Projects per year
Personal profile
Research interests
Beta cell biology
Pancreatic beta cells are responsible for secreting adequate amounts of insulin into the blood stream to maintain glucose homeostasis. Beta cells have a remarkable capacity to adapt to metabolic challenges, such as obesity, and to increase their secretory output accordingly. However, failure of beta cells to match secretory output with demand results in hyperglycaemia, type 2 diabetes and associated morbidities. Likewise, autoimmune destruction of beta cells during type 1 diabetes leads to a loss of glucose-stimulated insulin secretion resulting in dysregulated blood glucose. The global population is currently facing an obesity and diabetes epidemic, making research into this area an economic, medical and ethical priority.
The Cantley lab works at the interface of cell/islet biology, biochemistry and whole body metabolic physiology, to investigate the molecular mechanisms controlling pancreatic beta and alpha cell function. Of particular interest are how these mechanisms coordinate the pancreatic endocrine response with whole body metabolic status, how they adapt during obesity, and how they fail during diabetes. We are currently focussed on nutrient sensing (in particular lipid signalling), beta cell regeneration and inflammation. Publications: https://scholar.google.com/citations?hl=en&user=-dFOnA8AAAAJ
If you are interested in joining the lab as doctoral student or postdoc please get in contact with Dr. Cantley.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, University College London
1 Nov 2003 → 1 Mar 2007
Award Date: 31 Mar 2007
Master in Science, Imperial College London
1 Oct 2001 → 1 Sep 2002
Award Date: 30 Sep 2002
Bachelor of Science, University of Southampton
20 Sep 1998 → 1 Jul 2001
Award Date: 1 Jul 2001
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Role of the GSK-3NRF2 Axis In Beta Cell Decline In Type 2 Diabetes
Cantley, J., Hayes, J., McNeilly, A. & Sutherland, C.
18/04/21 → 17/04/24
Project: Research
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The Assessment of Bioenergetic Dysfunction in Chronic Disease
Ashford, M., Cantley, J. & McNeilly, A.
1/11/20 → 31/10/22
Project: Research
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Beta Cell Neogenesis Assay Development for Drug Discovery (Year 1)
1/11/19 → 31/12/19
Project: Research
Research output
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100 years of insulin: progress, current perspectives and future challenges
Cantley, J. & Eizirik, D. L., Mar 2022, In: Journal of Endocrinology. 252, 3, p. E1-E3 3 p.Research output: Contribution to journal › Editorial › peer-review
Open AccessFile27 Downloads (Pure) -
Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion
Veprik, A., Denwood, G., Liu, D., Bany Bakar, R., Morfin, V., McHugh, K., Tebeka, N. N., Vetterli, L., Yonova-Doing, E., Gribble, F., Reimann, F., Hoehn, K. L., Hemsley, P. A., Ahnfelt-Rønne, J., Rorsman, P., Zhang, Q., de Wet, H. & Cantley, J., 18 Mar 2022, In: Communications Biology. 5, 1, 13 p., 238.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Downloads (Pure) -
Bilirubin deficiency renders mice susceptible to hepatic steatosis in the absence of insulin resistance
Chen, W., Tumanov, S., Fazarkeley, D., Cantley, J., James, D. E., Dunn, L. L., Shaik, T., Suarna, C. & Stocker, R., Nov 2021, In: Redox Biology. 47, 13 p., 102152.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)17 Downloads (Pure) -
Insights into Acetyl-Coa-Carboxylase (ACC1) Phospho-Regulation in Pancreatic Beta Cells
Bany Bakar, R., Liberatori, S., Veprik, A., Tebeka, N. N., Kemp, B. E., Mohammed, S. & Cantley, J., 1 Jun 2021, In: Diabetes. 70, Supplement 1, 1 p., 1256-P.Research output: Contribution to journal › Conference article › peer-review
Open Access -
Prolyl-4-hydroxylase 3 maintains β-cell glucose metabolism during fatty acid excess in mice
Nasteska, D., Cuozzo, F., Viloria, K., Johnson, E. M., Thakker, A., Bany Bakar, R., Westbrook, R. L., Barlow, J. P., Hoang, M., Joseph, J. W., Lavery, G. G., Akerman, I., Cantley, J., Hodson, L., Tennant, D. A. & Hodson, D. J., 23 Aug 2021, In: JCI Insight. 6, 16, 21 p., e140288.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)17 Downloads (Pure)
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Journal of Endocrinology (Journal)
James Cantley (Editor)
1 Jan 2021 → 31 Dec 2021Activity: Publication peer-review and editorial work types › Editorial activity
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beLAB1407 Drug Discovery Partnership - Steering Committee (External organisation)
James Cantley (Member)
1 Oct 2021 → …Activity: Membership types › Membership of committee
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Enterprise skills training programme -ESTP
Colin Murdoch (Organiser), James Cantley (Organiser), Brian McNicoll (Organiser) & Alison Beattie (Organiser)
1 May 2021 → 1 Jul 2021Activity: Other activity types › Other
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PhD examiner for Kings College London (external)
James Cantley (Examiner)
15 Dec 2021Activity: Examination types › Examination
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Consultancy work
James Cantley (Consultant)
1 Nov 2021 → 31 Oct 2022Activity: Consultancy types › Consultancy