Leigh, Irene

Professor

  • 6245 Citations
  • 32 h-Index
1989 …2020

Research output per year

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Research Output

Article

A functional "knockout" of human keratin 14

Rugg, E. L., McLean, W. H., Lane, E. B., Pitera, R., McMillan, J. R., Dopping-Hepenstal, P. J., Navsaria, H. A., Leigh, I. M. & Eady, R. A., 1 Nov 1994, In : Genes & Development. 8, 21, p. 2563-2573 11 p.

Research output: Contribution to journalArticle

138 Citations (Scopus)

Allelic imbalances and microdeletions affecting the PTPRD gene in cutaneous squamous cell carcinomas detected using single nucleotide polymorphism microarray analysis

Purdie, K. J., Lambert, S. R., Teh, M-T., Chaplin, T., Molloy, G., Raghavan, M., Kelsell, D. P., Leigh, I. M., Harwood, C. A., Proby, C. M. & Young, B. D., Jul 2007, In : Genes, Chromosomes and Cancer. 46, 7, p. 661-669 9 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

An altered keratinocyte phenotype in oral submucous fibrosis: Correlation of keratin K17 expression with disease severity

Lalli, A., Tilakaratne, W. M., Ariyawardana, A., Fitchett, C., Leigh, I. M., Hagi-Pavli, E., Cruchley, A. T., Parkinson, E. K., Teh, M-T., Fortune, F. & Waseem, A., 2008, In : Journal of Oral Pathology and Medicine. 37, 4, p. 211-220 10 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

A quantitative molecular diagnostic system for predicting progression of vulval intraepithelial neoplasia to invasive squamous cell carcinoma

Purdie, K., Gibbon, K., Proby, C., Leigh, I., Harwood, C. & Teh, T., Apr 2012, In : British Journal of Dermatology. 166, 4, p. e29-e29 1 p., P-1.

Research output: Contribution to journalArticle

37 Citations (Scopus)

ARNT controls the expression of epidermal differentiation genes through HDAC- and EGFR-dependent pathways

Robertson, E. D., Weir, L., Romanowska, M., Leigh, I. M. & Panteleyev, A. A., 15 Jul 2012, In : Journal of Cell Science. 125, 14, p. 3320-3332 13 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

A surveillance model for skin cancer in organ transplant recipients: A 22-year prospective study in an ethnically diverse population

Harwood, C. A., Mesher, D., McGregor, J. M., Mitchell, L., Leedham-Green, M., Raftery, M., Cerio, R., Leigh, I. M., Sasieni, P. & Proby, C. M., Jan 2013, In : American Journal of Transplantation. 13, 1, p. 119-129 11 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)

A Unique Panel of Patient-Derived Cutaneous Squamous Cell Carcinoma Cell Lines Provides a Preclinical Pathway for Therapeutic Testing

Hassan, S., Purdie, K. J., Wang, J., Harwood, C. A., Proby, C. M., Pourreyron, C., Mladkova, N., Nagano, A., Dhayade, S., Athineos, D., Caley, M., Mannella, V., Blyth, K., Inman, G. J. & Leigh, I. M., 12 Jul 2019, In : International Journal of Molecular Sciences. 20, 14, p. 1-26 26 p., 3428.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
91 Downloads (Pure)

Clinical application of skin substitutes

Damodaran, G., Syed, M., Leigh, I., Myers, S. & Navsaria, H., 2008, In : Expert Review of Dermatology. 3, 3, p. 345-356 12 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Cutaneous Squamous Cell Carcinoma (SCC) and the DNA Damage Response: pATM Expression Patterns in Pre-Malignant and Malignant Keratinocyte Skin Lesions

Ismail, F., Ikram, M., Purdie, K., Harwood, C., Leigh, I. & Storey, A., 1 Jul 2011, In : PLoS ONE. 6, 7, p. - 14 p., e21271.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Cytokeratin profiles in dyskeratosis congenita: an immunocytochemical investigation of lingual hyperkeratosis

Ogden, G. R., Chisholm, D. M., Leigh, I. M. & Lane, E. B., Sep 1992, In : Journal of Oral Pathology and Medicine. 21, 8, p. 353-357 5 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Dermal matrix composition promotes development of aggressive squamous cell carcinoma in recessive dystrophic epidermolysis bullosa

Ng, Y., Pourreyron, C., Salas-Alanis, J., Cepeda-Valdes, R., Yan, W., Wright, S., Chen, M., Hogg, F., McGrath, J., Murrell, D., Leigh, I., Lane, E. & South, A., May 2012, In : Journal of Investigative Dermatology. 132, p. S20-S20 1 p.

Research output: Contribution to journalArticle

Development of a treatment algorithm for actinic keratoses: a European Consensus

Stockfleth, E., Ferrandiz, C., Grob, J. J., Leigh, I., Pehamberger, H., Kerl, H. & European Skin Acad, 2008, In : European Journal of Dermatology. 18, 6, p. 651-659 9 p.

Research output: Contribution to journalArticle

164 Citations (Scopus)

Exfoliative cytology of normal oral mucosa: Assessing the basal cell keratin phenotype

Ogden, G. R., Leigh, I., Chisholm, D. M., Cowpe, J. G. & Lane, E. B., 1 Sep 1996, In : Acta Cytologica. 40, 5, p. 933-936 4 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Fibroblast-derived dermal matrix drives development of aggressive cutaneous squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa

Ng, Y-Z., Pourreyron, C., Salas-Alanis, J. C., Dayal, J. H. S., Cepeda-Valdes, R., Yan, W., Wright, S., Chen, M., Fine, J-D., Hogg, F. J., McGrath, J. A., Murrell, D. F., Leigh, I. M., Lane, E. B. & South, A. P., 2012, In : Cancer Research. 72, 14, p. 3522-3534 13 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)

Gauging NOTCH1 activation in cancer using immunohistochemistry

Kluk, M. J., Ashworth, T., Wang, H., Knoechel, B., Mason, E. F., Morgan, E. A., Dorfman, D., Pinkus, G., Weigert, O., Hornick, J. L., Chirieac, L. R., Hirsch, M., Oh, D. J., South, A. P., Leigh, I. M., Pourreyron, C., Cassidy, A. J., DeAngelo, D. J., Weinstock, D. M., Krop, I. E. & 10 others, Dillon, D., Brock, J. E., Lazar, A. J. F., Peto, M., Cho, R. J., Stoeck, A., Haines, B. B., Sathayanrayanan, S., Rodig, S. & Aster, J. C., 2013, In : PLoS ONE. 8, 6, 14 p., e67306.

Research output: Contribution to journalArticle

67 Citations (Scopus)

Genetic and functional analyses of FH mutations in multiple cutaneous and uterine leiomyomatosis, hereditary leiomyomatosis and renal cancer, and fumarate hydratase deficiency

Alam, N. A., Rowan, A. J., Wortham, N. C., Pollard, P. J., Mitchell, M., Tyrer, J. P., Barclay, E., Calonje, E., Manek, S., Adams, S. J., Bowers, P. W., Burrows, N. P., Charles-Holmes, R., Cook, L. J., Daly, B. M., Ford, G. P., Fuller, L. C., Hadfield-Jones, S. E., Hardwick, N., Highet, A. S. & 22 others, Keefe, M., MacDonald-Hull, S. P., Potts, E. D. A., Crone, M., Wilkinson, S., Camacho-Martinez, F., Jablonska, S., Ratnavel, R., MacDonald, A., Mann, R. J., Grice, K., Guillet, G., Lewis-Jones, M. S., McGrath, H., Seukeran, D. C., Morrison, P. J., Fleming, S., Rahman, S., Kelsell, D., Leigh, I., Olpin, S. & Tomlinson, I. P. M., 2003, In : Human Molecular Genetics. 12, 11, p. 1241-1252 12 p.

Research output: Contribution to journalArticle

242 Citations (Scopus)

Genomic analysis of atypical fibroxanthoma

Lai, K., Harwood, C. A., Purdie, K. J., Proby, C. M., Leigh, I. M., Ravi, N., Mully, T. W., Brooks, L., Sandoval, P. M., Rosenblum, M. D. & Arron, S. T., 15 Nov 2017, In : PLoS ONE. 12, 11, p. 1-15 15 p., e0188272.

Research output: Contribution to journalArticle

Open Access
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11 Citations (Scopus)
226 Downloads (Pure)

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

Multiple Leiomyoma Consortium, Tomlinson, I. P. M., Alam, N. A., Rowan, A. J., Barclay, E., Jaeger, E. E. M., Kelsell, D., Leigh, I., Gorman, P., Lamlum, H., Rahman, S., Roylance, R. R., Olpin, S., Bevan, S., Barker, K., Hearle, N., Houlston, R. S., Kiuru, M., Lehtonen, R., Karhu, A. & 12 others, Vilkki, S., Laiho, P., Eklund, C., Vierimaa, O., Aittomaki, K., Hietala, M., Sistonen, P., Paetau, A., Salovaara, R., Herva, R., Launonen, V. & Aaltonen, L. A., 2002, In : Nature Genetics. 30, 4, p. 406-410 5 p.

Research output: Contribution to journalArticle

1005 Citations (Scopus)

High levels of type VII collagen expression in RDEB cSCC keratinocytes increases PI3K and MAPK signalling, cell migration and invasion

Pourreyron, C., Chen, M., McGrath, J. A., Salas-Alanis, J. C., South, A. P. & Leigh, I. M., 2014, In : British Journal of Dermatology. 170, 6, p. 1256-1265 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

High-resolution genomic profiling of human papillomavirus-associated vulval neoplasia

Purdie, K. J., Harwood, C. A., Gibbon, K., Chaplin, T., Young, B. D., Cazier, J. B., Singh, N., Leigh, I. M. & Proby, C. M., 16 Mar 2010, In : British Journal of Cancer. 102, 6, p. 1044-1051 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Hypoxia-mediated control of HIF/ARNT machinery in epidermal keratinocytes

Weir, L., Robertson, D., Leigh, I. M., Vass, J. K. & Panteleyev, A. A., Jan 2011, In : Biochimica et Biophysica Acta. Molecular Cell Research. 1813, 1, p. 60-72 13 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma

Cammareri, P., Rose, A., Vincent, D. F., Wang, J., Nagano, A., Libertini, S., Ridgway, R. A., Athineos, D., Coates, P. J. ., McHugh, A., Pourreyron, C., Dayal, J., Larsson, J., Weidlich, S., Spender, L., Sapkota, G., Purdie, K. J., Proby, C., Harwood, C. A., Leigh, I. & 9 others, Clevers, H., Barker, N., Karlsson, S., Pritchard, C., Marais, R., Chelala, C., South, A., Sansom, O. J. & Inman, G., 25 Aug 2016, In : Nature Communications. 7, p. 1-7 7 p., 12493.

Research output: Contribution to journalArticle

Open Access
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45 Citations (Scopus)
132 Downloads (Pure)

Inherited epidermolysis bullosa: updated recommendations on diagnosis and classification

Fine, J-D., Bruckner-Tuderman, L., Eady, R. A. J., Bauer, E. A., Bauer, J. W., Has, C., Heagerty, A., Hintner, H., Hovnanian, A., Jonkman, M. F., Leigh, I., Marinkovich, M. P., Martinez, A. E., McGrath, J. A., Mellerio, J. E., Moss, C., Murrell, D. F., Shimizu, H., Uitto, J., Woodley, D. & 1 others, Zambruno, G., Jun 2014, In : Journal of the American Academy of Dermatology. 70, 6, p. 1103-1126 24 p.

Research output: Contribution to journalArticle

457 Citations (Scopus)

Integrative mRNA profiling comparing cultured primary cells with clinical samples reveals PLK1 and C20orf20 as therapeutic targets in cutaneous squamous cell carcinoma

Watt, S., Pourreyron, C., Purdie, K., Hogan, C., Cole, C. L., Foster, N., Pratt, N., Bourdon, J-C., Appleyard, V., Murray, K., Thompson, A., Mao, X., Mein, C., Bruckner-Tuderman, L., Evans, A., McGrath, J. A., Proby, C. M., Foerster, J., Leigh, I. & South, A., Nov 2011, In : Oncogene. 30, 46, p. 4666-4677 12 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Intermediate filament–membrane attachments function synergistically with actin-dependent contacts to regulate intercellular adhesive strength

Huen, A. C., Park, J. K., Godsel, L. M., Chen, X., Bannon, L. J., Amargo, E. V., Hudson, T. Y., Mongiu, A. K., Leigh, I. M., Kelsell, D. P., Gumbiner, B. M. & Green, K. J., 23 Dec 2002, In : Journal of Cell Biology. 159, 6, p. 1005-1017 13 p.

Research output: Contribution to journalArticle

Open Access
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111 Citations (Scopus)
237 Downloads (Pure)

Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model

Kalin, J. H., Eroglu, A., Liu, H., Holtzclaw, W. D., Leigh, I., Proby, C. M., Fahey, J. W., Cole, P. A. & Dinkova-Kostova, A. T., 13 Mar 2019, In : PLoS ONE. 14, 3, p. 1-13 13 p., e0213095.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
115 Downloads (Pure)

Keratin 14-Null Cells as a Model to Test the Efficacy of Gene Therapy Approaches in Epithelial Cells

D'Alessandro, M., Coats, S. E., Jonkmann, M. F., Leigh, I. M. & Lane, B., Jul 2011, In : Journal of Investigative Dermatology. 131, 7, p. 1412-1419 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Keratin 16 and keratin 17 mutations cause pachyonychia congenita

McLean, W. H. I., Rugg, E. L., Lunny, D. P., Morley, S. M., Lane, E. B., Swensson, O., Dopping-Hepenstal, P. J. C., Griffiths, W. A. D., Eady, R. A. J., Higgins, C., Navsaria, H. A., Leigh, I. M., Strachan, T., Kunkeler, L. & Munro, C. S., Mar 1995, In : Nature Genetics. 9, 3, p. 273-278 6 p.

Research output: Contribution to journalArticle

270 Citations (Scopus)

Key differences identified between actinic keratosis and cutaneous squamous cell carcinoma by transcriptome profiling

Lambert, S. R., Mladkova, N., Gulati, A., Hamoudi, R., Purdie, K., Cerio, R., Leigh, I., Proby, C. & Harwood, C. A., 21 Jan 2013, In : British Journal of Cancer. 110, 2, p. 520-529 10 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Lack of plakophilin 1 increases keratinocyte migration and reduces desmosome stability

South, A. P., Wan, H., Stone, M. G., Dopping-Hepenstal, P. J. C., Purkis, P. E., Marshall, J. F., Leigh, I. M., Eady, R. A. J., Hart, I. R. & McGrath, J. A., 2003, In : Journal of Cell Science. 116, 16, p. 3303-3314 12 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma

Wang, N. J., Sanborn, Z., Arnett, K. L., Bayston, L. J., Liao, W., Proby, C. M., Leigh, I. M., Collisson, E. A., Gordon, P. B., Jakkula, L., Pennypacker, S., Zou, Y., Sharma, M., North, J. P., Vemula, S. S., Mauro, T. M., Neuhaus, I. M., LeBoit, P. E., Hur, J. S., Park, K. & 13 others, Huh, N., Kwok, P-Y., Arron, S. T., Massion, P. P., Bale, A. E., Haussler, D., Cleaver, J. E., Gray, J. W., Spellman, P. T., South, A. P., Aster, J. C., Blacklow, S. C. & Cho, R. J., 25 Oct 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 43, p. 17761-17766 6 p.

Research output: Contribution to journalArticle

260 Citations (Scopus)

Lysyl hydroxylase 3 localizes to epidermal basement membrane and Is reduced in patients with Recessive Dystrophic Epidermolysis Bullosa

Watt, S. A., Dayal, J. H. S., Wright, S., Riddle, M., Pourreyron, C., McMillan, J. R., Kimble, R. M., Prisco, M., Gartner, U., Warbrick, E., McLean, W. H. I., Leigh, I. M., McGrath, J. A., Salas-Alanis, J. C., Tolar, J. & South, A. P., 18 Sep 2015, In : PLoS ONE. 10, 9, 15 p., e0137639.

Research output: Contribution to journalArticle

Open Access
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12 Citations (Scopus)
184 Downloads (Pure)

Metastatic cutaneous squamous cell carcinoma shows frequent deletion in the protein tyrosine phosphatase receptor Type D gene

Lambert, S. R., Harwood, C. A., Purdie, K. J., Gulati, A., Matin, R. N., Romanowska, M., Cerio, R., Kelsell, D. P., Leigh, I. M. & Proby, C. M., 2012, In : International Journal of Cancer. 131, 3, p. E216-E226

Research output: Contribution to journalArticle

12 Citations (Scopus)

Methylated tissue factor pathway inhibitor 2 (TFPI2) DNA in serum is a biomarker of metastatic melanoma

Nigro, C. L., Wang, H., McHugh, A., Lattanzio, L., Matin, R., Harwood, C., Syed, N., Hatzimichael, E., Briasoulis, E., Merlano, M., Evans, A., Thompson, A., Leigh, I., Fleming, C., Inman, G. J., Proby, C. & Crook, T., May 2013, In : Journal of Investigative Dermatology. 133, 5, p. 1278-1285 8 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Missing links: Weber-Cockayne keratin mutations implicate the L12 linker domain in effective cytoskeleton function.

Rugg, EL., Morley, SM., Smith, FJ., Boxer, M., Tidman, MJ., Navsaria, H., Leigh, IM. & Lane, EB., Nov 1993, In : Nature Genetics. 5, 3, p. 294-300 7 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)

Mutations in ABCA12 underlie the severe congenital skin disease Harlequin Ichthyosis

Kelsell, P. D., Norgett, E. E., Unsworth, H., Teh, M-T., Cullup, T., Mein, C. A., Dopping-Hepenstal, J. P., Dale, A. B., Tadini, G., Fleckman, P., Stephens, G. K., Sybert, P. V., Mallory, B. S., North, V. B., Witt, R. D., Sprecher, E., Taylor, A. E. M., Ilchyshyn, A., Kennedy, T. C., Goodyear, H. & 7 others, Moss, C., Paige, D., Harper, I. J., Young, D. B., Leigh, M. I., Eady, A. J. R. & O'Toole, A. E., May 2005, In : American Journal of Human Genetics. 76, 5, p. 794-803 10 p.

Research output: Contribution to journalArticle

231 Citations (Scopus)

Mutations in AQP5, encoding a water-channel protein, cause autosomal-dominant diffuse nonepidermolytic palmoplantar keratoderma

Blaydon, D. C., Lind, L. K., Plagnol, V., Linton, K. J., Smith, F. J. D., Wilson, N. J., McLean, W. H. I., Munro, C. S., South, A. P., Leigh, I. M., O'Toole, E. A., Lundström, A. & Kelsell, D. P., 8 Aug 2013, In : American Journal of Human Genetics. 93, 2, p. 330-335 6 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Mutations in the Rod 1A Domain of Keratins 1 and 10 in Bullous Congenital Ichthyosiform Erythoderma (BCIE)

McLean, W. H. I., Eady, R. A. J., Dopping-Hepenstal, P. J. C., McMillan, J. R., Leigh, I. M., Navsaria, H. A., Higgins, C., Harper, J. I., Paige, D. G., Morley, S. M. & Lane, E. B., Jan 1994, In : Journal of Investigative Dermatology. 102, 1, p. 24-30 7 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

Nationwide Incidence of Metastatic Cutaneous Squamous Cell Carcinoma in England

Venables, Z. C., Autier, P., Nijsten, T., Wong, K. F., Langan, S. M., Rous, B., Broggio, J., Harwood, C., Henson, K., Proby, C. M., Rashbass, J. & Leigh, I. M., 28 Nov 2018, In : JAMA Dermatology. 153, 3, p. 298-306 9 p.

Research output: Contribution to journalArticle

Open Access
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17 Citations (Scopus)
217 Downloads (Pure)

Next-generation sequencing identifies Notch receptors as integral tumor suppressors in cutaneous and lung squamous cell carcinomas

Wang, N. J., Sanborn, Z., Arnett, K. L., Bayston, L. J., Liao, W., Proby, C. M., Leigh, I. M., Gordon, P. B., Sharma, M., North, J. P., Vemula, S. S., Mauro, T. M., Neuhaus, I. M., LeBoit, P. E., Kwok, P., Arron, S. T., Bale, A. E., Haussler, D., Cleaver, J. E., Gray, J. W. & 5 others, Spellman, P. T., South, A. P., Aster, J. C., Blacklow, S. C. & Cho, R. J., May 2012, In : Journal of Investigative Dermatology. 132, p. S23-S23 1 p.

Research output: Contribution to journalArticle

NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis

South, A. P., Purdie, K. J., Watt, S. A., Haldenby, S., den Breems, N., Dimon, M., Arron, S. T., Kluk, M. J., Aster, J. C., McHugh, A., Xue, D. J., Dayal, J. H. S., Robinson, K. S., Rizvi, S. M. H., Proby, C. M., Harwood, C. A. & Leigh, I. M., Oct 2014, In : Journal of Investigative Dermatology. 134, 10, p. 2630-2638 9 p.

Research output: Contribution to journalArticle

144 Citations (Scopus)

Novel CARD11 mutations in human cutaneous squamous cell carcinoma lead to aberrant NF-κB regulation

Watt, S. A., Purdie, K. J., den Breems, N. Y., Dimon, M., Arron, S. T., McHugh, A. T., Xue, D. J., Dayal, J. H. S., Proby, C. M., Harwood, C. A., Leigh, I. M. & South, A. P., Sep 2015, In : American Journal of Pathology. 185, 9, p. 2354-2363 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

NT5E (CD73) is epigenetically regulated in malignant melanoma and associated with metastatic site specificity

Wang, H., Lee, S., Lo Nigro, C., Lattanzio, L., Merlano, M., Monteverde, M., Matin, R., Purdie, K., Mladkova, N., Bergamaschi, D., Harwood, C., Syed, N., Szlosarek, P., Briasoulis, E., McHugh, A., Thompson, A., Evans, A., Leigh, I., Fleming, C., Inman, G. J. & 3 others, Hatzimichael, E., Proby, C. & Crook, T., 2012, In : British Journal of Cancer. 106, 8, p. 1446-52 7 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Plectin deficiency results in muscular dystrophy with epidermolysis bullosa

Smith, F. J. D., Eady, R. A. J., Leigh, I. M., McMillan, J. R., Rugg, E. L., Kelsell, D. P., Bryant, S. P., Spurr, N. K., Geddes, J. F., Kirtschig, G., Milana, G., De Bono, A. G., Owaribe, K., Wiche, G., Pulkkinen, L., Uitto, J., McLean, W. H. I. & Lane, E. B., 1996, In : Nature Genetics. 13, 4, p. 450-457 8 p.

Research output: Contribution to journalArticle

313 Citations (Scopus)

Potential of fibroblast cell therapy for recessive dystrophic epidermolysis bullosa

Wong, T., McGrath, J. A., Gammon, L., Leigh, I. M., Navsaria, H., Liu, L., Dopping-Hepenstal, P. J. C., Pacy, J., Mellerio, J. E., Elia, G. & Jeffery, R., 2008, In : Journal of Investigative Dermatology. 128, 9, p. 2179-2189 11 p.

Research output: Contribution to journalArticle

164 Citations (Scopus)

Preclinical comparison of proteasome and ubiquitin E1 enzyme inhibitors in cutaneous squamous cell carcinoma: the identification of mechanisms of differential sensitivity

McHugh, A., Fernandes, K., South, A., Mellerio, J. E., Salas-Alanis, J. C., Proby, C., Leigh, I. & Saville, M., 17 Apr 2018, In : Oncotarget. 9, p. 20265-20281 17 p.

Research output: Contribution to journalArticle

Open Access
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7 Citations (Scopus)
152 Downloads (Pure)

Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma

Rose, A. M., Spender, L. C., Stephen, C., Mitchell, A., Rickaby, W., Bray, S., Evans, A. T., Dayal, J., Purdie, K. J., Harwood, C. A., Proby, C. M., Leigh, I. M., Coates, P. J. . & Inman, G. J., 6 Mar 2018, In : Oncotarget. 9, 18, p. 14552-14566 15 p.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
190 Downloads (Pure)

Revised nomenclature and classification of inherited ichthyoses: Results of the First Ichthyosis Consensus Conference in Sorze 2009

Oji, V., Tadini, G., Akiyama, M., Blanchet Bardon, C., Bodemer, C., Bourrat, E., Coudiere, P., Digiovanna, J. J., Elias, P., Fischer, J., Fleckman, P., Gina, M., Harper, J., Hashimoto, T., Hausser, I., Hennies, H. C., Hohl, D., Hovnanian, A., Ishida-Yamamoto, A., Jacyk, W. K. & 17 others, Leachman, S., Leigh, I., Mazereeuw-Hautier, J., Milstone, L., Morice-Picard, F., Paller, A. S., Richard, G., Schmuth, M., Shimizu, H., Sprecher, E., van Steensel, M., Taïeb, A., Toro, J. R., Vabres, P., Vahlquist, A., Williams, M. & Traupe, H., 2010, In : Journal of the American Academy of Dermatology. 63, 4, p. 607-641 35 p.

Research output: Contribution to journalArticle

408 Citations (Scopus)

RHBDF2 Mutations Are Associated with Tylosis, a Familial Esophageal Cancer Syndrome

Blaydon, D. C., Etheridge, S. L., Risk, J. M., Hennies, H-C., Gay, L. J., Carroll, R., Plagnol, V., McRonald, F. E., Stevens, H. P., Spurr, N. K., Bishop, D. T., Ellis, A., Jankowski, J., Field, J. K., Leigh, I. M., South, A. P. & Kelsell, D. P., 10 Feb 2012, In : American Journal of Human Genetics. 90, 2, p. 340-346 7 p.

Research output: Contribution to journalArticle

109 Citations (Scopus)

Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16

Maruthappu, T., Chikh, A., Fell, B., Delaney, P. J., Brooke, M. A., Levet, C., Moncada-Pazos, A., Ishida-Yamamoto, A., Blaydon, D., Waseem, A., Leigh, I. M., Freeman, M. & Kelsell, D. P., 27 Jan 2017, In : Nature Communications. 8, p. 1-11 11 p., 14174.

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