., May 2012, In : Journal of Investigative Dermatology. 132, p. S23-S23 1 p.

Research output: Contribution to journalArticle