James Cantley

2024

Head-to-head comparison of BAM15, semaglutide, rosiglitazone, NEN, and calorie restriction on metabolic physiology in female db/db mice

Chen, S.-Y., Beretta, M., Olzomer, E. M., Alexopoulos, S. J., Shah, D. P., Byrne, F. L., Salamoun, J. M., Garcia, C. J., Smith, G. C., Larance, M., Philp, A., Turner, N., Santos, W. L., Cantley, J. & Hoehn, K. L. (Lead / Corresponding author), Jan 2024, In: BBA - Molecular Basis of Disease. 1870, 1, 12 p., 166908.

Research output: Contribution to journal › Article › peer-review

Open Access

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2 Citations (Scopus)

112 Downloads (Pure)

Independent activation of CREB3L2 by glucose fills a regulatory gap in mouse β-cells by co-ordinating insulin biosynthesis with secretory granule formation

Sue, N., Thai, L. M., Saito, A., Boyer, C. K., Fordham, A. M., Yan, C., Davenport, A., Tao, J., Bensellam, M., Cantley, J., Shi, Y.-C., Stephens, S. B., Imaizumi, K. & Biden, T. J. (Lead / Corresponding author), Jan 2024, In: Molecular Metabolism. 79, 16 p., 101845.

Research output: Contribution to journal › Article › peer-review

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1 Citation (Scopus)

57 Downloads (Pure)

Inhibition of glycogen synthase kinase-3 enhances NRF2 protein stability, nuclear localisation and target gene transcription in pancreatic beta cells

Patibandla, C. (Lead / Corresponding author), van Aalten, L., Dinkova-Kostova, A. T., Honda, T., Cuadrado, A., Fernández-Ginés, R., McNeilly, A. D., Hayes, J. D., Cantley, J. & Sutherland, C., May 2024, In: Redox Biology. 71, 12 p., 103117.

Research output: Contribution to journal › Article › peer-review

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6 Citations (Scopus)

121 Downloads (Pure)

Methods to estimate body temperature and energy expenditure dynamics in fed and fasted laboratory mice: effects of sleep deprivation and light exposure

van der Vinne, V. (Lead / Corresponding author), McKillop, L. E., Wilcox, S. L., Cantley, J., Peirson, S. N., Swoap, S. J. & Vyazovskiy, V. V. (Lead / Corresponding author), Jun 2024, In: Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology. 194, 3, p. 369-381 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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1 Citation (Scopus)

58 Downloads (Pure)

2023

100 years of glucagon anniversary

Cantley, J., Hull, R. L. (Lead / Corresponding author) & Poitout, V., 1 Sept 2023, In: Journal of Endocrinology. 258, 3, 3 p., e230138.

Research output: Contribution to journal › Editorial › peer-review

Open Access

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3 Citations (Scopus)

100 Downloads (Pure)

Inhibition of GSK3 enhances NRF2 stability and nuclear localisation in pancreatic beta cells

Patibandla, C., Van Aalten, L., Dinkova-Kostova, A., Honda, T., McNeilly, A., Hayes, J., Cantley, J. & Sutherland, C., Apr 2023, In: Diabetic Medicine. 40, p. 48 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

Open Access

Investigating gait-responsive somatosensory cueing from a wearable device to improve walking in Parkinson’s disease

Li, D., Hallack, A., Gwilym, S., Li, D., Hu, M. T. & Cantley, J. (Lead / Corresponding author), Dec 2023, In: BioMedical Engineering OnLine. 22, 1, 22 p., 108.

Research output: Contribution to journal › Article › peer-review

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4 Citations (Scopus)

96 Downloads (Pure)

Islet cells in human type 1 diabetes: from recent advances to novel therapies - a symposium-based roadmap for future research

Cantley, J. (Lead / Corresponding author), Eizirik, D. L., Latres, E. & Dayan, C. M., 31 Aug 2023, In: Journal of Endocrinology. 259, 1, 20 p., e230082.

Research output: Contribution to journal › Review article › peer-review

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4 Citations (Scopus)

71 Downloads (Pure)

Metabolic regulation of glucagon secretion

Armour, S. L., Stanley, J. E., Cantley, J. (Lead / Corresponding author), Dean, E. D. (Lead / Corresponding author) & Knudsen, J. G. (Lead / Corresponding author), 8 Sept 2023, In: Journal of Endocrinology. 259, 1, 15 p., e230081.

Research output: Contribution to journal › Review article › peer-review

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4 Citations (Scopus)

108 Downloads (Pure)

Targeting negative energy balance with calorie restriction and mitochondrial uncoupling in db/db mice

Chen, S.-Y., Beretta, M., Olzomer, E. M., Shah, D. P., Wong, D. Y. H., Alexopoulos, S. J., Aleksovska, I., Salamoun, J. M., Garcia, C. J., Cochran, B. J., Rye, K.-A., Smith, G. C., Byrne, F. L., Morris, M. J., Santos, W. L., Cantley, J. & Hoehn, K. L. (Lead / Corresponding author), Mar 2023, In: Molecular Metabolism. 69, 13 p., 101684.

Research output: Contribution to journal › Article › peer-review

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8 Citations (Scopus)

107 Downloads (Pure)

2022

100 years of insulin: progress, current perspectives and future challenges

Cantley, J. (Lead / Corresponding author) & Eizirik, D. L., Mar 2022, In: Journal of Endocrinology. 252, 3, p. E1-E3 3 p.

Research output: Contribution to journal › Editorial › peer-review

Open Access

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105 Downloads (Pure)

Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion

Veprik, A., Denwood, G., Liu, D., Bany Bakar, R., Morfin, V., McHugh, K., Tebeka, N. N., Vetterli, L., Yonova-Doing, E., Gribble, F., Reimann, F., Hoehn, K. L., Hemsley, P. A., Ahnfelt-Rønne, J., Rorsman, P., Zhang, Q., de Wet, H. & Cantley, J. (Lead / Corresponding author), 18 Mar 2022, In: Communications Biology. 5, 1, 13 p., 238.

Research output: Contribution to journal › Article › peer-review

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18 Citations (Scopus)

126 Downloads (Pure)

Investigating the Expression and Function of the Glucose Transporter GLUT6 in Obesity

Chen, S.-Y., Olzomer, E. M., Beretta, M., Cantley, J., Nunemaker, C. S., Hoehn, K. L. & Byrne, F. L. (Lead / Corresponding author), 29 Aug 2022, In: International Journal of Molecular Sciences. 23, 17, 11 p., 9798.

Research output: Contribution to journal › Article › peer-review

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2 Citations (Scopus)

81 Downloads (Pure)

2021

Bilirubin deficiency renders mice susceptible to hepatic steatosis in the absence of insulin resistance

Chen, W., Tumanov, S., Fazarkeley, D., Cantley, J., James, D. E., Dunn, L. L., Shaik, T., Suarna, C. & Stocker, R., Nov 2021, In: Redox Biology. 47, 13 p., 102152.

Research output: Contribution to journal › Article › peer-review

Open Access

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20 Citations (Scopus)

111 Downloads (Pure)

Hmox1 (Heme Oxygenase-1) Protects Against Ischemia-Mediated Injury via Stabilization of HIF-1α (Hypoxia-Inducible Factor-1α)

Dunn, L. L., Kong, S. M. Y., Tumanov, S., Chen, W., Cantley, J., Ayer, A., Maghzal, G. J., Midwinter, R. G., Chan, K. H., Ng, M. K. C. & Stocker, R. (Lead / Corresponding author), Jan 2021, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 41, 1, p. 317-330 14 p.

Research output: Contribution to journal › Article › peer-review

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69 Citations (Scopus)

332 Downloads (Pure)

Insights into Acetyl-Coa-Carboxylase (ACC1) Phospho-Regulation in Pancreatic Beta Cells

Bany Bakar, R., Liberatori, S., Veprik, A., Tebeka, N. N., Kemp, B. E., Mohammed, S. & Cantley, J., 1 Jun 2021, In: Diabetes. 70, Supplement 1, 1 p., 1256-P.

Research output: Contribution to journal › Conference article › peer-review

Open Access

Prolyl-4-hydroxylase 3 maintains β-cell glucose metabolism during fatty acid excess in mice

Nasteska, D., Cuozzo, F., Viloria, K., Johnson, E. M., Thakker, A., Bany Bakar, R., Westbrook, R. L., Barlow, J. P., Hoang, M., Joseph, J. W., Lavery, G. G., Akerman, I., Cantley, J., Hodson, L., Tennant, D. A. (Lead / Corresponding author) & Hodson, D. J. (Lead / Corresponding author), 23 Aug 2021, In: JCI Insight. 6, 16, 21 p., e140288.

Research output: Contribution to journal › Article › peer-review

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6 Citations (Scopus)

97 Downloads (Pure)

Proteomic profiling of glucose regulated ACC1 phospho-sites in pancreatic beta cells

Bany Bakar, R., Liberatori, S., Veprik, A., Tebeka, N. N., Morfin, V. A., Kemp, B. E., Mohammed, S. & Cantley, J., 28 Sept 2021.

Research output: Contribution to conference › Paper › peer-review

Targeted cue delivery system for gait regulation. Publication of PCT/patent application

Cantley, J. (Inventor) & Li, D. (Inventor), 29 Apr 2021, IPC No. PCT/GB2020/052665, WO2021079127A1, GB201915235A, Patent No. WO/2021/079127, 22 Oct 2020, Priority date 22 Oct 2019, Priority No. 1915235.4

Research output: Patent

The interferon-inducible protein viperin plays a role in beta cell survival

Tebeka, N. N. (Lead / Corresponding author), Gierlinkski, M., Bany Bakar, R., Veprik, A., Abbott, J. & Cantley, J., Apr 2021, In: Diabetic Medicine. 38, S1, p. 14 1 p., A29 (P69).

Research output: Contribution to journal › Conference article › peer-review

Open Access

The microvascular endothelial redoxome established through tandem mass tag mass spectrometry

Cottrill, S. B., Lermant, A., Cantley, J., Murdoch, C. E. & Sneddon, C., 14 Oct 2021, In: European Heart Journal. 42, Supplement 1, p. 3386 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

Open Access

2020

Continuous and non-invasive thermography of mouse skin accurately describes core body temperature patterns, but not absolute core temperature

van der Vinne, V. (Lead / Corresponding author), Pothecary, C. A., Wilcox, S. L., McKillop, L. E., Benson, L. A., Kolpakova, J., Tam, S. K. E., Krone, L. B., Fisk, A. S., Wilson, T. S., Yamagata, T., Cantley, J., Vyazovskiy, V. V. & Peirson, S. N., 26 Nov 2020, In: Scientific Reports. 10, 9 p., 20680.

Research output: Contribution to journal › Article › peer-review

Open Access

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18 Citations (Scopus)

84 Downloads (Pure)

Diabetes Causes Dysfunctional Dopamine Neurotransmission Favoring Nigrostriatal Degeneration in Mice

Pérez-Taboada, I., Alberquilla, S., Martín, E. D., Anand, R., Vietti-Michelina, S., Tebeka, N. N., Cantley, J., Cragg, S. J., Moratalla, R. & Vallejo, M. (Lead / Corresponding author), 1 Sept 2020, In: Movement Disorders. 35, 9, p. 1636-1648 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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51 Citations (Scopus)

167 Downloads (Pure)

2019

Abcc5 Knockout Mice Have Lower Fat Mass and Increased Levels of Circulating GLP-1

Cyranka, M., Veprik, A., McKay, E. J., van Loon, N., Thijsse, A., Cotter, L., Hare, N., Saibudeen, A., Lingam, S., Pires, E., Larraufie, P., Reimann, F., Gribble, F., Stewart, M., Bentley, E., Lear, P., McCullagh, J., Cantley, J., Cox, R. D. & de Wet, H., Aug 2019, In: Obesity. 27, 8, p. 1292-1304 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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13 Citations (Scopus)

118 Downloads (Pure)

Acetyl-CoA-Carboxylase 1 (ACC1) plays a critical role in glucagon and GLP1 secretion and controls whole body glucose homeostasis: Session: The endocrine role of the gut: incretins and other hormones

Veprik, A., Bakar, R. B., Vetterli, L., Ramracheya, R., Rorsman, P., Gribble, F. M., Reimann, F., de Wet, H. & Cantley, J., 19 Sept 2019, p. Abstract # 473.

Research output: Contribution to conference › Abstract › peer-review

Acetyl-CoA-Carboxylase 1 (ACC1) plays a critical role in glucagon and glucagon-like peptide 1 (GLP-1) secretion and controls whole-body glucose homeostasis

Veprik, A. (Lead / Corresponding author), Vetterli, L., Bany Bakar, R., Ramracheya, R., Rorsman, P., Gribble, F., Reimann, F., de-Wet, H. & Cantley, J., Mar 2019, In: Diabetic Medicine. 36, S1, p. 16-17 2 p., A33.

Research output: Contribution to journal › Conference article › peer-review

Correction: Q&A: insulin secretion and type 2 diabetes: Why do β-cells fail? (BMC Biology (2015) 13 (33) DOI: 10.1186/s12915-015-0140-6)

Cantley, J. & Ashcroft, F. M., 9 Apr 2019, In: BMC Biology. 17, 1, 32.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

4 Citations (Scopus)

Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass

Cantley, J., Davenport, A., Vetterli, L., Nemes, N. J., Whitworth, P. T., Boslem, E., Thai, L. M., Mellett, N., Meikle, P. J., Hoehn, K. L., James, D. E. & Biden, T. J., Jan 2019, In: Diabetologia. 62, 1, p. 99-111 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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29 Citations (Scopus)

96 Downloads (Pure)

Prolyl-hydroxylase 3 maintains [beta]-cell glucose-sensing under metabolic stress

Cuozzo, F., Nasteska, D., Thakker, A., Westbrook, R., Bakar, R., Cantley, J., Tennant, D. & Hodson, D., Nov 2019, In: Endocrine Abstracts. 65, p. 217 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

Open Access

Prolyl-hydroxylase 3 maintains β-cell glucose-sensing under metabolic stress

Cuozzo, F., Nasteska, D., Thakker, A., Westbrook, R., Bany Bakar, R., Cantley, J., Tennant, D. & Hodson, D. J., Nov 2019, In: Endocrine Abstracts. 65, OC1.5.

Research output: Contribution to journal › Conference article › peer-review

Open Access

2018

High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice

Burchfield, J. G., Kebede, M. A., Meoli, C. C., Stöckli, J., Whitworth, P. T., Wright, A. L., Hoffman, N. J., Minard, A. Y., Ma, X., Krycer, J. R., Nelson, M. E., Tan, S. X., Yau, B., Thomas, K. C., Wee, N. K. Y., Khor, E. C., Enriquez, R. F., Vissel, B., Biden, T. J. & Baldock, P. A. & 5 others, Hoehn, K. L., Cantley, J., Cooney, G. J., James, D. E. & Fazakerley, D. J., 13 Apr 2018, In: Journal of Biological Chemistry. 293, 15, p. 5731-5745 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

64 Citations (Scopus)

2017

Inhibition of Y1 receptor signaling improves islet transplant outcome

Loh, K., Shi, Y. C., Walters, S., Bensellam, M., Lee, K., Dezaki, K., Nakata, M., Ip, C. K., Chan, J. Y., Gurzov, E. N., Thomas, H. E., Waibel, M., Cantley, J., Kay, T. W., Yada, T., Laybutt, D. R., Grey, S. T. (Lead / Corresponding author) & Herzog, H. (Lead / Corresponding author), 1 Dec 2017, In: Nature Communications. 8, 1, 12 p., 490.

Research output: Contribution to journal › Article › peer-review

Open Access

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22 Citations (Scopus)

72 Downloads (Pure)

The radical-SAM enzyme Viperin catalyzes reductive addition of a 5′-deoxyadenosyl radical to UDP-glucose in vitro

Honarmand Ebrahimi, K., Carr, S. B., McCullagh, J., Wickens, J., Rees, N. H., Cantley, J. & Armstrong, F. A., Aug 2017, In: FEBS Letters. 591, 16, p. 2394-2405 12 p.

Research output: Contribution to journal › Letter › peer-review

28 Citations (Scopus)

2015

Circulating AFABP promotes insulin secretion

Wu, L. E., Fazakerley, D. J. & Cantley, J., Aug 2015, In: Obesity. 23, 8, 1 p.

Research output: Contribution to journal › Letter › peer-review

Nuclear factor κB-inducing kinase activation as a mechanism of pancreatic β cell failure in obesity

Malle, E. K., Zammit, N. W., Walters, S. N., Koay, Y. C., Wu, J., Tan, B. M., Villanueva, J. E., Brink, R., Loudovaris, T., Cantley, J., McAlpine, S. R., Hesselson, D. & Grey, S. T., 29 Jun 2015, In: Journal of Experimental Medicine. 212, 8, p. 1239-1254 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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53 Citations (Scopus)

83 Downloads (Pure)

Pancreatic PYY Is Critical in the Control of Insulin Secretion and Glucose Homeostasis in Female Mice

Shi, Y. C., Loh, K., Bensellam, M., Lee, K., Zhai, L., Lau, J., Cantley, J., Luzuriaga, J., Laybutt, D. R. & Herzog, H., 1 Sept 2015, In: Endocrinology. 156, 9, p. 3122-3136 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

40 Citations (Scopus)

Q&A: Insulin secretion and type 2 diabetes: Why do β-cells fail?

Cantley, J. & Ashcroft, F. M., 12 Dec 2015, In: BMC Biology. 13, 1, 33.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

111 Citations (Scopus)

The Human Diabetes Proteome Project (HDPP): The 2014 update

Schvartz, D., Bergsten, P., Baek, K. H., De La Rosa, A. B., Cantley, J., Dayon, L., Finamore, F., Fontana, P., Gaudet, P., Goo, Y. A., Moulder, R., Goodlett, D., Johnson, J. D., Konvalinka, A., Mulderm, H., Priego-Capote, F., Sechi, S., Snyder, M., Tiss, A. & Wiederkehr, A. & 3 others, Xenarios, I., Kussmann, M. & Sanchez, J.-C., 1 Dec 2015, In: Translational Proteomics. 8-9, p. 1-7 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Citations (Scopus)

2014

Doc2 isoforms play dual roles in insulin secretion and insulin-stimulated glucose uptake

Li, J., Cantley, J., Burchfield, J. G., Meoli, C. C., Stöckli, J., Whitworth, P. T., Pant, H., Chaudhuri, R., Groffen, A. J. A., Verhage, M. & James, D. E., 9 Jul 2014, In: Diabetologia. 57, 10, p. 2173-2182 10 p.

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Identification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity

Wu, L. E., Samocha-Bonet, D., Whitworth, P. T., Fazakerley, D. J., Turner, N., Biden, T. J., James, D. E. & Cantley, J., Jul 2014, In: Molecular Metabolism. 3, 4, p. 465-473 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

97 Citations (Scopus)

Lysosomal acid lipase and lipophagy are constitutive negative regulators of glucose-stimulated insulin secretion from pancreatic beta cells

Pearson, G. L., Mellett, N., Chu, K. Y., Cantley, J., Davenport, A., Bourbon, P., Cosner, C. C., Helquist, P., Meikle, P. J. & Biden, T. J., Jan 2014, In: Diabetologia. 57, 1, p. 129-139 11 p.

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

The control of insulin secretion by adipokines: current evidence for adipocyte-beta cell endocrine signalling in metabolic homeostasis

Cantley, J., 1 Oct 2014, In: Mammalian Genome. 25, 9-10, p. 442-454 13 p.

Research output: Contribution to journal › Review article › peer-review

49 Citations (Scopus)

The non-canonical NF kappa B pathway as a novel player in beta cell dysfunction in diabetes

Malle, E. K., Tan, B. M., Walters, S. N., Zammit, N. W., Brink, R., Cantley, J. & Grey, S. T., 1 Sept 2014, In: Diabetologia. 57, 1, p. S48

Research output: Contribution to journal › Meeting abstract › peer-review

The non-canonical NFκB pathway as a novel player in beta cell dysfunction in diabetes

Malle, E. K. (Lead / Corresponding author), Tan, B. M., Walters, S. N., Zammit, N. W., Brink, R., Cantley, J. & Grey, S. T., Sept 2014, In: Diabetologia. 57, Supplement 1, p. S48 1 p., 98.

Research output: Contribution to journal › Conference article › peer-review

2 Citations (Scopus)

2013

Acetyl-CoA carboxylase 1 is a critical regulator of beta cell mass

Cantley, J., Whitworth, P. T., Davenport, A., Hoehn, K. L., James, D. E. & Biden, T. J., 2013, p. Abstract # 165. 1 p.

Research output: Contribution to conference › Abstract › peer-review

Acetyl-CoA carboxylase-1 is a critical regulator of beta cell size and proliferation

Cantley, J. (Lead / Corresponding author), Whitworth, P. T., Davenport, A., Hoehn, K. L., James, D. E. & Biden, T. J., Mar 2013, In: Diabetic Medicine. 30, S1, p. 8 1 p., A23 (P11).

Research output: Contribution to journal › Conference article › peer-review

Acetyl-CoA carboxylase-1 is a critical regulator of beta cell size and proliferation

Cantley, J. (Lead / Corresponding author), Whitworth, T., Davenport, A., Hoehn, K., James, D. E. & Biden, T., 1 Mar 2013, p. 33. 1 p.

Research output: Contribution to conference › Poster › peer-review

Alteration of endoplasmic reticulum lipid rafts contributes to lipotoxicity in pancreatic β-cells

Boslem, E., Weir, J. M., MacIntosh, G., Sue, N., Cantley, J., Meikle, P. J. & Biden, T. J., 13 Sept 2013, In: Journal of Biological Chemistry. 288, 37, p. 26569-26582 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

109 Citations (Scopus)

A preexistent hypoxic gene signature predicts impaired islet graft function and glucose homeostasis

Cantley, J., Walters, S. N., Jung, M. H., Weinberg, A., Cowley, M. J., Whitworth, T. P., Kaplan, W., Hawthorne, W. J., O'Connell, P. J., Weir, G. & Grey, S. T., 1 Nov 2013, In: Cell Transplantation. 22, 11, p. 2147-2159 13 p.

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Glucose Homeostasis in Mice Is Transglutaminase 2 Independent

Iismaa, S. E., Aplin, M., Holman, S., Yiu, T. W., Jackson, K., Burchfield, J. G., Mitchell, C. J., O'Reilly, L., Davenport, A., Cantley, J., Schmitz-Peiffer, C., Biden, T. J., Cooney, G. J. & Graham, R. M., 22 May 2013, In: PLoS ONE. 8, 5, e63346.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Citations (Scopus)

Cantley, James

Research output

Search results