Cantley, James


  • 821 Citations
  • 18 h-Index

Research output per year

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Personal profile

Research interests

Beta cell biology

Pancreatic beta cells are responsible for secreting adequate amounts of insulin into the blood stream to maintain glucose homeostasis. Beta cells have a remarkable capacity to adapt to metabolic challenges, such as obesity, and to increase their secretory output accordingly. However, failure of beta cells to match secretory output with demand results in hyperglycaemia, type 2 diabetes and associated morbidities. Likewise, autoimmune destruction of beta cells during type 1 diabetes leads to a loss of glucose-stimulated insulin secretion resulting in dysregulated blood glucose. The global population is currently facing an obesity and diabetes epidemic, making research into this area an economic, medical and ethical priority.

The Cantley lab works at the interface of biochemistry, cell/islet biology and whole body metabolic physiology, to investigate the molecular mechanisms controlling pancreatic beta and alpha cell function. Of particular interest are how these mechanisms coordinate the pancreatic endocrine response with whole body metabolic status, how they adapt during obesity, and how they fail during diabetes. We are currently focussed on nutrient sensing (in particular lipid signalling), beta cell regeneration and viral/interferon response pathways.


If you are interested in joining the lab as doctoral student or postdoc please get in contact with Dr. Cantley.

Education/Academic qualification

Doctor of Philosophy, University College London

1 Nov 20031 Mar 2007

Award Date: 31 Mar 2007

Master in Science, Imperial College London

1 Oct 20011 Sep 2002

Award Date: 30 Sep 2002

Bachelor of Science, University of Southampton

20 Sep 19981 Jul 2001

Award Date: 1 Jul 2001

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Research Output

Abcc5 Knockout Mice Have Lower Fat Mass and Increased Levels of Circulating GLP-1

Cyranka, M., Veprik, A., McKay, E. J., van Loon, N., Thijsse, A., Cotter, L., Hare, N., Saibudeen, A., Lingam, S., Pires, E., Larraufie, P., Reimann, F., Gribble, F., Stewart, M., Bentley, E., Lear, P., McCullagh, J., Cantley, J., Cox, R. D. & de Wet, H., Aug 2019, In : Obesity. 27, 8, p. 1292-1304 13 p.

Research output: Contribution to journalArticle

Open Access
  • 20 Downloads (Pure)

    Acetyl-CoA-Carboxylase 1 (ACC1) plays a critical role in glucagon and GLP1 secretion and controls whole body glucose homeostasis: Session: The endocrine role of the gut: incretins and other hormones

    Veprik, A., Bakar, R. B., Vetterli, L., Ramracheya, R., Rorsman, P., Gribble, F. M., Reimann, F., de Wet, H. & Cantley, J., 19 Sep 2019, p. Abstract # 473.

    Research output: Contribution to conferenceAbstract

    Correction: Q&A: insulin secretion and type 2 diabetes: Why do β-cells fail? (BMC Biology (2015) 13 (33) DOI: 10.1186/s12915-015-0140-6)

    Cantley, J. & Ashcroft, F. M., 9 Apr 2019, In : BMC Biology. 17, 1, 32.

    Research output: Contribution to journalComment/debate

    Open Access
  • Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass

    Cantley, J., Davenport, A., Vetterli, L., Nemes, N. J., Whitworth, P. T., Boslem, E., Thai, L. M., Mellett, N., Meikle, P. J., Hoehn, K. L., James, D. E. & Biden, T. J., Jan 2019, In : Diabetologia. 62, 1, p. 99-111 13 p.

    Research output: Contribution to journalArticle

    Open Access
  • 4 Citations (Scopus)
    37 Downloads (Pure)

    Prolyl-hydroxylase 3 maintains [beta]-cell glucose-sensing under metabolic stress

    Cuozzo, F., Nasteska, D., Thakker, A., Westbrook, R., Bakar, R., Cantley, J., Tennant, D. & Hodson, D., Nov 2019, In : Endocrine Abstracts. 65, p. 217 1 p.

    Research output: Contribution to journalMeeting abstract