Mackenzie, Isla

Professor, Professor

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Personal profile


Professor Isla Mackenzie MBChB (Honours), PhD, FRCP Edin, FBPhS is Associate Dean for Research at the School of Medicine and Professor of Cardiovascular Medicine at the University of Dundee and Honorary Consultant Physician at Ninewells Hospital, Dundee.  Research interests include cardiovascular safety of drugs, clinical trials, hypertension and technology in research. Clinical interests include hypertension and adrenal disorders including phaeochromocytoma. Prof Mackenzie has led a number of randomised clinical trials and sits on several trial steering committees.



Isla Mackenzie contributes to undergraduate, postgraduate and multidisciplinary teaching and examining.


My research focuses on improving cardiovascular outcomes and drug safety using a combination of large multicentre randomised clinical trials and pharmacoepidemiological approaches to answer important clinical research questions. I am also interested in clinical trial methodology and improving patient and physician engagement in clinical research. I have a special interest in decentralised clinical trials and I am currently the academic lead of work packages in two IMI projects (Trials@Home and RealHOPE).


Membership of learned societies

•    British and Irish Hypertension Society (Fellow)
•    British Pharmacological Society (Fellow)
•    Caledonian Society of Clinical Pharmacology
•    Digital Health Institute
•    International Society for Pharmacoepidemiology
•    Royal College of Physicians Edinburgh (Fellow)
•    Scottish Heart and Arterial disease Risk Prevention (SHARP) Group
•    Scottish Society of Physicians

Committee appointments and administrative roles


Sports Resolutions Panel of Arbitrators and Mediators. Specialist Member of National Anti-Doping Panel (2018-present)
Trustee of Scottish Heart and Arterial disease Risk Prevention (SHARP) Group (2015-)
British and Irish Hypertension Society Collaborative Research Working Party (2014-present)
Deputy Director of Medicines Monitoring Unit and Hypertension Research Centre
Member of Thesis Monitoring Committee, University of Dundee (2013 - present)
Member of School of Medicine Equality, Diversity and Inclusion Committee (2016 - 2023)
Reviewer of potential REF outputs, Molecular and Clinical Medicine (2017-2023)
Member of School of Medicine Research Management Group (2017-2023). Chair (2023-present)

Member of School of Medicine Commercialisation Committee (2021-present)
Regularly sit on interview panels for University of Dundee/NHS appointments
Trial Steering Committees:

Standard care versus Celecoxib Outcome Trial (SCOT)
Febuxostat versus Allopurinol Streamlined Trial (FAST)
Prevention And Treatment of Resistant Hypertension With Algorithm based TherapY (PATHWAY) 1, 2 and 3 – University of Cambridge, Cambridge (BHF)
Allopurinol and cardiovascular outcomes in patients with ischaemic heart disease (ALL-HEART)
Treatment in the Morning vs the Evening study (TIME)
Lowering Events in Non-proliferative retinopathy in Scotland (LENS), University of Oxford, Oxford

Blood Donors Studies Steering Committee, University of Cambridge, Cambridge

Co-vice chair ASCEND PLUS steering committee (University of Oxford)



Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being
  • SDG 9 - Industry, Innovation, and Infrastructure
  • SDG 16 - Peace, Justice and Strong Institutions
  • SDG 17 - Partnerships for the Goals


  • R Medicine (General)
  • pharmacoepidemiology
  • Drug Safety
  • randomised clinical trials
  • clinical trial methodology
  • cardiovascular outcomes


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