McLean, Irwin

Research output

Research output per year 1994 2008 2009 2010 2011 2012 2013 2014 2015 2021

• 165 Article
• 37 Letter
• 31 Book/Film/Article review
• 12 Meeting abstract
• 22 More
  • 9 Review article
  • 4 Comment/debate
  • 3 Conference contribution
  • 3 Editorial
  • 2 Patent
  • 1 Special issue

Research output per year

Research output per year

Search results

• 2011

  Copy number variation within the filaggrin gene contributes to risk of atopic dermatitis

  Brown, S. J., Kroboth, K., Sandilands, A., Campbell, L. E., Pohler, E., Irvine, A. D., Cordell, H. J. & McLean, W., Apr 2011, In: Journal of Investigative Dermatology. 131, Supplement 1, p. S63-S63 1 p., 375.

  Research output: Contribution to journal › Book/Film/Article review › peer-review
  2 Citations (Scopus)

• Developing small molecule drugs to rescue nonsense mutations in disease-causing genes

  Nomura, T., Gartner, U., McElroy, S., Torrie, L., Pourreyron, C., South, A. P., Wood, G., Woodland, A., Frearson, J., Wyatt, P. & McLean, I., Apr 2011, In: Journal of Investigative Dermatology. 131, p. S67-S67 1 p., 397.

  Research output: Contribution to journal › Book/Film/Article review › peer-review
  1 Citation (Scopus)

• Environmental influences on a model of atopic dermatitis

  Fahy, C. M., McLean, W. H., Irvine, A. D. & Fallon, P. G., Apr 2011, In: Journal of Investigative Dermatology. 131, p. S61-S61 1 p.

  Research output: Contribution to journal › Book/Film/Article review › peer-review
  2 Citations (Scopus)

• Mutation-specific small-interfering RNA therapy for epidermolysis bullosa simplex

  Defty, C. L., Atkinson, S. D., McGilligan, V. E., Liao, H., Szeverenyi, I., Smith, F. J. D., Moore, C. B. T., McLean, W. H. I. & Heagerty, A. H. M., 2011, In: British Journal of Dermatology. 165, S1, p. 39 1 p., P-46.

  Research output: Contribution to journal › Book/Film/Article review › peer-review

• Variation in the development of phenotype in filaggrin-deficiency: a murine model of atopic dermatitis

  Fahy, C. M. R., McLean, W. H. I., Irvine, A. D. & Fallon, P. G., 11 Apr 2011, In: British Journal of Dermatology. 164, 4, p. 906-906 1 p., 05.

  Research output: Contribution to journal › Book/Film/Article review › peer-review
• 2010

  Additional genes involved in epidermolysis bullosa simplex

  Pohler, E., Terron-Kwiatkowski, A., Baty, D. U., Mellerio, J. E. & McLean, W. H. I., Apr 2010, In: British Journal of Dermatology. 162, 4, p. 939-940 2 p., P34.

  Research output: Contribution to journal › Book/Film/Article review › peer-review

• Allele-specific siRNA therapy for epidermolysis bullosa simplex

  Atkinson, S., McGilligan, V. E., Liao, H., Moore, T. C. & McLean, W. H. I., Apr 2010, In: British Journal of Dermatology. 162, 4, p. 926-926 1 p., Abstract O33.

  Research output: Contribution to journal › Book/Film/Article review › peer-review

• A wide spectrum of filaggrin mutations contribute to ichthyosis vulgaris and atopic dermatitis in the Singaporean Chinese population

  Chen, H., Common, J. E. A., Haines, R. L., Balakrishnan, A., Goh, C. S. M., Goh, D. M. L., Tang, M. B. Y., Van Bever, H. P., Giam, Y. C., McLean, W. H. I. & Lane, E. B., 2010, In: Journal of Investigative Dermatology. 130, p. S94 1 p., 564.

  Research output: Contribution to journal › Book/Film/Article review › peer-review

• Correction of a mutant keratin 6a gene in HEK293 cells using small oligonucleotides

  Zambrano, H., Zhou, J., Glazer, P. M., McLean, W., Leube, R. E. & Milstone, L. M., Apr 2010, In: Journal of Investigative Dermatology. 130, p. S89-S89 1 p.

  Research output: Contribution to journal › Book/Film/Article review › peer-review

• Filaggrin deficiency results in a dose-dependent impairment of the epidermal barrier in ichthyosis vulgaris

  Gruber, R., Crumrine, D., Sandilands, A., Presland, R. B., Fleckman, P., McLean, W., Janecke, A. R., Elias, P. M. & Schmuth, M., Feb 2010, In: Experimental Dermatology. 19, 2, p. 176-176 1 p.

  Research output: Contribution to journal › Book/Film/Article review › peer-review

• Filaggrin loss-of-function mutations are associated with early onset eczema, eczema severity, and transepidermal water loss at three months of age

  Flohr, C., England, K., Radulovic, S., McLean, W. H. I., Campbell, L. E., Barker, J., Perkin, M. & Lack, G., Sept 2010, In: Journal of Investigative Dermatology. 130, p. S70-S70 1 p., 420 [Oral 022].

  Research output: Contribution to journal › Book/Film/Article review › peer-review

• Novel and recurrent filaggrin gene mutations in Taiwanese ichthyosis vulgaris families

  Hsu, C.-K., Akiyama, M., Miyamura, Y., McLean, W. H. I., Lee, J.Y.-Y. & Shimizu, H., Sept 2010, In: Journal of Investigative Dermatology. 130, p. S78-S78 1 p., 467.

  Research output: Contribution to journal › Book/Film/Article review › peer-review

• Replication of eczema susceptibility loci identified from a genome-wide association study

  Brown, S. J., O'Regan, G. M., Campbell, L. E., Cordell, H. J., Irvine, A. D. & McLean, W. H. I., Apr 2010, In: British Journal of Dermatology. 162, 4, p. 925-925 1 p., O30.

  Research output: Contribution to journal › Book/Film/Article review › peer-review
• 2009

  Filaggrin-deficient mice exhibit enhanced percutaneous antigen priming

  Irvine, A. D., Fallon, P. G., Sasaki, T., Sandilands, A., Callanan, J. J., Presland, R. B., Fleckman, P., Kudoh, J., Amagai, M. & McLean, W., 2009, In: Journal of Investigative Dermatology. 129, p. S87 1 p., Abstract 519.

  Research output: Contribution to journal › Book/Film/Article review › peer-review

• Further pre-clinical characterization of TD101-the first siRNA to enter clinical trials for a skin disorder

  Hickerson, R. P., Leachman, S. A., Pho, L. N., Smith, F., McLean, W., Leake, D., Milstone, L. M. & Kaspar, R. L., Apr 2009, In: Journal of Investigative Dermatology. 129, p. S90-S90 1 p.

  Research output: Contribution to journal › Book/Film/Article review › peer-review

• Marie Unna hereditary hypotrichosis is caused by mutations of an upstream open reading frame in the human hairless gene

  Zhang, X., Wen, Y., Liu, Y., Xue, Y., Zhao, Y., Hua, R., Wang, K., Sun, M., McLean, W. & He, C., 2009, In: Journal of Investigative Dermatology. 129, s1, p. S86-S86 1 p., Abstract 512.

  Research output: Contribution to journal › Book/Film/Article review › peer-review

• Mutation-specific siRNA resolves callus in a pachyonychia congenita patient

  Leachman, S. A., Hickerson, R. P., Schwartz, M. E., Bullough, E. E., Hutcherson, S. L., Boucher, K. M., Hansen, C. D., Eliason, M. J., Srivatsa, G. S., Kornbrust, D. J., Smith, F., McLean, W., Milstone, L. M. & Kaspar, R. L., 2009, In: Journal of Investigative Dermatology. 129, p. S54 1 p., 322.

  Research output: Contribution to journal › Book/Film/Article review › peer-review

• Plectin mutations underlie epidermolysis bullosa simplex in patients with wild type KRT5 and KRT14 alleles

  Bolling, M. C., Jongbloed, J. D., Smith, F. J., McLean, I. & Jonkman, M. F., Sept 2009, In: Journal of Investigative Dermatology. 129, p. S45-S45 1 p., 269 [Oral 055].

  Research output: Contribution to journal › Book/Film/Article review › peer-review

• The effects of filaggrin mutations on barrier function in eczema patients

  Ghaffar, A. S., Tan, S. P., Campbell, L. E., Lee, L. H., Sergeant, A., McLean, W. & Weller, R., Sept 2009, In: Journal of Investigative Dermatology. 129, p. S15-S15 1 p.

  Research output: Contribution to journal › Book/Film/Article review › peer-review

• X-linked ichthyosis in a girl with a novel filaggrin mutation

  Ramesh, R., Rustin, M. H. A., Kukula, A. & McLean, W. H. I., Jun 2009, In: British Journal of Dermatology. 160, 6, p. 1149-1150 2 p.

  Research output: Contribution to journal › Book/Film/Article review › peer-review
• 2008

  Additional filaggrin polymorphisms in early-onset and persistent atopic eczema

  Brown, S. J., Sandilands, A., Zhao, Y., Liao, H., Relton, C. L., Meggitt, S. J., Reynolds, N. J., Barker, J. N. W. N., Trembath, R. C., Cordell, H. J. & McLean, W. H. I., Dec 2008, In: British Journal of Dermatology. 159, 6, p. 1241-1242 2 p., P4.

  Research output: Contribution to journal › Book/Film/Article review › peer-review

• A population study of common truncating polymorphisms of profilaggrin and dry skin phenotype

  Sergeant, A., Campbell, L. E., Porter, M., Hull, P. R., Smith, F. J. D., McLean, W. H. I. & Munro, C. S., Jul 2008, In: British Journal of Dermatology. 159, p. 68-69 2 p.

  Research output: Contribution to journal › Book/Film/Article review › peer-review
  25 Citations (Scopus)

• Development of a PCR-based quantitative clinical endpoint to determine the effectiveness of siRNA therapy in a phase 1b trial in pachyonychia congenita patients

  Hickerson, R. P., Leachman, S. A., Pho, L. N., Smith, F. J., Leake, D., McLean, W. & Kaspar, R. L., Apr 2008, In: Journal of Investigative Dermatology. 128, p. S129-S129 1 p., Abstract 772.

  Research output: Contribution to journal › Book/Film/Article review › peer-review

• Epidermolysis bullosa simplex with mottled pigmentation: clinical and molecular confirmation in five subjects

  Wong, T., Terron-Kwiatkowski, A., Wojnarowska, F. T., Baty, D. U., McLean, W. H. I., McGrath, J. A., Martinez, A. E. & Mellerio, J. E., Jul 2008, In: British Journal of Dermatology. 159, p. 27-27 1 p., P-8.

  Research output: Contribution to journal › Book/Film/Article review › peer-review

• Evidence for founder effect of filaggrin mutations p.R501X, c.2282del4 and p.R2447X in ichthyosis vulgaris

  Gruber, R., Janecke, A. R., Rabl, M., Oji, V., Traupe, H., Sandilands, A., McLean, W., Utermann, G., Frisch, P. O. & Schmuth, M., Mar 2008, In: Experimental Dermatology. 17, 3, p. 246-246 1 p., Abstract P027.

  Research output: Contribution to journal › Book/Film/Article review › peer-review

• Filaggrin mutations, atopic eczema, hay fever and asthma in children

  Rodriguez, E., Weidinger, S., O'Sullivan, M., Illig, T., Baurecht, H., Depner, M., Ruether, A., Klopp, N., Vogelberg, C., Weiland, S., McLean, W., von Mutius, E., Irvine, A. & Kabesch, M., 2008, In: Allergy. 63, p. 50-51 2 p., Abstract 105.

  Research output: Contribution to journal › Book/Film/Article review › peer-review

• Keratin K6c mutations cause focal keratoderma

  Wilson, N. J., Messenger, A. G., Leachmin, S. A., Lane, E. B., McLean, W. & Smith, F. J., Apr 2008, In: Journal of Investigative Dermatology. 128, p. S127-S127 1 p., Abstract 757.

  Research output: Contribution to journal › Book/Film/Article review › peer-review

• Novel mutation in desmoglein 1 (DSG1) causing autosomal dominant striate palmoplantar keratoderma

  Zamiri, M., Smith, F., Campbell, L. E., Tetley, L., McLean, W. H. I., Hodgins, M. B. & Munro, C. S., Apr 2008, In: British Journal of Dermatology. 158, 4, p. 908-909 2 p.

  Research output: Contribution to journal › Book/Film/Article review › peer-review

• Steatocystoma multiplex and persistent primary dentition due to a novel keratin 17 mutation

  Gass, J. K., Wilson, N. J., Smith, E. B. F., Lane, B., McLean, W. H. I., Salvary, I. & Burrows, N. P., 2008, In: British Journal of Dermatology. 159, S1, p. 119 1 p., PA-13.

  Research output: Contribution to journal › Book/Film/Article review › peer-review

• The genetic architecture and population genetics of filaggrin-related atopic dermatitis

  O'Regan, G. M., Irvine, A. D., Chen, H., Nomura, T., Campbell, L. E., Zhao, Y., Liao, H., Palmer, C. N., Smith, F. J., McLean, W. & Sandilands, A., Apr 2008, In: Journal of Investigative Dermatology. 128, S1, p. S128-S128 1 p.

  Research output: Contribution to journal › Book/Film/Article review › peer-review

• Unique and recurrent filaggrin mutations in Chinese ichthyosis vulgaris patients from Singapore

  Chen, H., Ho, J. C., Sandilands, A., Chan, Y. C., Giam, Y. C., Evans, A. T., Lane, E. & McLean, W., 2008, In: Journal of Investigative Dermatology. 128, p. S126 1 p., 755.

  Research output: Contribution to journal › Book/Film/Article review › peer-review