Personal profile
Biography
Teaching
Isla contributes to undergraduate, postgraduate and multidisciplinary teaching and examining.
Research
Her research focuses on improving cardiovascular outcomes and drug safety and efficacy using a combination of clinical trials and pharmacoepidemiological approaches to answer important clinical research questions. She has a particular interest in decentralised clinical trials and was the academic lead of a work package in the European IMI Trials@Home project (2019-2025).
Fellowship of learned societies
• British and Irish Hypertension Society (Fellow)
• British Pharmacological Society (Fellow)
• Royal College of Physicians Edinburgh (Fellow)
Committee appointments
National:
Sports Resolutions Panel of Arbitrators and Mediators. Specialist Member of National Anti-Doping Panel (2018-present)
Vice-chair and trustee of Scottish Heart and Arterial disease Risk Prevention (SHARP) Group (2015-)
British and Irish Hypertension Society Collaborative Research Working Party (2014-present)
Trial Steering Committees:
Chair of SUPPORT steering committee, Trinity College Dublin.
Co-vice chair of ASCEND PLUS steering committee, University of Oxford.
Member of LENS steering committee, University of Oxford.
Member of Blood Donors Studies Steering Committee, University of Cambridge.
Member of OCCUR steering committee, University of Keele.
Data Monitoring Committees:
Chair of CARE-UK data monitoring committee, Imperial College, London.
Chair of WAVE data monitoring committee, Queen Mary University of London.
Member of AFFECT data monitoring committee, University of Newcastle.
Keywords
- R Medicine (General)
- pharmacoepidemiology
- Drug Safety
- randomised clinical trials
- clinical trial methodology
- cardiovascular outcomes
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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SDG 4 Quality Education
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SDG 9 Industry, Innovation, and Infrastructure
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SDG 16 Peace, Justice and Strong Institutions
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SDG 17 Partnerships for the Goals
Fingerprint
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Collaborations and top research areas from the last five years
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Enabling more and better trials through effective use of health data
Mackenzie, I. (Investigator)
1/04/23 → 31/03/29
Project: Research
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Applicability of hypertension treatment recommendations for the prevention and management of multimorbidity in people with health inequalities
Cole, C. (Investigator), Mackenzie, I. (Investigator) & Morales, D. (Investigator)
Project: Research
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Real World Handling of Protein Drugs - Exploration, Evaluation and Education (RealHOPE) (joint with Research Institutes of Sweden (lead), Centre for Process Innovation Limited, Lunds University, University College London, University of Padua and 10 other organisations)
De Paoli, G. (Investigator), MacDonald, T. (Investigator) & Mackenzie, I. (Investigator)
COMMISSION OF THE EUROPEAN COMMUNITIES
1/07/21 → 30/06/25
Project: Research
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Why and how do we perform physical examination(s) in clinical trials? A use case of drug intervention trials in type 2 diabetes mellitus
Kopanz, J., Rogers, A., Pérez-Breva, L., Hall, E., Devaiah, P., Mackenzie, I. S., Lagerwaard, B., Grobbee, D. E., Zuidgeest, M. G. P. (Lead / Corresponding author) & Trials@Home Consortium, Jan 2026, In: British Journal of Clinical Pharmacology. 92, 1, p. 280-290 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile22 Downloads (Pure) -
Bringing Trial Activities to Participants—The Trials@Home RADIAL Proof-of-Concept Trial Investigating Decentralization of Trials
Zuidgeest, M. G. P. (Lead / Corresponding author), Heath, M., Lagerwaard, B., van Weelij, D. R., Rutgrink, L., Hanke, S., Vedenkannas, T., Kosonen, T., Collamati, S., Fons-Martínez, J., Veen, D., Gardarsdottir, H., Mackenzie, I. S., Dupont, S., Grobbee, D. E. & Trials@Home Consortium, 1 Sept 2025, (E-pub ahead of print) In: Clinical Pharmacology & Therapeutics. 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Link opens in a new tab Citations (Scopus)8 Downloads (Pure) -
Clinical trials reimagined: Integrating community engagement and artificial intelligence
Mackenzie, I. S., Brewer, L. C. & Zhavoronkov, A., 13 Jun 2025, In: Med. 6, 6, 100743.Research output: Contribution to journal › Comment/debate › peer-review
1 Link opens in a new tab Citation (Scopus) -
Comparative effectiveness and prescribing trends of modified release versus immediate release indapamide in patients with hypertension: cohort study
Yan, V. K. C., Ju, C., MacDonald, T. M., Mackenzie, I. S., Flynn, R., Williams, B., Chen, Y., Chan, E. W., George, J. & Wei, L. (Lead / Corresponding author), Feb 2025, In: BMJ Medicine. 4, 1, 13 p., e000857.Research output: Contribution to journal › Article › peer-review
Open AccessFile75 Downloads (Pure) -
Cost-effectiveness of fenofibrate versus standard care for reducing the progression of diabetic retinopathy: An economic evaluation based on data from the LENS trial
Scotland, G. (Lead / Corresponding author), Tsehaye, M., Styles, C., Logue, J., Sammons, E., Zayed, M., Emberson, J., Wallendszus, K., Wade, R., Stevens, W., Cretney, R., Harding, S., Leese, G., Currie, G., Armitage, J., Preiss, D. (Lead / Corresponding author) & The LENS Collaborative Group, Sept 2025, In: Diabetic Medicine. 42, 9, 14 p., e70098.Research output: Contribution to journal › Article › peer-review
Open AccessFile39 Downloads (Pure)
Prizes
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Grahame-Smith Prize for Clinical Pharmacology
Mackenzie, I. (Recipient), 2018
Prize: Prize (including medals and awards)
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Activities
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Handling of protein medications by patients: what really happens and what are the challenges?
Mackenzie, I. (Speaker)
13 May 2025Activity: Talk or presentation types › Invited talk
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How to be a Great CI – my story
Mackenzie, I. (Speaker)
9 Oct 2025Activity: Talk or presentation types › Invited talk
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Pragmatic clinical trials.
Mackenzie, I. (Speaker)
1 Dec 2025Activity: Talk or presentation types › Invited talk
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Decentralised Clinical Trials
Mackenzie, I. (Speaker)
11 Dec 2025Activity: Talk or presentation types › Invited talk
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Fitzgerald Peel Lecture. Making medicines safer – lessons from clinical trials and real world data.
Mackenzie, I. (Speaker)
18 Sept 2025Activity: Talk or presentation types › Keynote
Press/Media
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High salt levels in common medicines put patients at increased risk of cardiovascular events
George, J., MacDonald, T. M. & Mackenzie, I. S.
26/11/13
1 item of Media coverage
Press/Media: Research