Leigh, Irene

Professor

  • 5758 Citations
  • 31 h-Index
1989 …2019
If you made any changes in Pure these will be visible here soon.

Research Output 1989 2019

Filter
Article
2019
10 Downloads (Pure)

A Unique Panel of Patient-Derived Cutaneous Squamous Cell Carcinoma Cell Lines Provides a Preclinical Pathway for Therapeutic Testing

Hassan, S., Purdie, K. J., Wang, J., Harwood, C. A., Proby, C. M., Pourreyron, C., Mladkova, N., Nagano, A., Dhayade, S., Athineos, D., Caley, M., Mannella, V., Blyth, K., Inman, G. J. & Leigh, I. M., 12 Jul 2019, In : International Journal of Molecular Sciences. 20, 14, p. 1-26 26 p., 3428.

Research output: Contribution to journalArticle

Open Access
File
cultured cells
Squamous Cell Carcinoma
cancer
Cells
Cell Line
1 Citation (Scopus)
51 Downloads (Pure)

Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model

Kalin, J. H., Eroglu, A., Liu, H., Holtzclaw, W. D., Leigh, I., Proby, C. M., Fahey, J. W., Cole, P. A. & Dinkova-Kostova, A. T., 13 Mar 2019, In : PLoS ONE. 14, 3, p. 1-13 13 p., e0213095.

Research output: Contribution to journalArticle

Open Access
File
Hairless Mouse
histone deacetylase
Histone Deacetylase Inhibitors
squamous cell carcinoma
Squamous Cell Carcinoma
2018
1 Citation (Scopus)

Nationwide Incidence of Metastatic Cutaneous Squamous Cell Carcinoma in England

Venables, Z. C., Autier, P., Nijsten, T., Wong, K. F., Langan, S. M., Rous, B., Broggio, J., Harwood, C., Henson, K., Proby, C. M., Rashbass, J. & Leigh, I. M., 28 Nov 2018, In : JAMA Dermatology. 9 p.

Research output: Contribution to journalArticle

England
Squamous Cell Carcinoma
Skin
Incidence
Skin Neoplasms
5 Citations (Scopus)
67 Downloads (Pure)

Preclinical comparison of proteasome and ubiquitin E1 enzyme inhibitors in cutaneous squamous cell carcinoma: the identification of mechanisms of differential sensitivity

McHugh, A., Fernandes, K., South, A., Mellerio, J. E., Salas-Alanis, J. C., Proby, C., Leigh, I. & Saville, M., 17 Apr 2018, In : Oncotarget. 9, p. 20265-20281 17 p.

Research output: Contribution to journalArticle

Open Access
File
Enzyme Inhibitors
Proteasome Endopeptidase Complex
Ubiquitin
Proteasome Inhibitors
Squamous Cell Carcinoma
121 Downloads (Pure)

Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma

Rose, A. M., Spender, L. C., Stephen, C., Mitchell, A., Rickaby, W., Bray, S., Evans, A. T., Dayal, J., Purdie, K. J., Harwood, C. A., Proby, C. M., Leigh, I. M., Coates, P. J. . & Inman, G. J., 6 Mar 2018, In : Oncotarget. 9, 18, p. 14552-14566 15 p.

Research output: Contribution to journalArticle

Open Access
File
Squamous Cell Carcinoma
Skin
Transforming Growth Factor beta
Inhibin-beta Subunits
Neoplasms
6 Citations (Scopus)
58 Downloads (Pure)

Targeting the spliceosome for cutaneous squamous cell carcinoma therapy: a role for c-MYC and wild-type p53 in determining the degree of tumour selectivity

Hepburn, L., McHugh, A., Fernandes, K., Boag, G., Proby, C., Leigh, I. & Saville, M., 1 May 2018, In : Oncotarget. 9, 33, p. 23029-23046 18 p.

Research output: Contribution to journalArticle

Open Access
File
Spliceosomes
Cell- and Tissue-Based Therapy
Squamous Cell Carcinoma
Skin
Neoplasms
19 Citations (Scopus)
75 Downloads (Pure)

The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature

Inman, G. J., Wang, J., Nagano, A., Alexandrov, L. B., Purdie, K. J., Taylor, R. G., Sherwood, V., Thomson, J., Hogan, S., Spender, L. C., South, A. P., Stratton, M., Chelala, C., Harwood, C. A., Proby, C. M. & Leigh, I. M., 10 Sep 2018, In : Nature Communications. 9, 1, p. 1-14 14 p., 3667.

Research output: Contribution to journalArticle

Open Access
File
Azathioprine
Tumors
tumors
signatures
Skin
2 Citations (Scopus)
67 Downloads (Pure)

The Role of Human Papillomaviruses and Polyomaviruses in BRAF-Inhibitor Induced Cutaneous Squamous Cell Carcinoma and Benign Squamoproliferative Lesions

Purdie, K. J., Proby, C. M., Rizvi, H., Griffin, H., Doorbar, J., Sommerlad, M., Feltkamp, M. C., Van der Meijden, E., Inman, G. J., South, A. P., Leigh, I. M. & Harwood, C. A., 14 Aug 2018, In : Frontiers in Microbiology. 9, 16 p., 1806.

Research output: Contribution to journalArticle

Open Access
File
Polyomavirus
Squamous Cell Carcinoma
Skin
Mutation
Warts
2017
7 Citations (Scopus)
151 Downloads (Pure)

Genomic analysis of atypical fibroxanthoma

Lai, K., Harwood, C. A., Purdie, K. J., Proby, C. M., Leigh, I. M., Ravi, N., Mully, T. W., Brooks, L., Sandoval, P. M., Rosenblum, M. D. & Arron, S. T., 15 Nov 2017, In : PLoS ONE. 12, 11, p. 1-15 15 p., e0188272.

Research output: Contribution to journalArticle

Open Access
File
Tumors
genomics
neoplasms
Epithelial-Mesenchymal Transition
Genes
10 Citations (Scopus)
100 Downloads (Pure)

Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16

Maruthappu, T., Chikh, A., Fell, B., Delaney, P. J., Brooke, M. A., Levet, C., Moncada-Pazos, A., Ishida-Yamamoto, A., Blaydon, D., Waseem, A., Leigh, I. M., Freeman, M. & Kelsell, D. P., 27 Jan 2017, In : Nature Communications. 8, p. 1-11 11 p., 14174.

Research output: Contribution to journalArticle

Open Access
File
Keratin-16
rhomboids
keratins
protease
Peptide Hydrolases
2016
34 Citations (Scopus)
71 Downloads (Pure)

Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma

Cammareri, P., Rose, A., Vincent, D. F., Wang, J., Nagano, A., Libertini, S., Ridgway, R. A., Athineos, D., Coates, P. J. ., McHugh, A., Pourreyron, C., Dayal, J., Larsson, J., Weidlich, S., Spender, L., Sapkota, G., Purdie, K. J., Proby, C., Harwood, C. A., Leigh, I. & 9 others, Clevers, H., Barker, N., Karlsson, S., Pritchard, C., Marais, R., Chelala, C., South, A., Sansom, O. J. & Inman, G., 25 Aug 2016, In : Nature Communications. 7, p. 1-7 7 p., 12493.

Research output: Contribution to journalArticle

Open Access
File
stem cells
Stem cells
deactivation
Squamous Cell Carcinoma
Stem Cells
2015
12 Citations (Scopus)
107 Downloads (Pure)

Lysyl hydroxylase 3 localizes to epidermal basement membrane and Is reduced in patients with Recessive Dystrophic Epidermolysis Bullosa

Watt, S. A., Dayal, J. H. S., Wright, S., Riddle, M., Pourreyron, C., McMillan, J. R., Kimble, R. M., Prisco, M., Gartner, U., Warbrick, E., McLean, W. H. I., Leigh, I. M., McGrath, J. A., Salas-Alanis, J. C., Tolar, J. & South, A. P., 18 Sep 2015, In : PLoS ONE. 10, 9, 15 p., e0137639.

Research output: Contribution to journalArticle

Open Access
File
2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine
epidermolysis bullosa
Epidermolysis Bullosa Dystrophica
basement membrane
Basement Membrane
8 Citations (Scopus)

Novel CARD11 mutations in human cutaneous squamous cell carcinoma lead to aberrant NF-κB regulation

Watt, S. A., Purdie, K. J., den Breems, N. Y., Dimon, M., Arron, S. T., McHugh, A. T., Xue, D. J., Dayal, J. H. S., Proby, C. M., Harwood, C. A., Leigh, I. M. & South, A. P., Sep 2015, In : American Journal of Pathology. 185, 9, p. 2354-2363 10 p.

Research output: Contribution to journalArticle

Squamous Cell Carcinoma
Skin
Mutation
Psoriasis
Pityriasis Rubra Pilaris
2014
9 Citations (Scopus)

High levels of type VII collagen expression in RDEB cSCC keratinocytes increases PI3K and MAPK signalling, cell migration and invasion

Pourreyron, C., Chen, M., McGrath, J. A., Salas-Alanis, J. C., South, A. P. & Leigh, I. M., 2014, In : British Journal of Dermatology. 170, 6, p. 1256-1265 11 p.

Research output: Contribution to journalArticle

Collagen Type VII
Epidermolysis Bullosa Dystrophica
Phosphatidylinositol 3-Kinases
Keratinocytes
Cell Movement
371 Citations (Scopus)

Inherited epidermolysis bullosa: updated recommendations on diagnosis and classification

Fine, J-D., Bruckner-Tuderman, L., Eady, R. A. J., Bauer, E. A., Bauer, J. W., Has, C., Heagerty, A., Hintner, H., Hovnanian, A., Jonkman, M. F., Leigh, I., Marinkovich, M. P., Martinez, A. E., McGrath, J. A., Mellerio, J. E., Moss, C., Murrell, D. F., Shimizu, H., Uitto, J., Woodley, D. & 1 others, Zambruno, G., Jun 2014, In : Journal of the American Academy of Dermatology. 70, 6, p. 1103-1126 24 p.

Research output: Contribution to journalArticle

Epidermolysis Bullosa
Skin
Mutation
Onions
Genes
116 Citations (Scopus)

NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis

South, A. P., Purdie, K. J., Watt, S. A., Haldenby, S., den Breems, N., Dimon, M., Arron, S. T., Kluk, M. J., Aster, J. C., McHugh, A., Xue, D. J., Dayal, J. H. S., Robinson, K. S., Rizvi, S. M. H., Proby, C. M., Harwood, C. A. & Leigh, I. M., Oct 2014, In : Journal of Investigative Dermatology. 134, 10, p. 2630-2638 9 p.

Research output: Contribution to journalArticle

Skin
Carcinogenesis
Epithelial Cells
Mutation
Dermatology
14 Citations (Scopus)

Type VII collagen regulates expression of OATP1B3, promotes front-to-rear polarity and increases structural organisation in 3D spheroid cultures of RDEB tumour keratinocytes

Dayal, J. H. S., Cole, C. L., Pourreyron, C., Watt, S. A., Lim, Y. Z., Salas-Alanis, J. C., Murrell, D. F., McGrath, J. A., Stieger, B., Jahoda, C., Leigh, I. M. & South, A. P., 15 Feb 2014, In : Journal of Cell Science. 127, 4, p. 740-751 12 p.

Research output: Contribution to journalArticle

Collagen Type VII
Epidermolysis Bullosa Dystrophica
Keratinocytes
Skin
Squamous Cell Carcinoma
2013
70 Citations (Scopus)

A surveillance model for skin cancer in organ transplant recipients: A 22-year prospective study in an ethnically diverse population

Harwood, C. A., Mesher, D., McGregor, J. M., Mitchell, L., Leedham-Green, M., Raftery, M., Cerio, R., Leigh, I. M., Sasieni, P. & Proby, C. M., Jan 2013, In : American Journal of Transplantation. 13, 1, p. 119-129 11 p.

Research output: Contribution to journalArticle

Skin Neoplasms
Prospective Studies
Transplants
Population
Neoplasms
59 Citations (Scopus)

Gauging NOTCH1 activation in cancer using immunohistochemistry

Kluk, M. J., Ashworth, T., Wang, H., Knoechel, B., Mason, E. F., Morgan, E. A., Dorfman, D., Pinkus, G., Weigert, O., Hornick, J. L., Chirieac, L. R., Hirsch, M., Oh, D. J., South, A. P., Leigh, I. M., Pourreyron, C., Cassidy, A. J., DeAngelo, D. J., Weinstock, D. M., Krop, I. E. & 10 others, Dillon, D., Brock, J. E., Lazar, A. J. F., Peto, M., Cho, R. J., Stoeck, A., Haines, B. B., Sathayanrayanan, S., Rodig, S. & Aster, J. C., 2013, In : PLoS ONE. 8, 6, 14 p., e67306.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Key differences identified between actinic keratosis and cutaneous squamous cell carcinoma by transcriptome profiling

Lambert, S. R., Mladkova, N., Gulati, A., Hamoudi, R., Purdie, K., Cerio, R., Leigh, I., Proby, C. & Harwood, C. A., 21 Jan 2013, In : British Journal of Cancer. 110, 2, p. 520-529 10 p.

Research output: Contribution to journalArticle

Actinic Keratosis
Gene Expression Profiling
Squamous Cell Carcinoma
Skin
Mitogen-Activated Protein Kinases
29 Citations (Scopus)

Methylated tissue factor pathway inhibitor 2 (TFPI2) DNA in serum is a biomarker of metastatic melanoma

Nigro, C. L., Wang, H., McHugh, A., Lattanzio, L., Matin, R., Harwood, C., Syed, N., Hatzimichael, E., Briasoulis, E., Merlano, M., Evans, A., Thompson, A., Leigh, I., Fleming, C., Inman, G. J., Proby, C. & Crook, T., May 2013, In : Journal of Investigative Dermatology. 133, 5, p. 1278-1285 8 p.

Research output: Contribution to journalArticle

Biomarkers
Melanoma
DNA
Serum
CpG Islands
45 Citations (Scopus)

Mutations in AQP5, encoding a water-channel protein, cause autosomal-dominant diffuse nonepidermolytic palmoplantar keratoderma

Blaydon, D. C., Lind, L. K., Plagnol, V., Linton, K. J., Smith, F. J. D., Wilson, N. J., McLean, W. H. I., Munro, C. S., South, A. P., Leigh, I. M., O'Toole, E. A., Lundström, A. & Kelsell, D. P., 8 Aug 2013, In : American Journal of Human Genetics. 93, 2, p. 330-335 6 p.

Research output: Contribution to journalArticle

Aquaporin 5
Aquaporins
Mutation
Epidermis
Cell Membrane
2012
34 Citations (Scopus)

A quantitative molecular diagnostic system for predicting progression of vulval intraepithelial neoplasia to invasive squamous cell carcinoma

Purdie, K., Gibbon, K., Proby, C., Leigh, I., Harwood, C. & Teh, T., Apr 2012, In : British Journal of Dermatology. 166, 4, p. e29-e29 1 p., P-1.

Research output: Contribution to journalArticle

31 Citations (Scopus)

ARNT controls the expression of epidermal differentiation genes through HDAC- and EGFR-dependent pathways

Robertson, E. D., Weir, L., Romanowska, M., Leigh, I. M. & Panteleyev, A. A., 15 Jul 2012, In : Journal of Cell Science. 125, 14, p. 3320-3332 13 p.

Research output: Contribution to journalArticle

Dermal matrix composition promotes development of aggressive squamous cell carcinoma in recessive dystrophic epidermolysis bullosa

Ng, Y., Pourreyron, C., Salas-Alanis, J., Cepeda-Valdes, R., Yan, W., Wright, S., Chen, M., Hogg, F., McGrath, J., Murrell, D., Leigh, I., Lane, E. & South, A., May 2012, In : Journal of Investigative Dermatology. 132, p. S20-S20 1 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

Fibroblast-derived dermal matrix drives development of aggressive cutaneous squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa

Ng, Y-Z., Pourreyron, C., Salas-Alanis, J. C., Dayal, J. H. S., Cepeda-Valdes, R., Yan, W., Wright, S., Chen, M., Fine, J-D., Hogg, F. J., McGrath, J. A., Murrell, D. F., Leigh, I. M., Lane, E. B. & South, A. P., 2012, In : Cancer Research. 72, 14, p. 3522-3534 13 p.

Research output: Contribution to journalArticle

Epidermolysis Bullosa Dystrophica
Squamous Cell Carcinoma
Fibroblasts
Skin
Collagen Type XII
12 Citations (Scopus)

Metastatic cutaneous squamous cell carcinoma shows frequent deletion in the protein tyrosine phosphatase receptor Type D gene

Lambert, S. R., Harwood, C. A., Purdie, K. J., Gulati, A., Matin, R. N., Romanowska, M., Cerio, R., Kelsell, D. P., Leigh, I. M. & Proby, C. M., 2012, In : International Journal of Cancer. 131, 3, p. E216-E226

Research output: Contribution to journalArticle

Class 2 Receptor-Like Protein Tyrosine Phosphatases
Squamous Cell Carcinoma
Skin
Genes
Skin Neoplasms

Next-generation sequencing identifies Notch receptors as integral tumor suppressors in cutaneous and lung squamous cell carcinomas

Wang, N. J., Sanborn, Z., Arnett, K. L., Bayston, L. J., Liao, W., Proby, C. M., Leigh, I. M., Gordon, P. B., Sharma, M., North, J. P., Vemula, S. S., Mauro, T. M., Neuhaus, I. M., LeBoit, P. E., Kwok, P., Arron, S. T., Bale, A. E., Haussler, D., Cleaver, J. E., Gray, J. W. & 5 others, Spellman, P. T., South, A. P., Aster, J. C., Blacklow, S. C. & Cho, R. J., May 2012, In : Journal of Investigative Dermatology. 132, p. S23-S23 1 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

NT5E (CD73) is epigenetically regulated in malignant melanoma and associated with metastatic site specificity

Wang, H., Lee, S., Lo Nigro, C., Lattanzio, L., Merlano, M., Monteverde, M., Matin, R., Purdie, K., Mladkova, N., Bergamaschi, D., Harwood, C., Syed, N., Szlosarek, P., Briasoulis, E., McHugh, A., Thompson, A., Evans, A., Leigh, I., Fleming, C., Inman, G. J. & 3 others, Hatzimichael, E., Proby, C. & Crook, T., 2012, In : British Journal of Cancer. 106, 8, p. 1446-52 7 p.

Research output: Contribution to journalArticle

Melanoma
Methylation
CpG Islands
Viscera
Epigenomics
100 Citations (Scopus)

RHBDF2 Mutations Are Associated with Tylosis, a Familial Esophageal Cancer Syndrome

Blaydon, D. C., Etheridge, S. L., Risk, J. M., Hennies, H-C., Gay, L. J., Carroll, R., Plagnol, V., McRonald, F. E., Stevens, H. P., Spurr, N. K., Bishop, D. T., Ellis, A., Jankowski, J., Field, J. K., Leigh, I. M., South, A. P. & Kelsell, D. P., 10 Feb 2012, In : American Journal of Human Genetics. 90, 2, p. 340-346 7 p.

Research output: Contribution to journalArticle

RNAi depletion of PRSS21 induces apoptosis in cutaneous squamous cell carcinoma keratinocytes

Robinson, K., Watt, S., Leigh, I. & South, A., Apr 2012, In : British Journal of Dermatology. 166, 4, p. e25-e25 1 p., O-25.

Research output: Contribution to journalArticle

23 Citations (Scopus)

The retinoid signalling molecule, TRIM16, is repressed during squamous cell carcinoma skin carcinogenesis in vivo and reduces skin cancer cell migration in vitro

Cheung, B. B., Koach, J., Tan, O., Kim, P., Bell, J. L., D'andreti, C., Sutton, S., Malyukova, A., Sekyere, E., Norris, M., Haber, M., Kavallaris, M., Cunningham, A. M., Proby, C., Leigh, I., Wilmott, J. S., Cooper, C. L., Halliday, G. M., Scolyer, R. A. & Marshall, G. M., Feb 2012, In : Journal of Pathology. 226, 3, p. 451-462 12 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Two mechanisms regulate keratin K15 expression in keratinocytes: role of PKC/AP-1 and FOXM1 mediated signalling

Bose, A., Teh, M-T., Hutchison, I. L., Wan, H., Leigh, I. M. & Waseem, A., 2012, In : PLoS ONE. 7, 6, e38599.

Research output: Contribution to journalArticle

Keratin-15
keratin
keratinocytes
Transcription Factor AP-1
Keratins
10 Citations (Scopus)

Wnt5a inhibits the CpG oligodeoxynucleotide-triggered activation of human plasmacytoid dendritic cells

Hack, K., Reilly, L., Proby, C., Fleming, C., Leigh, I. & Foerster, J., Apr 2012, In : British Journal of Dermatology. 166, 4, p. e36-e36 1 p., P-24.

Research output: Contribution to journalArticle

10 Citations (Scopus)
Oligodeoxyribonucleotides
Dendritic Cells
Interferons
Melanoma
Immunity
2011
12 Citations (Scopus)

Cutaneous Squamous Cell Carcinoma (SCC) and the DNA Damage Response: pATM Expression Patterns in Pre-Malignant and Malignant Keratinocyte Skin Lesions

Ismail, F., Ikram, M., Purdie, K., Harwood, C., Leigh, I. & Storey, A., 1 Jul 2011, In : PLoS ONE. 6, 7, p. - 14 p., e21271.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Hypoxia-mediated control of HIF/ARNT machinery in epidermal keratinocytes

Weir, L., Robertson, D., Leigh, I. M., Vass, J. K. & Panteleyev, A. A., Jan 2011, In : Biochimica et Biophysica Acta. Molecular Cell Research. 1813, 1, p. 60-72 13 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Integrative mRNA profiling comparing cultured primary cells with clinical samples reveals PLK1 and C20orf20 as therapeutic targets in cutaneous squamous cell carcinoma

Watt, S., Pourreyron, C., Purdie, K., Hogan, C., Cole, C. L., Foster, N., Pratt, N., Bourdon, J-C., Appleyard, V., Murray, K., Thompson, A., Mao, X., Mein, C., Bruckner-Tuderman, L., Evans, A., McGrath, J. A., Proby, C. M., Foerster, J., Leigh, I. & South, A., Nov 2011, In : Oncogene. 30, 46, p. 4666-4677 12 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Keratin 14-Null Cells as a Model to Test the Efficacy of Gene Therapy Approaches in Epithelial Cells

D'Alessandro, M., Coats, S. E., Jonkmann, M. F., Leigh, I. M. & Lane, B., Jul 2011, In : Journal of Investigative Dermatology. 131, 7, p. 1412-1419 8 p.

Research output: Contribution to journalArticle

239 Citations (Scopus)

Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma

Wang, N. J., Sanborn, Z., Arnett, K. L., Bayston, L. J., Liao, W., Proby, C. M., Leigh, I. M., Collisson, E. A., Gordon, P. B., Jakkula, L., Pennypacker, S., Zou, Y., Sharma, M., North, J. P., Vemula, S. S., Mauro, T. M., Neuhaus, I. M., LeBoit, P. E., Hur, J. S., Park, K. & 13 others, Huh, N., Kwok, P-Y., Arron, S. T., Massion, P. P., Bale, A. E., Haussler, D., Cleaver, J. E., Gray, J. W., Spellman, P. T., South, A. P., Aster, J. C., Blacklow, S. C. & Cho, R. J., 25 Oct 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 43, p. 17761-17766 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

The reduction of water-soluble tetrazolium salt reagent on the plasma membrane of epidermal keratinocytes is oxygen dependent

Weir, L., Robertson, D., Leigh, I. M. & Panteleyev, A. A., 1 Jul 2011, In : Analytical Biochemistry. 414, 1, p. 31-37 7 p.

Research output: Contribution to journalArticle

2010
5 Citations (Scopus)

High-resolution genomic profiling of human papillomavirus-associated vulval neoplasia

Purdie, K. J., Harwood, C. A., Gibbon, K., Chaplin, T., Young, B. D., Cazier, J. B., Singh, N., Leigh, I. M. & Proby, C. M., 16 Mar 2010, In : British Journal of Cancer. 102, 6, p. 1044-1051 8 p.

Research output: Contribution to journalArticle

358 Citations (Scopus)

Revised nomenclature and classification of inherited ichthyoses: Results of the First Ichthyosis Consensus Conference in Sorze 2009

Oji, V., Tadini, G., Akiyama, M., Blanchet Bardon, C., Bodemer, C., Bourrat, E., Coudiere, P., Digiovanna, J. J., Elias, P., Fischer, J., Fleckman, P., Gina, M., Harper, J., Hashimoto, T., Hausser, I., Hennies, H. C., Hohl, D., Hovnanian, A., Ishida-Yamamoto, A., Jacyk, W. K. & 17 others, Leachman, S., Leigh, I., Mazereeuw-Hautier, J., Milstone, L., Morice-Picard, F., Paller, A. S., Richard, G., Schmuth, M., Shimizu, H., Sprecher, E., van Steensel, M., Taïeb, A., Toro, J. R., Vabres, P., Vahlquist, A., Williams, M. & Traupe, H., 2010, In : Journal of the American Academy of Dermatology. 63, 4, p. 607-641 35 p.

Research output: Contribution to journalArticle

Ichthyosis
Terminology
Epidermolytic Hyperkeratosis
Lamellar Ichthyosis
Congenital Ichthyosiform Erythroderma
29 Citations (Scopus)

Tyrosine dephosphorylation is required for Bak activation in apoptosis

Fox, J. L., Ismail, F., Azad, A., Ternette, N., Leverrier, S., Edelmann, M. J., Kessler, B. M., Leigh, I. M., Jackson, S. & Storey, A., 17 Nov 2010, In : EMBO Journal. 29, 22, p. 3853-3868 16 p.

Research output: Contribution to journalArticle

2009
29 Citations (Scopus)

Single Nucleotide Polymorphism Array Analysis Defines a Specific Genetic Fingerprint for Well-Differentiated Cutaneous SCCs

Purdie, K. J., Harwood, C. A., Gulati, A., Chaplin, T., Lambert, S. R., Cerio, R., Kelly, G. P., Cazier, J-B., Young, B. D., Leigh, I. M. & Proby, C. M., Jun 2009, In : Journal of Investigative Dermatology. 129, 6, p. 1562-1568 7 p.

Research output: Contribution to journalArticle

2008
26 Citations (Scopus)

An altered keratinocyte phenotype in oral submucous fibrosis: Correlation of keratin K17 expression with disease severity

Lalli, A., Tilakaratne, W. M., Ariyawardana, A., Fitchett, C., Leigh, I. M., Hagi-Pavli, E., Cruchley, A. T., Parkinson, E. K., Teh, M-T., Fortune, F. & Waseem, A., 2008, In : Journal of Oral Pathology and Medicine. 37, 4, p. 211-220 10 p.

Research output: Contribution to journalArticle

Oral Submucous Fibrosis
Keratins
Keratinocytes
Phenotype
Epithelium
8 Citations (Scopus)

Clinical application of skin substitutes

Damodaran, G., Syed, M., Leigh, I., Myers, S. & Navsaria, H., 2008, In : Expert Review of Dermatology. 3, 3, p. 345-356 12 p.

Research output: Contribution to journalArticle

Artificial Skin
Skin
Bioengineering
Biotechnology
Wound Healing
157 Citations (Scopus)

Development of a treatment algorithm for actinic keratoses: a European Consensus

Stockfleth, E., Ferrandiz, C., Grob, J. J., Leigh, I., Pehamberger, H., Kerl, H. & European Skin Acad, 2008, In : European Journal of Dermatology. 18, 6, p. 651-659 9 p.

Research output: Contribution to journalArticle

154 Citations (Scopus)

Potential of fibroblast cell therapy for recessive dystrophic epidermolysis bullosa

Wong, T., McGrath, J. A., Gammon, L., Leigh, I. M., Navsaria, H., Liu, L., Dopping-Hepenstal, P. J. C., Pacy, J., Mellerio, J. E., Elia, G. & Jeffery, R., 2008, In : Journal of Investigative Dermatology. 128, 9, p. 2179-2189 11 p.

Research output: Contribution to journalArticle

Collagen Type VII
Epidermolysis Bullosa Dystrophica
Fibroblasts
Cell- and Tissue-Based Therapy
Cells
617 Citations (Scopus)

The classification of inherited epidermolysis bullosa (EB): Report of the Third International Consensus Meeting on Diagnosis and Classification of EB

Fine, J-D., Eady, R. A. J., McGrath, J. A., Mellerio, J. E., Bauer, E. A., Bauer, J. W., Hintner, H., Bruckner-Tuderman, L., Heagerty, A., Hovnanian, A., Jonkman, M. F., Leigh, I., Murrell, D. F., Shimizu, H., Uitto, J., Vahlquist, A., Woodley, D. & Zambruno, G., 1 Jun 2008, In : Journal of the American Academy of Dermatology. 58, 6, p. 931-950 20 p.

Research output: Contribution to journalArticle

Epidermolysis Bullosa
Routine Diagnostic Tests
Publications