Leigh, Irene

Professor

  • 6253 Citations
  • 32 h-Index
1989 …2020

Research output per year

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Research Output

2012

NT5E (CD73) is epigenetically regulated in malignant melanoma and associated with metastatic site specificity

Wang, H., Lee, S., Lo Nigro, C., Lattanzio, L., Merlano, M., Monteverde, M., Matin, R., Purdie, K., Mladkova, N., Bergamaschi, D., Harwood, C., Syed, N., Szlosarek, P., Briasoulis, E., McHugh, A., Thompson, A., Evans, A., Leigh, I., Fleming, C., Inman, G. J. & 3 others, Hatzimichael, E., Proby, C. & Crook, T., 2012, In : British Journal of Cancer. 106, 8, p. 1446-52 7 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

RHBDF2 Mutations Are Associated with Tylosis, a Familial Esophageal Cancer Syndrome

Blaydon, D. C., Etheridge, S. L., Risk, J. M., Hennies, H-C., Gay, L. J., Carroll, R., Plagnol, V., McRonald, F. E., Stevens, H. P., Spurr, N. K., Bishop, D. T., Ellis, A., Jankowski, J., Field, J. K., Leigh, I. M., South, A. P. & Kelsell, D. P., 10 Feb 2012, In : American Journal of Human Genetics. 90, 2, p. 340-346 7 p.

Research output: Contribution to journalArticle

109 Citations (Scopus)

RNAi depletion of PRSS21 induces apoptosis in cutaneous squamous cell carcinoma keratinocytes

Robinson, K., Watt, S., Leigh, I. & South, A., Apr 2012, In : British Journal of Dermatology. 166, 4, p. e25-e25 1 p., O-25.

Research output: Contribution to journalArticle

The retinoid signalling molecule, TRIM16, is repressed during squamous cell carcinoma skin carcinogenesis in vivo and reduces skin cancer cell migration in vitro

Cheung, B. B., Koach, J., Tan, O., Kim, P., Bell, J. L., D'andreti, C., Sutton, S., Malyukova, A., Sekyere, E., Norris, M., Haber, M., Kavallaris, M., Cunningham, A. M., Proby, C., Leigh, I., Wilmott, J. S., Cooper, C. L., Halliday, G. M., Scolyer, R. A. & Marshall, G. M., Feb 2012, In : Journal of Pathology. 226, 3, p. 451-462 12 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Two mechanisms regulate keratin K15 expression in keratinocytes: role of PKC/AP-1 and FOXM1 mediated signalling

Bose, A., Teh, M-T., Hutchison, I. L., Wan, H., Leigh, I. M. & Waseem, A., 2012, In : PLoS ONE. 7, 6, e38599.

Research output: Contribution to journalArticle

22 Citations (Scopus)
12 Citations (Scopus)

Wnt5a inhibits the CpG oligodeoxynucleotide-triggered activation of human plasmacytoid dendritic cells

Hack, K., Reilly, L., Proby, C., Fleming, C., Leigh, I. & Foerster, J., Apr 2012, In : British Journal of Dermatology. 166, 4, p. e36-e36 1 p., P-24.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2011

ARNT deficiency leads to reduced HDAC activity, suppression of EGFR/ERK pathway and defects in epidermal differentiation

Robertson, D., Weir, L., Leigh, I. & Panteleyev, A., 11 Apr 2011, In : British Journal of Dermatology. 164, 4, p. 926-926 1 p.

Research output: Contribution to journalBook/Film/Article review

ARNT-dependent expression of amphiregulin and consequent activation of EGFR/Erk pathway is essential for normal epidermal differentiation

Robertson, D., Weir, L., Leigh, I. M. & Panteleyev, A. A., Apr 2011, In : Journal of Investigative Dermatology. 131, p. S44-S44 1 p.

Research output: Contribution to journalBook/Film/Article review

Cutaneous Squamous Cell Carcinoma (SCC) and the DNA Damage Response: pATM Expression Patterns in Pre-Malignant and Malignant Keratinocyte Skin Lesions

Ismail, F., Ikram, M., Purdie, K., Harwood, C., Leigh, I. & Storey, A., 1 Jul 2011, In : PLoS ONE. 6, 7, p. - 14 p., e21271.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Cutaneous Squamous Cell Carcinoma exhibits significant tumour heterogeneity

Murray, S., Foster, N., Leigh, I., Pratt, N. & South, A., Sep 2011, In : Journal of Investigative Dermatology. 131, p. S81-S81 1 p.

Research output: Contribution to journalBook/Film/Article review

Differential regulation of HIF-alpha splice variants by hypoxia in epidermal keratinocytes

Weir, L., Robertson, D., Leigh, I. M., Vass, J. K. & Panteleyev, A. A., Apr 2011, In : Journal of Investigative Dermatology. 131, p. S44-S44 1 p.

Research output: Contribution to journalBook/Film/Article review

1 Citation (Scopus)

Egln/PHD proteins and their role in control of hypoxia pathway in epidermal keratinocytes

Weir, L., Robertson, D., Leigh, I. M. & Panteleyev, A. A., Apr 2011, In : Journal of Investigative Dermatology. 131, p. S15-S15 1 p.

Research output: Contribution to journalBook/Film/Article review

Egln3 as a key factor of HIF activity in epidermal keratinocytes

Weir, L., Robertson, D., Leigh, I. & Panteleyev, A., 11 Apr 2011, In : British Journal of Dermatology. 164, 4, p. 912-913 2 p.

Research output: Contribution to journalBook/Film/Article review

Epidermal expression patterns of HIF-alpha splice variants and their differential regulation by hypoxia

Weir, L., Robertson, D., Leigh, I., Vass, K. & Panteleyev, A., 11 Apr 2011, In : British Journal of Dermatology. 164, 4, p. 928-928 1 p.

Research output: Contribution to journalBook/Film/Article review

Epigenetic dysregulation of novel candidate genes in malignant melanoma

Wang, H., McHugh, A. T., Matin, R., Fleming, C., Leigh, I. M., Harwood, C., Crook, T., Inman, G. & Proby, C., 11 Apr 2011, In : British Journal of Dermatology. 164, 4, p. 916-916 1 p.

Research output: Contribution to journalBook/Film/Article review

Epigenetic Dysregulation of Novel Genes in Melanoma

Wang, H., McHugh, A., Matin, R., Fleming, C., Leigh, I., Harwood, C., Crook, T., Inman, G. & Proby, C., Sep 2011, In : Journal of Investigative Dermatology. 131, p. S114-S114 1 p.

Research output: Contribution to journalBook/Film/Article review

HIF pathway in epidermal keratinocytes is controlled by Egln3 and Siah1 proteins

Weir, L., Robertson, D., Leigh, I., Vass, K. & Panteleyev, A., Sep 2011, In : Journal of Investigative Dermatology. 131, p. S3-S3 1 p.

Research output: Contribution to journalBook/Film/Article review

High Resolution Genomic Profiling of Vulval Neoplasia Reveals Genetic Differences between Human Papillomavirus-Associated and Human Papillomavirus-Independent Tumours

Purdie, K., Gibbon, K., Chaplin, T., Young, B., Leigh, I., Proby, C. & Harwood, C., Sep 2011, In : Journal of Investigative Dermatology. 131, p. S29-S29 1 p.

Research output: Contribution to journalBook/Film/Article review

5 Citations (Scopus)

High resolution microarray analysis of vulval neoplasia reveals genetic differences between human papillomavirus-positive and negative tumours

Purdie, K. J., Chaplin, T., Gibbon, K., Young, B. D., Leigh, I., Proby, C. & Harwood, C. A., 11 Apr 2011, In : British Journal of Dermatology. 164, 4, p. 935-935 1 p.

Research output: Contribution to journalBook/Film/Article review

Hypoxia-mediated control of HIF/ARNT machinery in epidermal keratinocytes

Weir, L., Robertson, D., Leigh, I. M., Vass, J. K. & Panteleyev, A. A., Jan 2011, In : Biochimica et Biophysica Acta. Molecular Cell Research. 1813, 1, p. 60-72 13 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Integrative mRNA profiling comparing cultured primary cells with clinical samples reveals PLK1 and C20orf20 as therapeutic targets in cutaneous squamous cell carcinoma

Watt, S., Pourreyron, C., Purdie, K., Hogan, C., Cole, C. L., Foster, N., Pratt, N., Bourdon, J-C., Appleyard, V., Murray, K., Thompson, A., Mao, X., Mein, C., Bruckner-Tuderman, L., Evans, A., McGrath, J. A., Proby, C. M., Foerster, J., Leigh, I. & South, A., Nov 2011, In : Oncogene. 30, 46, p. 4666-4677 12 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Keratin 14-Null Cells as a Model to Test the Efficacy of Gene Therapy Approaches in Epithelial Cells

D'Alessandro, M., Coats, S. E., Jonkmann, M. F., Leigh, I. M. & Lane, B., Jul 2011, In : Journal of Investigative Dermatology. 131, 7, p. 1412-1419 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma

Wang, N. J., Sanborn, Z., Arnett, K. L., Bayston, L. J., Liao, W., Proby, C. M., Leigh, I. M., Collisson, E. A., Gordon, P. B., Jakkula, L., Pennypacker, S., Zou, Y., Sharma, M., North, J. P., Vemula, S. S., Mauro, T. M., Neuhaus, I. M., LeBoit, P. E., Hur, J. S., Park, K. & 13 others, Huh, N., Kwok, P-Y., Arron, S. T., Massion, P. P., Bale, A. E., Haussler, D., Cleaver, J. E., Gray, J. W., Spellman, P. T., South, A. P., Aster, J. C., Blacklow, S. C. & Cho, R. J., 25 Oct 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 43, p. 17761-17766 6 p.

Research output: Contribution to journalArticle

261 Citations (Scopus)

Microarray expression profiling identifies novel targets and pathways involved in cutaneous squamous cell carcinoma oncogenesis

Lambert, S. R., Mladkova, N., Gulati, A., Leigh, I., Harwood, C. A. & Proby, C., 11 Apr 2011, In : British Journal of Dermatology. 164, 4, p. 933-934 2 p.

Research output: Contribution to journalMeeting abstract

RHBDF2 mutations in Tylosis with Oesophageal Cancer cause dysregulation of downstream EGF and EphrinB3 signalling

Etheridge, S., Blaydon, D., Risk, J., Hennies, H-C., Stevens, H., Field, J., Ellis, A., Leigh, I., South, A. & Kelsell, D., Sep 2011, In : Journal of Investigative Dermatology. 131, p. S63-S63 1 p.

Research output: Contribution to journalBook/Film/Article review

RNAi depletion of PRSS21 induces apoptosis in cutaneous squamous cell carcinoma keratinocytes

Robinson, K., Watt, S., South, A. & Leigh, I., Sep 2011, In : Journal of Investigative Dermatology. 131, p. S27-S27 1 p.

Research output: Contribution to journalBook/Film/Article review

Specific upregulation of non-canonical wnt signalling in non-melanoma skin cancer: Wnt 5a is strongly expressed and controls directional migration

Pourreyron, C., McLean, K., Reilly, L., Proby, C., Panteleyev, A., Evans, A., Leigh, I., South, A. & Foerster, J., Sep 2011, In : Journal of Investigative Dermatology. 131, p. S28-S28 1 p.

Research output: Contribution to journalBook/Film/Article review

The reduction of water-soluble tetrazolium salt reagent on the plasma membrane of epidermal keratinocytes is oxygen dependent

Weir, L., Robertson, D., Leigh, I. M. & Panteleyev, A. A., 1 Jul 2011, In : Analytical Biochemistry. 414, 1, p. 31-37 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Validation of the B1 bradykinin receptor as a potential therapeutic target in cutaneous squamous cell carcinoma

Gaw, S., Watt, S., Leigh, I. & South, A. P., 11 Apr 2011, In : British Journal of Dermatology. 164, 4, p. 934-935 2 p.

Research output: Contribution to journalBook/Film/Article review

Wnt5a inhibits maturation and interferon alpha production by human plasmacytoid dendritic cells

Hack, K., Proby, C., Fleming, C., Leigh, I., McLean, K., Reilly, L. & Foerster, J., Sep 2011, In : Journal of Investigative Dermatology. 131, p. S91-S91 1 p.

Research output: Contribution to journalBook/Film/Article review

2010

ARNT acts through EGFR- and HDAC-dependent pathways to control the expression of epidermal differentiation genes

Robertson, D., Weir, L., Leigh, I. M. & Panteleyev, A., Apr 2010, In : British Journal of Dermatology. 162, 4, p. 927-928 2 p.

Research output: Contribution to journalBook/Film/Article review

ARNT controls the expression of epidermal differentiation genes through EGER- and HDAC-dependent pathways

Robertson, D., Weir, L., Leigh, I. & Panteleyev, A., Sep 2010, In : Journal of Investigative Dermatology. 130, p. S84-S84 1 p.

Research output: Contribution to journalBook/Film/Article review

Dermal fibroblast expression profiling implicates tumour microenvironment in the development of aggressive squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa

Ng, Y. Z., Pourreyron, C., Proby, C., Salas, J., Murrell, D. F., McGrath, J. A., Lane, E. B., Leigh, I. M. & South, A. P., Apr 2010, In : British Journal of Dermatology. 162, 4, p. 948-948 1 p.

Research output: Contribution to journalBook/Film/Article review

Effects of hypoxia upon differentiation and proliferation of epidermal keratinocytes

Weir, L., Robertson, D., Leigh, I. M. & Panteleyev, A. A., Apr 2010, In : Journal of Investigative Dermatology. 130, p. S72-S72 1 p.

Research output: Contribution to journalBook/Film/Article review

EgIn3 as a key element of differential regulation of HIF1 activity by acute and chronic hypoxia in epidermal keratinocytes

Weir, L., Robertson, D., Leigh, I. & Panteleyev, A., Sep 2010, In : Journal of Investigative Dermatology. 130, p. S1-S1 1 p.

Research output: Contribution to journalBook/Film/Article review

High-resolution genomic profiling of human papillomavirus-associated vulval neoplasia

Purdie, K. J., Harwood, C. A., Chaplin, T., Gibbon, K., Singh, N., Young, B. D., Cazier, J. B., Leigh, I. M. & Proby, C. M., Apr 2010, In : British Journal of Dermatology. 162, 4, p. 945-945 1 p.

Research output: Contribution to journalBook/Film/Article review

5 Citations (Scopus)

High-resolution genomic profiling of human papillomavirus-associated vulval neoplasia

Purdie, K. J., Harwood, C. A., Gibbon, K., Chaplin, T., Young, B. D., Cazier, J. B., Singh, N., Leigh, I. M. & Proby, C. M., 16 Mar 2010, In : British Journal of Cancer. 102, 6, p. 1044-1051 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Hypoxia suppresses hypoxia inducible factor pathway proteins and affects differentiation of epidermal keratinocytes

Weir, L., Robertson, D., Leigh, I. M. & Panteleyev, A., Apr 2010, In : British Journal of Dermatology. 162, 4, p. 928-928 1 p.

Research output: Contribution to journalBook/Film/Article review

Identification of polo-like kinase 1 as a potential therapeutic target in squamous cell carcinoma

Watt, S. A., Pourreyron, C., Foerster, J., Hogan, C., Purdie, K., Bruckner-Tuderman, L., Proby, C., McGrath, J. A., Leigh, I. M. & South, A. P., Apr 2010, In : British Journal of Dermatology. 162, 4, p. 923-923 1 p.

Research output: Contribution to journalBook/Film/Article review

Identification of therapeutic and prognostic biomarkers in keratinocyte carcinogenesis

Gulati, A., Harwood, C. A., Purdie, K., Leigh, I. M., Kelsell, D. P. & Proby, C. M., Apr 2010, In : British Journal of Dermatology. 162, 4, p. 949-949 1 p.

Research output: Contribution to journalBook/Film/Article review

Increased type VII collagen in adipose-derived stem cell-keratinocyte co-culture compared with dermal fibroblast co-culture is dependent on MMP3

Pourreyron, C., Cole, C., McGrath, J. A., Leigh, I. M. & South, A. P., 2010, In : British Journal of Dermatology. 162, 4, p. 915 1 p.

Research output: Contribution to journalBook/Film/Article review

No Evidence That Human Papillomavirus Is Responsible for the Aggressive Nature of Recessive Dystrophic Epidermolysis Bullosa-Associated Squamous Cell Carcinoma

Purdie, K. J., Pourreyron, C., Fassihi, H., Cepeda-Valdes, R., Frew, J. W., Volz, A., Weissenborn, S. J., Pfister, H., Proby, C. M., Bruckner-Tuderman, L., Murrell, D. F., Salas-Alanis, J. C., McGrath, J. A., Leigh, I. M., Harwood, C. A. & South, A. P., Dec 2010, In : Journal of Investigative Dermatology. 130, 12, p. 2853-2855 4 p.

Research output: Contribution to journalLetter

8 Citations (Scopus)

p63 is implicated in apoptotic dysregulation in melanoma

Matin, R. N., Chikh, A., Warnes, G., Proby, C. M., Leigh, I. M., Harwood, C. A. & Bergamaschi, D., Apr 2010, In : British Journal of Dermatology. 162, 4, p. 921-921 1 p.

Research output: Contribution to journalBook/Film/Article review

Polo-like kinase 1 inhibitors hold potential as targeted therapies for squamous cell carcinoma

Watt, S., Pourreyron, C., Foerster, J., Hogan, C., Purdie, K., Bruckner-Tuderman, L., Proby, C., McGrath, J., Leigh, I. & South, A., Sep 2010, In : Journal of Investigative Dermatology. 130, p. S51-S51 1 p.

Research output: Contribution to journalBook/Film/Article review

Protein tyrosine phosphatase receptor type delta (PTPRD) is expressed in normal and cutaneous squamous cell carcinoma-derived keratinocytes

Romanowska, M., Proby, C. M., Lambert, S. R., Purdie, K., Gulati, A., Leigh, I. M., Harwood, C. A. & Foerster, J., Apr 2010, In : British Journal of Dermatology. 162, 4, p. 945-946 2 p.

Research output: Contribution to journalBook/Film/Article review

PTPRD microdeletions are associated with metastatic cutaneous squamous cell carcinoma

Lambert, S. R., Purdie, K., Gulati, A., Leigh, I. M., Kelsell, D. P., Harwood, C. A. & Proby, C., Apr 2010, In : British Journal of Dermatology. 162, 4, p. 923-924 2 p.

Research output: Contribution to journalBook/Film/Article review

Revised nomenclature and classification of inherited ichthyoses: Results of the First Ichthyosis Consensus Conference in Sorze 2009

Oji, V., Tadini, G., Akiyama, M., Blanchet Bardon, C., Bodemer, C., Bourrat, E., Coudiere, P., Digiovanna, J. J., Elias, P., Fischer, J., Fleckman, P., Gina, M., Harper, J., Hashimoto, T., Hausser, I., Hennies, H. C., Hohl, D., Hovnanian, A., Ishida-Yamamoto, A., Jacyk, W. K. & 17 others, Leachman, S., Leigh, I., Mazereeuw-Hautier, J., Milstone, L., Morice-Picard, F., Paller, A. S., Richard, G., Schmuth, M., Shimizu, H., Sprecher, E., van Steensel, M., Taïeb, A., Toro, J. R., Vabres, P., Vahlquist, A., Williams, M. & Traupe, H., 2010, In : Journal of the American Academy of Dermatology. 63, 4, p. 607-641 35 p.

Research output: Contribution to journalArticle

409 Citations (Scopus)