Leigh, Irene

Professor

  • 6245 Citations
  • 32 h-Index
1989 …2020

Research output per year

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Research Output

Adipose derived stem cells up-regulate type VII collagen in the presence of recessive dystrophic epidermolysis bullosa keratinocytes

Pourreyron, C., Cole, C. L., McGrath, J. A., Leigh, I. M. & South, A. P., Sep 2009, In : Journal of Investigative Dermatology. 129, p. S48-S48 1 p.

Research output: Contribution to journalBook/Film/Article review

A functional "knockout" of human keratin 14

Rugg, E. L., McLean, W. H., Lane, E. B., Pitera, R., McMillan, J. R., Dopping-Hepenstal, P. J., Navsaria, H. A., Leigh, I. M. & Eady, R. A., 1 Nov 1994, In : Genes & Development. 8, 21, p. 2563-2573 11 p.

Research output: Contribution to journalArticle

138 Citations (Scopus)

Allelic imbalances and microdeletions affecting the PTPRD gene in cutaneous squamous cell carcinomas detected using single nucleotide polymorphism microarray analysis

Purdie, K. J., Lambert, S. R., Teh, M-T., Chaplin, T., Molloy, G., Raghavan, M., Kelsell, D. P., Leigh, I. M., Harwood, C. A., Proby, C. M. & Young, B. D., Jul 2007, In : Genes, Chromosomes and Cancer. 46, 7, p. 661-669 9 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

An altered keratinocyte phenotype in oral submucous fibrosis: Correlation of keratin K17 expression with disease severity

Lalli, A., Tilakaratne, W. M., Ariyawardana, A., Fitchett, C., Leigh, I. M., Hagi-Pavli, E., Cruchley, A. T., Parkinson, E. K., Teh, M-T., Fortune, F. & Waseem, A., 2008, In : Journal of Oral Pathology and Medicine. 37, 4, p. 211-220 10 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

A quantitative molecular diagnostic system for predicting progression of vulval intraepithelial neoplasia to invasive squamous cell carcinoma

Purdie, K., Gibbon, K., Proby, C., Leigh, I., Harwood, C. & Teh, T., Apr 2012, In : British Journal of Dermatology. 166, 4, p. e29-e29 1 p., P-1.

Research output: Contribution to journalArticle

37 Citations (Scopus)

ARNT acts through EGFR- and HDAC-dependent pathways to control the expression of epidermal differentiation genes

Robertson, D., Weir, L., Leigh, I. M. & Panteleyev, A., Apr 2010, In : British Journal of Dermatology. 162, 4, p. 927-928 2 p.

Research output: Contribution to journalBook/Film/Article review

ARNT controls the expression of epidermal differentiation genes through EGER- and HDAC-dependent pathways

Robertson, D., Weir, L., Leigh, I. & Panteleyev, A., Sep 2010, In : Journal of Investigative Dermatology. 130, p. S84-S84 1 p.

Research output: Contribution to journalBook/Film/Article review

ARNT controls the expression of epidermal differentiation genes through HDAC- and EGFR-dependent pathways

Robertson, E. D., Weir, L., Romanowska, M., Leigh, I. M. & Panteleyev, A. A., 15 Jul 2012, In : Journal of Cell Science. 125, 14, p. 3320-3332 13 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

ARNT deficiency leads to reduced HDAC activity, suppression of EGFR/ERK pathway and defects in epidermal differentiation

Robertson, D., Weir, L., Leigh, I. & Panteleyev, A., 11 Apr 2011, In : British Journal of Dermatology. 164, 4, p. 926-926 1 p.

Research output: Contribution to journalBook/Film/Article review

ARNT-dependent expression of amphiregulin and consequent activation of EGFR/Erk pathway is essential for normal epidermal differentiation

Robertson, D., Weir, L., Leigh, I. M. & Panteleyev, A. A., Apr 2011, In : Journal of Investigative Dermatology. 131, p. S44-S44 1 p.

Research output: Contribution to journalBook/Film/Article review

A surveillance model for skin cancer in organ transplant recipients: A 22-year prospective study in an ethnically diverse population

Harwood, C. A., Mesher, D., McGregor, J. M., Mitchell, L., Leedham-Green, M., Raftery, M., Cerio, R., Leigh, I. M., Sasieni, P. & Proby, C. M., Jan 2013, In : American Journal of Transplantation. 13, 1, p. 119-129 11 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)

A two gene serum epigenetic signature detects metastatic melanoma with high sensitivity and specificity

Wang, H., McHugh, A., Matin, R., Fleming, C., Leigh, I., Harwood, C., Inman, G., Crook, T. & Proby, C., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S235 1 p., 1379.

Research output: Contribution to journalMeeting abstract

A Unique Panel of Patient-Derived Cutaneous Squamous Cell Carcinoma Cell Lines Provides a Preclinical Pathway for Therapeutic Testing

Hassan, S., Purdie, K. J., Wang, J., Harwood, C. A., Proby, C. M., Pourreyron, C., Mladkova, N., Nagano, A., Dhayade, S., Athineos, D., Caley, M., Mannella, V., Blyth, K., Inman, G. J. & Leigh, I. M., 12 Jul 2019, In : International Journal of Molecular Sciences. 20, 14, p. 1-26 26 p., 3428.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
91 Downloads (Pure)

Azathioprine: friend or foe?

Leigh, I. M., Proby, C. M., Inman, G. J. & Harwood, C. A., May 2019, In : British Journal of Dermatology. 180, 5, p. 961-963 3 p.

Research output: Contribution to journalEditorial

1 Citation (Scopus)

Clinical application of skin substitutes

Damodaran, G., Syed, M., Leigh, I., Myers, S. & Navsaria, H., 2008, In : Expert Review of Dermatology. 3, 3, p. 345-356 12 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

CREBBP mutation in human cutaneous squamous cell carcinoma

Watt, S. A., Purdie, K. J., den Breems, N. Y., Dimon, M., Tucker, S., Arron, S. T., Mchugh, A., Xue, D. J., Dayal, J. H. S., Harwood, C. A., Leigh, I. M., Proby, C. M. & South, A. P., Aug 2016, In : Experimental Dermatology. 25, 8, p. 650-651 2 p.

Research output: Contribution to journalLetter

Open Access
File
3 Citations (Scopus)
124 Downloads (Pure)

Cutaneous SCC and the RAS controversy

McHugh, A. T., Purdie, K., Pourreyron, C., Watt, S., Rose, A., Leigh, I., Harwood, C., South, A. & Proby, C., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S66 1 p., 386.

Research output: Contribution to journalMeeting abstract

Cutaneous Squamous Cell Carcinoma (SCC) and the DNA Damage Response: pATM Expression Patterns in Pre-Malignant and Malignant Keratinocyte Skin Lesions

Ismail, F., Ikram, M., Purdie, K., Harwood, C., Leigh, I. & Storey, A., 1 Jul 2011, In : PLoS ONE. 6, 7, p. - 14 p., e21271.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Cutaneous squamous cell carcinoma carries the highest burden of mutation of any human tumor type and harbors prevalent mutations in CARD11 and CREBBP

South, A. P., Watt, S. A., Purdie, K. J., Proby, C. M., Harwood, C. A. & Leigh, I. M., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S72 1 p., 427.

Research output: Contribution to journalMeeting abstract

Cutaneous squamous cell carcinoma derived cell lines are more sensitive to the proteasome inhibitor bortezomib than normal skin cells

Koerver, L., Tura, Z. H., Leigh, I. M., South, A. P. & Saville, M. K., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S183 1 p.

Research output: Contribution to journalMeeting abstract

Cutaneous Squamous Cell Carcinoma exhibits significant tumour heterogeneity

Murray, S., Foster, N., Leigh, I., Pratt, N. & South, A., Sep 2011, In : Journal of Investigative Dermatology. 131, p. S81-S81 1 p.

Research output: Contribution to journalBook/Film/Article review

Cytokeratin profiles in dyskeratosis congenita: an immunocytochemical investigation of lingual hyperkeratosis

Ogden, G. R., Chisholm, D. M., Leigh, I. M. & Lane, E. B., Sep 1992, In : Journal of Oral Pathology and Medicine. 21, 8, p. 353-357 5 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Depletion of MRG-binding protein invokes TIP60 histone acetyltransferase-dependent apoptosis in cutaneous squamous cell carcinoma cells

Watt, S. A., Arrand, K., Leigh, I. M. & South, A. P., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S71 1 p., 416.

Research output: Contribution to journalMeeting abstract

Dermal fibroblast expression profiling implicates tumour microenvironment in the development of aggressive squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa

Ng, Y. Z., Pourreyron, C., Proby, C., Salas, J., Murrell, D. F., McGrath, J. A., Lane, E. B., Leigh, I. M. & South, A. P., Apr 2010, In : British Journal of Dermatology. 162, 4, p. 948-948 1 p.

Research output: Contribution to journalBook/Film/Article review

Dermal matrix composition promotes development of aggressive squamous cell carcinoma in recessive dystrophic epidermolysis bullosa

Ng, Y., Pourreyron, C., Salas-Alanis, J., Cepeda-Valdes, R., Yan, W., Wright, S., Chen, M., Hogg, F., McGrath, J., Murrell, D., Leigh, I., Lane, E. & South, A., May 2012, In : Journal of Investigative Dermatology. 132, p. S20-S20 1 p.

Research output: Contribution to journalArticle

Development of a treatment algorithm for actinic keratoses: a European Consensus

Stockfleth, E., Ferrandiz, C., Grob, J. J., Leigh, I., Pehamberger, H., Kerl, H. & European Skin Acad, 2008, In : European Journal of Dermatology. 18, 6, p. 651-659 9 p.

Research output: Contribution to journalArticle

164 Citations (Scopus)

Differential regulation of HIF-alpha splice variants by hypoxia in epidermal keratinocytes

Weir, L., Robertson, D., Leigh, I. M., Vass, J. K. & Panteleyev, A. A., Apr 2011, In : Journal of Investigative Dermatology. 131, p. S44-S44 1 p.

Research output: Contribution to journalBook/Film/Article review

1 Citation (Scopus)

DUSP23, SLCO1B3, SNURF, SNRPN and TJAP1 are genes with differential expression in squamous cell carcinoma keratinocytes derived from patients with recessive dystrophic epidermolysis bullosa

Cole, C. L., Foerster, J., Pourreyron, C., Purdie, K., Hogan, C., Proby, C., Bruckner-Tuderman, L., McGrath, J. A., Leigh, I. M. & South, A. P., Apr 2009, In : British Journal of Dermatology. 160, 4, p. 906-906 1 p.

Research output: Contribution to journalBook/Film/Article review

Effects of hypoxia upon differentiation and proliferation of epidermal keratinocytes

Weir, L., Robertson, D., Leigh, I. M. & Panteleyev, A. A., Apr 2010, In : Journal of Investigative Dermatology. 130, p. S72-S72 1 p.

Research output: Contribution to journalBook/Film/Article review

EgIn3 as a key element of differential regulation of HIF1 activity by acute and chronic hypoxia in epidermal keratinocytes

Weir, L., Robertson, D., Leigh, I. & Panteleyev, A., Sep 2010, In : Journal of Investigative Dermatology. 130, p. S1-S1 1 p.

Research output: Contribution to journalBook/Film/Article review

Egln/PHD proteins and their role in control of hypoxia pathway in epidermal keratinocytes

Weir, L., Robertson, D., Leigh, I. M. & Panteleyev, A. A., Apr 2011, In : Journal of Investigative Dermatology. 131, p. S15-S15 1 p.

Research output: Contribution to journalBook/Film/Article review

Egln3 as a key factor of HIF activity in epidermal keratinocytes

Weir, L., Robertson, D., Leigh, I. & Panteleyev, A., 11 Apr 2011, In : British Journal of Dermatology. 164, 4, p. 912-913 2 p.

Research output: Contribution to journalBook/Film/Article review

Epidermal expression patterns of HIF-alpha splice variants and their differential regulation by hypoxia

Weir, L., Robertson, D., Leigh, I., Vass, K. & Panteleyev, A., 11 Apr 2011, In : British Journal of Dermatology. 164, 4, p. 928-928 1 p.

Research output: Contribution to journalBook/Film/Article review

Epigenetic dysregulation of novel candidate genes in malignant melanoma

Wang, H., McHugh, A. T., Matin, R., Fleming, C., Leigh, I. M., Harwood, C., Crook, T., Inman, G. & Proby, C., 11 Apr 2011, In : British Journal of Dermatology. 164, 4, p. 916-916 1 p.

Research output: Contribution to journalBook/Film/Article review

Epigenetic Dysregulation of Novel Genes in Melanoma

Wang, H., McHugh, A., Matin, R., Fleming, C., Leigh, I., Harwood, C., Crook, T., Inman, G. & Proby, C., Sep 2011, In : Journal of Investigative Dermatology. 131, p. S114-S114 1 p.

Research output: Contribution to journalBook/Film/Article review

Exfoliative cytology of normal oral mucosa: Assessing the basal cell keratin phenotype

Ogden, G. R., Leigh, I., Chisholm, D. M., Cowpe, J. G. & Lane, E. B., 1 Sep 1996, In : Acta Cytologica. 40, 5, p. 933-936 4 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Exome level sequencing identifies candidate genes mutated in cutaneous squamous cell carcinoma progression

South, A. P., Purdie, K. J., Watt, S. A., Harwood, C. A., Proby, C. & Leigh, I. M., Sep 2012, In : Journal of Investigative Dermatology. 132, p. S37-S37 1 p.

Research output: Contribution to journalMeeting abstract

Expression microarray analysis identifies key processes in the transition from actinic keratosis to cutaneous squamous cell carcinoma

Lambert, S. R., Mladkova, N., Gulati, A., Hamoudi, R., Purdie, K. J., Cerio, R., Leigh, I. M., Proby, C. M. & Harwood, C. A., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S67 1 p., 393.

Research output: Contribution to journalMeeting abstract

Expression of activated NOTCH1 induces terminal differentiation in squamous cell carcinoma keratinocytes

Robinson, K. S., Purdie, K. J., Cho, R. J., Aster, J. C., Leigh, I. M. & South, A. P., Sep 2012, In : Journal of Investigative Dermatology. 132, p. S40-S40 1 p.

Research output: Contribution to journalMeeting abstract

9 Citations (Scopus)

External anogenital premalignant and malignant disease

Gibbon, K. L., Ekeowa-Anderson, A. L. & Leigh, I. M., 2009, Skin Cancer after Organ Transplantation. Stockfleth, E., Ulrich, C., Euvrard, S., Proby, C., Bavinck, J-N. B. & Geissler, E. K. (eds.). Springer , Vol. 146. p. 279-298 20 p. (Cancer Treatment and Research; vol. 146, no. 3).

Research output: Chapter in Book/Report/Conference proceedingOther chapter contribution

Fibroblast-derived dermal matrix drives development of aggressive cutaneous squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa

Ng, Y-Z., Pourreyron, C., Salas-Alanis, J. C., Dayal, J. H. S., Cepeda-Valdes, R., Yan, W., Wright, S., Chen, M., Fine, J-D., Hogg, F. J., McGrath, J. A., Murrell, D. F., Leigh, I. M., Lane, E. B. & South, A. P., 2012, In : Cancer Research. 72, 14, p. 3522-3534 13 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)

Gauging NOTCH1 activation in cancer using immunohistochemistry

Kluk, M. J., Ashworth, T., Wang, H., Knoechel, B., Mason, E. F., Morgan, E. A., Dorfman, D., Pinkus, G., Weigert, O., Hornick, J. L., Chirieac, L. R., Hirsch, M., Oh, D. J., South, A. P., Leigh, I. M., Pourreyron, C., Cassidy, A. J., DeAngelo, D. J., Weinstock, D. M., Krop, I. E. & 10 others, Dillon, D., Brock, J. E., Lazar, A. J. F., Peto, M., Cho, R. J., Stoeck, A., Haines, B. B., Sathayanrayanan, S., Rodig, S. & Aster, J. C., 2013, In : PLoS ONE. 8, 6, 14 p., e67306.

Research output: Contribution to journalArticle

67 Citations (Scopus)

Gene expression profiling of cultured squamous cell carcinoma keratinocytes identifies a pattern of gene expression which predicts invasive capacity

South, A. P., Pourreyron, C., Foerster, J., Mao, X., Purdie, K., Hogan, C., Mein, C., Bruckner-Tuderman, L., Proby, C. M., Young, B., Kelsell, D. P., McGrath, J. A. & Leigh, I. M., Apr 2008, In : British Journal of Dermatology. 158, 4, p. 883-883 1 p.

Research output: Contribution to journalBook/Film/Article review

Genetic and functional analyses of FH mutations in multiple cutaneous and uterine leiomyomatosis, hereditary leiomyomatosis and renal cancer, and fumarate hydratase deficiency

Alam, N. A., Rowan, A. J., Wortham, N. C., Pollard, P. J., Mitchell, M., Tyrer, J. P., Barclay, E., Calonje, E., Manek, S., Adams, S. J., Bowers, P. W., Burrows, N. P., Charles-Holmes, R., Cook, L. J., Daly, B. M., Ford, G. P., Fuller, L. C., Hadfield-Jones, S. E., Hardwick, N., Highet, A. S. & 22 others, Keefe, M., MacDonald-Hull, S. P., Potts, E. D. A., Crone, M., Wilkinson, S., Camacho-Martinez, F., Jablonska, S., Ratnavel, R., MacDonald, A., Mann, R. J., Grice, K., Guillet, G., Lewis-Jones, M. S., McGrath, H., Seukeran, D. C., Morrison, P. J., Fleming, S., Rahman, S., Kelsell, D., Leigh, I., Olpin, S. & Tomlinson, I. P. M., 2003, In : Human Molecular Genetics. 12, 11, p. 1241-1252 12 p.

Research output: Contribution to journalArticle

242 Citations (Scopus)

Genomic analysis of atypical fibroxanthoma

Lai, K., Harwood, C. A., Purdie, K. J., Proby, C. M., Leigh, I. M., Ravi, N., Mully, T. W., Brooks, L., Sandoval, P. M., Rosenblum, M. D. & Arron, S. T., 15 Nov 2017, In : PLoS ONE. 12, 11, p. 1-15 15 p., e0188272.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
226 Downloads (Pure)

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

Multiple Leiomyoma Consortium, Tomlinson, I. P. M., Alam, N. A., Rowan, A. J., Barclay, E., Jaeger, E. E. M., Kelsell, D., Leigh, I., Gorman, P., Lamlum, H., Rahman, S., Roylance, R. R., Olpin, S., Bevan, S., Barker, K., Hearle, N., Houlston, R. S., Kiuru, M., Lehtonen, R., Karhu, A. & 12 others, Vilkki, S., Laiho, P., Eklund, C., Vierimaa, O., Aittomaki, K., Hietala, M., Sistonen, P., Paetau, A., Salovaara, R., Herva, R., Launonen, V. & Aaltonen, L. A., 2002, In : Nature Genetics. 30, 4, p. 406-410 5 p.

Research output: Contribution to journalArticle

1005 Citations (Scopus)

HIF pathway in epidermal keratinocytes is controlled by Egln3 and Siah1 proteins

Weir, L., Robertson, D., Leigh, I., Vass, K. & Panteleyev, A., Sep 2011, In : Journal of Investigative Dermatology. 131, p. S3-S3 1 p.

Research output: Contribution to journalBook/Film/Article review

High levels of type VII collagen expression in RDEB cSCC keratinocytes increases PI3K and MAPK signalling, cell migration and invasion

Pourreyron, C., Chen, M., McGrath, J. A., Salas-Alanis, J. C., South, A. P. & Leigh, I. M., 2014, In : British Journal of Dermatology. 170, 6, p. 1256-1265 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

High-resolution genomic profiling of human papillomavirus-associated vulval neoplasia

Purdie, K. J., Harwood, C. A., Chaplin, T., Gibbon, K., Singh, N., Young, B. D., Cazier, J. B., Leigh, I. M. & Proby, C. M., Apr 2010, In : British Journal of Dermatology. 162, 4, p. 945-945 1 p.

Research output: Contribution to journalBook/Film/Article review

5 Citations (Scopus)