Leigh, Irene

Professor

  • 6253 Citations
  • 32 h-Index
1989 …2020

Research output per year

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Research Output

1989

Survival of cultured allogeneic keratinocytes transplanted to deep dermal bed assessed with probe specific for Y chromosome

Brain, A., Purkis, P., Coates, P., Hackett, M., Navsaria, H. & Leigh, I., 8 Apr 1989, In : British Medical Journal. 298, 6678, p. 917-9 3 p.

Research output: Contribution to journalArticle

126 Citations (Scopus)
1992

Cytokeratin profiles in dyskeratosis congenita: an immunocytochemical investigation of lingual hyperkeratosis

Ogden, G. R., Chisholm, D. M., Leigh, I. M. & Lane, E. B., Sep 1992, In : Journal of Oral Pathology and Medicine. 21, 8, p. 353-357 5 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
1993

Missing links: Weber-Cockayne keratin mutations implicate the L12 linker domain in effective cytoskeleton function.

Rugg, EL., Morley, SM., Smith, FJ., Boxer, M., Tidman, MJ., Navsaria, H., Leigh, IM. & Lane, EB., Nov 1993, In : Nature Genetics. 5, 3, p. 294-300 7 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)
1994

A functional "knockout" of human keratin 14

Rugg, E. L., McLean, W. H., Lane, E. B., Pitera, R., McMillan, J. R., Dopping-Hepenstal, P. J., Navsaria, H. A., Leigh, I. M. & Eady, R. A., 1 Nov 1994, In : Genes & Development. 8, 21, p. 2563-2573 11 p.

Research output: Contribution to journalArticle

138 Citations (Scopus)

Mutations in the Rod 1A Domain of Keratins 1 and 10 in Bullous Congenital Ichthyosiform Erythoderma (BCIE)

McLean, W. H. I., Eady, R. A. J., Dopping-Hepenstal, P. J. C., McMillan, J. R., Leigh, I. M., Navsaria, H. A., Higgins, C., Harper, J. I., Paige, D. G., Morley, S. M. & Lane, E. B., Jan 1994, In : Journal of Investigative Dermatology. 102, 1, p. 24-30 7 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)
1995

Keratin 16 and keratin 17 mutations cause pachyonychia congenita

McLean, W. H. I., Rugg, E. L., Lunny, D. P., Morley, S. M., Lane, E. B., Swensson, O., Dopping-Hepenstal, P. J. C., Griffiths, W. A. D., Eady, R. A. J., Higgins, C., Navsaria, H. A., Leigh, I. M., Strachan, T., Kunkeler, L. & Munro, C. S., Mar 1995, In : Nature Genetics. 9, 3, p. 273-278 6 p.

Research output: Contribution to journalArticle

270 Citations (Scopus)
1996

Exfoliative cytology of normal oral mucosa: Assessing the basal cell keratin phenotype

Ogden, G. R., Leigh, I., Chisholm, D. M., Cowpe, J. G. & Lane, E. B., 1 Sep 1996, In : Acta Cytologica. 40, 5, p. 933-936 4 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Plectin deficiency results in muscular dystrophy with epidermolysis bullosa

Smith, F. J. D., Eady, R. A. J., Leigh, I. M., McMillan, J. R., Rugg, E. L., Kelsell, D. P., Bryant, S. P., Spurr, N. K., Geddes, J. F., Kirtschig, G., Milana, G., De Bono, A. G., Owaribe, K., Wiche, G., Pulkkinen, L., Uitto, J., McLean, W. H. I. & Lane, E. B., 1996, In : Nature Genetics. 13, 4, p. 450-457 8 p.

Research output: Contribution to journalArticle

313 Citations (Scopus)
2002

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

Multiple Leiomyoma Consortium, Tomlinson, I. P. M., Alam, N. A., Rowan, A. J., Barclay, E., Jaeger, E. E. M., Kelsell, D., Leigh, I., Gorman, P., Lamlum, H., Rahman, S., Roylance, R. R., Olpin, S., Bevan, S., Barker, K., Hearle, N., Houlston, R. S., Kiuru, M., Lehtonen, R., Karhu, A. & 12 others, Vilkki, S., Laiho, P., Eklund, C., Vierimaa, O., Aittomaki, K., Hietala, M., Sistonen, P., Paetau, A., Salovaara, R., Herva, R., Launonen, V. & Aaltonen, L. A., 2002, In : Nature Genetics. 30, 4, p. 406-410 5 p.

Research output: Contribution to journalArticle

1006 Citations (Scopus)

Intermediate filament–membrane attachments function synergistically with actin-dependent contacts to regulate intercellular adhesive strength

Huen, A. C., Park, J. K., Godsel, L. M., Chen, X., Bannon, L. J., Amargo, E. V., Hudson, T. Y., Mongiu, A. K., Leigh, I. M., Kelsell, D. P., Gumbiner, B. M. & Green, K. J., 23 Dec 2002, In : Journal of Cell Biology. 159, 6, p. 1005-1017 13 p.

Research output: Contribution to journalArticle

Open Access
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111 Citations (Scopus)
238 Downloads (Pure)
2003

Genetic and functional analyses of FH mutations in multiple cutaneous and uterine leiomyomatosis, hereditary leiomyomatosis and renal cancer, and fumarate hydratase deficiency

Alam, N. A., Rowan, A. J., Wortham, N. C., Pollard, P. J., Mitchell, M., Tyrer, J. P., Barclay, E., Calonje, E., Manek, S., Adams, S. J., Bowers, P. W., Burrows, N. P., Charles-Holmes, R., Cook, L. J., Daly, B. M., Ford, G. P., Fuller, L. C., Hadfield-Jones, S. E., Hardwick, N., Highet, A. S. & 22 others, Keefe, M., MacDonald-Hull, S. P., Potts, E. D. A., Crone, M., Wilkinson, S., Camacho-Martinez, F., Jablonska, S., Ratnavel, R., MacDonald, A., Mann, R. J., Grice, K., Guillet, G., Lewis-Jones, M. S., McGrath, H., Seukeran, D. C., Morrison, P. J., Fleming, S., Rahman, S., Kelsell, D., Leigh, I., Olpin, S. & Tomlinson, I. P. M., 2003, In : Human Molecular Genetics. 12, 11, p. 1241-1252 12 p.

Research output: Contribution to journalArticle

242 Citations (Scopus)

Lack of plakophilin 1 increases keratinocyte migration and reduces desmosome stability

South, A. P., Wan, H., Stone, M. G., Dopping-Hepenstal, P. J. C., Purkis, P. E., Marshall, J. F., Leigh, I. M., Eady, R. A. J., Hart, I. R. & McGrath, J. A., 2003, In : Journal of Cell Science. 116, 16, p. 3303-3314 12 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

Role of melanoma chondroitin sulphate proteoglycan in patterning stem cells in human interfollicular epidermis

Legg, J., Jensen, U. B., Broad, S., Leigh, I. & Watt, F. M., Dec 2003, In : Development. 130, 24, p. 6049-6063 15 p.

Research output: Contribution to journalArticle

118 Citations (Scopus)
2005

Mutations in ABCA12 underlie the severe congenital skin disease Harlequin Ichthyosis

Kelsell, P. D., Norgett, E. E., Unsworth, H., Teh, M-T., Cullup, T., Mein, C. A., Dopping-Hepenstal, J. P., Dale, A. B., Tadini, G., Fleckman, P., Stephens, G. K., Sybert, P. V., Mallory, B. S., North, V. B., Witt, R. D., Sprecher, E., Taylor, A. E. M., Ilchyshyn, A., Kennedy, T. C., Goodyear, H. & 7 others, Moss, C., Paige, D., Harper, I. J., Young, D. B., Leigh, M. I., Eady, A. J. R. & O'Toole, A. E., May 2005, In : American Journal of Human Genetics. 76, 5, p. 794-803 10 p.

Research output: Contribution to journalArticle

231 Citations (Scopus)
2007

Allelic imbalances and microdeletions affecting the PTPRD gene in cutaneous squamous cell carcinomas detected using single nucleotide polymorphism microarray analysis

Purdie, K. J., Lambert, S. R., Teh, M-T., Chaplin, T., Molloy, G., Raghavan, M., Kelsell, D. P., Leigh, I. M., Harwood, C. A., Proby, C. M. & Young, B. D., Jul 2007, In : Genes, Chromosomes and Cancer. 46, 7, p. 661-669 9 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)
2008

An altered keratinocyte phenotype in oral submucous fibrosis: Correlation of keratin K17 expression with disease severity

Lalli, A., Tilakaratne, W. M., Ariyawardana, A., Fitchett, C., Leigh, I. M., Hagi-Pavli, E., Cruchley, A. T., Parkinson, E. K., Teh, M-T., Fortune, F. & Waseem, A., 2008, In : Journal of Oral Pathology and Medicine. 37, 4, p. 211-220 10 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Clinical application of skin substitutes

Damodaran, G., Syed, M., Leigh, I., Myers, S. & Navsaria, H., 2008, In : Expert Review of Dermatology. 3, 3, p. 345-356 12 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Development of a treatment algorithm for actinic keratoses: a European Consensus

Stockfleth, E., Ferrandiz, C., Grob, J. J., Leigh, I., Pehamberger, H., Kerl, H. & European Skin Acad, 2008, In : European Journal of Dermatology. 18, 6, p. 651-659 9 p.

Research output: Contribution to journalArticle

164 Citations (Scopus)

Gene expression profiling of cultured squamous cell carcinoma keratinocytes identifies a pattern of gene expression which predicts invasive capacity

South, A. P., Pourreyron, C., Foerster, J., Mao, X., Purdie, K., Hogan, C., Mein, C., Bruckner-Tuderman, L., Proby, C. M., Young, B., Kelsell, D. P., McGrath, J. A. & Leigh, I. M., Apr 2008, In : British Journal of Dermatology. 158, 4, p. 883-883 1 p.

Research output: Contribution to journalBook/Film/Article review

Identification of genomic and epi-genomic lesions in squamous cell carcinomas using expression profiling of quiescent cultured keratinocytes

Pourreyron, C., Foerster, J., Mao, X., Purdie, K., Bruckner-Tuderman, L., Proby, C., McGrath, J., Leigh, I. & South, A., Apr 2008, In : Journal of Investigative Dermatology. 128, p. S36-S36 1 p.

Research output: Contribution to journalBook/Film/Article review

Potential of fibroblast cell therapy for recessive dystrophic epidermolysis bullosa

Wong, T., McGrath, J. A., Gammon, L., Leigh, I. M., Navsaria, H., Liu, L., Dopping-Hepenstal, P. J. C., Pacy, J., Mellerio, J. E., Elia, G. & Jeffery, R., 2008, In : Journal of Investigative Dermatology. 128, 9, p. 2179-2189 11 p.

Research output: Contribution to journalArticle

165 Citations (Scopus)

Squamous cell carcinoma keratinocytes isolated from patients with recessive dystrophic epidermolysis bullosa invade collagen-matrigel organotypic skin equivalents in an autonomous fashion

Pourreyron, C., Purdie, K., Bruckner-Tuderman, L., Proby, C. M., McGrath, J. A., Leigh, I. M. & South, A. P., Apr 2008, In : British Journal of Dermatology. 158, 4, p. 911-911 1 p.

Research output: Contribution to journalBook/Film/Article review

The classification of inherited epidermolysis bullosa (EB): Report of the Third International Consensus Meeting on Diagnosis and Classification of EB

Fine, J-D., Eady, R. A. J., McGrath, J. A., Mellerio, J. E., Bauer, E. A., Bauer, J. W., Hintner, H., Bruckner-Tuderman, L., Heagerty, A., Hovnanian, A., Jonkman, M. F., Leigh, I., Murrell, D. F., Shimizu, H., Uitto, J., Vahlquist, A., Woodley, D. & Zambruno, G., 1 Jun 2008, In : Journal of the American Academy of Dermatology. 58, 6, p. 931-950 20 p.

Research output: Contribution to journalArticle

637 Citations (Scopus)
2009

Adipose derived stem cells up-regulate type VII collagen in the presence of recessive dystrophic epidermolysis bullosa keratinocytes

Pourreyron, C., Cole, C. L., McGrath, J. A., Leigh, I. M. & South, A. P., Sep 2009, In : Journal of Investigative Dermatology. 129, p. S48-S48 1 p.

Research output: Contribution to journalBook/Film/Article review

DUSP23, SLCO1B3, SNURF, SNRPN and TJAP1 are genes with differential expression in squamous cell carcinoma keratinocytes derived from patients with recessive dystrophic epidermolysis bullosa

Cole, C. L., Foerster, J., Pourreyron, C., Purdie, K., Hogan, C., Proby, C., Bruckner-Tuderman, L., McGrath, J. A., Leigh, I. M. & South, A. P., Apr 2009, In : British Journal of Dermatology. 160, 4, p. 906-906 1 p.

Research output: Contribution to journalBook/Film/Article review

External anogenital premalignant and malignant disease

Gibbon, K. L., Ekeowa-Anderson, A. L. & Leigh, I. M., 2009, Skin Cancer after Organ Transplantation. Stockfleth, E., Ulrich, C., Euvrard, S., Proby, C., Bavinck, J-N. B. & Geissler, E. K. (eds.). Springer , Vol. 146. p. 279-298 20 p. (Cancer Treatment and Research; vol. 146, no. 3).

Research output: Chapter in Book/Report/Conference proceedingOther chapter contribution

Quiescent cultured keratinocytes derived from squamous cell carcinoma retain a cancer-specific gene expression signature capable of differentiating squamous cell carcinoma from normal skin in vivo

Pourreyron, C., Foerster, J., Hogan, C., Purdie, K., Bruckner-Tuderman, L., Proby, C., McGrath, J. A., Leigh, I. M. & South, A. P., Sep 2009, In : Journal of Investigative Dermatology. 129, p. S73-S73 1 p., 426[Oral077].

Research output: Contribution to journalBook/Film/Article review

Recombinant type VII collagen significantly increases transwell migration in squamous cell carcinoma keratinocytes isolated from patients with recessive dystrophic epidermolysis bullosa

Pourreyron, C., Hogan, C., Cole, C. L., Bruckner-Tuderman, L., McGrath, J. A., Leigh, I. M. & South, A. P., Apr 2009, In : British Journal of Dermatology. 160, 4, p. 925-925 1 p.

Research output: Contribution to journalBook/Film/Article review

Single Nucleotide Polymorphism Array Analysis Defines a Specific Genetic Fingerprint for Well-Differentiated Cutaneous SCCs

Purdie, K. J., Harwood, C. A., Gulati, A., Chaplin, T., Lambert, S. R., Cerio, R., Kelly, G. P., Cazier, J-B., Young, B. D., Leigh, I. M. & Proby, C. M., Jun 2009, In : Journal of Investigative Dermatology. 129, 6, p. 1562-1568 7 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

SLCO1B3 expression in recessive dystrophic epidermolysis bullosa associated squamous cell carcinoma is reduced by recombinant type VII collagen

Cole, C. L., Pourreyron, C., Foerster, J., Purdie, K., Salas-Alanis, J. C., Murrell, D. F., Bruckner-Tuderman, L., McGrath, J. A., Leigh, I. M. & South, A. P., Sep 2009, In : Journal of Investigative Dermatology. 129, p. S57-S57 1 p., 325.

Research output: Contribution to journalBook/Film/Article review

Type VII collagen increases invasion and migration of squamous cell carcinoma keratinocytes isolated from patients with recessive dystrophic epidermolysis bullosa.

Pourreyron, C., Hogan, C., Cole, C., Purdie, K., Bruckner-Tuderman, L., McGrath, J., Leigh, I. & South, A., 2009, In : Journal of Investigative Dermatology. 129, S1, p. S40 1 p., 236.

Research output: Contribution to journalMeeting abstract

2010

ARNT acts through EGFR- and HDAC-dependent pathways to control the expression of epidermal differentiation genes

Robertson, D., Weir, L., Leigh, I. M. & Panteleyev, A., Apr 2010, In : British Journal of Dermatology. 162, 4, p. 927-928 2 p.

Research output: Contribution to journalBook/Film/Article review

ARNT controls the expression of epidermal differentiation genes through EGER- and HDAC-dependent pathways

Robertson, D., Weir, L., Leigh, I. & Panteleyev, A., Sep 2010, In : Journal of Investigative Dermatology. 130, p. S84-S84 1 p.

Research output: Contribution to journalBook/Film/Article review

Dermal fibroblast expression profiling implicates tumour microenvironment in the development of aggressive squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa

Ng, Y. Z., Pourreyron, C., Proby, C., Salas, J., Murrell, D. F., McGrath, J. A., Lane, E. B., Leigh, I. M. & South, A. P., Apr 2010, In : British Journal of Dermatology. 162, 4, p. 948-948 1 p.

Research output: Contribution to journalBook/Film/Article review

Effects of hypoxia upon differentiation and proliferation of epidermal keratinocytes

Weir, L., Robertson, D., Leigh, I. M. & Panteleyev, A. A., Apr 2010, In : Journal of Investigative Dermatology. 130, p. S72-S72 1 p.

Research output: Contribution to journalBook/Film/Article review

EgIn3 as a key element of differential regulation of HIF1 activity by acute and chronic hypoxia in epidermal keratinocytes

Weir, L., Robertson, D., Leigh, I. & Panteleyev, A., Sep 2010, In : Journal of Investigative Dermatology. 130, p. S1-S1 1 p.

Research output: Contribution to journalBook/Film/Article review

High-resolution genomic profiling of human papillomavirus-associated vulval neoplasia

Purdie, K. J., Harwood, C. A., Chaplin, T., Gibbon, K., Singh, N., Young, B. D., Cazier, J. B., Leigh, I. M. & Proby, C. M., Apr 2010, In : British Journal of Dermatology. 162, 4, p. 945-945 1 p.

Research output: Contribution to journalBook/Film/Article review

5 Citations (Scopus)

High-resolution genomic profiling of human papillomavirus-associated vulval neoplasia

Purdie, K. J., Harwood, C. A., Gibbon, K., Chaplin, T., Young, B. D., Cazier, J. B., Singh, N., Leigh, I. M. & Proby, C. M., 16 Mar 2010, In : British Journal of Cancer. 102, 6, p. 1044-1051 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Hypoxia suppresses hypoxia inducible factor pathway proteins and affects differentiation of epidermal keratinocytes

Weir, L., Robertson, D., Leigh, I. M. & Panteleyev, A., Apr 2010, In : British Journal of Dermatology. 162, 4, p. 928-928 1 p.

Research output: Contribution to journalBook/Film/Article review

Identification of polo-like kinase 1 as a potential therapeutic target in squamous cell carcinoma

Watt, S. A., Pourreyron, C., Foerster, J., Hogan, C., Purdie, K., Bruckner-Tuderman, L., Proby, C., McGrath, J. A., Leigh, I. M. & South, A. P., Apr 2010, In : British Journal of Dermatology. 162, 4, p. 923-923 1 p.

Research output: Contribution to journalBook/Film/Article review

Identification of therapeutic and prognostic biomarkers in keratinocyte carcinogenesis

Gulati, A., Harwood, C. A., Purdie, K., Leigh, I. M., Kelsell, D. P. & Proby, C. M., Apr 2010, In : British Journal of Dermatology. 162, 4, p. 949-949 1 p.

Research output: Contribution to journalBook/Film/Article review

Increased type VII collagen in adipose-derived stem cell-keratinocyte co-culture compared with dermal fibroblast co-culture is dependent on MMP3

Pourreyron, C., Cole, C., McGrath, J. A., Leigh, I. M. & South, A. P., 2010, In : British Journal of Dermatology. 162, 4, p. 915 1 p.

Research output: Contribution to journalBook/Film/Article review

No Evidence That Human Papillomavirus Is Responsible for the Aggressive Nature of Recessive Dystrophic Epidermolysis Bullosa-Associated Squamous Cell Carcinoma

Purdie, K. J., Pourreyron, C., Fassihi, H., Cepeda-Valdes, R., Frew, J. W., Volz, A., Weissenborn, S. J., Pfister, H., Proby, C. M., Bruckner-Tuderman, L., Murrell, D. F., Salas-Alanis, J. C., McGrath, J. A., Leigh, I. M., Harwood, C. A. & South, A. P., Dec 2010, In : Journal of Investigative Dermatology. 130, 12, p. 2853-2855 4 p.

Research output: Contribution to journalLetter

8 Citations (Scopus)

p63 is implicated in apoptotic dysregulation in melanoma

Matin, R. N., Chikh, A., Warnes, G., Proby, C. M., Leigh, I. M., Harwood, C. A. & Bergamaschi, D., Apr 2010, In : British Journal of Dermatology. 162, 4, p. 921-921 1 p.

Research output: Contribution to journalBook/Film/Article review

Polo-like kinase 1 inhibitors hold potential as targeted therapies for squamous cell carcinoma

Watt, S., Pourreyron, C., Foerster, J., Hogan, C., Purdie, K., Bruckner-Tuderman, L., Proby, C., McGrath, J., Leigh, I. & South, A., Sep 2010, In : Journal of Investigative Dermatology. 130, p. S51-S51 1 p.

Research output: Contribution to journalBook/Film/Article review

Protein tyrosine phosphatase receptor type delta (PTPRD) is expressed in normal and cutaneous squamous cell carcinoma-derived keratinocytes

Romanowska, M., Proby, C. M., Lambert, S. R., Purdie, K., Gulati, A., Leigh, I. M., Harwood, C. A. & Foerster, J., Apr 2010, In : British Journal of Dermatology. 162, 4, p. 945-946 2 p.

Research output: Contribution to journalBook/Film/Article review

PTPRD microdeletions are associated with metastatic cutaneous squamous cell carcinoma

Lambert, S. R., Purdie, K., Gulati, A., Leigh, I. M., Kelsell, D. P., Harwood, C. A. & Proby, C., Apr 2010, In : British Journal of Dermatology. 162, 4, p. 923-924 2 p.

Research output: Contribution to journalBook/Film/Article review

Revised nomenclature and classification of inherited ichthyoses: Results of the First Ichthyosis Consensus Conference in Sorze 2009

Oji, V., Tadini, G., Akiyama, M., Blanchet Bardon, C., Bodemer, C., Bourrat, E., Coudiere, P., Digiovanna, J. J., Elias, P., Fischer, J., Fleckman, P., Gina, M., Harper, J., Hashimoto, T., Hausser, I., Hennies, H. C., Hohl, D., Hovnanian, A., Ishida-Yamamoto, A., Jacyk, W. K. & 17 others, Leachman, S., Leigh, I., Mazereeuw-Hautier, J., Milstone, L., Morice-Picard, F., Paller, A. S., Richard, G., Schmuth, M., Shimizu, H., Sprecher, E., van Steensel, M., Taïeb, A., Toro, J. R., Vabres, P., Vahlquist, A., Williams, M. & Traupe, H., 2010, In : Journal of the American Academy of Dermatology. 63, 4, p. 607-641 35 p.

Research output: Contribution to journalArticle

409 Citations (Scopus)

The control of epidermal differentiation gene expression by ARNT through EGFR- and HDAC-dependent pathways

Robertson, D., Weir, L., Leigh, I. M. & Panteleyev, A. A., Apr 2010, In : Journal of Investigative Dermatology. 130, p. S75-S75 1 p.

Research output: Contribution to journalBook/Film/Article review