Cantley, James


  • 796 Citations
  • 18 h-Index
If you made any changes in Pure these will be visible here soon.

Personal profile

Research interests

Beta cell biology

Pancreatic beta cells are responsible for secreting adequate amounts of insulin into the blood stream to maintain glucose homeostasis. Beta cells have a remarkable capacity to adapt to metabolic challenges, such as obesity, and to increase their secretory output accordingly. However, failure of beta cells to match secretory output with demand results in hyperglycaemia, type 2 diabetes and associated morbidities. Likewise, autoimmune destruction of beta cells during type 1 diabetes leads to a loss of glucose-stimulated insulin secretion resulting in dysregulated blood glucose. The global population is currently facing an obesity and diabetes epidemic, making research into this area an economic, medical and ethical priority.

The Cantley lab works at the interface of biochemistry, cell/islet biology and whole body metabolic physiology, to investigate the molecular mechanisms controlling pancreatic beta and alpha cell function. Of particular interest are how these mechanisms coordinate the pancreatic endocrine response with whole body metabolic status, how they adapt during obesity, and how they fail during diabetes. We are currently focussed on nutrient sensing (in particular lipid signalling), beta cell regeneration and viral/interferon response pathways.


If you are interested in joining the lab as doctoral student or postdoc please get in contact with Dr. Cantley.

Education/Academic qualification

Doctor of Philosophy, University College London

1 Nov 20031 Mar 2007

Master in Science, Imperial College London

1 Oct 20011 Sep 2002

Bachelor of Science, University of Southampton

20 Sep 19981 Jul 2001

Fingerprint Dive into the research topics where James Cantley is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 3 Similar Profiles
Insulin Medicine & Life Sciences
Glucose Medicine & Life Sciences
Homeostasis Medicine & Life Sciences
Type 2 Diabetes Mellitus Medicine & Life Sciences
Medical problems Chemical Compounds
Lipids Medicine & Life Sciences
Obesity Medicine & Life Sciences
Protein Kinase C Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2019 2020

Research Output 2006 2019

4 Downloads (Pure)

Abcc5 Knockout Mice Have Lower Fat Mass and Increased Levels of Circulating GLP-1

Cyranka, M., Veprik, A., McKay, E. J., van Loon, N., Thijsse, A., Cotter, L., Hare, N., Saibudeen, A., Lingam, S., Pires, E., Larraufie, P., Reimann, F., Gribble, F., Stewart, M., Bentley, E., Lear, P., McCullagh, J., Cantley, J., Cox, R. D. & de Wet, H., Aug 2019, In : Obesity. 27, 8, p. 1292-1304 13 p.

Research output: Contribution to journalArticle

Open Access
Glucagon-Like Peptide 1
Knockout Mice
Glucose Tolerance Test
Clustered Regularly Interspaced Short Palindromic Repeats

Acetyl-CoA-Carboxylase 1 (ACC1) plays a critical role in glucagon and GLP1 secretion and controls whole body glucose homeostasis: Session: The endocrine role of the gut: incretins and other hormones

Veprik, A., Bakar, R. B., Vetterli, L., Ramracheya, R., Rorsman, P., Gribble, F. M., Reimann, F., de Wet, H. & Cantley, J., 19 Sep 2019, p. Abstract # 473.

Research output: Contribution to conferenceAbstract

Correction: Q&A: insulin secretion and type 2 diabetes: Why do β-cells fail? (BMC Biology (2015) 13 (33) DOI: 10.1186/s12915-015-0140-6)

Cantley, J. & Ashcroft, F. M., 9 Apr 2019, In : BMC Biology. 17, 1, 32.

Research output: Contribution to journalComment/debate

Open Access
research support
insulin secretion
Medical problems
noninsulin-dependent diabetes mellitus
4 Citations (Scopus)
4 Downloads (Pure)

Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass

Cantley, J., Davenport, A., Vetterli, L., Nemes, N. J., Whitworth, P. T., Boslem, E., Thai, L. M., Mellett, N., Meikle, P. J., Hoehn, K. L., James, D. E. & Biden, T. J., Jan 2019, In : Diabetologia. 62, 1, p. 99-111 13 p.

Research output: Contribution to journalArticle

Open Access
Acetyl-CoA Carboxylase
Gene Deletion

Prolyl-hydroxylase 3 maintains [beta]-cell glucose-sensing under metabolic stress

Cuozzo, F., Nasteska, D., Thakker, A., Westbrook, R., Bakar, R., Cantley, J., Tennant, D. & Hodson, D., Nov 2019, In : Endocrine Abstracts. 65, p. 217 1 p.

Research output: Contribution to journalMeeting abstract

Prolyl Hydroxylases
Physiological Stress
Fatty Acids