Leigh, Irene

Professor

  • 5758 Citations
  • 31 h-Index
1989 …2019
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Research Output 1989 2019

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Book/Film/Article review
2011

ARNT deficiency leads to reduced HDAC activity, suppression of EGFR/ERK pathway and defects in epidermal differentiation

Robertson, D., Weir, L., Leigh, I. & Panteleyev, A., 11 Apr 2011, In : British Journal of Dermatology. 164, 4, p. 926-926 1 p.

Research output: Contribution to journalBook/Film/Article review

ARNT-dependent expression of amphiregulin and consequent activation of EGFR/Erk pathway is essential for normal epidermal differentiation

Robertson, D., Weir, L., Leigh, I. M. & Panteleyev, A. A., Apr 2011, In : Journal of Investigative Dermatology. 131, p. S44-S44 1 p.

Research output: Contribution to journalBook/Film/Article review

Cutaneous Squamous Cell Carcinoma exhibits significant tumour heterogeneity

Murray, S., Foster, N., Leigh, I., Pratt, N. & South, A., Sep 2011, In : Journal of Investigative Dermatology. 131, p. S81-S81 1 p.

Research output: Contribution to journalBook/Film/Article review

1 Citation (Scopus)

Differential regulation of HIF-alpha splice variants by hypoxia in epidermal keratinocytes

Weir, L., Robertson, D., Leigh, I. M., Vass, J. K. & Panteleyev, A. A., Apr 2011, In : Journal of Investigative Dermatology. 131, p. S44-S44 1 p.

Research output: Contribution to journalBook/Film/Article review

Egln/PHD proteins and their role in control of hypoxia pathway in epidermal keratinocytes

Weir, L., Robertson, D., Leigh, I. M. & Panteleyev, A. A., Apr 2011, In : Journal of Investigative Dermatology. 131, p. S15-S15 1 p.

Research output: Contribution to journalBook/Film/Article review

Egln3 as a key factor of HIF activity in epidermal keratinocytes

Weir, L., Robertson, D., Leigh, I. & Panteleyev, A., 11 Apr 2011, In : British Journal of Dermatology. 164, 4, p. 912-913 2 p.

Research output: Contribution to journalBook/Film/Article review

Epidermal expression patterns of HIF-alpha splice variants and their differential regulation by hypoxia

Weir, L., Robertson, D., Leigh, I., Vass, K. & Panteleyev, A., 11 Apr 2011, In : British Journal of Dermatology. 164, 4, p. 928-928 1 p.

Research output: Contribution to journalBook/Film/Article review

Epigenetic dysregulation of novel candidate genes in malignant melanoma

Wang, H., McHugh, A. T., Matin, R., Fleming, C., Leigh, I. M., Harwood, C., Crook, T., Inman, G. & Proby, C., 11 Apr 2011, In : British Journal of Dermatology. 164, 4, p. 916-916 1 p.

Research output: Contribution to journalBook/Film/Article review

Epigenetic Dysregulation of Novel Genes in Melanoma

Wang, H., McHugh, A., Matin, R., Fleming, C., Leigh, I., Harwood, C., Crook, T., Inman, G. & Proby, C., Sep 2011, In : Journal of Investigative Dermatology. 131, p. S114-S114 1 p.

Research output: Contribution to journalBook/Film/Article review

HIF pathway in epidermal keratinocytes is controlled by Egln3 and Siah1 proteins

Weir, L., Robertson, D., Leigh, I., Vass, K. & Panteleyev, A., Sep 2011, In : Journal of Investigative Dermatology. 131, p. S3-S3 1 p.

Research output: Contribution to journalBook/Film/Article review

5 Citations (Scopus)

High Resolution Genomic Profiling of Vulval Neoplasia Reveals Genetic Differences between Human Papillomavirus-Associated and Human Papillomavirus-Independent Tumours

Purdie, K., Gibbon, K., Chaplin, T., Young, B., Leigh, I., Proby, C. & Harwood, C., Sep 2011, In : Journal of Investigative Dermatology. 131, p. S29-S29 1 p.

Research output: Contribution to journalBook/Film/Article review

High resolution microarray analysis of vulval neoplasia reveals genetic differences between human papillomavirus-positive and negative tumours

Purdie, K. J., Chaplin, T., Gibbon, K., Young, B. D., Leigh, I., Proby, C. & Harwood, C. A., 11 Apr 2011, In : British Journal of Dermatology. 164, 4, p. 935-935 1 p.

Research output: Contribution to journalBook/Film/Article review

RHBDF2 mutations in Tylosis with Oesophageal Cancer cause dysregulation of downstream EGF and EphrinB3 signalling

Etheridge, S., Blaydon, D., Risk, J., Hennies, H-C., Stevens, H., Field, J., Ellis, A., Leigh, I., South, A. & Kelsell, D., Sep 2011, In : Journal of Investigative Dermatology. 131, p. S63-S63 1 p.

Research output: Contribution to journalBook/Film/Article review

RNAi depletion of PRSS21 induces apoptosis in cutaneous squamous cell carcinoma keratinocytes

Robinson, K., Watt, S., South, A. & Leigh, I., Sep 2011, In : Journal of Investigative Dermatology. 131, p. S27-S27 1 p.

Research output: Contribution to journalBook/Film/Article review

Specific upregulation of non-canonical wnt signalling in non-melanoma skin cancer: Wnt 5a is strongly expressed and controls directional migration

Pourreyron, C., McLean, K., Reilly, L., Proby, C., Panteleyev, A., Evans, A., Leigh, I., South, A. & Foerster, J., Sep 2011, In : Journal of Investigative Dermatology. 131, p. S28-S28 1 p.

Research output: Contribution to journalBook/Film/Article review

Validation of the B1 bradykinin receptor as a potential therapeutic target in cutaneous squamous cell carcinoma

Gaw, S., Watt, S., Leigh, I. & South, A. P., 11 Apr 2011, In : British Journal of Dermatology. 164, 4, p. 934-935 2 p.

Research output: Contribution to journalBook/Film/Article review

Wnt5a inhibits maturation and interferon alpha production by human plasmacytoid dendritic cells

Hack, K., Proby, C., Fleming, C., Leigh, I., McLean, K., Reilly, L. & Foerster, J., Sep 2011, In : Journal of Investigative Dermatology. 131, p. S91-S91 1 p.

Research output: Contribution to journalBook/Film/Article review

2010

ARNT acts through EGFR- and HDAC-dependent pathways to control the expression of epidermal differentiation genes

Robertson, D., Weir, L., Leigh, I. M. & Panteleyev, A., Apr 2010, In : British Journal of Dermatology. 162, 4, p. 927-928 2 p.

Research output: Contribution to journalBook/Film/Article review

ARNT controls the expression of epidermal differentiation genes through EGER- and HDAC-dependent pathways

Robertson, D., Weir, L., Leigh, I. & Panteleyev, A., Sep 2010, In : Journal of Investigative Dermatology. 130, p. S84-S84 1 p.

Research output: Contribution to journalBook/Film/Article review

Dermal fibroblast expression profiling implicates tumour microenvironment in the development of aggressive squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa

Ng, Y. Z., Pourreyron, C., Proby, C., Salas, J., Murrell, D. F., McGrath, J. A., Lane, E. B., Leigh, I. M. & South, A. P., Apr 2010, In : British Journal of Dermatology. 162, 4, p. 948-948 1 p.

Research output: Contribution to journalBook/Film/Article review

Effects of hypoxia upon differentiation and proliferation of epidermal keratinocytes

Weir, L., Robertson, D., Leigh, I. M. & Panteleyev, A. A., Apr 2010, In : Journal of Investigative Dermatology. 130, p. S72-S72 1 p.

Research output: Contribution to journalBook/Film/Article review

EgIn3 as a key element of differential regulation of HIF1 activity by acute and chronic hypoxia in epidermal keratinocytes

Weir, L., Robertson, D., Leigh, I. & Panteleyev, A., Sep 2010, In : Journal of Investigative Dermatology. 130, p. S1-S1 1 p.

Research output: Contribution to journalBook/Film/Article review

5 Citations (Scopus)

High-resolution genomic profiling of human papillomavirus-associated vulval neoplasia

Purdie, K. J., Harwood, C. A., Chaplin, T., Gibbon, K., Singh, N., Young, B. D., Cazier, J. B., Leigh, I. M. & Proby, C. M., Apr 2010, In : British Journal of Dermatology. 162, 4, p. 945-945 1 p.

Research output: Contribution to journalBook/Film/Article review

Hypoxia suppresses hypoxia inducible factor pathway proteins and affects differentiation of epidermal keratinocytes

Weir, L., Robertson, D., Leigh, I. M. & Panteleyev, A., Apr 2010, In : British Journal of Dermatology. 162, 4, p. 928-928 1 p.

Research output: Contribution to journalBook/Film/Article review

Identification of polo-like kinase 1 as a potential therapeutic target in squamous cell carcinoma

Watt, S. A., Pourreyron, C., Foerster, J., Hogan, C., Purdie, K., Bruckner-Tuderman, L., Proby, C., McGrath, J. A., Leigh, I. M. & South, A. P., Apr 2010, In : British Journal of Dermatology. 162, 4, p. 923-923 1 p.

Research output: Contribution to journalBook/Film/Article review

Identification of therapeutic and prognostic biomarkers in keratinocyte carcinogenesis

Gulati, A., Harwood, C. A., Purdie, K., Leigh, I. M., Kelsell, D. P. & Proby, C. M., Apr 2010, In : British Journal of Dermatology. 162, 4, p. 949-949 1 p.

Research output: Contribution to journalBook/Film/Article review

Increased type VII collagen in adipose-derived stem cell-keratinocyte co-culture compared with dermal fibroblast co-culture is dependent on MMP3

Pourreyron, C., Cole, C., McGrath, J. A., Leigh, I. M. & South, A. P., 2010, In : British Journal of Dermatology. 162, 4, p. 915 1 p.

Research output: Contribution to journalBook/Film/Article review

p63 is implicated in apoptotic dysregulation in melanoma

Matin, R. N., Chikh, A., Warnes, G., Proby, C. M., Leigh, I. M., Harwood, C. A. & Bergamaschi, D., Apr 2010, In : British Journal of Dermatology. 162, 4, p. 921-921 1 p.

Research output: Contribution to journalBook/Film/Article review

Polo-like kinase 1 inhibitors hold potential as targeted therapies for squamous cell carcinoma

Watt, S., Pourreyron, C., Foerster, J., Hogan, C., Purdie, K., Bruckner-Tuderman, L., Proby, C., McGrath, J., Leigh, I. & South, A., Sep 2010, In : Journal of Investigative Dermatology. 130, p. S51-S51 1 p.

Research output: Contribution to journalBook/Film/Article review

Protein tyrosine phosphatase receptor type delta (PTPRD) is expressed in normal and cutaneous squamous cell carcinoma-derived keratinocytes

Romanowska, M., Proby, C. M., Lambert, S. R., Purdie, K., Gulati, A., Leigh, I. M., Harwood, C. A. & Foerster, J., Apr 2010, In : British Journal of Dermatology. 162, 4, p. 945-946 2 p.

Research output: Contribution to journalBook/Film/Article review

PTPRD microdeletions are associated with metastatic cutaneous squamous cell carcinoma

Lambert, S. R., Purdie, K., Gulati, A., Leigh, I. M., Kelsell, D. P., Harwood, C. A. & Proby, C., Apr 2010, In : British Journal of Dermatology. 162, 4, p. 923-924 2 p.

Research output: Contribution to journalBook/Film/Article review

The control of epidermal differentiation gene expression by ARNT through EGFR- and HDAC-dependent pathways

Robertson, D., Weir, L., Leigh, I. M. & Panteleyev, A. A., Apr 2010, In : Journal of Investigative Dermatology. 130, p. S75-S75 1 p.

Research output: Contribution to journalBook/Film/Article review

Tumour microenvironment is implicated by dermal fibroblast expression profiling in the development of aggressive squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa

Ng, Y. Z., Pourreyron, C., Salas-Alanis, J. C., Murrell, D. F., McGrath, J. A., Lane, E. B., Leigh, I. & South, A., Sep 2010, In : Journal of Investigative Dermatology. 130, p. S83-S83 1 p.

Research output: Contribution to journalBook/Film/Article review

Viral Oncogenesis and Skin Cancers

Proby, C., Harwood, C., Storey, A. & Leigh, I., Sep 2010, In : Journal of Pathology. 222, p. S14-S15 2 p.

Research output: Contribution to journalBook/Film/Article review

2009

Adipose derived stem cells up-regulate type VII collagen in the presence of recessive dystrophic epidermolysis bullosa keratinocytes

Pourreyron, C., Cole, C. L., McGrath, J. A., Leigh, I. M. & South, A. P., Sep 2009, In : Journal of Investigative Dermatology. 129, p. S48-S48 1 p.

Research output: Contribution to journalBook/Film/Article review

DUSP23, SLCO1B3, SNURF, SNRPN and TJAP1 are genes with differential expression in squamous cell carcinoma keratinocytes derived from patients with recessive dystrophic epidermolysis bullosa

Cole, C. L., Foerster, J., Pourreyron, C., Purdie, K., Hogan, C., Proby, C., Bruckner-Tuderman, L., McGrath, J. A., Leigh, I. M. & South, A. P., Apr 2009, In : British Journal of Dermatology. 160, 4, p. 906-906 1 p.

Research output: Contribution to journalBook/Film/Article review

Quiescent cultured keratinocytes derived from squamous cell carcinoma retain a cancer-specific gene expression signature capable of differentiating squamous cell carcinoma from normal skin in vivo

Pourreyron, C., Foerster, J., Hogan, C., Purdie, K., Bruckner-Tuderman, L., Proby, C., McGrath, J. A., Leigh, I. M. & South, A. P., Sep 2009, In : Journal of Investigative Dermatology. 129, p. S73-S73 1 p., 426[Oral077].

Research output: Contribution to journalBook/Film/Article review

Recombinant type VII collagen significantly increases transwell migration in squamous cell carcinoma keratinocytes isolated from patients with recessive dystrophic epidermolysis bullosa

Pourreyron, C., Hogan, C., Cole, C. L., Bruckner-Tuderman, L., McGrath, J. A., Leigh, I. M. & South, A. P., Apr 2009, In : British Journal of Dermatology. 160, 4, p. 925-925 1 p.

Research output: Contribution to journalBook/Film/Article review

SLCO1B3 expression in recessive dystrophic epidermolysis bullosa associated squamous cell carcinoma is reduced by recombinant type VII collagen

Cole, C. L., Pourreyron, C., Foerster, J., Purdie, K., Salas-Alanis, J. C., Murrell, D. F., Bruckner-Tuderman, L., McGrath, J. A., Leigh, I. M. & South, A. P., Sep 2009, In : Journal of Investigative Dermatology. 129, p. S57-S57 1 p., 325.

Research output: Contribution to journalBook/Film/Article review

2008

Gene expression profiling of cultured squamous cell carcinoma keratinocytes identifies a pattern of gene expression which predicts invasive capacity

South, A. P., Pourreyron, C., Foerster, J., Mao, X., Purdie, K., Hogan, C., Mein, C., Bruckner-Tuderman, L., Proby, C. M., Young, B., Kelsell, D. P., McGrath, J. A. & Leigh, I. M., Apr 2008, In : British Journal of Dermatology. 158, 4, p. 883-883 1 p.

Research output: Contribution to journalBook/Film/Article review

Identification of genomic and epi-genomic lesions in squamous cell carcinomas using expression profiling of quiescent cultured keratinocytes

Pourreyron, C., Foerster, J., Mao, X., Purdie, K., Bruckner-Tuderman, L., Proby, C., McGrath, J., Leigh, I. & South, A., Apr 2008, In : Journal of Investigative Dermatology. 128, p. S36-S36 1 p.

Research output: Contribution to journalBook/Film/Article review

Squamous cell carcinoma keratinocytes isolated from patients with recessive dystrophic epidermolysis bullosa invade collagen-matrigel organotypic skin equivalents in an autonomous fashion

Pourreyron, C., Purdie, K., Bruckner-Tuderman, L., Proby, C. M., McGrath, J. A., Leigh, I. M. & South, A. P., Apr 2008, In : British Journal of Dermatology. 158, 4, p. 911-911 1 p.

Research output: Contribution to journalBook/Film/Article review