Leigh, Irene

Professor

  • 5758 Citations
  • 31 h-Index
1989 …2019
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Research Output 1989 2019

2019
10 Downloads (Pure)

A Unique Panel of Patient-Derived Cutaneous Squamous Cell Carcinoma Cell Lines Provides a Preclinical Pathway for Therapeutic Testing

Hassan, S., Purdie, K. J., Wang, J., Harwood, C. A., Proby, C. M., Pourreyron, C., Mladkova, N., Nagano, A., Dhayade, S., Athineos, D., Caley, M., Mannella, V., Blyth, K., Inman, G. J. & Leigh, I. M., 12 Jul 2019, In : International Journal of Molecular Sciences. 20, 14, p. 1-26 26 p., 3428.

Research output: Contribution to journalArticle

Open Access
File
cultured cells
Squamous Cell Carcinoma
cancer
Cells
Cell Line

Azathioprine: friend or foe?

Leigh, I. M., Proby, C. M., Inman, G. J. & Harwood, C. A., May 2019, In : British Journal of Dermatology. 180, 5, p. 961-963 3 p.

Research output: Contribution to journalEditorial

1 Citation (Scopus)
51 Downloads (Pure)

Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model

Kalin, J. H., Eroglu, A., Liu, H., Holtzclaw, W. D., Leigh, I., Proby, C. M., Fahey, J. W., Cole, P. A. & Dinkova-Kostova, A. T., 13 Mar 2019, In : PLoS ONE. 14, 3, p. 1-13 13 p., e0213095.

Research output: Contribution to journalArticle

Open Access
File
Hairless Mouse
histone deacetylase
Histone Deacetylase Inhibitors
squamous cell carcinoma
Squamous Cell Carcinoma
2018
1 Citation (Scopus)

Nationwide Incidence of Metastatic Cutaneous Squamous Cell Carcinoma in England

Venables, Z. C., Autier, P., Nijsten, T., Wong, K. F., Langan, S. M., Rous, B., Broggio, J., Harwood, C., Henson, K., Proby, C. M., Rashbass, J. & Leigh, I. M., 28 Nov 2018, In : JAMA Dermatology. 9 p.

Research output: Contribution to journalArticle

England
Squamous Cell Carcinoma
Skin
Incidence
Skin Neoplasms
5 Citations (Scopus)
67 Downloads (Pure)

Preclinical comparison of proteasome and ubiquitin E1 enzyme inhibitors in cutaneous squamous cell carcinoma: the identification of mechanisms of differential sensitivity

McHugh, A., Fernandes, K., South, A., Mellerio, J. E., Salas-Alanis, J. C., Proby, C., Leigh, I. & Saville, M., 17 Apr 2018, In : Oncotarget. 9, p. 20265-20281 17 p.

Research output: Contribution to journalArticle

Open Access
File
Enzyme Inhibitors
Proteasome Endopeptidase Complex
Ubiquitin
Proteasome Inhibitors
Squamous Cell Carcinoma
121 Downloads (Pure)

Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma

Rose, A. M., Spender, L. C., Stephen, C., Mitchell, A., Rickaby, W., Bray, S., Evans, A. T., Dayal, J., Purdie, K. J., Harwood, C. A., Proby, C. M., Leigh, I. M., Coates, P. J. . & Inman, G. J., 6 Mar 2018, In : Oncotarget. 9, 18, p. 14552-14566 15 p.

Research output: Contribution to journalArticle

Open Access
File
Squamous Cell Carcinoma
Skin
Transforming Growth Factor beta
Inhibin-beta Subunits
Neoplasms
6 Citations (Scopus)
56 Downloads (Pure)

Targeting the spliceosome for cutaneous squamous cell carcinoma therapy: a role for c-MYC and wild-type p53 in determining the degree of tumour selectivity

Hepburn, L., McHugh, A., Fernandes, K., Boag, G., Proby, C., Leigh, I. & Saville, M., 1 May 2018, In : Oncotarget. 9, 33, p. 23029-23046 18 p.

Research output: Contribution to journalArticle

Open Access
File
Spliceosomes
Cell- and Tissue-Based Therapy
Squamous Cell Carcinoma
Skin
Neoplasms
19 Citations (Scopus)
75 Downloads (Pure)

The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature

Inman, G. J., Wang, J., Nagano, A., Alexandrov, L. B., Purdie, K. J., Taylor, R. G., Sherwood, V., Thomson, J., Hogan, S., Spender, L. C., South, A. P., Stratton, M., Chelala, C., Harwood, C. A., Proby, C. M. & Leigh, I. M., 10 Sep 2018, In : Nature Communications. 9, 1, p. 1-14 14 p., 3667.

Research output: Contribution to journalArticle

Open Access
File
Azathioprine
Tumors
tumors
signatures
Skin
2 Citations (Scopus)
67 Downloads (Pure)

The Role of Human Papillomaviruses and Polyomaviruses in BRAF-Inhibitor Induced Cutaneous Squamous Cell Carcinoma and Benign Squamoproliferative Lesions

Purdie, K. J., Proby, C. M., Rizvi, H., Griffin, H., Doorbar, J., Sommerlad, M., Feltkamp, M. C., Van der Meijden, E., Inman, G. J., South, A. P., Leigh, I. M. & Harwood, C. A., 14 Aug 2018, In : Frontiers in Microbiology. 9, 16 p., 1806.

Research output: Contribution to journalArticle

Open Access
File
Polyomavirus
Squamous Cell Carcinoma
Skin
Mutation
Warts
2017
7 Citations (Scopus)
151 Downloads (Pure)

Genomic analysis of atypical fibroxanthoma

Lai, K., Harwood, C. A., Purdie, K. J., Proby, C. M., Leigh, I. M., Ravi, N., Mully, T. W., Brooks, L., Sandoval, P. M., Rosenblum, M. D. & Arron, S. T., 15 Nov 2017, In : PLoS ONE. 12, 11, p. 1-15 15 p., e0188272.

Research output: Contribution to journalArticle

Open Access
File
Tumors
genomics
neoplasms
Epithelial-Mesenchymal Transition
Genes
1 Citation (Scopus)

Keratinocyte skin cancers in the spotlight

Nijsten, T. & Leigh, I. M., 18 Aug 2017, In : British Journal of Dermatology. 177, 2, p. 334-335 2 p.

Research output: Contribution to journalEditorial

10 Citations (Scopus)
99 Downloads (Pure)

Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16

Maruthappu, T., Chikh, A., Fell, B., Delaney, P. J., Brooke, M. A., Levet, C., Moncada-Pazos, A., Ishida-Yamamoto, A., Blaydon, D., Waseem, A., Leigh, I. M., Freeman, M. & Kelsell, D. P., 27 Jan 2017, In : Nature Communications. 8, p. 1-11 11 p., 14174.

Research output: Contribution to journalArticle

Open Access
File
Keratin-16
rhomboids
keratins
protease
Peptide Hydrolases
2016
3 Citations (Scopus)
63 Downloads (Pure)

CREBBP mutation in human cutaneous squamous cell carcinoma

Watt, S. A., Purdie, K. J., den Breems, N. Y., Dimon, M., Tucker, S., Arron, S. T., Mchugh, A., Xue, D. J., Dayal, J. H. S., Harwood, C. A., Leigh, I. M., Proby, C. M. & South, A. P., Aug 2016, In : Experimental Dermatology. 25, 8, p. 650-651 2 p.

Research output: Contribution to journalLetter

Open Access
File
34 Citations (Scopus)
70 Downloads (Pure)

Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma

Cammareri, P., Rose, A., Vincent, D. F., Wang, J., Nagano, A., Libertini, S., Ridgway, R. A., Athineos, D., Coates, P. J. ., McHugh, A., Pourreyron, C., Dayal, J., Larsson, J., Weidlich, S., Spender, L., Sapkota, G., Purdie, K. J., Proby, C., Harwood, C. A., Leigh, I. & 9 others, Clevers, H., Barker, N., Karlsson, S., Pritchard, C., Marais, R., Chelala, C., South, A., Sansom, O. J. & Inman, G., 25 Aug 2016, In : Nature Communications. 7, p. 1-7 7 p., 12493.

Research output: Contribution to journalArticle

Open Access
File
stem cells
Stem cells
deactivation
Squamous Cell Carcinoma
Stem Cells
2 Citations (Scopus)
110 Downloads (Pure)

MEK is a therapeutic and chemopreventative target in squamous cell carcinoma

Adelmann, C. H., Truong, K. A., Liang, R. J., Bansal, V., Gandee, L., Saporito, R., Lee, W., Du, L., Nicholas, C., Napoli, M., Mino, B., South, A. P., Proby, C. M., Leigh, I. M., Coarfa, C., Flores, E. R. & Tsai, K. Y., Sep 2016, In : Journal of Investigative Dermatology. 136, 9, p. 1920-1924 5 p.

Research output: Contribution to journalLetter

Open Access
File

The European Union's investment and future role in dermatologic research

Leigh, I. M., Jul 2016, In : Journal of Investigative Dermatology. 136, 7, p. 1307-1310 4 p.

Research output: Contribution to journalEditorial

5 Citations (Scopus)
118 Downloads (Pure)

WNT Signaling in Cutaneous Squamous Cell Carcinoma: A Future Treatment Strategy?

Sherwood, V. & Leigh, I., Sep 2016, In : Journal of Investigative Dermatology. 136, 9, p. 1760-1767 8 p.

Research output: Contribution to journalReview article

Open Access
File
Squamous Cell Carcinoma
Skin
Oncology
Skin Neoplasms
Tumors
2015
12 Citations (Scopus)
107 Downloads (Pure)

Lysyl hydroxylase 3 localizes to epidermal basement membrane and Is reduced in patients with Recessive Dystrophic Epidermolysis Bullosa

Watt, S. A., Dayal, J. H. S., Wright, S., Riddle, M., Pourreyron, C., McMillan, J. R., Kimble, R. M., Prisco, M., Gartner, U., Warbrick, E., McLean, W. H. I., Leigh, I. M., McGrath, J. A., Salas-Alanis, J. C., Tolar, J. & South, A. P., 18 Sep 2015, In : PLoS ONE. 10, 9, 15 p., e0137639.

Research output: Contribution to journalArticle

Open Access
File
2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine
epidermolysis bullosa
Epidermolysis Bullosa Dystrophica
basement membrane
Basement Membrane
8 Citations (Scopus)

Novel CARD11 mutations in human cutaneous squamous cell carcinoma lead to aberrant NF-κB regulation

Watt, S. A., Purdie, K. J., den Breems, N. Y., Dimon, M., Arron, S. T., McHugh, A. T., Xue, D. J., Dayal, J. H. S., Proby, C. M., Harwood, C. A., Leigh, I. M. & South, A. P., Sep 2015, In : American Journal of Pathology. 185, 9, p. 2354-2363 10 p.

Research output: Contribution to journalArticle

Squamous Cell Carcinoma
Skin
Mutation
Psoriasis
Pityriasis Rubra Pilaris
2014
9 Citations (Scopus)

High levels of type VII collagen expression in RDEB cSCC keratinocytes increases PI3K and MAPK signalling, cell migration and invasion

Pourreyron, C., Chen, M., McGrath, J. A., Salas-Alanis, J. C., South, A. P. & Leigh, I. M., 2014, In : British Journal of Dermatology. 170, 6, p. 1256-1265 11 p.

Research output: Contribution to journalArticle

Collagen Type VII
Epidermolysis Bullosa Dystrophica
Phosphatidylinositol 3-Kinases
Keratinocytes
Cell Movement
371 Citations (Scopus)

Inherited epidermolysis bullosa: updated recommendations on diagnosis and classification

Fine, J-D., Bruckner-Tuderman, L., Eady, R. A. J., Bauer, E. A., Bauer, J. W., Has, C., Heagerty, A., Hintner, H., Hovnanian, A., Jonkman, M. F., Leigh, I., Marinkovich, M. P., Martinez, A. E., McGrath, J. A., Mellerio, J. E., Moss, C., Murrell, D. F., Shimizu, H., Uitto, J., Woodley, D. & 1 others, Zambruno, G., Jun 2014, In : Journal of the American Academy of Dermatology. 70, 6, p. 1103-1126 24 p.

Research output: Contribution to journalArticle

Epidermolysis Bullosa
Skin
Mutation
Onions
Genes
116 Citations (Scopus)

NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis

South, A. P., Purdie, K. J., Watt, S. A., Haldenby, S., den Breems, N., Dimon, M., Arron, S. T., Kluk, M. J., Aster, J. C., McHugh, A., Xue, D. J., Dayal, J. H. S., Robinson, K. S., Rizvi, S. M. H., Proby, C. M., Harwood, C. A. & Leigh, I. M., Oct 2014, In : Journal of Investigative Dermatology. 134, 10, p. 2630-2638 9 p.

Research output: Contribution to journalArticle

Skin
Carcinogenesis
Epithelial Cells
Mutation
Dermatology
8 Citations (Scopus)

Progress in skin cancer: the U.K. experience

Leigh, I. M., Sep 2014, In : British Journal of Dermatology. 171, 3, p. 443-445 3 p.

Research output: Contribution to journalEditorial

14 Citations (Scopus)

Type VII collagen regulates expression of OATP1B3, promotes front-to-rear polarity and increases structural organisation in 3D spheroid cultures of RDEB tumour keratinocytes

Dayal, J. H. S., Cole, C. L., Pourreyron, C., Watt, S. A., Lim, Y. Z., Salas-Alanis, J. C., Murrell, D. F., McGrath, J. A., Stieger, B., Jahoda, C., Leigh, I. M. & South, A. P., 15 Feb 2014, In : Journal of Cell Science. 127, 4, p. 740-751 12 p.

Research output: Contribution to journalArticle

Collagen Type VII
Epidermolysis Bullosa Dystrophica
Keratinocytes
Skin
Squamous Cell Carcinoma
2013
70 Citations (Scopus)

A surveillance model for skin cancer in organ transplant recipients: A 22-year prospective study in an ethnically diverse population

Harwood, C. A., Mesher, D., McGregor, J. M., Mitchell, L., Leedham-Green, M., Raftery, M., Cerio, R., Leigh, I. M., Sasieni, P. & Proby, C. M., Jan 2013, In : American Journal of Transplantation. 13, 1, p. 119-129 11 p.

Research output: Contribution to journalArticle

Skin Neoplasms
Prospective Studies
Transplants
Population
Neoplasms

A two gene serum epigenetic signature detects metastatic melanoma with high sensitivity and specificity

Wang, H., McHugh, A., Matin, R., Fleming, C., Leigh, I., Harwood, C., Inman, G., Crook, T. & Proby, C., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S235 1 p., 1379.

Research output: Contribution to journalMeeting abstract

Cutaneous SCC and the RAS controversy

McHugh, A. T., Purdie, K., Pourreyron, C., Watt, S., Rose, A., Leigh, I., Harwood, C., South, A. & Proby, C., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S66 1 p., 386.

Research output: Contribution to journalMeeting abstract

Cutaneous squamous cell carcinoma carries the highest burden of mutation of any human tumor type and harbors prevalent mutations in CARD11 and CREBBP

South, A. P., Watt, S. A., Purdie, K. J., Proby, C. M., Harwood, C. A. & Leigh, I. M., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S72 1 p., 427.

Research output: Contribution to journalMeeting abstract

Cutaneous squamous cell carcinoma derived cell lines are more sensitive to the proteasome inhibitor bortezomib than normal skin cells

Koerver, L., Tura, Z. H., Leigh, I. M., South, A. P. & Saville, M. K., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S183 1 p.

Research output: Contribution to journalMeeting abstract

Depletion of MRG-binding protein invokes TIP60 histone acetyltransferase-dependent apoptosis in cutaneous squamous cell carcinoma cells

Watt, S. A., Arrand, K., Leigh, I. M. & South, A. P., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S71 1 p., 416.

Research output: Contribution to journalMeeting abstract

Expression microarray analysis identifies key processes in the transition from actinic keratosis to cutaneous squamous cell carcinoma

Lambert, S. R., Mladkova, N., Gulati, A., Hamoudi, R., Purdie, K. J., Cerio, R., Leigh, I. M., Proby, C. M. & Harwood, C. A., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S67 1 p., 393.

Research output: Contribution to journalMeeting abstract

59 Citations (Scopus)

Gauging NOTCH1 activation in cancer using immunohistochemistry

Kluk, M. J., Ashworth, T., Wang, H., Knoechel, B., Mason, E. F., Morgan, E. A., Dorfman, D., Pinkus, G., Weigert, O., Hornick, J. L., Chirieac, L. R., Hirsch, M., Oh, D. J., South, A. P., Leigh, I. M., Pourreyron, C., Cassidy, A. J., DeAngelo, D. J., Weinstock, D. M., Krop, I. E. & 10 others, Dillon, D., Brock, J. E., Lazar, A. J. F., Peto, M., Cho, R. J., Stoeck, A., Haines, B. B., Sathayanrayanan, S., Rodig, S. & Aster, J. C., 2013, In : PLoS ONE. 8, 6, 14 p., e67306.

Research output: Contribution to journalArticle

Immunohistochemical assessment of MRG-binding protein and polo-like kinase 1 over-expression in human cutaneous SCC

Harkins, C., Watt, S. A., Pourreyron, C., Leigh, I. M., Proby, C. M. & South, A. P., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S70 1 p., 414.

Research output: Contribution to journalMeeting abstract

37 Citations (Scopus)

Key differences identified between actinic keratosis and cutaneous squamous cell carcinoma by transcriptome profiling

Lambert, S. R., Mladkova, N., Gulati, A., Hamoudi, R., Purdie, K., Cerio, R., Leigh, I., Proby, C. & Harwood, C. A., 21 Jan 2013, In : British Journal of Cancer. 110, 2, p. 520-529 10 p.

Research output: Contribution to journalArticle

Actinic Keratosis
Gene Expression Profiling
Squamous Cell Carcinoma
Skin
Mitogen-Activated Protein Kinases
29 Citations (Scopus)

Methylated tissue factor pathway inhibitor 2 (TFPI2) DNA in serum is a biomarker of metastatic melanoma

Nigro, C. L., Wang, H., McHugh, A., Lattanzio, L., Matin, R., Harwood, C., Syed, N., Hatzimichael, E., Briasoulis, E., Merlano, M., Evans, A., Thompson, A., Leigh, I., Fleming, C., Inman, G. J., Proby, C. & Crook, T., May 2013, In : Journal of Investigative Dermatology. 133, 5, p. 1278-1285 8 p.

Research output: Contribution to journalArticle

Biomarkers
Melanoma
DNA
Serum
CpG Islands

MMP1, 2 and 7 but not 9 or 13 promote cutaneous SCC keratinocyte invasion and migration

Pourreyron, C., Pautu, V., Simons, M. R., Proby, C. M., Leigh, I. M. & South, A. P., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S156 1 p., 917.

Research output: Contribution to journalMeeting abstract

Mutant p53 in cutaneous squamous cell carcinoma

Saundh, H., Leigh, I. M., South, A. P. & Saville, M. K., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S70 1 p., 413.

Research output: Contribution to journalMeeting abstract

45 Citations (Scopus)

Mutations in AQP5, encoding a water-channel protein, cause autosomal-dominant diffuse nonepidermolytic palmoplantar keratoderma

Blaydon, D. C., Lind, L. K., Plagnol, V., Linton, K. J., Smith, F. J. D., Wilson, N. J., McLean, W. H. I., Munro, C. S., South, A. P., Leigh, I. M., O'Toole, E. A., Lundström, A. & Kelsell, D. P., 8 Aug 2013, In : American Journal of Human Genetics. 93, 2, p. 330-335 6 p.

Research output: Contribution to journalArticle

Aquaporin 5
Aquaporins
Mutation
Epidermis
Cell Membrane

RNAi depletion of PRSS21 in cutaneous squamous cell carcinoma keratinocytes induces maspin dependent apoptosis

Robinson, K. S., Watt, S. A., Leigh, I. M. & South, A. P., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S72 1 p., 423.

Research output: Contribution to journalMeeting abstract

The development of cutaneous squamous lesions in patients treated with vemurafenib: a possible role for human papillomavirus in addition to activated RAS

Purdie, K., South, A., Sommerlad, M., Leigh, I., Proby, C. & Harwood, C., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S61 1 p., 357.

Research output: Contribution to journalMeeting abstract

Type VII collagen regulates front-to-rear polarity in primary cutaneous squamous cell carcinoma keratinocytes

Dayal, J. H., Pourreyron, C., Watt, S. A., Leigh, I. M. & South, A. P., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S157 1 p., 921.

Research output: Contribution to journalMeeting abstract

2012
34 Citations (Scopus)

A quantitative molecular diagnostic system for predicting progression of vulval intraepithelial neoplasia to invasive squamous cell carcinoma

Purdie, K., Gibbon, K., Proby, C., Leigh, I., Harwood, C. & Teh, T., Apr 2012, In : British Journal of Dermatology. 166, 4, p. e29-e29 1 p., P-1.

Research output: Contribution to journalArticle

31 Citations (Scopus)

ARNT controls the expression of epidermal differentiation genes through HDAC- and EGFR-dependent pathways

Robertson, E. D., Weir, L., Romanowska, M., Leigh, I. M. & Panteleyev, A. A., 15 Jul 2012, In : Journal of Cell Science. 125, 14, p. 3320-3332 13 p.

Research output: Contribution to journalArticle

Dermal matrix composition promotes development of aggressive squamous cell carcinoma in recessive dystrophic epidermolysis bullosa

Ng, Y., Pourreyron, C., Salas-Alanis, J., Cepeda-Valdes, R., Yan, W., Wright, S., Chen, M., Hogg, F., McGrath, J., Murrell, D., Leigh, I., Lane, E. & South, A., May 2012, In : Journal of Investigative Dermatology. 132, p. S20-S20 1 p.

Research output: Contribution to journalArticle

Exome level sequencing identifies candidate genes mutated in cutaneous squamous cell carcinoma progression

South, A. P., Purdie, K. J., Watt, S. A., Harwood, C. A., Proby, C. & Leigh, I. M., Sep 2012, In : Journal of Investigative Dermatology. 132, p. S37-S37 1 p.

Research output: Contribution to journalMeeting abstract

8 Citations (Scopus)

Expression of activated NOTCH1 induces terminal differentiation in squamous cell carcinoma keratinocytes

Robinson, K. S., Purdie, K. J., Cho, R. J., Aster, J. C., Leigh, I. M. & South, A. P., Sep 2012, In : Journal of Investigative Dermatology. 132, p. S40-S40 1 p.

Research output: Contribution to journalMeeting abstract

59 Citations (Scopus)

Fibroblast-derived dermal matrix drives development of aggressive cutaneous squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa

Ng, Y-Z., Pourreyron, C., Salas-Alanis, J. C., Dayal, J. H. S., Cepeda-Valdes, R., Yan, W., Wright, S., Chen, M., Fine, J-D., Hogg, F. J., McGrath, J. A., Murrell, D. F., Leigh, I. M., Lane, E. B. & South, A. P., 2012, In : Cancer Research. 72, 14, p. 3522-3534 13 p.

Research output: Contribution to journalArticle

Epidermolysis Bullosa Dystrophica
Squamous Cell Carcinoma
Fibroblasts
Skin
Collagen Type XII
12 Citations (Scopus)

Metastatic cutaneous squamous cell carcinoma shows frequent deletion in the protein tyrosine phosphatase receptor Type D gene

Lambert, S. R., Harwood, C. A., Purdie, K. J., Gulati, A., Matin, R. N., Romanowska, M., Cerio, R., Kelsell, D. P., Leigh, I. M. & Proby, C. M., 2012, In : International Journal of Cancer. 131, 3, p. E216-E226

Research output: Contribution to journalArticle

Class 2 Receptor-Like Protein Tyrosine Phosphatases
Squamous Cell Carcinoma
Skin
Genes
Skin Neoplasms

Next-generation sequencing identifies Notch receptors as integral tumor suppressors in cutaneous and lung squamous cell carcinomas

Wang, N. J., Sanborn, Z., Arnett, K. L., Bayston, L. J., Liao, W., Proby, C. M., Leigh, I. M., Gordon, P. B., Sharma, M., North, J. P., Vemula, S. S., Mauro, T. M., Neuhaus, I. M., LeBoit, P. E., Kwok, P., Arron, S. T., Bale, A. E., Haussler, D., Cleaver, J. E., Gray, J. W. & 5 others, Spellman, P. T., South, A. P., Aster, J. C., Blacklow, S. C. & Cho, R. J., May 2012, In : Journal of Investigative Dermatology. 132, p. S23-S23 1 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

NT5E (CD73) is epigenetically regulated in malignant melanoma and associated with metastatic site specificity

Wang, H., Lee, S., Lo Nigro, C., Lattanzio, L., Merlano, M., Monteverde, M., Matin, R., Purdie, K., Mladkova, N., Bergamaschi, D., Harwood, C., Syed, N., Szlosarek, P., Briasoulis, E., McHugh, A., Thompson, A., Evans, A., Leigh, I., Fleming, C., Inman, G. J. & 3 others, Hatzimichael, E., Proby, C. & Crook, T., 2012, In : British Journal of Cancer. 106, 8, p. 1446-52 7 p.

Research output: Contribution to journalArticle

Melanoma
Methylation
CpG Islands
Viscera
Epigenomics