Leigh, Irene

Professor

  • 5901 Citations
  • 31 h-Index
1989 …2019
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Research Output 1989 2019

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Meeting abstract
2013

A two gene serum epigenetic signature detects metastatic melanoma with high sensitivity and specificity

Wang, H., McHugh, A., Matin, R., Fleming, C., Leigh, I., Harwood, C., Inman, G., Crook, T. & Proby, C., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S235 1 p., 1379.

Research output: Contribution to journalMeeting abstract

Cutaneous SCC and the RAS controversy

McHugh, A. T., Purdie, K., Pourreyron, C., Watt, S., Rose, A., Leigh, I., Harwood, C., South, A. & Proby, C., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S66 1 p., 386.

Research output: Contribution to journalMeeting abstract

Cutaneous squamous cell carcinoma carries the highest burden of mutation of any human tumor type and harbors prevalent mutations in CARD11 and CREBBP

South, A. P., Watt, S. A., Purdie, K. J., Proby, C. M., Harwood, C. A. & Leigh, I. M., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S72 1 p., 427.

Research output: Contribution to journalMeeting abstract

Cutaneous squamous cell carcinoma derived cell lines are more sensitive to the proteasome inhibitor bortezomib than normal skin cells

Koerver, L., Tura, Z. H., Leigh, I. M., South, A. P. & Saville, M. K., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S183 1 p.

Research output: Contribution to journalMeeting abstract

Depletion of MRG-binding protein invokes TIP60 histone acetyltransferase-dependent apoptosis in cutaneous squamous cell carcinoma cells

Watt, S. A., Arrand, K., Leigh, I. M. & South, A. P., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S71 1 p., 416.

Research output: Contribution to journalMeeting abstract

Expression microarray analysis identifies key processes in the transition from actinic keratosis to cutaneous squamous cell carcinoma

Lambert, S. R., Mladkova, N., Gulati, A., Hamoudi, R., Purdie, K. J., Cerio, R., Leigh, I. M., Proby, C. M. & Harwood, C. A., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S67 1 p., 393.

Research output: Contribution to journalMeeting abstract

Immunohistochemical assessment of MRG-binding protein and polo-like kinase 1 over-expression in human cutaneous SCC

Harkins, C., Watt, S. A., Pourreyron, C., Leigh, I. M., Proby, C. M. & South, A. P., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S70 1 p., 414.

Research output: Contribution to journalMeeting abstract

MMP1, 2 and 7 but not 9 or 13 promote cutaneous SCC keratinocyte invasion and migration

Pourreyron, C., Pautu, V., Simons, M. R., Proby, C. M., Leigh, I. M. & South, A. P., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S156 1 p., 917.

Research output: Contribution to journalMeeting abstract

Mutant p53 in cutaneous squamous cell carcinoma

Saundh, H., Leigh, I. M., South, A. P. & Saville, M. K., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S70 1 p., 413.

Research output: Contribution to journalMeeting abstract

RNAi depletion of PRSS21 in cutaneous squamous cell carcinoma keratinocytes induces maspin dependent apoptosis

Robinson, K. S., Watt, S. A., Leigh, I. M. & South, A. P., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S72 1 p., 423.

Research output: Contribution to journalMeeting abstract

The development of cutaneous squamous lesions in patients treated with vemurafenib: a possible role for human papillomavirus in addition to activated RAS

Purdie, K., South, A., Sommerlad, M., Leigh, I., Proby, C. & Harwood, C., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S61 1 p., 357.

Research output: Contribution to journalMeeting abstract

Type VII collagen regulates front-to-rear polarity in primary cutaneous squamous cell carcinoma keratinocytes

Dayal, J. H., Pourreyron, C., Watt, S. A., Leigh, I. M. & South, A. P., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S157 1 p., 921.

Research output: Contribution to journalMeeting abstract

2012

Exome level sequencing identifies candidate genes mutated in cutaneous squamous cell carcinoma progression

South, A. P., Purdie, K. J., Watt, S. A., Harwood, C. A., Proby, C. & Leigh, I. M., Sep 2012, In : Journal of Investigative Dermatology. 132, p. S37-S37 1 p.

Research output: Contribution to journalMeeting abstract

8 Citations (Scopus)

Expression of activated NOTCH1 induces terminal differentiation in squamous cell carcinoma keratinocytes

Robinson, K. S., Purdie, K. J., Cho, R. J., Aster, J. C., Leigh, I. M. & South, A. P., Sep 2012, In : Journal of Investigative Dermatology. 132, p. S40-S40 1 p.

Research output: Contribution to journalMeeting abstract

2011

Microarray expression profiling identifies novel targets and pathways involved in cutaneous squamous cell carcinoma oncogenesis

Lambert, S. R., Mladkova, N., Gulati, A., Leigh, I., Harwood, C. A. & Proby, C., 11 Apr 2011, In : British Journal of Dermatology. 164, 4, p. 933-934 2 p.

Research output: Contribution to journalMeeting abstract

2009

Type VII collagen increases invasion and migration of squamous cell carcinoma keratinocytes isolated from patients with recessive dystrophic epidermolysis bullosa.

Pourreyron, C., Hogan, C., Cole, C., Purdie, K., Bruckner-Tuderman, L., McGrath, J., Leigh, I. & South, A., 2009, In : Journal of Investigative Dermatology. 129, S1, p. S40 1 p., 236.

Research output: Contribution to journalMeeting abstract