Projects per year
Personal profile
Biography
Teaching
Isla Mackenzie contributes to undergraduate, postgraduate and multidisciplinary teaching and examining.
Research
My research focuses on improving cardiovascular outcomes and drug safety using a combination of large multicentre randomised clinical trials and pharmacoepidemiological approaches to answer important clinical research questions. I am also interested in clinical trial methodology and improving patient and physician engagement in clinical research. I have a special interest in decentralised clinical trials and I am currently the academic lead of work packages in two IMI projects (Trials@Home and RealHOPE).
Research
Membership of learned societies
• British and Irish Hypertension Society (Fellow)
• British Pharmacological Society (Fellow)
• Caledonian Society of Clinical Pharmacology
• Digital Health Institute
• International Society for Pharmacoepidemiology
• Royal College of Physicians Edinburgh (Fellow)
• Scottish Heart and Arterial disease Risk Prevention (SHARP) Group
• Scottish Society of Physicians
Committee appointments and administrative roles
National:
Sports Resolutions Panel of Arbitrators and Mediators. Specialist Member of National Anti-Doping Panel (2018-present)
Trustee of Scottish Heart and Arterial disease Risk Prevention (SHARP) Group (2015-)
British and Irish Hypertension Society Collaborative Research Working Party (2014-present)
Local:
Deputy Director of Medicines Monitoring Unit and Hypertension Research Centre
Member of Thesis Monitoring Committee, University of Dundee (2013 - present)
Member of School of Medicine Equality, Diversity and Inclusion Committee (2016 - 2023)
Reviewer of potential REF outputs, Molecular and Clinical Medicine (2017-2023)
Member of School of Medicine Research Management Group (2017-2023). Chair (2023-present)
Member of School of Medicine Commercialisation Committee (2021-present)
Regularly sit on interview panels for University of Dundee/NHS appointments
Trial Steering Committees:
Standard care versus Celecoxib Outcome Trial (SCOT)
Febuxostat versus Allopurinol Streamlined Trial (FAST)
Prevention And Treatment of Resistant Hypertension With Algorithm based TherapY (PATHWAY) 1, 2 and 3 – University of Cambridge, Cambridge (BHF)
Allopurinol and cardiovascular outcomes in patients with ischaemic heart disease (ALL-HEART)
Treatment in the Morning vs the Evening study (TIME)
Lowering Events in Non-proliferative retinopathy in Scotland (LENS), University of Oxford, Oxford
Blood Donors Studies Steering Committee, University of Cambridge, Cambridge
Co-vice chair ASCEND PLUS steering committee (University of Oxford)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Keywords
- R Medicine (General)
- pharmacoepidemiology
- Drug Safety
- randomised clinical trials
- clinical trial methodology
- cardiovascular outcomes
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
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Enabling more and better trials through effective use of health data
Mackenzie, I. (Investigator)
1/04/23 → 31/03/28
Project: Research
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Real World Handling of Protein Drugs - Exploration, Evaluation and Education (RealHOPE) (joint with Research Institutes of Sweden (lead), Centre for Process Innovation Limited, Lunds University, University College London, University of Padua and 10 other organisations)
De Paoli, G. (Investigator), MacDonald, T. (Investigator) & Mackenzie, I. (Investigator)
COMMISSION OF THE EUROPEAN COMMUNITIES
1/07/21 → 30/06/25
Project: Research
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Applicability of hypertension treatment recommendations for the prevention and management of multimorbidity in people with health inequalities
Cole, C. (Investigator), Mackenzie, I. (Investigator) & Morales, D. (Investigator)
Project: Research
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Allopurinol and cardiovascular outcomes in patients with ischaemic heart disease: the ALL-HEART RCT and economic evaluation
Mackenzie, I. S. (Lead / Corresponding author), Hawkey, C. J., Ford, I., Greenlaw, N., Pigazzani, F., Rogers, A., Struthers, A. D., Begg, A. G., Wei, L., Avery, A. J., Taggar, J. S., Walker, A., Duce, S. L., Barr, R. J., Dumbleton, J. S., Rooke, E. D., Townend, J. N., Ritchie, L. D., MacDonald, T. M. & ALL-HEART study group, Mar 2024, In: Health Technology Assessment. 28, 18, 86 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)84 Downloads (Pure) -
Effect of statin treatment on the risk of cancer in patients with heart failure: A target trial emulation study
Ju, C., Lau, W. C. Y., Chambers, P., Man, K. K. C., Forster, M. D., Mackenzie, I. S., Manisty, C. & Wei, L. (Lead / Corresponding author), Mar 2024, In: Pharmacoepidemiology and Drug Safety. 33, 3, 12 p., e5775.Research output: Contribution to journal › Article › peer-review
Open AccessFile79 Downloads (Pure) -
Effect of timed dosing of usual antihypertensives according to patient chronotype on cardiovascular outcomes: the Chronotype sub-study cohort of the Treatment in Morning versus Evening (TIME) study
Pigazzani, F. (Lead / Corresponding author), Dyar, K. A. (Lead / Corresponding author), Morant, S. V., Vetter, C., Rogers, A., Flynn, R. W. V., Rorie, D. A., Mackenzie, I. S., Cappuccio, F. P., Manfredini, R. & MacDonald, T. M., Jul 2024, In: eClinicalMedicine. 72, 12 p., 102633.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)56 Downloads (Pure) -
Getting our ducks in a row: The need for data utility comparisons of healthcare systems data for clinical trials
Sydes, M. R. (Lead / Corresponding author), Murray, M. L., Ahmed, S., Apostolidou, S., Bliss, J. M., Bloomfield, C., Cannings-John, R., Carpenter, J., Clayton, T., Clout, M., Cosgriff, R., Farrin, A. J., Gentry-Maharaj, A., Gilbert, D. C., Harper, C., James, N. D., Langley, R. E., Lessels, S., Lugg-Widger, F. & Mackenzie, I. S. & 8 others, , Jun 2024, In: Contemporary Clinical Trials. 141, 8 p., 107514.Research output: Contribution to journal › Article › peer-review
Open AccessFile48 Downloads (Pure) -
Impact of Post Manufacturing Handling of Protein-Based Biologic Drugs on Product Quality and User Centricity
Cappelletto, E., Kwok, S. C., Sorret, L., Fuentes, N., Medina, A., Burleigh, S., Fast, J., Mackenzie, I. S., Fureby, A. M., Paulsson, M., Wahlgren, M., Elofsson, U., Flynn, A., Miolo, G., Nyström, L., De Laureto, P. P. & De Paoli, G. (Lead / Corresponding author), Aug 2024, In: Journal of Pharmaceutical Sciences. 113, 8, p. 2055-2064 10 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile8 Downloads (Pure)
Prizes
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Grahame-Smith Prize for Clinical Pharmacology
Mackenzie, I. (Recipient), 2018
Prize: Prize (including medals and awards)
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Activities
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27th Scottish Cardiovascular Forum
Murdoch, C. (Organiser), Pitt, S. J. (Organiser), Mackenzie, I. (Keynote/plenary speaker) & Crossman, D. (Keynote/plenary speaker)
3 Feb 2024Activity: Participating in or organising an event types › Participation in conference
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Guest clinical trialist for American College of Cardiology (ACC) Medical Student Community Journal Club.
Mackenzie, I. (Participant)
12 Oct 2023Activity: Participating in or organising an event types › Participation in workshop, seminar, course
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Decentralised clinical trials
Mackenzie, I. (Speaker)
17 Mar 2023Activity: Talk or presentation types › Invited talk
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British and Irish Hypertension Society Annual Scientific Meeting
Mackenzie, I. (Participant)
19 Sept 2023Activity: Participating in or organising an event types › Participation in conference
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Febuxostat: another repurposing drug? From hyperuricaemia to cardiovascular disease.
Mackenzie, I. (Speaker)
6 Oct 2023Activity: Talk or presentation types › Invited talk
Press/Media
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High salt levels in common medicines put patients at increased risk of cardiovascular events
George, J., MacDonald, T. M. & Mackenzie, I. S.
26/11/13
1 item of Media coverage
Press/Media: Research