Projects per year
Personal profile
Biography
Teaching
Undergraduate teaching
- Teaching in Clinical Pharmacology/Therapeutics and Medicine
- BMSc Cardiovascular Medicine and Diabetes (2018)
Postgraduate and multidisciplinary teaching
- Educational Supervisor, CPT Training Lead for East of Scotland.
- Multidisciplinary teaching on clinical trials and cardiovascular medicine.
Research
My research focuses on improving cardiovascular outcomes and drug safety using a combination of large multicentre randomised clinical trials and pharmacoepidemiological approaches to answer important clinical research questions. I am also interested in clinical trial methodology and improving patient and physician engagement in clinical research. I have a special interest in decentralised clinical trials and I am currently the academic lead of work packages in two IMI projects (Trials@Home and RealHOPE).
Research
Membership of learned societies
• British and Irish Hypertension Society (Fellow)
• British Pharmacological Society (Fellow)
• Caledonian Society of Clinical Pharmacology
• Digital Health Institute
• International Society for Pharmacoepidemiology
• Royal College of Physicians Edinburgh (Fellow)
• Scottish Heart and Arterial disease Risk Prevention (SHARP) Group
• Scottish Society of Physicians
Committee appointments and administrative roles
National:
Sports Resolutions Panel of Arbitrators and Mediators. Specialist Member of National Anti-Doping Panel (2018-2021)
Trustee of Scottish Heart and Arterial disease Risk Prevention (SHARP) Group (2015-)
British and Irish Hypertension Society Collaborative Research Working Party (2014-present)
Local:
Deputy Director of Medicines Monitoring Unit and Hypertension Research Centre
Member of Thesis Monitoring Committee, University of Dundee (2013 - present)
Member of School of Medicine Equality, Diversity and Inclusion Committee (2016 - present)
Member of Medicines Monitoring Unit Information Security Forum (2016-present)
Reviewer of potential REF outputs, Molecular and Clinical Medicine (2017-present)
Member of School of Medicine Research Management Group (2017-present)
Member of School of Medicine Commercialisation Committee (2021-present)
Regularly sit on interview panels for University of Dundee/NHS appointments
Trial Steering Committees:
Standard care versus Celecoxib Outcome Trial (SCOT)
Febuxostat versus Allopurinol Streamlined Trial (FAST)
Prevention And Treatment of Resistant Hypertension With Algorithm based TherapY (PATHWAY) 1, 2 and 3 – University of Cambridge, Cambridge (BHF)
Allopurinol and cardiovascular outcomes in patients with ischaemic heart disease (ALL-HEART)
Treatment in the Morning vs the Evening study (TIME)
Lowering Events in Non-proliferative retinopathy in Scotland (LENS), University of Oxford, Oxford
Co-vice chair ASCEND PLUS steering committee (University of Oxford)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Keywords
- R Medicine (General)
- pharmacoepidemiology
- Drug Safety
- randomised clinical trials
- clinical trial methodology
- cardiovascular outcomes
Fingerprint
- 1 Similar Profiles
Network
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Real World Handling of Protein Drugs - Exploration, Evaluation and Education (RealHOPE) (joint with Research Institutes of Sweden (lead), Centre for Process Innovation Limited, Lunds University, University College London, University of Padua and 10 other organisations)
De Paoli, G., MacDonald, T. & Mackenzie, I.
COMMISSION OF THE EUROPEAN COMMUNITIES
1/07/21 → 30/06/25
Project: Research
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The Impact of EU Label Changes for Diclofenac
MacDonald, T., Mackenzie, I. & Morales, D.
6/09/17 → 5/03/19
Project: Research
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A cross-sectional survey on the early impact of COVID-19 on the uptake of decentralised trial methods in the conduct of clinical trials
Suman, A., van Es, J., Gardarsdottir, H., Grobbee, D. E., Hawkins, K., Heath, M. A., Mackenzie, I. S., van Thiel, G. & Zuidgeest, M. G. P., 6 Oct 2022, In: Trials. 23, 12 p., 856.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Downloads (Pure) -
Adverse events and overall health and wellbeing after COVID-19 vaccination: interim results from the VAC4COVID cohort safety study
Rogers, A., Rooke, E., Morant, S., Guthrie, G., Doney, A., Duncan, A., Mackenzie, I., Barr, R., Pigazzani, F., Zutis, K. & MacDonald, T., 1 Jun 2022, In: BMJ Open. 12, 6, 10 p., e060583.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)16 Downloads (Pure) -
Allopurinol versus usual care in UK patients with ischaemic heart disease (ALL-HEART): a multicentre, prospective, randomised, open-label, blinded-endpoint trial
Mackenzie, I. S., Hawkey, C. J., Ford, I., Greenlaw, N., Pigazzani, F., Rogers, A., Struthers, A. D., Begg, A. G., Wei, L., Avery, A. J., Taggar, J. S., Walker, A., Duce, S. L., Barr, R. J., Dumbleton, J. S., Rooke, E. D., Townend, J. N., Ritchie, L. D., MacDonald, T. M. & ALL-HEART study group, 8 Oct 2022, In: The Lancet. 400, 10359, p. 1195-1205 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)14 Downloads (Pure) -
A secondary qualitative analysis of stakeholder views about participant recruitment, retention, and adherence in decentralised clinical trials (DCTs)
Coyle, J., Rogers, A., Copland, R., De Paoli, G., MacDonald, T. M. & Mackenzie, I. S., 30 Jul 2022, In: Trials. 23, 11 p., 614.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Downloads (Pure) -
A Systematic Review of Methods used to Conduct Decentralised Clinical Trials
Rogers, A., De Paoli, G., Subbarayan, S., Copland, R., Harwood, K., Coyle, J., Mitchell, L., MacDonald, T. M. & Mackenzie, I. S., Jun 2022, In: British Journal of Clinical Pharmacology. 88, 6, p. 2843-2862 20 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)133 Downloads (Pure)
Prizes
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Grahame-Smith Prize for Clinical Pharmacology
Mackenzie, Isla (Recipient), 2018
Prize: Prize (including medals and awards)
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Activities
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ALL-HEART study - hotline presentation
Isla Mackenzie (Speaker)
27 Aug 2022Activity: Talk or presentation types › Invited talk
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Decentralised clinical trials
Isla Mackenzie (Speaker)
6 Oct 2022Activity: Talk or presentation types › Invited talk
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Talk to Rotary Club of Dundee about Blood Pressure
Isla Mackenzie (Member)
17 Mar 2022Activity: Other activity types › Public engagement and outreach - public lecture/debate/seminar
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DCT Case Studies
Amy Rogers (Invited speaker), Isla Mackenzie (Chair) & Kazem Rahimi (Invited speaker)
8 Jun 2022Activity: Talk or presentation types › Keynote
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Qualitative research on real handling of protein drug products in RealHOPE
Giorgia De Paoli (Speaker), Thomas MacDonald (Contributor), Lyn Mitchell (Contributor), Shanti Shanmugananthan (Contributor), Angela Flynn (Contributor), Marie Walhgreen (Contributor), Stephen Burleigh (Contributor) & Isla Mackenzie (Contributor)
31 Mar 2022Activity: Talk or presentation types › Oral presentation
Press/Media
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High salt levels in common medicines put patients at increased risk of cardiovascular events
Jacob George, Thomas M MacDonald & Isla S. Mackenzie
26/11/13
1 item of Media coverage
Press/Media: Research