Leigh, Irene

Professor

  • 6305 Citations
  • 32 h-Index
1989 …2020

Research output per year

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Research Output

2010

Tumour microenvironment is implicated by dermal fibroblast expression profiling in the development of aggressive squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa

Ng, Y. Z., Pourreyron, C., Salas-Alanis, J. C., Murrell, D. F., McGrath, J. A., Lane, E. B., Leigh, I. & South, A., Sep 2010, In : Journal of Investigative Dermatology. 130, p. S83-S83 1 p.

Research output: Contribution to journalBook/Film/Article review

Tyrosine dephosphorylation is required for Bak activation in apoptosis

Fox, J. L., Ismail, F., Azad, A., Ternette, N., Leverrier, S., Edelmann, M. J., Kessler, B. M., Leigh, I. M., Jackson, S. & Storey, A., 17 Nov 2010, In : EMBO Journal. 29, 22, p. 3853-3868 16 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Viral Oncogenesis and Skin Cancers

Proby, C., Harwood, C., Storey, A. & Leigh, I., Sep 2010, In : Journal of Pathology. 222, p. S14-S15 2 p.

Research output: Contribution to journalBook/Film/Article review

2011

ARNT deficiency leads to reduced HDAC activity, suppression of EGFR/ERK pathway and defects in epidermal differentiation

Robertson, D., Weir, L., Leigh, I. & Panteleyev, A., 11 Apr 2011, In : British Journal of Dermatology. 164, 4, p. 926-926 1 p.

Research output: Contribution to journalBook/Film/Article review

ARNT-dependent expression of amphiregulin and consequent activation of EGFR/Erk pathway is essential for normal epidermal differentiation

Robertson, D., Weir, L., Leigh, I. M. & Panteleyev, A. A., Apr 2011, In : Journal of Investigative Dermatology. 131, p. S44-S44 1 p.

Research output: Contribution to journalBook/Film/Article review

Cutaneous Squamous Cell Carcinoma (SCC) and the DNA Damage Response: pATM Expression Patterns in Pre-Malignant and Malignant Keratinocyte Skin Lesions

Ismail, F., Ikram, M., Purdie, K., Harwood, C., Leigh, I. & Storey, A., 1 Jul 2011, In : PLoS ONE. 6, 7, p. - 14 p., e21271.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Cutaneous Squamous Cell Carcinoma exhibits significant tumour heterogeneity

Murray, S., Foster, N., Leigh, I., Pratt, N. & South, A., Sep 2011, In : Journal of Investigative Dermatology. 131, p. S81-S81 1 p.

Research output: Contribution to journalBook/Film/Article review

Differential regulation of HIF-alpha splice variants by hypoxia in epidermal keratinocytes

Weir, L., Robertson, D., Leigh, I. M., Vass, J. K. & Panteleyev, A. A., Apr 2011, In : Journal of Investigative Dermatology. 131, p. S44-S44 1 p.

Research output: Contribution to journalBook/Film/Article review

1 Citation (Scopus)

Egln/PHD proteins and their role in control of hypoxia pathway in epidermal keratinocytes

Weir, L., Robertson, D., Leigh, I. M. & Panteleyev, A. A., Apr 2011, In : Journal of Investigative Dermatology. 131, p. S15-S15 1 p.

Research output: Contribution to journalBook/Film/Article review

Egln3 as a key factor of HIF activity in epidermal keratinocytes

Weir, L., Robertson, D., Leigh, I. & Panteleyev, A., 11 Apr 2011, In : British Journal of Dermatology. 164, 4, p. 912-913 2 p.

Research output: Contribution to journalBook/Film/Article review

Epidermal expression patterns of HIF-alpha splice variants and their differential regulation by hypoxia

Weir, L., Robertson, D., Leigh, I., Vass, K. & Panteleyev, A., 11 Apr 2011, In : British Journal of Dermatology. 164, 4, p. 928-928 1 p.

Research output: Contribution to journalBook/Film/Article review

Epigenetic dysregulation of novel candidate genes in malignant melanoma

Wang, H., McHugh, A. T., Matin, R., Fleming, C., Leigh, I. M., Harwood, C., Crook, T., Inman, G. & Proby, C., 11 Apr 2011, In : British Journal of Dermatology. 164, 4, p. 916-916 1 p.

Research output: Contribution to journalBook/Film/Article review

Epigenetic Dysregulation of Novel Genes in Melanoma

Wang, H., McHugh, A., Matin, R., Fleming, C., Leigh, I., Harwood, C., Crook, T., Inman, G. & Proby, C., Sep 2011, In : Journal of Investigative Dermatology. 131, p. S114-S114 1 p.

Research output: Contribution to journalBook/Film/Article review

HIF pathway in epidermal keratinocytes is controlled by Egln3 and Siah1 proteins

Weir, L., Robertson, D., Leigh, I., Vass, K. & Panteleyev, A., Sep 2011, In : Journal of Investigative Dermatology. 131, p. S3-S3 1 p.

Research output: Contribution to journalBook/Film/Article review

High Resolution Genomic Profiling of Vulval Neoplasia Reveals Genetic Differences between Human Papillomavirus-Associated and Human Papillomavirus-Independent Tumours

Purdie, K., Gibbon, K., Chaplin, T., Young, B., Leigh, I., Proby, C. & Harwood, C., Sep 2011, In : Journal of Investigative Dermatology. 131, p. S29-S29 1 p.

Research output: Contribution to journalBook/Film/Article review

5 Citations (Scopus)

High resolution microarray analysis of vulval neoplasia reveals genetic differences between human papillomavirus-positive and negative tumours

Purdie, K. J., Chaplin, T., Gibbon, K., Young, B. D., Leigh, I., Proby, C. & Harwood, C. A., 11 Apr 2011, In : British Journal of Dermatology. 164, 4, p. 935-935 1 p.

Research output: Contribution to journalBook/Film/Article review

Hypoxia-mediated control of HIF/ARNT machinery in epidermal keratinocytes

Weir, L., Robertson, D., Leigh, I. M., Vass, J. K. & Panteleyev, A. A., Jan 2011, In : Biochimica et Biophysica Acta. Molecular Cell Research. 1813, 1, p. 60-72 13 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Integrative mRNA profiling comparing cultured primary cells with clinical samples reveals PLK1 and C20orf20 as therapeutic targets in cutaneous squamous cell carcinoma

Watt, S., Pourreyron, C., Purdie, K., Hogan, C., Cole, C. L., Foster, N., Pratt, N., Bourdon, J-C., Appleyard, V., Murray, K., Thompson, A., Mao, X., Mein, C., Bruckner-Tuderman, L., Evans, A., McGrath, J. A., Proby, C. M., Foerster, J., Leigh, I. & South, A., Nov 2011, In : Oncogene. 30, 46, p. 4666-4677 12 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Keratin 14-Null Cells as a Model to Test the Efficacy of Gene Therapy Approaches in Epithelial Cells

D'Alessandro, M., Coats, S. E., Jonkmann, M. F., Leigh, I. M. & Lane, B., Jul 2011, In : Journal of Investigative Dermatology. 131, 7, p. 1412-1419 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma

Wang, N. J., Sanborn, Z., Arnett, K. L., Bayston, L. J., Liao, W., Proby, C. M., Leigh, I. M., Collisson, E. A., Gordon, P. B., Jakkula, L., Pennypacker, S., Zou, Y., Sharma, M., North, J. P., Vemula, S. S., Mauro, T. M., Neuhaus, I. M., LeBoit, P. E., Hur, J. S., Park, K. & 13 others, Huh, N., Kwok, P-Y., Arron, S. T., Massion, P. P., Bale, A. E., Haussler, D., Cleaver, J. E., Gray, J. W., Spellman, P. T., South, A. P., Aster, J. C., Blacklow, S. C. & Cho, R. J., 25 Oct 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 43, p. 17761-17766 6 p.

Research output: Contribution to journalArticle

264 Citations (Scopus)

Microarray expression profiling identifies novel targets and pathways involved in cutaneous squamous cell carcinoma oncogenesis

Lambert, S. R., Mladkova, N., Gulati, A., Leigh, I., Harwood, C. A. & Proby, C., 11 Apr 2011, In : British Journal of Dermatology. 164, 4, p. 933-934 2 p.

Research output: Contribution to journalMeeting abstract

RHBDF2 mutations in Tylosis with Oesophageal Cancer cause dysregulation of downstream EGF and EphrinB3 signalling

Etheridge, S., Blaydon, D., Risk, J., Hennies, H-C., Stevens, H., Field, J., Ellis, A., Leigh, I., South, A. & Kelsell, D., Sep 2011, In : Journal of Investigative Dermatology. 131, p. S63-S63 1 p.

Research output: Contribution to journalBook/Film/Article review

RNAi depletion of PRSS21 induces apoptosis in cutaneous squamous cell carcinoma keratinocytes

Robinson, K., Watt, S., South, A. & Leigh, I., Sep 2011, In : Journal of Investigative Dermatology. 131, p. S27-S27 1 p.

Research output: Contribution to journalBook/Film/Article review

Specific upregulation of non-canonical wnt signalling in non-melanoma skin cancer: Wnt 5a is strongly expressed and controls directional migration

Pourreyron, C., McLean, K., Reilly, L., Proby, C., Panteleyev, A., Evans, A., Leigh, I., South, A. & Foerster, J., Sep 2011, In : Journal of Investigative Dermatology. 131, p. S28-S28 1 p.

Research output: Contribution to journalBook/Film/Article review

The reduction of water-soluble tetrazolium salt reagent on the plasma membrane of epidermal keratinocytes is oxygen dependent

Weir, L., Robertson, D., Leigh, I. M. & Panteleyev, A. A., 1 Jul 2011, In : Analytical Biochemistry. 414, 1, p. 31-37 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Validation of the B1 bradykinin receptor as a potential therapeutic target in cutaneous squamous cell carcinoma

Gaw, S., Watt, S., Leigh, I. & South, A. P., 11 Apr 2011, In : British Journal of Dermatology. 164, 4, p. 934-935 2 p.

Research output: Contribution to journalBook/Film/Article review

Wnt5a inhibits maturation and interferon alpha production by human plasmacytoid dendritic cells

Hack, K., Proby, C., Fleming, C., Leigh, I., McLean, K., Reilly, L. & Foerster, J., Sep 2011, In : Journal of Investigative Dermatology. 131, p. S91-S91 1 p.

Research output: Contribution to journalBook/Film/Article review

2012

A quantitative molecular diagnostic system for predicting progression of vulval intraepithelial neoplasia to invasive squamous cell carcinoma

Purdie, K., Gibbon, K., Proby, C., Leigh, I., Harwood, C. & Teh, T., Apr 2012, In : British Journal of Dermatology. 166, 4, p. e29-e29 1 p., P-1.

Research output: Contribution to journalArticle

39 Citations (Scopus)

ARNT controls the expression of epidermal differentiation genes through HDAC- and EGFR-dependent pathways

Robertson, E. D., Weir, L., Romanowska, M., Leigh, I. M. & Panteleyev, A. A., 15 Jul 2012, In : Journal of Cell Science. 125, 14, p. 3320-3332 13 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Dermal matrix composition promotes development of aggressive squamous cell carcinoma in recessive dystrophic epidermolysis bullosa

Ng, Y., Pourreyron, C., Salas-Alanis, J., Cepeda-Valdes, R., Yan, W., Wright, S., Chen, M., Hogg, F., McGrath, J., Murrell, D., Leigh, I., Lane, E. & South, A., May 2012, In : Journal of Investigative Dermatology. 132, p. S20-S20 1 p.

Research output: Contribution to journalArticle

Exome level sequencing identifies candidate genes mutated in cutaneous squamous cell carcinoma progression

South, A. P., Purdie, K. J., Watt, S. A., Harwood, C. A., Proby, C. & Leigh, I. M., Sep 2012, In : Journal of Investigative Dermatology. 132, p. S37-S37 1 p.

Research output: Contribution to journalMeeting abstract

Expression of activated NOTCH1 induces terminal differentiation in squamous cell carcinoma keratinocytes

Robinson, K. S., Purdie, K. J., Cho, R. J., Aster, J. C., Leigh, I. M. & South, A. P., Sep 2012, In : Journal of Investigative Dermatology. 132, p. S40-S40 1 p.

Research output: Contribution to journalMeeting abstract

9 Citations (Scopus)

Fibroblast-derived dermal matrix drives development of aggressive cutaneous squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa

Ng, Y-Z., Pourreyron, C., Salas-Alanis, J. C., Dayal, J. H. S., Cepeda-Valdes, R., Yan, W., Wright, S., Chen, M., Fine, J-D., Hogg, F. J., McGrath, J. A., Murrell, D. F., Leigh, I. M., Lane, E. B. & South, A. P., 2012, In : Cancer Research. 72, 14, p. 3522-3534 13 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)

Metastatic cutaneous squamous cell carcinoma shows frequent deletion in the protein tyrosine phosphatase receptor Type D gene

Lambert, S. R., Harwood, C. A., Purdie, K. J., Gulati, A., Matin, R. N., Romanowska, M., Cerio, R., Kelsell, D. P., Leigh, I. M. & Proby, C. M., 2012, In : International Journal of Cancer. 131, 3, p. E216-E226

Research output: Contribution to journalArticle

12 Citations (Scopus)

Next-generation sequencing identifies Notch receptors as integral tumor suppressors in cutaneous and lung squamous cell carcinomas

Wang, N. J., Sanborn, Z., Arnett, K. L., Bayston, L. J., Liao, W., Proby, C. M., Leigh, I. M., Gordon, P. B., Sharma, M., North, J. P., Vemula, S. S., Mauro, T. M., Neuhaus, I. M., LeBoit, P. E., Kwok, P., Arron, S. T., Bale, A. E., Haussler, D., Cleaver, J. E., Gray, J. W. & 5 others, Spellman, P. T., South, A. P., Aster, J. C., Blacklow, S. C. & Cho, R. J., May 2012, In : Journal of Investigative Dermatology. 132, p. S23-S23 1 p.

Research output: Contribution to journalArticle

NT5E (CD73) is epigenetically regulated in malignant melanoma and associated with metastatic site specificity

Wang, H., Lee, S., Lo Nigro, C., Lattanzio, L., Merlano, M., Monteverde, M., Matin, R., Purdie, K., Mladkova, N., Bergamaschi, D., Harwood, C., Syed, N., Szlosarek, P., Briasoulis, E., McHugh, A., Thompson, A., Evans, A., Leigh, I., Fleming, C., Inman, G. J. & 3 others, Hatzimichael, E., Proby, C. & Crook, T., 2012, In : British Journal of Cancer. 106, 8, p. 1446-52 7 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

RHBDF2 Mutations Are Associated with Tylosis, a Familial Esophageal Cancer Syndrome

Blaydon, D. C., Etheridge, S. L., Risk, J. M., Hennies, H-C., Gay, L. J., Carroll, R., Plagnol, V., McRonald, F. E., Stevens, H. P., Spurr, N. K., Bishop, D. T., Ellis, A., Jankowski, J., Field, J. K., Leigh, I. M., South, A. P. & Kelsell, D. P., 10 Feb 2012, In : American Journal of Human Genetics. 90, 2, p. 340-346 7 p.

Research output: Contribution to journalArticle

112 Citations (Scopus)

RNAi depletion of PRSS21 induces apoptosis in cutaneous squamous cell carcinoma keratinocytes

Robinson, K., Watt, S., Leigh, I. & South, A., Apr 2012, In : British Journal of Dermatology. 166, 4, p. e25-e25 1 p., O-25.

Research output: Contribution to journalArticle

The retinoid signalling molecule, TRIM16, is repressed during squamous cell carcinoma skin carcinogenesis in vivo and reduces skin cancer cell migration in vitro

Cheung, B. B., Koach, J., Tan, O., Kim, P., Bell, J. L., D'andreti, C., Sutton, S., Malyukova, A., Sekyere, E., Norris, M., Haber, M., Kavallaris, M., Cunningham, A. M., Proby, C., Leigh, I., Wilmott, J. S., Cooper, C. L., Halliday, G. M., Scolyer, R. A. & Marshall, G. M., Feb 2012, In : Journal of Pathology. 226, 3, p. 451-462 12 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Two mechanisms regulate keratin K15 expression in keratinocytes: role of PKC/AP-1 and FOXM1 mediated signalling

Bose, A., Teh, M-T., Hutchison, I. L., Wan, H., Leigh, I. M. & Waseem, A., 2012, In : PLoS ONE. 7, 6, e38599.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Wnt5a inhibits the CpG oligodeoxynucleotide-triggered activation of human plasmacytoid dendritic cells

Hack, K., Reilly, L., Proby, C., Fleming, C., Leigh, I. & Foerster, J., Apr 2012, In : British Journal of Dermatology. 166, 4, p. e36-e36 1 p., P-24.

Research output: Contribution to journalArticle

12 Citations (Scopus)
12 Citations (Scopus)
2013

A surveillance model for skin cancer in organ transplant recipients: A 22-year prospective study in an ethnically diverse population

Harwood, C. A., Mesher, D., McGregor, J. M., Mitchell, L., Leedham-Green, M., Raftery, M., Cerio, R., Leigh, I. M., Sasieni, P. & Proby, C. M., Jan 2013, In : American Journal of Transplantation. 13, 1, p. 119-129 11 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)

A two gene serum epigenetic signature detects metastatic melanoma with high sensitivity and specificity

Wang, H., McHugh, A., Matin, R., Fleming, C., Leigh, I., Harwood, C., Inman, G., Crook, T. & Proby, C., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S235 1 p., 1379.

Research output: Contribution to journalMeeting abstract

Cutaneous SCC and the RAS controversy

McHugh, A. T., Purdie, K., Pourreyron, C., Watt, S., Rose, A., Leigh, I., Harwood, C., South, A. & Proby, C., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S66 1 p., 386.

Research output: Contribution to journalMeeting abstract

Cutaneous squamous cell carcinoma carries the highest burden of mutation of any human tumor type and harbors prevalent mutations in CARD11 and CREBBP

South, A. P., Watt, S. A., Purdie, K. J., Proby, C. M., Harwood, C. A. & Leigh, I. M., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S72 1 p., 427.

Research output: Contribution to journalMeeting abstract

Cutaneous squamous cell carcinoma derived cell lines are more sensitive to the proteasome inhibitor bortezomib than normal skin cells

Koerver, L., Tura, Z. H., Leigh, I. M., South, A. P. & Saville, M. K., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S183 1 p.

Research output: Contribution to journalMeeting abstract

Depletion of MRG-binding protein invokes TIP60 histone acetyltransferase-dependent apoptosis in cutaneous squamous cell carcinoma cells

Watt, S. A., Arrand, K., Leigh, I. M. & South, A. P., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S71 1 p., 416.

Research output: Contribution to journalMeeting abstract